-
1
-
-
34247871586
-
The expanding role for ITAM-based signaling pathways in immune cells
-
Abram, C.L. & Lowell, C.A. The expanding role for ITAM-based signaling pathways in immune cells. Sci. STKE 2007, re2 (2007).
-
(2007)
Sci. STKE
, vol.2007
-
-
Abram, C.L.1
Lowell, C.A.2
-
3
-
-
33644860951
-
Inhibition of immune responses by ITAM-bearing receptors
-
Hamerman, J.A. & Lanier, L.L. Inhibition of immune responses by ITAM-bearing receptors. Sci. STKE 2006, re1 (2006).
-
(2006)
Sci. STKE
, vol.2006
-
-
Hamerman, J.A.1
Lanier, L.L.2
-
4
-
-
48349105543
-
DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk
-
Zou, W., Reeve, J.L., Liu, Y., Teitelbaum, S.L. & Ross, F.P. DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk. Mol. Cell 31, 422-431 (2008).
-
(2008)
Mol. Cell
, vol.31
, pp. 422-431
-
-
Zou, W.1
Reeve, J.L.2
Liu, Y.3
Teitelbaum, S.L.4
Ross, F.P.5
-
5
-
-
52949087160
-
A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathways
-
Ivashkiv, L.B. A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathways. Nat. Rev. Immunol. 8, 816-822 (2008).
-
(2008)
Nat. Rev. Immunol
, vol.8
, pp. 816-822
-
-
Ivashkiv, L.B.1
-
6
-
-
33748666884
-
Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells
-
Abtahian, F. et al. Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol. Cell. Biol. 26, 6936-6949 (2006).
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 6936-6949
-
-
Abtahian, F.1
-
7
-
-
33846295127
-
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs
-
Mocsai, A. et al. Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat. Immunol. 7, 1326-1333 (2006).
-
(2006)
Nat. Immunol
, vol.7
, pp. 1326-1333
-
-
Mocsai, A.1
-
8
-
-
33947240223
-
3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption
-
3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J. Cell Biol. 176, 877-888 (2007).
-
(2007)
J. Cell Biol
, vol.176
, pp. 877-888
-
-
Zou, W.1
-
9
-
-
0034613151
-
Immune inhibitory receptors
-
Ravetch, J.V. & Lanier, L.L. Immune inhibitory receptors. Science 290, 84-89 (2000).
-
(2000)
Science
, vol.290
, pp. 84-89
-
-
Ravetch, J.V.1
Lanier, L.L.2
-
10
-
-
33846562134
-
Activating and inhibitory functions of DAP12
-
Turnbull, I.R. & Colonna, M. Activating and inhibitory functions of DAP12. Nat. Rev. Immunol. 7, 155-161 (2007).
-
(2007)
Nat. Rev. Immunol
, vol.7
, pp. 155-161
-
-
Turnbull, I.R.1
Colonna, M.2
-
12
-
-
33746875981
-
Cutting edge: Inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12
-
Hamerman, J.A. et al. Cutting edge: Inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J. Immunol. 177, 2051-2055 (2006).
-
(2006)
J. Immunol
, vol.177
, pp. 2051-2055
-
-
Hamerman, J.A.1
-
13
-
-
20644443886
-
-
Hamerman, J.A., Tchao, N.K., Lowell, C.A. & Lanier, L.L. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat. Immunol. 6, 579-586 (2005).
-
Hamerman, J.A., Tchao, N.K., Lowell, C.A. & Lanier, L.L. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat. Immunol. 6, 579-586 (2005).
-
-
-
-
14
-
-
33748517428
-
Cutting edge: TREM-2 attenuates macrophage activation
-
Turnbull, I.R. et al. Cutting edge: TREM-2 attenuates macrophage activation. J. Immunol., 177, 3520-3524 (2006).
-
(2006)
J. Immunol
, vol.177
, pp. 3520-3524
-
-
Turnbull, I.R.1
-
15
-
-
23744513114
-
DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis
-
Turnbull, I.R. et al. DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis. J. Exp. Med. 202, 363-369 (2005).
-
(2005)
J. Exp. Med
, vol.202
, pp. 363-369
-
-
Turnbull, I.R.1
-
16
-
-
42149085674
-
Inhibitory ITAM signaling by FcαRI-FcRγ chain controls multiple activating responses and prevents renal inflammation
-
Kanamaru, Y. et al. Inhibitory ITAM signaling by FcαRI-FcRγ chain controls multiple activating responses and prevents renal inflammation. J. Immunol. 180, 2669-2678 (2008).
