A Cell-Permeant Amiloride Derivative Induces Caspase-Independent, AIF-Mediated Programmed Necrotic Death of Breast Cancer Cells

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Leon, Leonardo J ^a,b   Pasupuleti, Nagarekha ^a   Gorin, Fredric ^a,b   Carraway III, Kermit L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE DERIVATIVE; ANTINEOPLASTIC AGENT; ION TRANSPORT AFFECTING AGENT; LACTATE DEHYDROGENASE; UCD 38 B; UCD 74 A; UNCLASSIFIED DRUG; 5-BENZYLGLYCINYL AMILORIDE; AMILORIDE; APOPTOSIS INDUCING FACTOR; CALCIUM; CALPAIN; CASPASE; GLYCINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL MEDIATED CYTOTOXICITY; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG STRUCTURE; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM; FLUORESCENCE MICROSCOPY; IMMUNOBLOTTING; ANALOGS AND DERIVATIVES; BREAST TUMOR; CELL CYCLE; CELL DEATH; CELL NUCLEUS; CHEMISTRY; DRUG EFFECTS; FEMALE; HUMAN; METABOLISM; PROTEIN TRANSPORT; TOXICITY; TUMOR CELL LINE; ULTRASTRUCTURE;

AMILORIDE; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BREAST NEOPLASMS; CALCIUM; CALPAIN; CASPASES; CELL CYCLE; CELL DEATH; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; CELL NUCLEUS; ENDOPLASMIC RETICULUM; FEMALE; GLYCINE; HUMANS; PROTEIN TRANSPORT;

EID: 84876977360     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063038     Document Type: Article

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