Metabolomic profiling of cellular responses to carvedilol enantiomers in vascular smooth muscle cells

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Wang, Mingxuan ^a   Bai, Jing ^a   Chen, Wei Ning ^a   Ching, Chi Bun ^a  

^a Nanyang Technological University   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CARVEDILOL; INOSITOL; MYRISTIC ACID; PALMITIC ACID; PYROGLUTAMIC ACID; SERINE; THREONINE; ALANINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM; CARBAZOLE DERIVATIVE; PROPANOLAMINE DERIVATIVE;

ARTICLE; CALCIUM CELL LEVEL; CELL LINE; CELL METABOLISM; CONTROLLED STUDY; DRUG EFFECT; IN VITRO STUDY; MASS FRAGMENTOGRAPHY; METABOLITE; METABOLOMICS; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; ANIMAL; CHEMISTRY; CYTOLOGY; INTRACELLULAR SPACE; METABOLISM; METABOLOME; METHODOLOGY; PRINCIPAL COMPONENT ANALYSIS; RAT; STEREOISOMERISM;

ADRENERGIC BETA-ANTAGONISTS; ALANINE; ANIMALS; CALCIUM; CARBAZOLES; CELL LINE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; INTRACELLULAR SPACE; METABOLOME; METABOLOMICS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PRINCIPAL COMPONENT ANALYSIS; PROPANOLAMINES; RATS; STEREOISOMERISM;

EID: 78649638444     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015441     Document Type: Article

References (41)