-
(2008)
J. Immunol
, vol.180
, pp. 2669-2678
-
-
Kanamaru, Y.1
-
17
-
-
19944430878
-
Identification of FcαRI as an inhibitory receptor that controls inflammation: Dual role of FcRγ ITAM
-
Pasquier. B. et al. Identification of FcαRI as an inhibitory receptor that controls inflammation: Dual role of FcRγ ITAM; Immunity 22, 31-42 (2005).
-
(2005)
Immunity
, vol.22
, pp. 31-42
-
-
Pasquier, B.1
-
18
-
-
35948941869
-
CD16 promotes Escherichia coli sepsis through an FcRγ inhibitory pathway that prevents phagocytosis and facilitates inflammation
-
Pinheiro da Silva, F. et al. CD16 promotes Escherichia coli sepsis through an FcRγ inhibitory pathway that prevents phagocytosis and facilitates inflammation. Nat. Med. 13, 1368-1374 (2007).
-
(2007)
Nat. Med
, vol.13
, pp. 1368-1374
-
-
Pinheiro da Silva, F.1
-
19
-
-
33846316333
-
The TREM receptor family and signal integration
-
Klesney-Tait, J., Tumbull, I.R. & Colonna, M. The TREM receptor family and signal integration. Nat. Immunol. 7, 1266-1273 (2006).
-
(2006)
Nat. Immunol
, vol.7
, pp. 1266-1273
-
-
Klesney-Tait, J.1
Tumbull, I.R.2
Colonna, M.3
-
20
-
-
45149127782
-
Osteoimmunology: Interactions of the bone and immune system
-
Lorenzo, J., Horowitz, M. & Choi, Y. Osteoimmunology: Interactions of the bone and immune system. Endocr. Rev. 29, 403-440 (2008).
-
(2008)
Endocr. Rev
, vol.29
, pp. 403-440
-
-
Lorenzo, J.1
Horowitz, M.2
Choi, Y.3
-
21
-
-
33947583822
-
Shared mechanisms and crosstalk between the immune and bone systems
-
Takayanagi, H. Osteoimmunology: Shared mechanisms and crosstalk between the immune and bone systems. Nat. Rev. Immunol. 7, 292-304 (2007).
-
(2007)
Nat. Rev. Immunol
, vol.7
, pp. 292-304
-
-
Takayanagi, H.O.1
-
22
-
-
33144481680
-
Osteoclasts; culprits in inflammatory osteolysis
-
Teitelbaum, S.L. Osteoclasts; culprits in inflammatory osteolysis. Arthritis Res. Ther. 8, 201 (2006).
-
(2006)
Arthritis Res. Ther
, vol.8
, pp. 201
-
-
Teitelbaum, S.L.1
-
23
-
-
18744366041
-
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
-
Takayanagi, H. et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev. Cell 3, 889-901 (2002).
-
(2002)
Dev. Cell
, vol.3
, pp. 889-901
-
-
Takayanagi, H.1
-
24
-
-
55849088412
-
NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism
-
Aliprantis, A.O. et al. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J. Clin. Invest. 118, 3775-3789 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 3775-3789
-
-
Aliprantis, A.O.1
-
25
-
-
33144467142
-
TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function
-
Humphrey, M.B. et al. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. J. Bone Miner. Res. 21, 237-245 (2006).
-
(2006)
J. Bone Miner. Res
, vol.21
, pp. 237-245
-
-
Humphrey, M.B.1
-
26
-
-
11144354330
-
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
-
Kega, T. et al. Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 428, 758-763 (2004).
-
(2004)
Nature
, vol.428
, pp. 758-763
-
-
Kega, T.1
-
27
-
-
33750597150
-
PLCγ2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2
-
Mao, D., Epple, H., Uthgenannt, B., Novack, D.V. & Faccio, R. PLCγ2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2. J. Clin. Invest. 116, 2869-2879 (2006).
