Biodegradable block copolymers as injectable drug-delivery systems

Nature

Volumn 388, Issue 6645, 1997, Pages 860-862

  Jeong, Byeongmoon ^a   Bae, You Han ^a   Lee, Doo Sung ^a   Kim, Sung Wan ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; BIOSYNTHESIS; DRUG PRODUCTS; DRUG THERAPY; ELECTRIC FIELD EFFECTS; HYDROGELS; PH EFFECTS; POLYETHYLENE OXIDES; RING OPENING POLYMERIZATION; THERMAL EFFECTS;

BIODEGRADABLE BLOCK COPOLYMERS; POLYLACTIC ACID;

BLOCK COPOLYMERS;

COPOLYMER; MACROGOL; MICROSPHERE; ORGANIC SOLVENT; POLY(N ISOPROPYLACRYLAMIDE); POLYLACTIC ACID; POLYPROPYLENE;

AQUEOUS SOLUTION; ARTICLE; BIODEGRADATION; DRUG DELIVERY SYSTEM; DRUG IMPLANT; DRUG MANUFACTURE; ENCAPSULATION; HEAT SENSITIVITY; HYDROGEL; PHASE TRANSITION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DENATURATION; SOLID STATE; SUBCUTANEOUS DRUG ADMINISTRATION; SUSTAINED RELEASE PREPARATION; TEMPERATURE DEPENDENCE;

ANIMALS; BIODEGRADATION, ENVIRONMENTAL; DELAYED-ACTION PREPARATIONS; DEXTRANS; DRUG DELIVERY SYSTEMS; FLUORESCEIN-5-ISOTHIOCYANATE; GELS; INJECTIONS; LACTIC ACID; POLYETHYLENE GLYCOLS; POLYMERS; RATS;

EID: 0001319478     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/42218     Document Type: Article

References (13)

1. Langer, R. New methods of drug delivery. Science 249, 1527-1533 (1990).
2. Ishihara, K., Muramoto, N. & Shinohara, I. Controlled release of organic substances using polymer membrane with responsive function for amino compounds. J. Appl Polym. Sci. 29, 211-217 (1984).
3. Thomas, J. L., You, H. & Tirrel, D. A. Tuning the response of a pH-sensitive membrane switch. J. Am. Chem. Soc. 117, 2949-2950 (1995).
4. Kwon, I. C., Bae, Y. H. & Kim, S. W. Electrically credible polymer gel for controlled release of drugs. Nature 354, 291-293 (1991).
5. Bae, Y. H., Okano, T., Hsu, R. & Kim, S. W. Thermo-sensitive polymers as on-off switches for drug release. Makromol. Chem. Rapid Commun. 8, 481-485 (1987).
6. Chen, G. H. & Hoffman, A. S. Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH, Nature 373, 49-52 (1995).
7. Malstom, M. & Lindman, B. Self-assembly in aqueous block copolymer solutions. Macromolecules 25, 5440-5445 (1992).
8. Youxin, L. & Kissel, T. Synthesis and properties of biodegradable ABA triblock copolymers consisting of poly(L-lactic acid) or poly(L-lactic-co-glycolic acid) A-blocks attached to central poly(oxyethylene) B-blocks. J. Controlled Release 27, 247-257 (1993).
9. Alexandrisdis, P., Holzwarth, J. F. & Hatton, T. A. Micellization of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers in aqueous solution: Thermodynamics of copolymer association. Macromolecules 27, 2414-2425 (1994).
10. Moritz, A. R. & Henrique, F. C. Jr Studies on thermal injury II. The relative importance of time and surface temperature in the causation of cutaneous burns. Am. J. Pathol. 23, 695-720 (1947).
11. Ronneberger, B., Kao, W. J., Anderson, J. A. & Kissel, T. In-vivo biocompatibility study of ABA triblock copolymers consisting of poly(L-lactic-co-glycolic acid) A blocks attached to central poly(oxyethylene) B blocks. J. Biomed. Mater. Res. 30, 31-40 (1996).
12. Zhu, K. J., Lin, X. & Yang, S. Preparation, characterization, and properties of polylactide (PLA)-poly(ethyleneglycol) (PEG) copolymers: potential drug carriers. J. Appl. Polym. Sci. 39, 1-9 (1990).
13. Wout, Z. G. M., Pec, E. A., Maggiore, R. H., Palicharla, P. & Johnston, T. Poloxamer 407-mediated changes in plasma cholesterol and triglycerides following intraperitoneal injection to rats. J. Parenteral Sci. Technol. 46, 192-200 (1992).