Acetaldehyde stimulates the activation of latent transforming growth factor-β1 and induces expression of the type II receptor of the cytokine in rat cultured hepatic stellate cells

Biochemical Journal

Volumn 368, Issue 3, 2002, Pages 683-693

  Chen, Anping ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Alcohol; Gene expression; Hepatic fibrogenesis; Myofibroblast like cell

Indexed keywords

ALDEHYDES; CHEMICAL ACTIVATION; COLLAGEN; GENETIC ENGINEERING; GROWTH KINETICS; METABOLITES;

FIBROGENESIS;

ANIMAL CELL CULTURE;

ACETALDEHYDE; COLLAGEN TYPE 1; CYTOKINE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; LIVER CELL; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; STELLATE CELL; WESTERN BLOTTING;

ACETALDEHYDE; ALCOHOLS; ANIMALS; BLOTTING, WESTERN; CELL LINE; COLLAGEN; CULTURE MEDIA, SERUM-FREE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; LIVER; MALE; MODELS, BIOLOGICAL; OLIGONUCLEOTIDES, ANTISENSE; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RIBONUCLEASES; RNA; SIGNAL TRANSDUCTION; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

ANIMALIA;

EID: 0037115736     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020949     Document Type: Article

References (45)

1. Schuppan, D., Atkinson, J., Ruehl, M. and Riecken, E. O. (1995) Alcohol and liver fibrosis - Pathobiochemistry and treatment. Z. Gastroenterol. 33, 546-550
2. Friedman, S. L. (2000) Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 275, 2247-2250
3. Dooley, S., Delvoux, B., Lahme, B., Mangasser-Stephan, K. and Gressner, A. M. (2000) Modulation of transforming growth factor β response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts. Hepatology 31, 1094-1106
4. Friedman, S. L., Yamasaki, G. and Wong, L. (1994) Modulation of transforming growth factor β receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo. J. Biol. Chem. 269, 10551-10558
5. Massague, J. and Chen, Y. G. (2000) Controlling TGF-β signaling. Genes Dev. 14, 627-644
6. De Bleser, P. J., Niki, T., Rogiers, V. and Geerts, A. (1997) Transforming growth factor-β gene expression in normal and fibrotic rat liver. J. Hepatol. 26, 886-893
7. Baker, J. C. and Harland, R. M. (1997) From receptor to nucleus: The Smad pathway. Curr. Opin. Genet. Dev. 7, 467-473
8. Ignotz, R. A. and Massague, J. (1986) Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J. Biol. Chem. 261, 4337-4345
9. Czaja, M. J., Weiner, F. R., Flanders, K. C., Giambrone, M. A., Wind, R., Biempica, L. and Zern, M. A. (1989) In vitro and in vivo association of transforming growth factor-β 1 with hepatic fibrosis. J. Cell Biol. 108, 2477-2482
10. Sanderson, N., Factor, V., Nagy, P., Kopp, J., Kondaiah, P., Wakefield, L.., Roberts, A. B., Sporn, M. B. and Thorgeirsson, S. S. (1995) Hepatic expression of mature transforming growth factor β 1 in transgenic mice results in multiple tissue lesions. Proc. Natl. Acad. Sci. U.S.A. 92, 2572-2576
11. Nakamura, T., Sakata, R., Ueno, T., Sara, M. and Ueno, H. (2000) Inhibition of transforming growth factor β prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats. Hepatotogy 32, 247-255
12. Qi, Z., Atsuchi, N., Ooshima, A., Takeshita, A. and Ueno, H. (1999) Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. Proc. Natl. Acad. Sci. U.S.A. 96, 2345-2349
13. Ueno, H., Sakamoto, T., Nakamura, T., Qi, Z., Astuchi, N., Takeshita, A., Shimizu, K. and Ohashi, H. (2000) A soluble transforming growth factor β receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats. Hum. Gene Ther. 11, 33-42
14. Bauer, M. and Schuppan, D. (2001) TGFβ1 in liver fibrosis: Time to change paradigms? FEBS Lett. 502, 1-3
15. Anania, F. A., Womack, L., Jiang, M. and Saxena, N. K. (2001) Aldehydes potentiate α(2)(I) collagen gene activity by JNK in hepatic stellate cells. Free Radicals Biol. Med. 30, 846-857
16. 2+-independent protein kinase C activation in cultured rat hepatic stellate cells. Alcohol Clin. Exp. Res. 23, 279-284
17. Chen, A. and Davis, B. H. (2000) The DNA binding protein BTEB mediates acetaldehyde-induced, jun N- terminal kinase-dependent αI(I) collagen gene expression in rat hepatic stellate cells. Mol. Cell. Biol. 20, 2818-2826
18. Svegliati-Baroni, G., Ridolfi, F., Di Sario, A., Saccomanno, S., Bendia, E., Benedetti, A. and Greenwel, P. (2001) Intracellular signaling pathways involved in acetaldehyde-induced collagen and fibronectin gene expression in human hepatic stellate cells. Hepatology 33, 1130-1140
19. Brenner, D. A. and Chojkier, M. (1987) Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. J. Biol. Chem. 262, 17690-17695
20. Casini, A., Cunningham, M., Rojkind, M. and Lieber, C. S. (1991) Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism. Hepatology 13, 758-765
21. Pares, A., Potter, J. J., Rennie, L. and Mezey, E. (1994) Acetaldehyde activates the promoter of the mouse α2(I) collagen gene. Hepatology 19, 498-503
