Phenytoin and Cyclosporine A Specifically Regulate Macrophage Phenotype and Expression of Platelet-Derived Growth Factor and Interleukin-1 in Vitro and in Vivo: Possible Molecular Mechanism of Drug-Induced Gingival Hyperplasia

Journal of Periodontology

Volumn 68, Issue 1, 1997, Pages 73-83

  Iacopino, Anthony M ^a   Doxey, Deborah ^a   Cutler, Christopher W ^a   Nares, Salvador ^a   Stoever, Kim ^a   Fojt, James ^a   Gonzales, Andrea ^a   Dill, Russell E ^a  

^a BAYLOR COLLEGE OF DENTISTRY   (United States)

Author keywords

Cyclosporine A adverse effects; Gene expression; Gingival hyperplasia etiology; Growth factor, platelet derived; Interleukin 1; Macrophages; Phenytoin adverse effects

Indexed keywords

CYCLOSPORIN A; INTERLEUKIN 1; INTERLEUKIN 1BETA; MESSENGER RNA; PHENYTOIN; PLATELET DERIVED GROWTH FACTOR; ANTICONVULSIVE AGENT; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GINGIVA HYPERPLASIA; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; NONHUMAN; PHENOTYPE; RAT; ADULT; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOLOGY; IMMUNOPHENOTYPING; METABOLISM; MIDDLE AGED;

ADULT; ANIMALS; ANTICONVULSANTS; CELLS, CULTURED; CYCLOSPORINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; GINGIVAL HYPERPLASIA; HUMANS; IMMUNOPHENOTYPING; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-1; MACROPHAGES; MIDDLE AGED; PHENYTOIN; PLATELET-DERIVED GROWTH FACTOR; RATS; RNA, MESSENGER;

EID: 0030614422     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.1997.68.1.73     Document Type: Article

References (63)

