Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (min) mice and human familial adenomatous polyposis patients

Cancer Research

Volumn 57, Issue 1, 1997, Pages 169-175

  Zhang, Tong ^a   Nanney, Lillian B ^a   Luongo, Cindy ^b   Lamps, Laura ^a   Heppner, Kathleen J ^a   Dubois, Raymond N ^a   Beauchamp, R Daniel ^a,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CYCLIN D1; CYCLIN DEPENDENT KINASE;

ADENOMA; ADENOMATOUS POLYP; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DYSPLASIA; FAMILIAL CANCER; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; INTESTINE CRYPT; INTESTINE EPITHELIUM; INTESTINE TUMOR; MALE; MOUSE; MULTIPLE CANCER; NONHUMAN; PRIORITY JOURNAL;

ADENOMATOUS POLYPOSIS COLI; ANIMALS; CELL DIVISION; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; CYCLINS; HUMANS; INTESTINAL NEOPLASMS; MICE; MICE, INBRED AKR; NEOPLASM PROTEINS; NEOPLASMS, EXPERIMENTAL; NEOPLASMS, MULTIPLE PRIMARY; ONCOGENE PROTEINS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENE PROTEINS;

EID: 0031028265     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Townsend, C. M., Jr., and Beauchamp, R. D. New developments in colorectal cancer. Curr. Opin. Gastroenterol., 11: 36-42, 1995
2. Nishisho, I., Nakamura, Y., Miyoshi, Y., Miki, Y., Ando, H., Horii, A., Koyama, K., Utsunomiya, J., Baba, S., and Hedge, P. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science (Washington DC), 253: 665-669, 1991.
3. Powell, S. M., Zilz, N., Beazer-Barclay, Y., Bryan, T. M., Hamilton, S. R., Thibodeau, S. N., Vogelstein, B., and Kinzler, K. W. APC mutations occur early during colorectal tumorigenesis. Nature (Lond.), 359: 235-237, 1992.
4. Miyoshi, Y., Nagase, H., Ando, H., Horii, A., Ichii, S., Nakatsuru, S., Aoki, T., Miki, Y., Mon, T., and Nakamura, Y. Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum. Mol. Genet., 1: 229-233, 1992.
5. Taso, J., and Shibata, D. Further evidence that one of the earliest alterations in colorectal carcinogenesis involves APC. Am. J. Pathol., 145: 531-534, 1994.
6. Su, L. K., Kinzler, K. W., Vogelstein, B., Preisenger, A. C., Moser, A. R., Luongo, C., Gould, K. A., and Dove, W. F. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science (Washington DC), 256: 668-670, 1992.
7. Hunter, T., and Pines, J. Cyclins and cancer. Cell, 66: 1071-1074, 1991.
8. Hartwell, L. H., and Kastan, M. B. Cell cycle control and cancer. Science (Washington DC), 266: 1821-1828, 1994.
9. Hunter, T., and Pines, J. Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell, 79: 573-582, 1994.
10. Sherr, C. J. D-type cyclins. Trends Biochem. Sci., 20: 187-190, 1995.
11. Motokura, T., Bloom, T., Kim, H. G., Juppner, H., Ruderman, J. V., Kronenberg, H. M., and Arnold, A. A novel cyclin encoded by a bell-linked candidate oncogene. Nature (Lond.), 350: 512-515, 1991.
12. Lukas, J., Pagano, M., Staskova, Z., Draetta, G., and Bartek, J. Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene, 9: 707-718, 1994.
13. Gillett, C., Fantl, V., Smith, R., Fisher, C., Bartek, J., Dickson, C., Bames, D., and Peters, G. Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res., 54: 1812-1817, 1994.
14. Kanda, Y., Nishyama, Y., Shimada, Y., Imamura, M., Nomura, H., Hiai, H., and Fukumoto, M. Analysis of gene amplification and overexpression in human esophageal-carcinoma cell lines. Int. J. Cancer, 58: 291-297, 1994.
15. 1 regulation in human head and neck cancer. Cancer Res., 55: 949-956, 1995.
16. Ewen, M. E., Sluss, H. K., Sherr, C. J., Matsushime, H., Kato, J., and Livingston, D. M. Functional interactions of the retinoblastoma protein with D-type cyclins. Cell, 73: 487-497, 1993.
17. Kato, J., Matsushime, H., Hiebert, S. W., Ewen, M. E., and Sherr, C. J. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev., 7: 331-342, 1993.
18. INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines. Cancer Res., 55: 4833-4836, 1995.