-
(2006)
J. Clin. Invest
, vol.116
, pp. 2869-2879
-
-
Mao, D.1
Epple, H.2
Uthgenannt, B.3
Novack, D.V.4
Faccio, R.5
-
28
-
-
11144355389
-
The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase
-
Mocsai, A. et al. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc. Natl. Acad. Sci. USA 101, 6158-6163 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 6158-6163
-
-
Mocsai, A.1
-
29
-
-
0037314230
-
Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice
-
Kaifu, T. et al. Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J. Clin. Invest. 111, 323-332 (2003).
-
(2003)
J. Clin. Invest
, vol.111
, pp. 323-332
-
-
Kaifu, T.1
-
30
-
-
19944423049
-
Brain and bone damage in KARAP/DAP12 loss-of-function mice correlate with alterations in microglia and osteoclast lineages
-
Nataf, S. et al. Brain and bone damage in KARAP/DAP12 loss-of-function mice correlate with alterations in microglia and osteoclast lineages. Am. J. Pathol. 166, 275-286 (2005).
-
(2005)
Am. J. Pathol
, vol.166
, pp. 275-286
-
-
Nataf, S.1
-
31
-
-
0041920899
-
Impaired differentiation of osteoclasts in TREM-2-deficient individuals
-
Cella, M. et al. Impaired differentiation of osteoclasts in TREM-2-deficient individuals. J. Exp. Med. 198, 645-651 (2003).
-
(2003)
J. Exp. Med
, vol.198
, pp. 645-651
-
-
Cella, M.1
-
32
-
-
0033945864
-
Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts
-
Paloneva, J. et al. Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts. Nat. Genet. 25, 357-361 (2000).
-
(2000)
Nat. Genet
, vol.25
, pp. 357-361
-
-
Paloneva, J.1
-
33
-
-
18544390923
-
Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype
-
Paloneva, J. et al. Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Am. J. Hum. Genet. 71, 656-662 (2002).
-
(2002)
Am. J. Hum. Genet
, vol.71
, pp. 656-662
-
-
Paloneva, J.1
-
34
-
-
27744432009
-
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis
-
Asagiri, M. et al. Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J. Exp. Med. 202, 1261-1269 (2005).
-
(2005)
J. Exp. Med
, vol.202
, pp. 1261-1269
-
-
Asagiri, M.1
-
35
-
-
45549099188
-
The tec family tyrosine kinase Btk regulates RANKL-induced osteoclast maturation
-
Lee, S.H., Kim, T., Jeong, D., Kim, N. & Choi, Y. The tec family tyrosine kinase Btk regulates RANKL-induced osteoclast maturation. J. Biol. Chem. 283, 11526-11534 (2008).
-
(2008)
J. Biol. Chem
, vol.283
, pp. 11526-11534
-
-
Lee, S.H.1
Kim, T.2
Jeong, D.3
Kim, N.4
Choi, Y.5
-
36
-
-
39749180445
-
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals
-
Shinohara, M. et al. Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell 132, 794-806 (2008).
-
(2008)
Cell
, vol.132
, pp. 794-806
-
-
Shinohara, M.1
-
37
-
-
34447337993
-
Compartmentalization of ITAM and integrin signaling by adapter molecules
-
Bezman, N. & Koretzky, G.A. Compartmentalization of ITAM and integrin signaling by adapter molecules. Immunol. Rev. 218, 9-28 (2007).
-
(2007)
Immunol. Rev
, vol.218
, pp. 9-28
-
-
Bezman, N.1
Koretzky, G.A.2
-
38
-
-
44349124603
-
Phospholipase Cγ2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase
-
Epple, H. et al. Phospholipase Cγ2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase. Mol. Cell. Biol. 28, 3610-3622 (2008).
-
(2008)
Mol. Cell. Biol
, vol.28
, pp. 3610-3622
-
-
Epple, H.1
-
39
-
-
59849123078
-
Calcineurin negatively regulates TLR-mediated activation pathways
-
Kang, Y.J. et al. Calcineurin negatively regulates TLR-mediated activation pathways. J. Immunol. 179, 4598-4607 (2007).
-
(2007)
J. Immunol
, vol.179
, pp. 4598-4607
-
-
Kang, Y.J.1
-
40
-
-
9244249240
-
Amplification of IFN-α-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors
-
Tassiulas, I. et al. Amplification of IFN-α-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors. Nat. Immunol. 5, 1181-1189 (2004).
