메뉴 건너뛰기




Volumn 43, Issue , 2007, Pages 95-103

Cholesterol production inhibitor (statin) increased bone healing in surgically created femoral defect in an animal model

Author keywords

Biochemical markers; Drug delivery system; Fracture; Healing; Osteogenic agent; Simvastatin; Statins; Tricalcium phosphate lysine

Indexed keywords

BIOLOGICAL ORGANS; BIOMARKERS; CHOLESTEROL; DRUG DELIVERY; AMINO ACIDS; BIOCHEMISTRY; BONE; DEFECTS; FRACTURE; INSTRUMENTS; LANDFORMS; MUSCLE;

EID: 34247600945     PISSN: 00678856     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (9)

References (50)
  • 1
    • 0035078127 scopus 로고    scopus 로고
    • Current trends in the enhancement of fracture healing
    • Hannouche, D, Petite, H, Sedel, L. Current trends in the enhancement of fracture healing. J Bone Joint Surg. 2001; 83-B:157-164.
    • (2001) J Bone Joint Surg , vol.83-B , pp. 157-164
    • Hannouche, D.1    Petite, H.2    Sedel, L.3
  • 5
    • 0028341364 scopus 로고
    • Effects of transforming growth factor B on bone nodule formation expression of bone morphogenetic protein-2, osteocalcin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts
    • Harris, SE, Bonewald, LF, Harris, MA, Sabatini, M, Dallas, S, Feng, JQ, Ghosh-Choudhury, N, Wozney, J, and Mundy, GR. Effects of transforming growth factor B on bone nodule formation expression of bone morphogenetic protein-2, osteocalcin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts. Journal of Bone and Mineral Research. 1994;9(6): 855-862.
    • (1994) Journal of Bone and Mineral Research , vol.9 , Issue.6 , pp. 855-862
    • Harris, S.E.1    Bonewald, L.F.2    Harris, M.A.3    Sabatini, M.4    Dallas, S.5    Feng, J.Q.6    Ghosh-Choudhury, N.7    Wozney, J.8    Mundy, G.R.9
  • 8
    • 0035929257 scopus 로고    scopus 로고
    • Pravastatin enchanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts
    • Ohnaka, K, Shimoda, S, Nawata, H, Shimokawa, H, Kaibuchi K, Iwamoto, Y, and Takayanagi, R. Pravastatin enchanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts. Biochem Biophys Res Commun. 2001;287(2):337-342.
    • (2001) Biochem Biophys Res Commun , vol.287 , Issue.2 , pp. 337-342
    • Ohnaka, K.1    Shimoda, S.2    Nawata, H.3    Shimokawa, H.4    Kaibuchi, K.5    Iwamoto, Y.6    Takayanagi, R.7
  • 9
    • 0035985804 scopus 로고    scopus 로고
    • The role of statins as potential targets for bone formation
    • Garrett, R, and Mundy, GR. The role of statins as potential targets for bone formation. Arthritis Res. 2002;4 (4):237-240.
    • (2002) Arthritis Res , vol.4 , Issue.4 , pp. 237-240
    • Garrett, R.1    Mundy, G.R.2
  • 10
    • 0037214223 scopus 로고    scopus 로고
    • The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity
    • Staal, A, Frith, JC, French, MH, Swartz, J, Gungor, T, Harrity, TW, Tamasi, J, Rogers, and Feyen, JH. The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity. J Bone Miner Res. 2003;18(1):88-96.
    • (2003) J Bone Miner Res , vol.18 , Issue.1 , pp. 88-96
    • Staal, A.1    Frith, J.C.2    French, M.H.3    Swartz, J.4    Gungor, T.5    Harrity, T.W.6    Tamasi, J.7    Rogers8    Feyen, J.H.9
  • 11
    • 0036242398 scopus 로고    scopus 로고
    • Statins and modulators of bone formation
    • Edwards, CJ, and Spector, TD, (2002). Statins and modulators of bone formation. Arthritis Res. 2002;4(3):151-153.
