AIF-mediated caspase-independent necroptosis: A new chance for targeted therapeutics

IUBMB Life

Volumn 63, Issue 4, 2011, Pages 221-232

  Delavallée, Laure ^a,b,c   Cabon, Lauriane ^a,b,c   Galán Malo, Patricia ^a,b,c   Lorenzo, Hans K ^d,e,f   Susin, Santos A ^a,b,c  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d UNIVERSITÉ PARIS SACLAY   (France)

^e BICÊTRE HOSPITAL   (France)

^f INSTITUT ANDRÉ LWOFF   (France)

Author keywords

AIF; apoptosis; BAX; BCL 2; calpains; caspase independent cell death; DNA damage; mitochondria; MNNG; necroptosis; PARP 1; programmed necrosis

Indexed keywords

2 AMINO N [4 [5 (2 PHENANTHRENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]PHENYL]ACETAMIDE; 8 FLUORO 3,4 DIHYDRO 2 [4 (METHYLAMINOMETHYL)PHENYL]PYRROLO[3,4,5 E,F][2]BENZAZEPIN 6(5H) ONE; [1 [(1 FORMYL 2 PHENYLETHYL)CARBAMOYL] 2 METHYLPROPYL]CARBAMIC ACID BENZYL ESTER; AK 275; AK 295; ALOXISTATIN; APOPTOSIS INDUCING FACTOR; ATIPRIMOD; BEZIELLE; BOBEL 24; CALPASTATIN; CASPASE; DY 9760E; FLAVOPIRIDOL; INO 1001; MINOCYCLINE; OLAPARIB; PARTHANATOS PROTEIN; PLANT EXTRACT; PROGRAMMED DEATH 1 RECEPTOR; SNJ 1945; SORAFENIB; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG; VELIPARIB;

ACUTE HEART INFARCTION; ACUTE KIDNEY FAILURE; ADVANCED CANCER; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; ARCHAEBACTERIUM; BACTERIUM; BRAIN ISCHEMIA; BRAIN TUMOR; BREAST CANCER; CARBOXY TERMINAL SEQUENCE; CARCINOID; CARCINOMA; CELL DEATH; CHRONIC LYMPHATIC LEUKEMIA; COLORECTAL CANCER; DNA DEGRADATION; DRUG CYTOTOXICITY; DRUG TARGETING; EMBRYO DEVELOPMENT; ENDOMETRIUM CARCINOMA; ESOPHAGUS CANCER; EXCITOTOXICITY; GLIOMA; HUMAN; HUNTINGTON CHOREA; INVERTEBRATE; ISCHEMIA; KIDNEY CARCINOMA; LIVER CELL CARCINOMA; LUNG NON SMALL CELL CANCER; MELANOMA; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL TARGETING SIGNAL; MITOCHONDRION; MULTIPLE MYELOMA; MULTIPLE SCLEROSIS; NECROPTOSIS; NERVE CELL NECROSIS; OVARY CANCER; OXIDATIVE STRESS; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PHENOTYPE; POSTOPERATIVE COMPLICATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SECRETION; REVIEW; SIGNAL TRANSDUCTION; SOLID TUMOR; SQUAMOUS CELL CARCINOMA; STOMACH CANCER; VERTEBRATE;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS INDUCING FACTOR; CASPASES; CELL DEATH; CONSERVED SEQUENCE; HUMANS; MITOCHONDRIA; MOLECULAR TARGETED THERAPY;

EID: 79954520766     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.432     Document Type: Review

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