-
(2004)
Nat. Immunol
, vol.5
, pp. 1181-1189
-
-
Tassiulas, I.1
-
41
-
-
38449093322
-
Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages
-
Wang, L. et al. 'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages. Nat. Immunol. 9, 186-193 (2008).
-
(2008)
Nat. Immunol
, vol.9
, pp. 186-193
-
-
Wang, L.1
-
42
-
-
33744815942
-
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis
-
Takegahara, N. et al. Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Nat. Cell Biol. 8, 615-622 (2006).
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 615-622
-
-
Takegahara, N.1
-
43
-
-
71849093985
-
TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells
-
Radhakrishnan, S. et al. TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells. J. Immunol. 181, 7863-7872 (2008).
-
(2008)
J. Immunol
, vol.181
, pp. 7863-7872
-
-
Radhakrishnan, S.1
-
44
-
-
56349091862
-
Tonic B cell antigen receptor signals supply an NF-κB substrate for prosurvival BLyS signaling
-
Stadanlick, J.E. et al. Tonic B cell antigen receptor signals supply an NF-κB substrate for prosurvival BLyS signaling. Nat. Immunol. 9, 1379-1387 (2008).
-
(2008)
Nat. Immunol
, vol.9
, pp. 1379-1387
-
-
Stadanlick, J.E.1
-
45
-
-
34547124586
-
NF-κB p5O and p52 regulate receptor activator of NF-κB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1
-
Yamashita, T. et al. NF-κB p5O and p52 regulate receptor activator of NF-κB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J. Biol. Chem. 282, 18245-18253 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, pp. 18245-18253
-
-
Yamashita, T.1
-
46
-
-
41649089360
-
ReIB is the NF-κB subunit downstream of NIK responsible for osteoclast differentiation
-
Vaira, S. et al. ReIB is the NF-κB subunit downstream of NIK responsible for osteoclast differentiation. Proc. Natl. Acad. Sci. USA 105, 389-3902 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 389-3902
-
-
Vaira, S.1
-
47
-
-
0038558248
-
Dectin-1 mediates the biological effects of β-glucans
-
Brown, G.D. et al. Dectin-1 mediates the biological effects of β-glucans. J. Exp. Med. 197, 1119-1124 (2003).
-
(2003)
J. Exp. Med
, vol.197
, pp. 1119-1124
-
-
Brown, G.D.1
-
48
-
-
0038558249
-
Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2
-
Gantner, B.N., Simmons, R.M., Canavera, S.J., Akira, S. & Underhill, D.M. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J. Exp. Med. 197, 1107-1117 (2003).
-
(2003)
J. Exp. Med
, vol.197
, pp. 1107-1117
-
-
Gantner, B.N.1
Simmons, R.M.2
Canavera, S.J.3
Akira, S.4
Underhill, D.M.5
-
49
-
-
20244363662
-
Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins
-
Rogers, N.C. et al. Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 22, 507-517 (2005).
-
(2005)
Immunity
, vol.22
, pp. 507-517
-
-
Rogers, N.C.1
-
50
-
-
3042548183
-
Toll-like receptor 9-dependent and independent dendritic cell activation by chromatin-immunoglobulin G complexes
-
Boule, M.W. et al. Toll-like receptor 9-dependent and independent dendritic cell activation by chromatin-immunoglobulin G complexes. J. Exp. Med. 199, 1631-1640 (2004).
-
(2004)
J. Exp. Med
, vol.199
, pp. 1631-1640
-
-
Boule, M.W.1
-
51
-
-
34249026701
-
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
-
LeibundGut-Landmann, S. et al. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat. Immunol. 8, 630-638 (2007).
-
(2007)
Nat. Immunol
, vol.8
, pp. 630-638
-
-
LeibundGut-Landmann, S.1
-
52
-
-
0034129778
-
2 integrins are involved in cytokine responses to whole Gram-positive bacteria
-
2 integrins are involved in cytokine responses to whole Gram-positive bacteria. J. Immunol. 164, 5871-5876 (2000).
-
(2000)
J. Immunol
, vol.164
, pp. 5871-5876
-
-
Cuzzola, M.1
-
53
-
-
45549098345
-
3 complex senses bacterial lipopeptides via vitronectin
-
3 complex senses bacterial lipopeptides via vitronectin. Nat. Immunol. 9 761-768 (2008).
