Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells

Biochemical Pharmacology

Volumn 83, Issue 7, 2012, Pages 849-857

  Park, Jung Jin ^a,c   Yi, Jae Youn ^a   Jin, Yeung Bae ^a   Lee, Yoon Jin ^a   Lee, Jae Seon ^a   Lee, Yun Sil ^b   Ko, Young Gyu ^c   Lee, Minyoung ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Ewha Womans University   (South Korea)

^c Korea University   (South Korea)

Author keywords

Colon cancer; EGFR; Gefitinib; Sialylation; ST6Gal I

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; SIALYLTRANSFERASE;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER PATIENT; CANCER RESISTANCE; CARCINOGENESIS; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CHEMOSENSITIVITY; COLON CANCER; COLORECTAL CARCINOMA; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; DOWNSTREAM PROCESSING; ENZYME SUBSTRATE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; SIALYLATION; WILD TYPE;

ANIMALS; ANTIGENS, CD; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; HT29 CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN SITU NICK-END LABELING; MICE; MICE, NUDE; PHOSPHORYLATION; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIALIC ACIDS; SIALYLTRANSFERASES; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84862814575     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.01.007     Document Type: Article

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