Alleviation of CCl4-induced cirrhosis in rats by tetramethylpyrazine is associated with downregulation of leptin and TGF-β1 pathway

Drug and Chemical Toxicology

Volumn 33, Issue 3, 2010, Pages 310-315

  Lu, Bin ^a   Yu, Leimin ^a   Li, Shangao ^a   Si, Shuying ^a   Zeng, Yanjun ^b  

^a ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Hepatic cirrhosis; Leptin; Smad; Tetramethylpyrazine; TGF 1

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; CHLOROFORM; COLLAGEN; GENE PRODUCT; GLUCOSE; LEPTIN; OBESE GENE RECEPTOR; SMAD3 PROTEIN; SMAD7 PROTEIN; TETRAMETHYLPYRAZINE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; CARBON TETRACHLORIDE; FIBRINOLYTIC AGENT; LEPTIN RECEPTOR; MESSENGER RNA; PYRAZINE DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER HISTOLOGY; MALE; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CYTOCHEMISTRY; DRUG EFFECT; GENETICS; METABOLISM; RANDOMIZATION; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; BLOTTING, WESTERN; CARBON TETRACHLORIDE; DOWN-REGULATION; FIBRINOLYTIC AGENTS; HISTOCYTOCHEMISTRY; LEPTIN; LIVER CIRRHOSIS; MALE; PYRAZINES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LEPTIN; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77953250659     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.3109/01480540903418504     Document Type: Article

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