Cytotoxicity studies of some novel fluoro acridone derivatives against sensitive and resistant cancer cell lines and their mechanistic studies

European Journal of Pharmaceutical Sciences

Volumn 43, Issue 4, 2011, Pages 217-224

  Rajendra Prasad, V V S ^b   Peters, G J ^a   Lemos, Clara ^a,c   Kathmann, Ietje ^c   Mayur, Y C ^a,d  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Sitha Institute of Pharmaceutical Sciences   (India)

^c University of Porto   (Portugal)

^d Shri Vithal Education and Research Institute's College of Pharmacy   (India)

Author keywords

Acridone; Calmodulin; Doxorubicin; Multidrug resistance (MDR); P glycoprotein

Indexed keywords

4 FLUOROACRDONE DERIVATIVE; ACRIDONE DERIVATIVE; CALMODULIN INHIBITOR; CARBONYL DERIVATIVE; CYCLIC AMP PHOSPHODIESTERASE; DOUBLE STRANDED DNA; DOXORUBICIN; GLYCOPROTEIN P; IMIDACRINE; MITOXANTRONE; MULTIDRUG RESISTANCE PROTEIN; UNCLASSIFIED DRUG; VINCRISTINE;

ARTICLE; BASE PAIRING; BINDING AFFINITY; CANCER CELL CULTURE; CANCER RESISTANCE; CONCENTRATION RESPONSE; CYTOTOXICITY; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYDROGEN BOND; LIPOPHILICITY; LUNG NON SMALL CELL CANCER; MULTIDRUG RESISTANCE; PHENOTYPE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA;

3',5'-CYCLIC-AMP PHOSPHODIESTERASES; ACRIDONES; AMINOACRIDINES; ANIMALS; CALCIUM; CALMODULIN; CELL LINE, TUMOR; DNA; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HEK293 CELLS; HL-60 CELLS; HUMANS; MALE; P-GLYCOPROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79959576109     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.04.010     Document Type: Article

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