Regulation of villin by Wnt5a/Ror2 signaling in human intestinal cells

Frontiers in Physiology

Volumn 2 SEP, Issue , 2011, Pages

  Cheung, Rebecca ^a,b   Kelly, Jacqueline ^a,b   Macleod, R John ^a,b  

^a QUEEN S UNIVERSITY   (Canada)

^b KINGSTON GENERAL HOSPITAL   (Canada)

Author keywords

Extracellular calcium sensing receptor; Ror2; Villin; Wnt signaling

Indexed keywords

EID: 84866161290     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2011.00058     Document Type: Article

References (35)

1. Abdullah, H. I., Pedraza, P. L., McGiff, J. C., and Ferreri, N. R. (2008). CaR activation increases TNF production by mTAL cells via a Gidependent mechanism. Am. J. Physiol. Renal Physiol. 294, F345-F354.
2. Akbarzadeh, S., Wheldon, L. M., Sweet, S. M., Talma, S., Mardakheh, F. K., and Heath, J. K. (2008). The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src. PLoS ONE 3, e1873. doi: 10.1371/journal.pone.0001873
3. Alessi, D. R., Cuenda, A., Ohen, P., Udley, D. T., and Altiel, A. R. (1995). PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270, 27489-27494.
4. Aliaga, J. C., Deschenes, C., Beaulieu, J. F., Calvo, E. L., and Rivard, N. (1999). Requirement of the MAP kinase cascade for cell cycle progression and differentiation of human intestinal cells. Am. J. Physiol. 277, G631-G641.
5. Billiard, J., Way, D. S., Seestaller-Wehr, L. M., Moran, R. A., Mangine, A., and Bodine, P. V. (2005). The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells. Mol. Endocrinol. 19, 90-101.
6. Bryja, V., Schulte, G., Rawal, N., Grahn, A., and Arenas, E. (2007). Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. J. Cell Sci. 120(Pt 4), 586-595.
7. Clerk, A., Michael, A., and Sugden, P. H. (1998). Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes. Biochem. J. 333(Pt 3), 581-589.
8. Coluccio, L. M., and Bretscher, A. (1989). Reassociation of microvillar core proteins: making a microvillar core in vitro. J. Cell Biol. 108, 495-502.
9. Costa De Beauregard, M. A., Pringault, E., Robine, S., and Louvard, D. (1995). Suppression of villin expression by antisense RNA impairs brush border assembly in polarized epithelial intestinal cells. EMBO J. 14, 409-421.
10. Dudouet, B., Robine, S., Huet, C., Sahuquillo-Merino, C., Blair, L., Coudrier, E., and Louvard, D. (1987). Changes in villin synthesis and subcellular distribution during intestinal differentiation of HT29-18 clones. J. Cell Biol. 105, 359-369.
11. George,S. P.,Wang,Y., Mathew, S., Srinivasan, K., and Khurana, S. (2007). Dimerization and actin-bundling properties of villin and its role in the assembly of epithelial cell brush borders. J. Biol. Chem. 282, 26528-26541.
12. Houde, M., Laprise, P., Jean, D., Blais, M., Asselin, C., and Rivard, N. (2001). Intestinal epithelial cell differentiation involves activation of p38 mitogen-activated protein kinase that regulates the homeobox transcription factor CDX2. J. Biol. Chem. 276, 21885-21894.
13. Kani, S., Oishi, I., Yamamoto, H., Yoda, A., Suzuki, H., Nomachi, A., Iozumi, K., Nishita, M., Kikuchi, A., Takumi, T., and Minami, Y. (2004). The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon. J. Biol. Chem. 279, 50102-50109.
14. Khurana, S., and George, S. P. (2008). Regulation of cell structure and function by actin-binding proteins: villin's perspective. FEBS Lett. 582, 2128-2139.
15. Li, C., Chen, H., Hu, L., Xing, Y., Sasaki, T., Villosis, M. F., Li, J., Nishita, M., Minami, Y., and Minoo, P. (2008). Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol. Biol. 9, 11. doi: 10.1186/1471-2199-9-11
16. Liu, Y., Rubin, B., Bodine, P. V., and Billiard, J. (2008). Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase. J. Cell. Biochem. 105, 497-502.
17. MacLeod, R. J., Hayes, M., and Pacheco, I. (2007). Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G403-G411.