    • (2002) Arthritis Res , vol.4 , Issue.3 , pp. 151-153
    • Edwards, C.J.1    Spector, T.D.2
  • 12
    • 0036143126 scopus 로고    scopus 로고
    • Rhabdomyolysis and statin therapy: Relevance to the elderly
    • Sica, DA, and Gehr, TW. Rhabdomyolysis and statin therapy: Relevance to the elderly. Am J Geriatr Cardiol. 2002;1(1):48-55.
    • (2002) Am J Geriatr Cardiol , vol.1 , Issue.1 , pp. 48-55
    • Sica, D.A.1    Gehr, T.W.2
  • 13
    • 0032805692 scopus 로고    scopus 로고
    • New insights into the pharmacodynamic and pharmacokinetic properties of statins
    • Corsini, A Bellosta, S, Baetta, R, Fumagalli, R, Paoletti, R, and Bernini, F. New insights into the pharmacodynamic and pharmacokinetic properties of statins. Pharmacol Ther. 2000; 84 (3):413-428.
    • (2000) Pharmacol Ther , vol.84 , Issue.3 , pp. 413-428
    • Corsini, A.1    Bellosta, S.2    Baetta, R.3    Fumagalli, R.4    Paoletti, R.5    Bernini, F.6
  • 14
    • 0942276470 scopus 로고    scopus 로고
    • Use of statins and fracture: Results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trials
    • Bauer, DC, Mundy, GR, Jamal, SA, Black, DM, Cauley, JA, Insrud, KE, van der Klift, M, and Pols, HA. Use of statins and fracture: results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trials. Arch Inter Med. 2004;164(2):146-152.
    • (2004) Arch Inter Med , vol.164 , Issue.2 , pp. 146-152
    • Bauer, D.C.1    Mundy, G.R.2    Jamal, S.A.3    Black, D.M.4    Cauley, J.A.5    Insrud, K.E.6    van der Klift, M.7    Pols, H.A.8
  • 15
    • 17044435414 scopus 로고    scopus 로고
    • Evaluation pf the male reproductive organs after treatment with continuous sustained delivery of statin for fracture healing
    • Adah, F, Benghuzzi, H, Tucci, M, Russell, G, Tsao, A, Olivier, J, England, B. Evaluation pf the male reproductive organs after treatment with continuous sustained delivery of statin for fracture healing. Biomedical Sciences Instrumentation, 2005;41:54-61.
    • (2005) Biomedical Sciences Instrumentation , vol.41 , pp. 54-61
    • Adah, F.1    Benghuzzi, H.2    Tucci, M.3    Russell, G.4    Tsao, A.5    Olivier, J.6    England, B.7
  • 16
    • 0031172648 scopus 로고    scopus 로고
    • Calcium phosphate ceramic coatings as carriers of vancomycin
    • Radin, S, Campbell, JT, Ducheyne, P, and Cuckler, JM. Calcium phosphate ceramic coatings as carriers of vancomycin. Biomaterials. 1997;18(11):777-782.
    • (1997) Biomaterials , vol.18 , Issue.11 , pp. 777-782
    • Radin, S.1    Campbell, J.T.2    Ducheyne, P.3    Cuckler, J.M.4
  • 17
    • 0036153515 scopus 로고    scopus 로고
    • The use of vancomycin-impregnated cement beads in the management of infection of prosthetic joints
    • Taggart, T, Kerry, RM, Normal, P, and Stockey, I. The use of vancomycin-impregnated cement beads in the management of infection of prosthetic joints. J of Bone & Joint Surg. 2002;84(1): 70-72.
    • (2002) J of Bone & Joint Surg , vol.84 , Issue.1 , pp. 70-72
    • Taggart, T.1    Kerry, R.M.2    Normal, P.3    Stockey, I.4
  • 19
    • 1642341604 scopus 로고    scopus 로고
    • Simvastatin treatment partially prevents overiectomy-induced bone loss while increasing cortical bone formation
    • Oxlund, H, and Andreassen, TT. Simvastatin treatment partially prevents overiectomy-induced bone loss while increasing cortical bone formation. Bone, 2004;34(4):609-618.
