Differential Use of TLR2 and TLR9 in the Regulation of Immune Responses during the Infection with Trypanosoma cruzi

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Gravina, Humberto D ^b   Antonelli, Lis ^a   Gazzinelli, Ricardo T ^a,b,c   Ropert, Catherine ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 23; INTERLEUKIN 23P40; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTACOID; CYTOKINE; LIPOPOLYSACCHARIDE; OLIGODEOXYRIBONUCLEOTIDE; TLR2 PROTEIN, MOUSE; TLR9 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; HOST RESISTANCE; IMMUNE RESPONSE; IMMUNOREGULATION; LYMPHOCYTE SUBPOPULATION; MACROPHAGE; MOLECULAR INTERACTION; MONOCYTE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TH1 CELL; ACUTE PHASE RESPONSE; ADOPTIVE TRANSFER; AGONISTS; ANIMAL; C57BL MOUSE; CELL CULTURE; GENE EXPRESSION; HOST PARASITE INTERACTION; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PARASITOLOGY; PATHOLOGY; PERITONEUM MACROPHAGE; PHYSIOLOGY; SPLEEN; TRANSPLANTATION; TRYPANOSOMA CRUZI;

MUS; TRYPANOSOMA CRUZI;

ACUTE-PHASE REACTION; ADOPTIVE TRANSFER; ANIMALS; CELLS, CULTURED; CHAGAS DISEASE; CYTOKINES; DENDRITIC CELLS; GENE EXPRESSION; HOST-PARASITE INTERACTIONS; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGODEOXYRIBONUCLEOTIDES; SPLEEN; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 9; TRYPANOSOMA CRUZI;

EID: 84877015195     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063100     Document Type: Article

References (41)