1. Wallukat G (2002) The beta-adrenergic receptors. Herz 27: 683-690.
2. Ruffolo RR, Jr., Feuerstein GZ (1997) Pharmacology of carvedilol: rationale for use in hypertension, coronary artery disease, and congestive heart failure. Cardiovasc Drugs Ther 11 Suppl 1: 247-256.
3. Nakajima T, Ma J, Iida H, Iwasawa K, Jo T, et al. (2003) Inhibitory effects of carvedilol on calcium channels in vascular smooth muscle cells. Jpn Heart J 44: 963-978.
4. Bartsch W, Sponer G, Strein K, Muller-Beckmann B, Kling L, et al. (1990) Pharmacological characteristics of the stereoisomers of carvedilol. Eur J Clin Pharmacol 38 Suppl 2: S104-107.
5. Gagyi L, Gyeresi A, Kilar F (2008) Role of chemical structure in stereoselective recognition of beta-blockers by cyclodextrins in capillary zone electrophoresis. J Biochem Biophys Methods 70: 1268-1275.
6. Rainaldi G, Romano R, Indovina P, Ferrante A, Motta A, et al. (2008) Metabolomics using 1H-NMR of apoptosis and Necrosis in HL60 leukemia cells: differences between the two types of cell death and independence from the stimulus of apoptosis used. Radiat Res 169: 170-180.
7. Mayr M, Zampetaki A, Sidibe A, Mayr U, Yin X, et al. (2008) Proteomic and metabolomic analysis of smooth muscle cells derived from the arterial media and adventitial progenitors of apolipoprotein E-deficient mice. Circ Res 102: 1046-1056.
8. Sui J, Tan TL, Zhang J, Ching CB, Chen WN (2007) iTRAQ-coupled 2D LCMS/ MS analysis on protein profile in vascular smooth muscle cells incubated with S- and R-enantiomers of propranolol: possible role of metabolic enzymes involved in cellular anabolism and antioxidant activity. J Proteome Res 6: 1643-1651.
9. Sui J, Zhang J, Tan TL, Ching CB, Chen WN (2008) Comparative proteomics analysis of vascular smooth muscle cells incubated with S- and R-enantiomers of atenolol using iTRAQ-coupled two-dimensional LC-MS/MS. Mol Cell Proteomics 7: 1007-1018.
10. Wang M, Wang X, Ching CB, Chen WN (2010) Proteomic profiling of cellular responses to Carvedilol enantiomers in vascular smooth muscle cells by iTRAQcoupled 2-D LC-MS/MS. J Proteomics 73: 1601-1611.
11. Fernandez C, Fransson U, Hallgard E, Spegel P, Holm C, et al. (2008) Metabolomic and proteomic analysis of a clonal insulin-producing beta-cell line (INS-1 832/13). J Proteome Res 7: 400-411.
12. Takeda S, Sim PG, Horrobin DF, Sanford T, Chisholm KA, et al. (1993) Mechanism of lipid peroxidation in cancer cells in response to gamma-linolenic acid (GLA) analyzed by GC-MS(I): Conjugated dienes with peroxyl (or hydroperoxyl) groups and cell-killing effects. Anticancer Res 13: 193-199.
13. Filipiak W, Sponring A, Filipiak A, Ager C, Schubert J, et al. (2010) TD-GC-MS analysis of volatile metabolites of human lung cancer and normal cells in vitro. Cancer Epidemiol Biomarkers Prev 19: 182-195.
14. Danielsson AP, Moritz T, Mulder H, Spegel P (2010) Development and optimization of a metabolomic method for analysis of adherent cell cultures. Anal Biochem 404: 30-39.
15. Tiziani S, Lodi A, Khanim FL, Viant MR, Bunce CM, et al. (2009) Metabolomic profiling of drug responses in acute myeloid leukaemia cell lines. PLoS One 4: e4251.
16. Fiehn O, Kopka J, Dormann P, Altmann T, Trethewey RN, et al. (2000) Metabolite profiling for plant functional genomics. Nat Biotechnol 18: 1157-1161.
17. Devantier R, Scheithauer B, Villas-Boas SG, Pedersen S, Olsson L (2005) Metabolite profiling for analysis of yeast stress response during very high gravity ethanol fermentations. Biotechnol Bioeng 90: 703-714.
18. Chrysanthopoulos PK, Goudar CT, Klapa MI (2010) Metabolomics for highresolution monitoring of the cellular physiological state in cell culture engineering. Metab Eng 12: 212-222.
19. Smith DF (1989) The stereoselectivity of drug action. Pharmacol Toxicol 65: 321-331.
20. Filo RS, Bohr DF, Ruegg JC (1965) Glycerinated Skeletal and Smooth Muscle: Calcium and Magnesium Dependence. Science 147: 1581-1583.
21. Webb RC (2003) Smooth muscle contraction and relaxation. Adv Physiol Educ 27: 201-206.
22. Bolton TB (1979) Mechanisms of action of transmitters and other substances on smooth muscle. Physiol Rev 59: 606-718.
23. van Breemen C, Saida K (1989) Cellular mechanisms regulating [Ca2+]i smooth muscle. Annu Rev Physiol 51: 315-329.
24. Jalil JE (2008) Blood pressure reduction, potassium channels, and the endothelium: insights from L-serine. Hypertension 51: 626-628.
25. Mishra RC, Tripathy S, Desai KM, Quest D, Lu Y, et al. (2008) Nitric oxide synthase inhibition promotes endothelium-dependent vasodilatation and the antihypertensive effect of L-serine. Hypertension 51: 791-796.
26. Ravnikar PD, Somerville RL (1987) Genetic characterization of a highly efficient alternate pathway of serine biosynthesis in Escherichia coli. J Bacteriol 169: 2611-2617.
27. Kumar A, Bachhawat AK (2010) A futile cycle, formed between two ATPdependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis? J Biosci 35: 21-25.
28. Zhu W, Smart EJ (2005) Myristic acid stimulates endothelial nitric-oxide synthase in a CD36- and an AMP kinase-dependent manner. J Biol Chem 280: 29543-29550.
29. Naseem KM (2005) The role of nitric oxide in cardiovascular diseases. Mol Aspects Med 26: 33-65.
30. Takahashi S, Lin H, Geshi N, Mori Y, Kawarabayashi Y, et al. (2008) Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6. J Physiol 586: 4209-4223.
31. Bian K, Doursout MF, Murad F (2008) Vascular system: role of nitric oxide in cardiovascular diseases. J Clin Hypertens (Greenwich) 10: 304-310.
32. Lincoln TM, Dey N, Sellak H (2001) Invited review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression. J Appl Physiol 91: 1421-1430.
33. Feil R, Lohmann SM, de Jonge H, Walter U, Hofmann F (2003) Cyclic GMPdependent protein kinases and the cardiovascular system: insights from genetically modified mice. Circ Res 93: 907-916.
34. Koller A, Schlossmann J, Ashman K, Uttenweiler-Joseph S, Ruth P, et al. (2003) Association of phospholamban with a cGMP kinase signaling complex. Biochem Biophys Res Commun 300: 155-160.
35. Taccetta-Chapnick M (2002) Using carvedilol to treat heart failure. Crit Care Nurse 22: 36-40, 42-36, 48 passim.
36. (1996) Effect of carvedilol on mortality and morbidity in patients with chronic heart failure. Circulation 94: 592.
37. Ohlstein EH, Douglas SA, Sung CP, Yue TL, Louden C, et al. (1993) Carvedilol, a cardiovascular drug, prevents vascular smooth muscle cell proliferation, migration, and neointimal formation following vascular injury. Proc Natl Acad Sci U S A 90: 6189-6193.
38. Sui J, Zhang J, Ching CB, Chen WN (2008) Comparative proteomic analysis of extracellular proteins reveals secretion of T-kininogen from vascular smooth muscle cells in response to incubation with s-enantiomer of propranolol. Mol Pharm 5: 885-890.
39. Sui J, Wang M, Zhang J, Ching CB, Chen WN (2010) Identification of differentially secreted proteins using two-dimensional liquid chromatography/ tandem mass spectrometry in vascular smooth muscle cells incubated with S- and R-atenolol. Rapid Commun Mass Spectrom 24: 1717-1719.
40. Oddis CV, Finkel MS (1995) Cytokine-stimulated nitric oxide production inhibits mitochondrial activity in cardiac myocytes. Biochem Biophys Res Commun 213: 1002-1009.
41. Mal M, Koh PK, Cheah PY, Chan EC (2009) Development and validation of a gas chromatography/mass spectrometry method for the metabolic profiling of human colon tissue. Rapid Commun Mass Spectrom 23: 487-494.