-
(2008)
Nat. Immunol
, vol.9
, pp. 761-768
-
-
Gerold, G.1
-
54
-
-
33646908228
-
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling
-
Kagan, J.C. & Medzhitov, R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 125, 943-955 (2006).
-
(2006)
Cell
, vol.125
, pp. 943-955
-
-
Kagan, J.C.1
Medzhitov, R.2
-
55
-
-
3142724031
-
Toll-like receptor signalling
-
Akira, S. & Takeda, K. Toll-like receptor signalling. Nat. Rev. Immunol. 4, 499-511 (2004).
-
(2004)
Nat. Rev. Immunol
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
56
-
-
33747036397
-
Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
-
Gross, O. et al. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442, 651-656 (2006).
-
(2006)
Nature
, vol.442
, pp. 651-656
-
-
Gross, O.1
-
57
-
-
45449111197
-
Multiple ITAM-coupled NK-cell receptors engage the Bcl 10/Malt1 complex via Carmal for NF-κB and MAPK activation to selectively control cytokine production
-
Gross, O. et al. Multiple ITAM-coupled NK-cell receptors engage the Bcl 10/Malt1 complex via Carmal for NF-κB and MAPK activation to selectively control cytokine production. Blood 112, 2421-2428 (2008).
-
(2008)
Blood
, vol.112
, pp. 2421-2428
-
-
Gross, O.1
-
58
-
-
34249048617
-
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
-
Hira, H. et al. The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat. Immunol. 8, 619-629 (2007).
-
(2007)
Nat. Immunol
, vol.8
, pp. 619-629
-
-
Hira, H.1
-
59
-
-
49049110352
-
Cell type-specific regulation of ITAM-mediated NF-κB activation by, the adaptors, CARMA1 and CARD9
-
Hara, H. et al. Cell type-specific regulation of ITAM-mediated NF-κB activation by, the adaptors, CARMA1 and CARD9. J. Immunol. 181, 918-930 (2008).
-
(2008)
J. Immunol
, vol.181
, pp. 918-930
-
-
Hara, H.1
-
60
-
-
33846469538
-
The adaptor protein-CARD9 is required for innate immune responses to intracellular pathogens
-
Hsu, Y.M. et al. The adaptor protein-CARD9 is required for innate immune responses to intracellular pathogens. Nat. Immunol. 8 198-205 (2007).
-
(2007)
Nat. Immunol
, vol.8
, pp. 198-205
-
-
Hsu, Y.M.1
-
61
-
-
58549115247
-
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-κB activation through Raf-1 and Syk
-
Gringhuis, S.I. et al. Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-κB activation through Raf-1 and Syk. Nat. Immunol. 10, 203-213 (2009).
-
(2009)
Nat. Immunol
, vol.10
, pp. 203-213
-
-
Gringhuis, S.I.1
-
62
-
-
44649191160
-
T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76
-
Nguyen, K., Sylvain, N.R. & Bunnell, S.C. T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76. Immunity 28, 810-821 (2008).
-
(2008)
Immunity
, vol.28
, pp. 810-821
-
-
Nguyen, K.1
Sylvain, N.R.2
Bunnell, S.C.3
-
63
-
-
44649161194
-
The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens
-
Chaturvedi, A., Dorward, D. & Pierce, S.K. The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens. Immunity 28, 799-809 (2008).
-
(2008)
Immunity
, vol.28
, pp. 799-809
-
-
Chaturvedi, A.1
Dorward, D.2
Pierce, S.K.3
-
64
-
-
55349123588
-
Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells
-
Ng, G. et al. Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity 29, 807-818 (2008).
-
(2008)
Immunity
, vol.29
, pp. 807-818
-
-
Ng, G.1
-
65
-
-
38349057561
-
Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRγ
-
Chu, C.L. et al. Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRγ. Eur. J. Immunol. 38, 166-173 (2008).
-
(2008)
Eur. J. Immunol
, vol.38
, pp. 166-173
-
-
Chu, C.L.1
-
66
-
-
33745026450
-
Plasmacytoid dendritic cell-specific receptor ILT7-FcεRI γ inhibits Toll-like receptor-induced interferon production
-
Cao, W. et al. Plasmacytoid dendritic cell-specific receptor ILT7-FcεRI γ inhibits Toll-like receptor-induced interferon production. J. Exp. Med. 203, 1399-1405 (2006).