1. Stinnett E, Rodu B, Grizzle WE. New developments in understanding phenytoin-induced gingival hyperplasia. J Am Dent Assoc 1987;114:814-817.
2. Hassell TM. Epilepsy and the Oral Manifestations of Phenytoin Therapy. New York: S. Karger; 1981;93-107.
3. Hassell TM, Hefti AF. Drug-induced gingival overgrowth: old problem, new problem. Crit Rev Oral Biol Med 1991;2:103-137.
4. Johnson JP. Aquired craniofacial features associated with chronic phenytoin therapy. Clin Pediatr 1984;23:671-674.
5. Angelopoulos AP, Goaz PW. Incidence of diphenylhydantoin gingival hyperplasia. Oral Surg Oral Med Oral Pathol 1972;34:898-906.
6. Hall BK, Squire CA. Ultrastructural quantitation of connective tissue changes in phenytoin-induced gingival overgrowth in the ferret. J Dent Res 1982;61:942-952.
7. Modeer T, Dahllof G, Otteskog P. Potentiation of fibroblast DNA synthesis by a phenytoin-induced mononuclear cell derived factor. Scand J Dent Res 1989;97:186-190.
8. Hassell TM, O'Donnell J, Pearlman J, Tesini D, Murphy T, Best H. Phenytoin-induced gingival overgrowth in institutionalized epileptics. J Clin Periodontol 1984;11:242-253.
9. Hassell TM, Roebuck S, Page RC, Wray SH. Quantitative histopathologic assessment of developing phenytoin-induced gingival overgrowth in the cat. J Clin Periodontol 1982;9:365-372.
10. Nuki K, Cooper SH. The role of inflammation in the pathogenesis of gingival enlargement during the administration of diphenylhydantoin sodium in cats. J Periodont Res 1972;7:102-110.
11. Proceedings of the Second International Congress on Cyclosporine. Washington DC, Philadelphia: Grune and Stratton; 1988;1-25.
12. Pisanty S, Shoshan S, Chajek T, Maftsir G, Sacks B, BenEzra D. The effect of cyclosporine A treatment on gingival tissue of patients with Behcet's disease. J Periodontol 1988;59:599-603.
13. Seymour RA, Heasman PA. Drugs and the periodontium. J Clin Periodontol 1988;15:1-16.
14. Stone C, Eshenaur A, Hassell T. Gingival enlargements in cyclosporine-treated multiple sclerosis patients. J Dent Res 1989;68:285-289.
15. Palestine AG, Nussenblatt RB, Chan CC. Side effects of systemic cyclosporine in patients not undergoing transplantation. Am J Med 1984;77:652-656.
16. Ross R, Raines EW, Bowen-Pope DE The biology of platelet-derived growth factor. Cell 1986;4:155-169.
17. Martin P, Hopkins-Woolley J, McCluskey J. Growth factors and cutaneous wound repair. Prog Growth Factor Res 1992;4:25-44.
18. Cohen IK, Diegelmann RF, Lindblad WJ. Wound Healing: Biochemical and Clinical Aspects. Philadelphia: WB Saunders, 1992:55-72.
19. Kiristy CP, Lynch SE. Role of growth factors in cutaneous healing: a review. Crit Rev Oral Biol Med 1993;4:729-760.
20. Raines EW, Dower SK, Ross R. Mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF. Science 1990;243:393-396.
21. Pierce GF, Rudolph R, Tarpley J, Mustoe TA. Platelet-derived growth factor-BB and transforming growth factor beta 1 selectively modulate glycosaminoglycans, collagen, and fibroblasts. Am J Pathol 1991;138:629-646.
22. Hosgood G. Wound healing: the role of platelet-derived growth factor and transforming growth factor beta. Vet Surg 1993;22:490-495.
23. Page RC. The role of inflammatory mediators in the pathogenesis of periodontal disease. J Periodont Res 1991;26:230-242.
24. Seppa H, Grotendorst G, Seppa S, Schiffmann E, Martin GR. Platelet-derived growth factor is chemotactic for fibroblasts. J Cell Biol 1982;92:584-588.
25. Shimokado, K, Raines EW, Madtes DK, Barrett TB, Benditt EP, Ross R. Significant part of macrophage-derived growth factor consists of two forms of PDGF. Cell 1985;43:277-286.
26. DiCorleto PE, Bowen-Pope DF. Cultured endothelial cells produce a platelet-/derived growth factor-like protein. Proc Natl Acad Sci (USA) 1983;80:1919-1923.
27. Nilsson JM, Sjolund L, Palmberg J, Thyberg C, Heldin CH. Arterial smooth muscle cells produce a platelet-derived growth factor-like protein. Proc Natl Acad Sci (USA) 1985;82:4418-4422.
28. Grotendorst GR, Martin GM, Pencev D, Sodek J, Harvey AK. Stimulation of granulation tissue formation by platelet-derived growth factor. J Clin Invest 1985;76:2323-2329.
29. Deuel TF, Kawahara RS, Mustoe TA, Pierce GF. Growth factors and wound healing: platelet-derived growth factor as a model cytokine. Ann Rev Med 1991;42:567-584.
30. Jobling SA, Auron PE, Rosenasser LJ, Gehrke L. Biological activity and receptor binding of human interleukin-1β. J Biol Chem 1988;263:16372-16377.
31. Butler LD, Layman NK, Sharp J, Bedate AM. Interleukin-1 induced pathophysiology. Clin Immunol Immunopathol 1989;53:400-406.
32. Dinarello CA. Interleukin-1 and interleukin-1 antagonism. Blood 1991;8:1627-1652.