22. Santos, R. M., Norton, P., Degli Esposti, S. and Zern, M. A. (1998) TGF-β isoforms in alcoholic liver disease. J. Gastroenterol. 33, 383-389
23. Tsukamoto, H., Horne, W., Kamimura, S., Niemela, O., Parkkila, S., Yla-Herttuala, S. and Brittenham, G. M. (1995) Experimental liver cirrhosis induced by alcohol and iron. J. Clin. Invest. 96, 620-630
24. Anania, F. A., Potter, J. J., Rennie-Tankersley, L. and Mezey, E. (1996) Activation by acetaldehyde of the promoter of the mouse α2(I) collagen gene when transfected into rat activated stellate cells. Arch. Biochem. Biophys. 331, 187-193
25. Chen, A., Beno, D. W. A. and Davis, B. H. (1996) Suppression of stellate cell type I collagen gene expression involves AP-2 transmodulation of nuclear factor-1-dependent gene transcription. J. Biol. Chem. 271, 25994-25998
26. Chen, A. and Davis, B. H. (1999) UV irradiation activates JNK and increases αI(I) collagen gene expression in rat hepatic stellate cells. J. Biol. Chem. 274, 158-164
27. Galli, A., Crabb, D., Price, D., Ceni, E., Salzano, R., Surrenti, C. and Casini, A. (2000) Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells. Hepatology 31, 101-108
28. Massague, J. (1987) Identification of receptors for type-β transforming growth factor. Methods Enzymol. 146, 174-195
29. Scatchard, G. (1949) The attractions of protein for small molecules and ions. Ann. N.Y. Acad. Sci. 51, 660-671
30. Bae, H. W., Geiser, A. G., Kim, D. H., Chung, M. T., Burmester, J. K., Sporn, M. B., Roberts, A. B. and Kim, S. J. (1995) Characterization of the promoter region of the human transforming growth factor-β type II receptor gene. J. Biol. Chem. 270, 29460-29468
31. Davis, B. H., Chen, A. and Beno, D. W. (1996) Raf and mitogen-activated protein kinase regulate stellate cell collagen gene expression. J. Biol. Chem. 271, 11039-11042
32. Imataka, H, Sogawa, K., Yasumoto, K., Kikuchi, Y., Sasano, K., Kobayashi, A., Hayami, M. and Fujii-Kuriyama, Y. (1992) Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene. EMBO J. 11, 3663-3671
33. Centrella, M., Ji, C., Casinghino, S. and McCarthy, T. L. (1996) Rapid flux in transforming growth factor-β receptors on bone cells. J. Biol. Chem. 271, 18616-18622
34. Chen, A., Davis, B. H., Bissonnette, M, Scaglione-Sewell, B. and Brasitus, T. A. (1999) 1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent caco-2 cell differentiation. J. Biol. Chem. 274, 35505-35513
35. Wang, H., Xie, Z. and Scott, R. E. (1996) Differentiation modulates the balance of positive and negative Jun/AP-1 DNA binding activities to regulate cellular proliferative potential: Different effects in nontransformed and transformed cells. J. Cell. Biol. 135, 1151-1162
36. Attisano, L., Carcamo, J., Ventura, F., Weis, F. M., Massague, J. and Wrana, J. L. (1993) Identification of human activin and TGF β type I receptors that form heteromeric kinase complexes with type II receptors. Cell 75, 671-680
37. Carcamo, J., Zentella, A. and Massague, J. (1995) Disruption of transforming growth factor β signaling by a mutation that prevents transphosphorylation within the receptor complex. Mol. Cell. Biol. 15, 1573-1581
38. Kobayashi, A., Sogawa, K., Imataka, H and Fujii-Kuriyama, Y. (1995) Analysis of functional domains of a GC box-binding protein, BTEB. J. Biochem. (Tokyo) 117, 91-95
39. Baker, B. F., Condon, T. P., Koller, E., McKay, R. A., Siwkowski, A. M., Vickers, T. A. and Monia, B. P. (2001) Discovery and analysis of antisense oligonucleotide activity in cell culture. Methods 23, 191-198
40. Lebedeva, I. and Stein, C. A. (2001) Antisense oligonucleotides: Promise and reality. Annu. Rev. Pharmacol. Toxicol. 41. 403-419
41. Ritzenthaler, J. D., Goldstein, R. H., Fine, A., Lichtler, A., Rowe, D. W. and Smith, B. D. (1991) Transforming-growth-factor-β activation elements in the distal promoter regions of the rat α1 type I collagen gene. Biochem. J. 280, 157-162
42. Ritzenthaler, J. D., Goldstein, R. H., Fine, A. and Smith, B. D. (1993) Regulation of the α1(I) collagen promoter via a transforming growth factor-β activation element J. Biol. Chem. 268, 13625-13631
43. Adnane, J., Seijo, E., Chen, Z., Bizouarn, F., Leal, M., Sebti, S. M. and Munoz-Antonia. T. (2002) RhoB, not RhoA, represses the transcription of the transforming growth factor β type II receptor by a mechanism involving activator protein 1. J. Biol. Chem. 277, 8500-8507
44. Ratziu, V., Lalazar, A., Wong, L., Dang, Q., Collins, C., Shaulian, E., Jensen, S. and Friedman, S. L. (1998) Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis. Proc Natl. Acad. Sci. U.S.A. 95, 9500-9505
45. Meisler, N. T., Chiu, J. F. and Cutroneo, K. R. (1999) Promoter competitors as novel antifibrotics that inhibit transforming growth factor-β induction of collagen and noncollagen protein synthesis in fibroblasts. J. Cell. Biochem. 75, 196-205