Na+:H+ exchange inhibition induces intracellular acidosis and differentially impairs cell growth and viability of human and rat hepatocarcinoma cells

Toxicology Letters

Volumn 106, Issue 2-3, 1999, Pages 215-228

  Garcia Canero R ^a   Trilla, C ^a   Perez De Diego J ^b   Diaz Gil J J ^a   Cobo, J M ^c  

^a Clin Puerta H   (Spain)

^b UNIVERSIDAD ALFONSO X EL SABIO   (Spain)

^c UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

Hexamethylene amiloride; Human hepatocarcinoma; Intracellular pH; Na+:H+ exchange

Indexed keywords

5 (N,N HEXAMETHYLENE)AMILORIDE; ACETYLCYSTEINE; AMILORIDE; AMILORIDE DERIVATIVE; CELL PROTEIN; DEFEROXAMINE; FREE RADICAL; GLUTATHIONE; PROTON; SODIUM ION;

ACIDOSIS; ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CELL PH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; HUMAN; HUMAN CELL; ION EXCHANGE; LIVER CELL CARCINOMA; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RNA SYNTHESIS;

ACIDOSIS; AMILORIDE; ANIMALS; ANTINEOPLASTIC AGENTS; CALCIUM; CARCINOMA, HEPATOCELLULAR; CELL DIVISION; CELL SURVIVAL; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIVER NEOPLASMS; RATS; SODIUM; TUMOR CELLS, CULTURED;

EID: 0345517131     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(99)00072-7     Document Type: Article

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