    • (2004) Bone , vol.34 , Issue.4 , pp. 609-618
    • Oxlund, H.1    Andreassen, T.T.2
  • 20
    • 0034725352 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors and the risk of fractures
    • Meier, CR, Schlienger, RG, Kraenzlin, ME, Schlegel, B, and Jick, H. HMG-CoA reductase inhibitors and the risk of fractures. JAMA. 2000;283(24): 3205-3210.
    • (2000) JAMA , vol.283 , Issue.24 , pp. 3205-3210
    • Meier, C.R.1    Schlienger, R.G.2    Kraenzlin, M.E.3    Schlegel, B.4    Jick, H.5
  • 21
    • 0034725357 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients.(comment)
    • Wang, PS, Solomon, DH, Mogun, H, and Avorn, J. HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients.(comment). JAMA. 2000;283(24): 3211-3216.
    • (2000) JAMA , vol.283 , Issue.24 , pp. 3211-3216
    • Wang, P.S.1    Solomon, D.H.2    Mogun, H.3    Avorn, J.4
  • 23
    • 0034709764 scopus 로고    scopus 로고
    • Oral stains and increased bone-mineral density in post-menopausal women
    • Edwards, CJ, Hart, DJ, and Spector, TD. Oral stains and increased bone-mineral density in post-menopausal women. Lancet. 2000;355 (9222): 2218-2219.
    • (2000) Lancet , vol.355 , Issue.9222 , pp. 2218-2219
    • Edwards, C.J.1    Hart, D.J.2    Spector, T.D.3
  • 24
    • 0035901052 scopus 로고    scopus 로고
    • Effect of pravastatin on frequency of fracture in the LIPID study: Secondary analysis of a randomised controlled trial. Long term intervention with pravastatin in ischaemic disease
    • Reid, IR, Hague, W, Emberson, J, Baker, J, Tonkin, A, Hunt, D, MacMahon, S, and Sharpe, N. Effect of pravastatin on frequency of fracture in the LIPID study: secondary analysis of a randomised controlled trial. Long term intervention with pravastatin in ischaemic disease. Lancet. 2001;357(9255):509-512.
    • (2001) Lancet , vol.357 , Issue.9255 , pp. 509-512
    • Reid, I.R.1    Hague, W.2    Emberson, J.3    Baker, J.4    Tonkin, A.5    Hunt, D.6    MacMahon, S.7    Sharpe, N.8
  • 26
    • 0031399294 scopus 로고    scopus 로고
    • The effect of sustained delivery of androstendion on the functional activities of adult male rats
    • Benghuzzi, H. The effect of sustained delivery of androstendion on the functional activities of adult male rats. Biomedical Sciences Instrumentation. 1998;34:7-12.
    • (1998) Biomedical Sciences Instrumentation , vol.34 , pp. 7-12
    • Benghuzzi, H.1
  • 27
    • 0029072965 scopus 로고
    • The effect of sustained delivery of danazol and antioxidants on lipoprotein profiles of adult female mice
    • Benghuzzi, HA, and England, BG. The effect of sustained delivery of danazol and antioxidants on lipoprotein profiles of adult female mice. Biomedical Sciences Instrumentation. 1995;31:171-176.
    • (1995) Biomedical Sciences Instrumentation , vol.31 , pp. 171-176
    • Benghuzzi, H.A.1    England, B.G.2
  • 28
    • 0031419660 scopus 로고    scopus 로고
    • Cellular responses to various levels of sustained delivery of testosterone in the ventral prostate
    • Cavett, W, Tucci, M, Cason, Z, Lemos, L, and England, B. Cellular responses to various levels of sustained delivery of testosterone in the ventral prostate. Biomedical Sciences Instrumentation. 1997;33: 155-160.