-
(2006)
J. Exp. Med
, vol.203
, pp. 1399-1405
-
-
Cao, W.1
-
67
-
-
20644450804
-
Negative regulation of toll-like receptor-mediated immune responses
-
Liew, F.Y., Xu, D., Brint, E.K. & O'Neill, L.A. Negative regulation of toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5, 446-458 (2005).
-
(2005)
Nat. Rev. Immunol
, vol.5
, pp. 446-458
-
-
Liew, F.Y.1
Xu, D.2
Brint, E.K.3
O'Neill, L.A.4
-
68
-
-
55149093640
-
Regulation of IFN and TLR signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms
-
Hu, X., Chakravarty, S.D. & Ivashkiv, L.B. Regulation of IFN and TLR signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms. Immunol. Rev. 226, 41-56 (2008).
-
(2008)
Immunol. Rev
, vol.226
, pp. 41-56
-
-
Hu, X.1
Chakravarty, S.D.2
Ivashkiv, L.B.3
-
69
-
-
0037606153
-
Inhibition of interleukin 10 signaling after Fc receptor ligation and during rheumatoid arthritis
-
Ji, J.D. et al. Inhibition of interleukin 10 signaling after Fc receptor ligation and during rheumatoid arthritis. J. Exp. Med. 197, 1573-1583 (2003).
-
(2003)
J. Exp. Med
, vol.197
, pp. 1573-1583
-
-
Ji, J.D.1
-
70
-
-
34249660614
-
SOCS proteins, cytokine signalling and immune regulation
-
Yoshimura, A., Naka, T. & Kubo, M. SOCS proteins, cytokine signalling and immune regulation. Nat. Rev. Immunol. 7, 454-465 (2007).
-
(2007)
Nat. Rev. Immunol
, vol.7
, pp. 454-465
-
-
Yoshimura, A.1
Naka, T.2
Kubo, M.3
-
71
-
-
0035168326
-
The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription
-
Bode, J.G. et al. The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription. Biol. Chem. 382, 1447-1453 (2001).
-
(2001)
Biol. Chem
, vol.382
, pp. 1447-1453
-
-
Bode, J.G.1
-
72
-
-
0035337139
-
Reversing lipopolysaccharide toxicity by ligating the macrophage Fcγ receptors
-
20bl
-
Gerber, J.S. & Mosser, D.M. Reversing lipopolysaccharide toxicity by ligating the macrophage Fcγ receptors. J. Immunol. 166, 6861-6868 (20bl).
-
J. Immunol
, vol.166
, pp. 6861-6868
-
-
Gerber, J.S.1
Mosser, D.M.2
-
73
-
-
34250803183
-
Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR-induced IL-12 and IL-10 by Fcγ receptor ligation in murine macrophages
-
Polumuri, S.K., Toshchakov, V.Y. & Vogel, S.N. Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR-induced IL-12 and IL-10 by Fcγ receptor ligation in murine macrophages. J. Immunol. 179, 236-246 (2007).
-
(2007)
J. Immunol
, vol.179
, pp. 236-246
-
-
Polumuri, S.K.1
Toshchakov, V.Y.2
Vogel, S.N.3
-
74
-
-
21244502077
-
ERK activation following macrophage FcγR ligation leads to chromatin modifications at the IL-10 locus
-
Lucas M., Zhang, X., Prasanna, V. & Mosser, D.M. ERK activation following macrophage FcγR ligation leads to chromatin modifications at the IL-10 locus. J. Immunol. 175, 469-477 (2005).
-
(2005)
J. Immunol
, vol.175
, pp. 469-477
-
-
Lucas, M.1
Zhang, X.2
Prasanna, V.3
Mosser, D.M.4
-
75
-
-
33745815324
-
Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription
-
Zhang, X., Edwards, J.P. & Mosser, D.M. Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription. J. Immunol. 177, 1282-1288 (2006).
-
(2006)
J. Immunol
, vol.177
, pp. 1282-1288
-
-
Zhang, X.1
Edwards, J.P.2
Mosser, D.M.3
-
76
-
-
32944463876
-
Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance
-
Dillon, S. et al. Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance. J. Clin. Invest. 116, 916-928 (2006).
