Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice

Development

Volumn 128, Issue 23, 2001, Pages 4899-4910

  Suter, A ^a   Everts, V ^a   Boyde, A ^a   Jones, S J ^a   Lullmann Rauch R ^a   Hartman, D ^a   Hayman, A R ^a   Cox, T M ^a   Evans, M J ^a   Meister, T ^a   Von Figura, K ^a   Saftig, P ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Bone resorption; Kupffer cells; Lysosomal storage; Macrophages; Mouse; Osteoclasts; Osteopontin

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; CEREBROSIDE SULFATASE; LYSOSOME ENZYME; MANNOSE 6 PHOSPHATE; OSTEOPONTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL LINEAGE; CELL VACUOLE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENDOCYTOSIS; ENZYME DEFICIENCY; ENZYME SUBSTRATE; GAIT DISORDER; GENETIC COMPLEMENTATION; GROWTH DISORDER; GROWTH PLATE; HEPATOSPLENOMEGALY; HISTOLOGY; KIDNEY; LIVER; LONG BONE; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; OSTEOCLAST; PHAGOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCANNING ELECTRON MICROSCOPY; SOFT TISSUE; SPLEEN;

ACID PHOSPHATASE; ANIMALS; BONE AND BONES; HEPATOMEGALY; ISOENZYMES; KIDNEY; LIVER; LYSOSOMAL STORAGE DISEASES; LYSOSOMES; MANNOSEPHOSPHATES; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; OSTEOPONTIN; PHENOTYPE; PHOSPHORYLATION; SIALOGLYCOPROTEINS; SPLEEN; SPLENOMEGALY;

ANIMALIA;

EID: 0035208079     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. The tartrate-resistant purple acid phosphatase of bone osteoclasts-a protein phosphatase with multivalent substrate specificity and regulation
2. Regulation and expression of type V (tartrate-resistant) acid phosphatase in human mononuclear phagocytes
3. Lysosomal acid phosphatase is transported to lysosomes via the cell surface
4. Lysosomal acid phosphatase is not involved in the dephosphorylation of mannose 6-phosphate containing lysosomal proteins
5. Dephosphorylation of the mannose-6-phosphate recognition marker is localized in later compartments of the endocytic route. Identification of purple acid phosphatase (uteroferrin) as the candidate phosphatase
6. Mice lacking tartrate-resistant acid phosphatase (Acp5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen Staphylococcus aureus
7. Ultrastructural localization of tartrate-resistant, purple acid phosphatase in rat osteoclasts by histochemistry and immunocytochemistry
8. Subcellular distribution of low- and high-molecular-weight acid phosphatases
9. Characterization and expression of tartrate-resistant acid phosphatase (TRAP) in hematopoietic cells
10. Antibodies to porcine uteroferrin used in measurement of human tartrate-resistant acid phosphatase
11. Dephosphorylation of osteopontin and bone sialoprotein by osteoclastic tartrate-resistant acid phosphatase. Modulation of osteoclast adhesion in vitro
12. RGD-directed attachment of isolated rat osteoclasts to osteopontin, bone sialoprotein, and fibronectin
13. Tartrate-inhibitable acid phosphatase. Purification from placenta, characterization and subcellular distribution in fibroblasts
14. Sequential processing of lysosomal acid phosphatase by a cytoplasmic thiol proteinase and a lysosomal aspartyl proteinase
15. Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis
16. Osteoclastic tartrate-resistant acid phosphatase (Acp 5): Its localization to dendritic cells and diverse murine tissues
17. Lysosomal acid phosphatase is internalized via clathrin-coated pits
18. Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes
19. The phosphorus content of lysosomes in hepatocytes and Kupffer cells. A study using electron-spectroscopic imaging
20. Osteopontin at mineralized tissue interfaces in bone, teeth, and osseointegrated implants: Ultrastructural distribution and implications for mineralized tissue formation, turnover, and repair
21. Bone acid phosphatase: Tartrate-resistant acid phosphatase as a marker of osteoclast function
22. Lipid storage disorders
23. The two mannose 6-phosphate receptors transport distinct complements of lysosomal
24. Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system
25. Function and properties of chimeric MPR 46-MPR 300 mannose 6-phosphate receptors
26. Molecular cloning and sequence analysis of cDNA encoding human prostatic acid phosphatase
27. An enzyme with a double identity: Purple acid phosphatase and tartrate-resistant acid phosphatase
28. Immunological characterization of human acid phosphatase gene products
29. Immunohistochemical detection of tartrate-resistant acid phosphatase in non-hematopoietic human tissues