Acridone Derivative 8a Induces Oxidative Stress-Mediated Apoptosis in CCRF-CEM Leukemia Cells: Application of Metabolomics in Mechanistic Studies of Antitumor Agents

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Wang, Yini ^a,b   Gao, Dan ^a,b   Chen, Zhe ^a   Li, Shangfu ^a   Gao, Chunmei ^a   Cao, Deliang ^a   Liu, Feng ^a   Liu, Hongxia ^a,b   Jiang, Yuyang ^a,c  

^a TSINGHUA UNIVERSITY   (China)

^b Key Laboratory of Tumor Metabolomics at Shenzhen City   (China)

^c Tsinghua University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOACETAMIDO 10 (3,5 DIMETHOXY)BENZYL 9 (10H)ACRIDONE HYDROCHLORIDE; ANTINEOPLASTIC AGENT; CASPASE 3; CYSTEINYLGLYCINE; CYTOCHROME C; GLUTAMIC ACID; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLYCEROPHOSPHOLIPID; LYSOPHOSPHATIDYLCHOLINE; MALONALDEHYDE; PHOSPHATIDYLCHOLINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BLOOD LEVEL; CELL DAMAGE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; LEUKEMIA CELL; LIPID PEROXIDATION; METABOLOMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PHOSPHOLIPID METABOLISM; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ACRIDINES; ACRIDONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOLOGICAL MARKERS; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATOGRAPHY, LIQUID; DISCRIMINANT ANALYSIS; HUMANS; LEAST-SQUARES ANALYSIS; LEUKEMIA; MALONDIALDEHYDE; MASS SPECTROMETRY; METABOLOMICS; MITOCHONDRIA; MODELS, BIOLOGICAL; OXIDATIVE STRESS; PRINCIPAL COMPONENT ANALYSIS; REACTIVE OXYGEN SPECIES;

EID: 84877120111     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063572     Document Type: Article

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