33. Stashenko P, Obernesser MS, Prostak L, Haffajee AD, Socransky SS. Levels of interleukin-1β in tissue sites of active periodontal disease. J Clin Periodontol 1991;18:548-554.
34. 2, and tumor necrosis factor in experimental gingivitis in humans. J Periodont Res 1993;28:241-247.
35. Offenbacher S, Collins JG, Heasman PA. Diagnostic potential of host response mediators. Adv Dent Res 1993;7:175-181.
36. Clark RAF, Henson PM. The Molecular and Cellular Biology of Wound Repair. New York: Plenum Press; 1988:1-36.
37. Andreesen R, Brugger W, Scheinenbogen C. Surface phenotype analysis of human monocyte to macrophage differentiation. J Leuk Biol 1990;47:490-497.
38. Messadi DV, Bertolami CN. General principles of healing pertinent to the periodontal problem. Dent Clin North Am 1991;35:443-457.
39. Kreutz M, Krause SW, Rehm A. Macrophage heterogeneity and differentiation. Res Immunol 1992;143:107-115.
40. Wikesjö UME, Nilveus RE, Selvig KA. Significance of early healing events on periodontal repair: a review. J Periodontol 1992;63:158-165.
41. Sunderkotter C, Bhardwaj R, Sorg C. Macrophages and angiogenesis. J Leuk Biol 1994;55:410-422.
42. Prieto J, Eklund A, Patarroyo M. Regulated expression of integrins and other adhesion molecules during differentiation of monocytes into macrophages. Cell Immunol 1994;156:191-211.
43. Van XQ, Brady G, Iscove NN. Platelet-derived growth factor (PDGF) activates precursors in PDGF receptor-expressing macrophages. J Immunol 1993;150:2440-2448.
44. Rueterdahl C, Funa K, Gerdin B. Localization of receptors for platelet-derived growth factor B chain during wound repair in humans. J Clin Invest 1993;91:2065-2075.
45. Noble PW, Henson PM, Carre PC. Transforming growth factor beta primes macrophages to express gene products in response to stimuli by an autocrine/paracrine mechanism. J Immunol 1993;151:979-989.
46. Inaba T, Shimano H, Watanabe Y. Expression of platelet-derived growth factor receptor on human monocyte-derived macrophages and effects of platelet-derived growth factor-BB dimer on cellular functions. J Biol Chem 1993;268:24353-24360.
47. Zwadlo G, Brocker EB, Ulrich F, Sorg C. A monoclonal antibody to a differentiation antigen present on mature human macrophages and absent from monocytes. J Immunol 1985;134:1487-1492.
48. Zwaldo G, Schlegel R, Sorg C. A monoclonal antibody to a subset of human monocytes found in the peripheral blood and inflammatory tissues. J Immunol 1986;137:512-518.
49. Zwaldo G, Voegeli R, Osthoff KS, Sorg C. A monoclonal antibody to a novel differentiation antigen on human macrophages associated with the down-regulatory phase of the inflammatory process. Exp Cell Biol 1987;55:295-304.
50. Sorg C. Macrophages in acute and chronic inflammation. Chest 1991;100:173S-175S.
51. Topoll HH, Zwaldo G, Lange DE. Phenotypic dynamics of macrophage subpopulations during human experimental gingivitis. J Periodont Res 1989;24:106-112.
52. Kunz M, Roth J, Sorg C. Epidermal expression of the calcium binding surface antigen 27E10 in inflammatory skin diseases. Arch Dermatol Res 1992;284:386-390.
53. Striz I, Wang WM, Svarcova I. The phenotype of alveolar macrophages and its correlation with immune cells in bronchoalveolar lavage. Eur Resp J 1993;6:1287-1294.
54. Dill RE, Miller EK, Weil T, Lesley S, Farmer GR, Iacopino AM. Phenytoin increases gene expression for platelet-derived growth factor B chain in macrophages and monocytes. J Periodontol 1993;64: 169-173.
55. Nares S, Ng MC, Dill RE, Cutler CW, Iacopino AM. Cyclosporine A upregulates platelet-derived growth factor B chain in hyperplastic human gingiva. J Periodontol 1996;67:271-278.
56. Sambrooke J, Fritsch EF and Maniatis T. Molecular Cloning: A Laboratory Manual. New York: Cold Spring Harbor Laboratory Press; 1989:401-409.
57. Williamson MS, Miller EK, Plemmons J, Rees T, Iacopino AM. Cyclosporine A upregulates interleukin-6 gene expression in human gingiva: possible mechanism for gingival overgrowth. J Periodontol 1994;65:895-903.
58. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate/phenol-chloroform extraction. Anal Biochem 1987;62:156-159.
59. Plemons JM, Dill RE, Rees TD, Ng MC, Iacopino AM. PDGF-B producing cells and PDGF-B gene expression in normal gingiva and cyclosporine A induced gingival overgrowth. J Periodontol 1996;67:264-270.
60. Genco RJ, Goldman HM, Cohen DW. Contemporary Periodontics. St. Louis: Mosby; 1990:5-22.
61. Carranza FA. Glickman's Clinical Periodontology. Philadelphia: WB Saunders; 1990:3-18.
62. Iacopino AM. Diabetic periodontitis: possible lipid-induced defect in tissue repair. Oral Diseases 1995;1:214-229.
63. Doxey DL, Dill RE, Iacopino AM. Platelet-derived growth factor levels in wounds of diabetic rats. Life Sci 1995;57:1111-1123.