    • (1997) Biomedical Sciences Instrumentation , vol.33 , pp. 155-160
    • Cavett, W.1    Tucci, M.2    Cason, Z.3    Lemos, L.4    England, B.5
  • 29
    • 0031418936 scopus 로고    scopus 로고
    • Germinal cell alterations associated with sustained delivery of testosterone enanthate in adult male rats
    • Varnado, M, Tucci, M, Cason, Z, Mohamed, A, and Benghuzzi, H. Germinal cell alterations associated with sustained delivery of testosterone enanthate in adult male rats. Biomedical Sciences Intrumentation. 1997;33:161-165.
    • (1997) Biomedical Sciences Intrumentation , vol.33 , pp. 161-165
    • Varnado, M.1    Tucci, M.2    Cason, Z.3    Mohamed, A.4    Benghuzzi, H.5
  • 30
    • 0028567346 scopus 로고
    • Development of a ceramic matrix system for continuous delivery of azidothymidine
    • Nagy, EA, and Bajpai, PK. Development of a ceramic matrix system for continuous delivery of azidothymidine. Biomedical Sciences Instrumentation. 1994;30:181-186.
    • (1994) Biomedical Sciences Instrumentation , vol.30 , pp. 181-186
    • Nagy, E.A.1    Bajpai, P.K.2
  • 31
    • 0025865854 scopus 로고
    • The effect of various testosterone concentrations released from ceramic delivery systems on the circulating hormone levels of adult castrated rams
    • England, BG, Benghuzzi, HA, Possley, RM, and Bajpai, PK. The effect of various testosterone concentrations released from ceramic delivery systems on the circulating hormone levels of adult castrated rams. Biomedical Sciences Instrumentation. 1991;27:89-195.
    • (1991) Biomedical Sciences Instrumentation , vol.27 , pp. 89-195
    • England, B.G.1    Benghuzzi, H.A.2    Possley, R.M.3    Bajpai, P.K.4
  • 32
    • 0025780150 scopus 로고
    • Tricalcium phosphate amino acid capsules as a drug delivery system for steroid hormones
    • Benghuzzi, HA, England, BG, and Bajpai, PK. Tricalcium phosphate amino acid capsules as a drug delivery system for steroid hormones. Biomedical Sciences Instrumentation. 1991;27:197-203.
    • (1991) Biomedical Sciences Instrumentation , vol.27 , pp. 197-203
    • Benghuzzi, H.A.1    England, B.G.2    Bajpai, P.K.3
  • 34
    • 0028605564 scopus 로고
    • Pulsatile delivery of progesterone and estradiol to mimic the ovulatory surge in adult ewes by means of TCPL implants
    • Benghuzzi, HA, Possley, R, and England, BG. Pulsatile delivery of progesterone and estradiol to mimic the ovulatory surge in adult ewes by means of TCPL implants. Biomedical Sciences Instrumentation. 1994;30:187-196.
    • (1994) Biomedical Sciences Instrumentation , vol.30 , pp. 187-196
    • Benghuzzi, H.A.1    Possley, R.2    England, B.G.3
  • 36
    • 0035032172 scopus 로고    scopus 로고
    • Morphometric analysis of cortical bone upon the exposure to sustained delivery of anabolic promoting agents using adult male rats as a model
    • Tramontana J, Benghuzzi H, Tucci M, Tsao A, and Hughes J. Morphometric analysis of cortical bone upon the exposure to sustained delivery of anabolic promoting agents using adult male rats as a model. Biomedical Science Intrumentaion. 2001;37:293-298.
    • (2001) Biomedical Science Intrumentaion , vol.37 , pp. 293-298
    • Tramontana, J.1    Benghuzzi, H.2    Tucci, M.3    Tsao, A.4    Hughes, J.5
  • 37
    • 33745202291 scopus 로고    scopus 로고
    • Effects of sustained release of statin by means of tricalcium phosphate lysine delivery system in defect and segmental femoral injuries on certain biochemical markers in vivovaluation pf the male reproductive organs after treatment with continuous sustained delivery of statin for fracture healing
    • Adah, F, Benghuzzi, H, Tucci, M, Russell, G, and England, B. Effects of sustained release of statin by means of tricalcium phosphate lysine delivery system in defect and segmental femoral injuries on certain biochemical markers in vivovaluation pf the male reproductive organs after treatment with continuous sustained delivery of statin for fracture healing. Biomedical Sciences Instrumentation, 2006;42:126-135.