1. Takeuchi O and Akira S (2010) Pattern recognition receptors and inflammation. Cell 140(6), 805-820.
2. Gazzinelli RT and Denkers EY (2006) Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism. Nat Rev Immunol 6(12), 895-906.
3. Kopp E and Medzhitov R (2003) Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol 15(3), 335-401.
4. Ouyang X, Negishi H, Takeda R, Fujita Y, Taniguchi T, et al. (2007) Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation. Biochem Biophys Res Commun 354(4), 1045-51.
5. Krummen M, Balkow S, Shen L, Heinz S, Loquai C, et al. (2010) Release of IL-12 by dendritic cells activated by TLR ligation is dependent on MyD88 signaling, whereas TRIF signaling is indispensable for TLR synergy. J Leukoc Biol 88(1), 189-99.
6. Mäkelä SM, Strengell M, Pietilä TE, Osterlund P, Julkunen I (2009) Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells. J Leukoc Biol 85(4), 664-72.
7. Lee KS, Scanga CA, Bachelder EM, Chen Q, Snapper CM (2007) TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus pneumoniae. Cell Immunol 245(2), 103-110.
8. Bhan U, Ballinger MN, Zeng X, Newstead MJ, Cornicelli MD, et al. (2010) Cooperative interactions between TLR4 and TLR9 regulate interleukin 23 and 17 production in a murine model of gram negative bacterial pneumonia. PLoS One 5(3), e9896.
9. Almeida IC, Camargo MM, Procopio DO, Silva LS, Mehlert A, et al. (1999) Highly purified glycosylphosphatidylinositols from Trypanosoma cruzi are potent proinflammatory agents. EMBO J 19(7), 1476-1485.
10. Campos MA, Almeida IC, Takeuchi O, Akira S, Valente EP, et al. (2001) Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite. J Immunol 167(1), 416-423.
11. Bafica A, Santiago HC, Goldszmid R, Ropert C, Gazzinelli RT, et al. (2006) Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection. J Immunol 177(6), 3515-3519.
12. Bartholomeu DC, Ropert C, Melo MB, Parroche P, Junqueira CF, et al. (2008) Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi. J Immunol 181(2), 1333-1344.
13. Rodrigues MM, Oliveira AC, Bellio M (2012) The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development. J Parasitol Res 2012: 507874.
14. Cardillo F, Voltarelli JC, Reed SG, Silva JS (1996) Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin 10: role of NK cells. Infect Immun 64(1), 128-134.
15. Aliberti JCS, Cardoso MAG, Martins GA, Gazzinelli RT, Vieira LQ, et al. (1986) IL-12 mediates resistance to Trypanosoma cruzi infection in mice and is produced by normal murine macrophages in response to live trypomastigote. Infect Immun 64(6), 1961-1967.
16. Ropert C, Gazzinelli RT (2004) Regulatory role of Toll-like receptor 2 during infection with Trypanosoma cruzi. J. Endotoxin Res 10(6), 425-430.
17. Hunter CA, Ellis-Neyes LA, Slifer T, Kanaly S, Grunig G, et al. (1997) IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. J Immunol 158(7), 3311-3316.
18. Cook DN, Pisetsky DS, Swartz DA (2004) Toll-like receptors in the pathogenesis of human disease. Nat Immunol 5(10), 975-979.
19. O'Neill LA, Bryant CE, Doyle SL (2009) Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev 61(2), 177-197.
20. Ford AQ, Smith E, Noben-Trauth N, Keegan AD (2009) Alternatively activated macrophages participate in the recruitment of eosinophils to the lung in a murine model of allergic lung inflammation. Suppl J Immunol 182, 79-82.
21. Sieve AN, Meeks KD, Lee S, Berg RE (2010) A Novel Immunoregulatory Function for IL-23: Inhibition of IL-12 Dependent IFN-γ Production. Eur J Immunol 40(8), 2236-2247.
22. Trinchieri G, Sher A (2007) Cooperation of Toll-like receptor signals in innate immune defense. Nat Immun Rev 7(3), 179-190.
23. Wang J, Hu Y, Deng WW, Sun B (2009) Negative Regulation of Toll-like receptor signaling pathway. Microbes Infect 11(3), 321-327.
24. Lima ESL, Garcia I, Vicentelli M-H, Vassalli P, Minoprio P (2007) Evidence for a Protective Role of Tumor Necrosis Factor in the Acute Phase of Trypanosoma cruzi Infection in Mice. Infect Immun 65(2), 457-465.
25. Silva JS, Vespa GN, Cardoso MA, Aliberti JC, Cunha FQ (1995) Tumor necrosis factor alpha mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophages. Infect Immun 63(12), 4862-4867.
26. Silva GK, Gutierrez FR, Guedes PM, Horta CV, Cunha LD, et al. (2010) Cutting edge: Nucleotide-Binding Oligomerization domain1-dependent responses account for murine resistance against Trypanosoma cruzi infection. J Immunol 184(3), 1148-1152.
27. Pompei L, Jang S, Zamlynny B, Ravikumar S, McBride A, et al. (2007) Disparity in IL-12 release in dendritic cells and macrophages in response to Mycobacterium tuberculosis is due to use of distinct TLRs. J Immunol 178(8), 5192-5199.
28. Hou B, Benson A, Kuzmich L, DeFranco AL, Yarovinsky F (2011) Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors. Proc Natl Acad Sci USA 108(1), 278-283.
29. Janssens S, Burns K, Tschopp J, Beyaert R (2002) Regulation of Interleukin-1 and lipopolysaccharide-induced NF-kappa B activation by alternative splicing of MyD88. Curr Biol 12, 467-471.
30. Kobayashi K, Hernandez LD, Galán JE, Janeway CAJr, Medzhitov R, et al. (2002) IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110, 191-202.
31. Sengupta D, Koblansky A, Gaines J, Brown T, West AP, et al. (2010) Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adaptor Mal. J Immunol 184(2), 956-964.
32. Franklin BS, Parroche P, Ataíde MA, Lauw F, Ropert C, et al. (2009) Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function. Proc Natl Acad Sci USA 106(14), 5789-94.
33. Quesniaux V, Fremond C, Jacobs M, Parida S, Nicolle D, et al. (2004) Toll-like receptor pathways in the immune response to Mycobacteria. Microbes and Infect 6(10), 946-959.
34. Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, et al. (2009) Commensal bacteria regulate Toll-like receptor 3- dependent inflammation after skin injury. Nat Med 15(12), 1377-82.
35. Redecke V, Häcker H, Datta SK, Fermin A, Pitha PM, et al. (2004) Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol 172(5), 2739-2743.
36. Agrawal A, Dillon S, Denning TL, Pulendran B (2006) ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis. J Immunol 176(10), 5788-5796.
37. Dillon S, Agrawal A, Van Dyke T, Landreth G, McCauley L, et al. (2004) Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells. J Immunol 172(8), 4733-4743.
38. Wenink MH, Santegoets KCM, Broen JCA, van Bon L, Abdollahi-Roodsaz S, et al. (2009) TLR2 promotes Th2/Th17 responses via TLR4 and TLR7/8 by abrogating the type I IFN amplification loop. J Immunol 183(11), 6960-6970.
39. Mellett M, Atzei P, Jackson R, O'Neill LA, Moynagh PN (2011) Mal mediates TLR-induced activation of CREB and expression of IL-10. J Immunol 186(8), 4925-4935.
40. Ivashkiv LB (2011) Inflammatory signaling in macrophages: transitions from acute to tolerant and alternative activation states. European J Immunol 41(9), 2477-2481.
41. Murray PJ, Wynn TA (2011) Obstacles and opportunities for understanding macrophage polarization. J Leuk Biol 89(4), 557-563.