Extracellular calcium-sensing receptor/PTH knockout mice colons have increased Wnt/β-catenin signaling, reduced non-canonical Wnt signaling, and increased susceptibility to azoxymethane-induced aberrant crypt foci

Laboratory Investigation

Volumn 93, Issue 5, 2013, Pages 520-527

  MacLeod, R John ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

ACF; AOM; calcium chemoprevention; CaSR; MMP 7; Wnt3a; Wnt5a and Ror2

Indexed keywords

AZOXYMETHANE; BETA CATENIN; CALCIUM SENSING RECEPTOR; MATRILYSIN; MYELOPEROXIDASE; PARATHYROID HORMONE; PROTEIN; PROTEIN ROR2; SODIUM CHLORIDE; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3A PROTEIN; WNT5A PROTEIN;

ABERRANT CRYPT FOCUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON CANCER; COLON MUCOSA; CONTROLLED STUDY; EXTRACELLULAR CALCIUM; INFLAMMATION; KNOCKOUT MOUSE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMALL INTESTINE;

ABERRANT CRYPT FOCI; ANIMALS; AZOXYMETHANE; BETA CATENIN; BLOTTING, WESTERN; COLON; CYCLIN D1; GENETIC PREDISPOSITION TO DISEASE; INTESTINE, SMALL; MATRIX METALLOPROTEINASE 7; MICE; MICE, KNOCKOUT; PARATHYROID HORMONE; PEROXIDASE; RECEPTOR TYROSINE KINASE-LIKE ORPHAN RECEPTORS; RECEPTORS, CALCIUM-SENSING; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; WNT PROTEINS; WNT3A PROTEIN;

EID: 84877280375     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2013.51     Document Type: Article

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