18. Mallo, G. V., Rechreche, H., Frigerio, J. M., Rocha, D., Zweibaum, A., Lacasa, M., Jordan, B. R., Dusetti, N. J., Dagorn, J. C., and Iovanna, J. L. (1997). Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int. J. Cancer 74, 35-44.
19. Mathew, S., George, S. P., Wang, Y., Siddiqui, M. R., Srinivasan, K., Tan, L., and Khurana, S. (2008). Potential molecular mechanism for c-Src kinase-mediated regulation of intestinal cell migration. J. Biol. Chem. 283, 22709-22722.
20. Maunoury, R., Robine, S., Pringault, E., Leonard, N., Gaillard, J. A., and Louvard, D. (1992). Developmental regulation of villin gene expression in the epithelial cell lineages of mouse digestive and urogenital tracts. Development 115, 717-728.
21. Mikels, A. J., and Nusse, R. (2006). Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol. 4, e115. doi: 10.1371/journal.pbio.0040115
22. Pacheco, I. I., and MacLeod, R. J. (2008). Extracellular calcium-sensing receptor (CaSR) stimulates secretion of Wnt5a from colonic myofibroblasts to stimulate CDX2 and sucrase isomaltase using Ror2 on intestinal epithelia. Am. J. Physiol. Gastrointest. Liver Physiol. 295, G748-G759.
23. Pinson, K. I., Dunbar, L., Samuelson, L., and Gumucio, D. L. (1998). Targeted disruption of the mouse villin gene does not impair the morphogenesis of microvilli. Dev. Dyn. 211, 109-121.
24. Pinto, M., Robine-Leon, S., Appay, M. D., Triadou, N., Dussaulx, E., Lacroix, B., Simon-Assmann, P., Haffen, K., Fogh, J., and Zweibaum, A. (1983). Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture. Biol. Cell 47, 323-330.
25. Rena, G., Bain, J., Elliott, M., and Cohen, P. (2004). D4476, a cell-permanent inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 5, 60-65.
26. Rieder, G., Tessier, A. J., Qiao, X. T., Madison, B., Gumucio, D. L., Merchant, J. L. (2005). Helicobacter-induced intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin. J. Biol. Chem. 280, 4906-4912.
27. Toullec, D.,Pianetti,P., Coste, H.,Bellevergue, P., Grand-Perret, T., Ajakane, M., Baudet, V., Boissin, P., Boursier, E., and Loriolle, F. (1991). The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266, 15771-15781.
28. Tu,Y., and Perdue,M.H. (2006). CD23-mediated transport of IgE/immune complexes across human intestinal epithelium: role of p38 MAPK. Am. J. Physiol. Gastrointest. Liver Physiol. 291, G532-G538.
29. Umar, S., Wang, Y., Morris, A. P., and Sellin, J. H. (2007). Dual alterations in casein kinase I-epsilon and GSK-3beta modulate betacatenin stability in hyperproliferating colonic epithelia. Am. J. Physiol. Gastrointest. Liver Physiol. 292, G599-G607.
30. Vachon, P. H., and Beaulieu, J. F. (1992). Transient mosaic patterns of morphological and functional differentiation in the Caco-2 cell line. Gastroenterology 103, 414-423.
31. Vayro, S., and Silverman, M. (1999). PKC regulates turnover rate of rabbit intestinal Na+-glucose transporter expressed in COS-7 cells. Am. J. Physiol. 276(Pt 1), C1053-C1060.
32. Yamamichi, N., Inada, K., Furukawa, C., Sakurai, K., Tando, T., Ishizaka, A., Haraguchi, T., Mizutani, T., Fujishiro, M., Shimomura, R., Oka, M., Ichinose, M., Tsutsumi, Y., Omata, M., and Iba, H. (2009). Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells. Exp. Cell Res. 315, 1779-1789.
33. Yamamoto, S., Nishimura, O., Misaki, K., Nishita, M., Minami, Y., Yonemura, S., Tarui, H., and Sasaki, H. (2008). Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev. Cell 15, 23-36.
34. Yamanaka, H., Moriguchi, T., Masuyama, N., Kusakabe, M., Hanafusa, H., Takada, R., Takada, S., and Nishida, E. (2002). JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep. 3, 69-75.
35. Zhou, Y., Wang, Q., Evers, B. M., and Chung, D. H. (2005). Signal transduction pathways involved in oxidative stress-induced intestinal epithelial cell apoptosis. Pediatr. Res. 58, 1192-1197.