-
(2006)
J. Clin. Invest
, vol.116
, pp. 916-928
-
-
Dillon, S.1
-
77
-
-
34250370468
-
Selective blockade ofthe inhibitory Fcγ receptor (FcγRIIB) in human dendritic cells and monocytes induces a type I interferon response program
-
Dhodapkar, K.M. et al. Selective blockade ofthe inhibitory Fcγ receptor (FcγRIIB) in human dendritic cells and monocytes induces a type I interferon response program. J. Exp. Med. 204, 1359-1369 (2007).
-
(2007)
J. Exp. Med
, vol.204
, pp. 1359-1369
-
-
Dhodapkar, K.M.1
-
78
-
-
58149195670
-
Essential role of DAP12 signaling in macrophage programming into a fusion-competent state
-
Helming, L. et al. Essential role of DAP12 signaling in macrophage programming into a fusion-competent state. Sci. Signal. 1, ra11 (2008).
-
(2008)
Sci. Signal
, vol.1
-
-
Helming, L.1
-
79
-
-
58549089167
-
Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is requrred for IL-3-induced IL-4 production in basophils
-
Hida, S. et al. Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is requrred for IL-3-induced IL-4 production in basophils. Nat. Immunol. 10, 214-222 (2009).
-
(2009)
Nat. Immunol
, vol.10
, pp. 214-222
-
-
Hida, S.1
-
80
-
-
0345281581
-
Inhibition of interleukin 2 signaling and signal transducer and activator of transcription (STAT)5 activation during T cell receptor mediated feedback inhibition of T cell expansion
-
Lee, I.H., Li, W.P., Hisert, K.B. & Ivashkiv, L.B. Inhibition of interleukin 2 signaling and signal transducer and activator of transcription (STAT)5 activation during T cell receptor mediated feedback inhibition of T cell expansion. J. Exp. Med. 190, 1263-1274 (1999).
-
(1999)
J. Exp. Med
, vol.190
, pp. 1263-1274
-
-
Lee, I.H.1
Li, W.P.2
Hisert, K.B.3
Ivashkiv, L.B.4
-
81
-
-
0034675851
-
Transient inhibition of interleukin 4 signaling by T cell receptor ligation
-
Zhu, J. et al. Transient inhibition of interleukin 4 signaling by T cell receptor ligation. J. Exp. Med. 192, 1125-1134 (2000).
-
(2000)
J. Exp. Med
, vol.192
, pp. 1125-1134
-
-
Zhu, J.1
-
82
-
-
34548748171
-
Coreceptor tuning': Cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR
-
Park, J.H. et al. 'Coreceptor tuning': Cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat. Immunol. 8, 1049-1059 (2007).
-
(2007)
Nat. Immunol
, vol.8
, pp. 1049-1059
-
-
Park, J.H.1
-
83
-
-
33645761634
-
Selective regulation of IL-10 signalling and function by zymosan
-
Du, Z. et al. Selective regulation of IL-10 signalling and function by zymosan. J. Immunol. 176, 4785-4792 (2006).
-
(2006)
J. Immunol
, vol.176
, pp. 4785-4792
-
-
Du, Z.1
-
84
-
-
22544474648
-
Inhibition of IFN-α signaling by a PKC- and protein tyrosine phosphatase SHP-2-cippenclent pathway
-
Du, Z. et al. Inhibition of IFN-α signaling by a PKC- and protein tyrosine phosphatase SHP-2-cippenclent pathway. Proc. Natl. Acad. Sci. USA 102, 10267-10272 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 10267-10272
-
-
Du, Z.1
-
85
-
-
33846225960
-
FcγRIII-dependent inhibition of interferon-γ responses mediates suppressive effects of intravenous immune globulin
-
Park-Min, K.H. et al. FcγRIII-dependent inhibition of interferon-γ responses mediates suppressive effects of intravenous immune globulin. Immunity 26, 67-78 (2007).
-
(2007)
Immunity
, vol.26
, pp. 67-78
-
-
Park-Min, K.H.1
-
86
-
-
34547470906
-
Pathological role of osteoclast costimulation in arthritis-induced bone loss
-
Ochi, S. et al. Pathological role of osteoclast costimulation in arthritis-induced bone loss. Proc. Natl. Acad Sci. USA 104, 11394-11399 (2007).