19. Khatib, Z. A., Matsushime, H., Valentine, M., Shapiro, D. N., Sherr, C. J., and Look, A. T. Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. Cancer Res., 53: 5535-5541, 1993.
20. Sgambato, A., Han, E. K., Zhang, Y. J., Moon, R. C., Santella, R. M., and Weinstein, I. B. Deregulated expression of cyclin D1 and other cell cycle-related genes in carcinogen-induced rat mammary tumors. Carcinogenesis, 16: 2193-2198, 1995.
21. Jass, R., and Sobiu, L. H. WHO International Histological Classification of Tumors Vol. 15, pp. 29-30. Berlin: Springer-Verlag, 1989.
22. Chwalinski, S., Potten, C. S., and Evans, G. Double labelling with bromodeoxyuridine and [3H]thymidine of proliferative cells in small intestinal epithelium in steady state and after irradiation. Cell Tissue Kinet., 21: 317-329, 1988.
23. Lebwohl, D. E., Muise-Helmericks, R., Sepp-Lorenzino, L., Serve, S., Timaul, M., Bol, R., Borgen, P., and Rosen, N. A truncated cyclin D1 gene encodes a stable mRNA in a human breast cancer cell line. Oncogene, 9: 1925-1929, 1994.
24. Leach, F. S., Elledge, S. J., Sherr, C. J., Willson, J. K., Markowitz, S., Kinzler, K. W., and Vogelstein, B. Amplification of cyclin genes in colorectal carcinomas. Cancer Res., 53: 1986-1989, 1993.
25. Bartkova, J., Lukas, J., Strauss, M., and Bartek, J. The PRAD-1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas. Int. J. Cancer, 58: 568-573, 1994.
26. Bartkova, J., Lukas, J., Strauss, M., and Bartek, J. Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis. Oncogene, 10: 775-778, 1995.
27. Arber, N., Hibshoosh, H., Moss, S. F., Sutter, T., Zhang, Y., Begg, M., Wang, S., Weinstein, I. B., and Holt, P. R. Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis. Gastroenterology, 110: 669-674, 1996.
28. Jiang, W., Kahn, S. M., Zhou, P., Zhang, Y. J., Cacace, A. M., Infante, A. S., Doi, S., Santella, R. M., and Weinstein, I. B. Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression. Oncogene, 8: 3447-3457, 1993.
29. Wang, T. C., Cardiff, R. D., Zukerberg, L., Lees, E., Arnold, A., and Schmidt, E. V. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic. Nature (Lond.), 369: 669-671, 1994.
30. 1 phase in rodent fibroblasts. Genes Dev., 7: 1559-1571, 1993.
31. 1 to complete the cell cycle. Proc. Natl. Acad. Sci. USA, 91: 8022-8026, 1994.
32. 1-to-S transition. Mol. Cell. Biol., 15: 3463-3469, 1995.
33. 1. Genes Dev., 7: 812-821, 1993.
34. Zhou, P., Jiang, W., Weghorst, C. M., and Weinstein, I. B. Overexpression of cyclin D1 enhances gene amplification. Cancer Res., 56: 36-39, 1996.
35. Cip1. Ann. Surg., 223: 620-628, 1996.
36. INK4. Science (Washington DC), 267: 249-252, 1995.
37. Lukas, J., Parry, D., Aagaard, L., Mann, D. J., Bartkova, J., Strauss, M., Peters, G., and Bartek, J. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature (Lond.), 375: 503-506, 1995.
38. Koh, J., Enders, G. H., Dynlacht, B. D., and Harlow, E. Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature (Lond.), 375: 506-510, 1995.
39. INK4 in human cancer. Proc. Natl. Acad. Sci. USA, 91: 11045-11049, 1994.
40. Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., III, Johnson, B. E., and Skolnick, M. H. A cell cycle regulator potentially involved in genesis of many tumor types. Science (Washington DC), 264: 436-440, 1994.
41. Jen, J., Harper, J. W., Bigner, S. H., Bigner, D. D., Papadopoulos, N., Markowitz, S., Willson, J. K., Kinzler, K. W., and Vogelstein, B. Deletion of p16 and p15 genes in brain tumors. Cancer Res., 54: 6353-6358, 1994.
42. INK4B/ MTS2, and p18 genes in primary and metastatic lung cancer. Cancer Res., 55: 1448-1451, 1995.
43. Oshima, M., Oshima, H., Kitagawa, K., Kobayashi, M., Itakura, C., and Taketo, M. Loss of Ape heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc. Natl. Acad. Sci. USA, 92: 4482-4486, 1995.