    • (2006) Biomedical Sciences Instrumentation , vol.42 , pp. 126-135
    • Adah, F.1    Benghuzzi, H.2    Tucci, M.3    Russell, G.4    England, B.5
  • 38
    • 0035030588 scopus 로고    scopus 로고
    • The Use of estrogen, DHEA, and diosgenin in a sustained delivery setting as a novel treatment approach for osteoporosis in the ovariectomized adult rat model
    • Higdon, K, Scott, A, Tucci, M, Benghuzzi, H, Tsao, A, Puckett, A, Cason, Z, and Hughes, J. The Use of estrogen, DHEA, and diosgenin in a sustained delivery setting as a novel treatment approach for osteoporosis in the ovariectomized adult rat model. Biomedical Sciences Instrumentation. 2001;(37):281-286.
    • (2001) Biomedical Sciences Instrumentation , vol.37 , pp. 281-286
    • Higdon, K.1    Scott, A.2    Tucci, M.3    Benghuzzi, H.4    Tsao, A.5    Puckett, A.6    Cason, Z.7    Hughes, J.8
  • 41
    • 0036828513 scopus 로고    scopus 로고
    • Simvastatin improves fracture healing in mice
    • Skoglund, B, Forslund, C, and Aspenberg, P. Simvastatin improves fracture healing in mice. J Bone Miner Res. 2002; (11): 2004-2008.
    • (2002) J Bone Miner Res , vol.11 , pp. 2004-2008
    • Skoglund, B.1    Forslund, C.2    Aspenberg, P.3
  • 42
    • 0036063969 scopus 로고    scopus 로고
    • Relation of statin use and bone loss: A prospective population-based cohort study in early post-menmopausal women
    • Sirola, J, Honkanen, R, Kroger, H, Jurbelin, JS, Maenpaa, P, and Saarikoski, S. Relation of statin use and bone loss: A prospective population-based cohort study in early post-menmopausal women. Osteoporosis International. 2002; 13(7): 537-541.
    • (2002) Osteoporosis International , vol.13 , Issue.7 , pp. 537-541
    • Sirola, J.1    Honkanen, R.2    Kroger, H.3    Jurbelin, J.S.4    Maenpaa, P.5    Saarikoski, S.6
  • 45
    • 0035211808 scopus 로고    scopus 로고
    • Statin given perorally to adult rats increases cancellous bone mass and compressive strength
    • Oxlund, H, Dalstra, M, and Andressen, TT. Statin given perorally to adult rats increases cancellous bone mass and compressive strength. Calcified Tissue International. 2001;69(5):299-304.
    • (2001) Calcified Tissue International , vol.69 , Issue.5 , pp. 299-304
    • Oxlund, H.1    Dalstra, M.2    Andressen, T.T.3
  • 47
    • 0030879089 scopus 로고    scopus 로고
    • Treatment of osteomyelitis with a biodegradable antibiotic implant
    • Calhoun, JH, and Mader, JT. Treatment of osteomyelitis with a biodegradable antibiotic implant. Clin Orthopedic and Related Research. 1997;(341):206-214.
    • (1997) Clin Orthopedic and Related Research , vol.341 , pp. 206-214
    • Calhoun, J.H.1    Mader, J.T.2
  • 48
    • 0030248144 scopus 로고    scopus 로고
    • Comparative investigation of drug delivery of collagen implants saturated in antibiotic solutions and a sponge containing gentimicin
    • Wachol-Drewek, Z, Pfeiffer, M, and Scholl, E. Comparative investigation of drug delivery of collagen implants saturated in antibiotic solutions and a sponge containing gentimicin. Biomaterials. 1996;17(17):1773-1778.
    • (1996) Biomaterials , vol.17 , Issue.17 , pp. 1773-1778
    • Wachol-Drewek, Z.1    Pfeiffer, M.2    Scholl, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.