-
(2007)
Proc. Natl. Acad Sci. USA
, vol.104
, pp. 11394-11399
-
-
Ochi, S.1
-
87
-
-
0026347205
-
Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: Transcriptional induction by γ-interferon is mediated through common DNA response elements
-
Pearse, R.N., Feinman, R. & Ravetch, J.V. Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by γ-interferon is mediated through common DNA response elements. Proc. Natl. Acad. Sci. USA 88, 11305-11309 (1991).
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 11305-11309
-
-
Pearse, R.N.1
Feinman, R.2
Ravetch, J.V.3
-
88
-
-
58849137589
-
TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells
-
Bekeredjian-Ding, I. et al. TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells. J. Immunol. 161 8267-8277 (2008).
-
(2008)
J. Immunol
, vol.161
, pp. 8267-8277
-
-
Bekeredjian-Ding, I.1
-
89
-
-
18244373195
-
Cytokine-mediated regulation of activating and inhibitory Fcγ receptors in human monocytes
-
Liu, Y. et al. Cytokine-mediated regulation of activating and inhibitory Fcγ receptors in human monocytes. J. Leukoc. Biol. 77, 767-776 (2005).
-
(2005)
J. Leukoc. Biol
, vol.77
, pp. 767-776
-
-
Liu, Y.1
-
90
-
-
39749117423
-
Infliximab treatment shifts the balance between stimulatory and inhibitory Fcγ receptor type II isoforms on neutrophils in patients with rheumatoid arthritis
-
Belostocki, K. et al. Infliximab treatment shifts the balance between stimulatory and inhibitory Fcγ receptor type II isoforms on neutrophils in patients with rheumatoid arthritis. Arthritis Rheum. 58, 384-388 (2008).
-
(2008)
Arthritis Rheum
, vol.58
, pp. 384-388
-
-
Belostocki, K.1
-
91
-
-
14444268978
-
Pyk is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway
-
Miyazaki, T. et al. Pyk is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway. Genes Dev. 12, 770-775 (1998).
-
(1998)
Genes Dev
, vol.12
, pp. 770-775
-
-
Miyazaki, T.1
-
92
-
-
0033522422
-
Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPKand Stat1 in IFN-γbut not IFN-α, signaling
-
Takaoka, A. et al. Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPKand Stat1 in IFN-γbut not IFN-α, signaling. EMBO J. 18, 2480-2488 (1999).
-
(1999)
EMBO J
, vol.18
, pp. 2480-2488
-
-
Takaoka, A.1
-
93
-
-
36248957695
-
NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway
-
Horng, T., Bezbradica, J.S. & Medzhitov, R. NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol. 8, 1345-1352 (2007).
-
(2007)
Nat Immunol
, vol.8
, pp. 1345-1352
-
-
Horng, T.1
Bezbradica, J.S.2
Medzhitov, R.3
-
94
-
-
33845382697
-
The integrin α9β1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling
-
Chen, C. et al. The integrin α9β1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling. Immunity 25, 895-906 (2006).
-
(2006)
Immunity
, vol.25
, pp. 895-906
-
-
Chen, C.1
-
95
-
-
36849033963
-
TAM receptors are pleiotropic inhibitors of the innate immune response
-
Rathlin, C.V.; Ghosh, S., Zuniga, E.I., Oldstone, M.B. & Lemke, G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131, 1124-1136 (2007).
-
(2007)
Cell
, vol.131
, pp. 1124-1136
-
-
Rathlin, C.V.1
Ghosh, S.2
Zuniga, E.I.3
Oldstone, M.B.4
Lemke, G.5
-
96
-
-
34247891506
-
Structural basis of integrin regulation and signaling
-
Luo, B.H., Carman, C.V. & Springer, JA. Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 25, 619-647 (2007).
-
(2007)
Annu. Rev. Immunol
, vol.25
, pp. 619-647
-
-
Luo, B.H.1
Carman, C.V.2
Springer, J.A.3
-
97
-
-
0035910411
-
Tumor necrosis factor-α activatlon of the c-Jun N-terminal kinase pathway in human neutrophils. Integrin involvement in a pathway leading from cytoplasmic tyrosine kinases apoptosis
-
Avdi, N.J. et al. Tumor necrosis factor-α activatlon of the c-Jun N-terminal kinase pathway in human neutrophils. Integrin involvement in a pathway leading from cytoplasmic tyrosine kinases apoptosis. J. Biol. Chem. 276, 2189-2199 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 2189-2199
-
-
Avdi, N.J.1
|