V-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation

Nature Medicine

Volumn 12, Issue 12, 2006, Pages 1403-1409

  Lee, Seoung Hoon ^a   Rho, Jaerang ^a,d   Jeong, Daewon ^a,d,e   Sul, Jai Yoon ^a   Kim, Taesoo ^a   Kim, Nacksung ^a,d,f   Kang, Ju Seob ^a,d,g   Miyamoto, Takeshi ^b   Suda, Toshio ^b   Lee, Sun Kyeong ^c   Pignolo, Robert J ^a   Koczon Jaremko, Boguslawa ^c   Lorenzo, Joseph ^c   Choi, Yongwon ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b KEIO UNIVERSITY   (Japan)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^d Chungnam National University   (South Korea)

^e Yeungnam University College of Medicine   (South Korea)

^f Chonnam National University Medical School   (South Korea)

^g Hanyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; MESSENGER RNA; COLONY STIMULATING FACTOR 1; ISOPROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; PROTON PUMP; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATP6V0D2 GENE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL FUSION; CELL LINEAGE; CELL MATURATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME SUBUNIT; GENE; GENE EXPRESSION; GENE INACTIVATION; HISTOPATHOLOGY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; PRIORITY JOURNAL; ANIMAL; BONE DEVELOPMENT; C57BL MOUSE; CELL CULTURE; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; GENETICS; HUMAN; MOUSE MUTANT; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ANIMALS; CELL DIFFERENTIATION; CELL FUSION; CELLS, CULTURED; HUMANS; MACROPHAGE COLONY-STIMULATING FACTOR; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OSTEOCLASTS; OSTEOGENESIS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTON PUMPS; RANK LIGAND; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 33845537394     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1514     Document Type: Article

References (22)

1. Walsh, M.C. et al. Osteoimmunology: interplay between the immune system and bone metabolism. Annu. Rev. Immunol. 24, 33-63 (2006).
2. Teitelbaum, S.L. Bone resorption by osteoclasts. Science 289, 1504-1508 (2000).
3. Yagi, M. et al. DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J. Exp. Med. 202, 345-351 (2005).
4. Nishi, T., Kawasaki-Nishi, S. & Forgac, M. Expression and function of the mouse V-ATPase d subunit isoforms. J. Biol. Chem. 278, 46396-46402 (2003).
5. Sun-Wada, G.H., Yoshimizu, T., Imai-Senga, Y., Wada, Y. & Futai, M. Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits. Gene 302, 147-153 (2003).
6. Smith, A.N., Borthwick, K.J. & Karet, F.E. Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis. Gene 297, 169-177 (2002).
7. Rho, J. et al. Gene expression profiling of osteoclast differentiation by combined suppression subtractive hybridization (SSH) and cDNA microarray analysis. DNA Cell Biol. 21, 541-549 (2002).
8. Nishi, T. & Forgac, M. The vacuolar (H+)-ATPases - nature's most versatile proton pumps. Nat. Rev. Mol. Cell Biol. 3, 94-103 (2002).
9. Stevens, T.H. & Forgac, M. Structure, function and regulation of the vacuolar (H+)-ATPase. Annu. Rev. Cell Dev. Biol. 13, 779-808 (1997).
10. Suda, T., Jimi, E., Nakamura, I. & Takahashi, N. Role of 1α,25-dihydroxyvitamin D3 in osteoclast differentiation and function. Methods Enzymol. 282, 223-235 (1997).
11. Kadono, Y. et al. Strength of TRAF6 signalling determines osteoclastogenesis. EMBO Rep. 6, 171-176 (2005).
12. Li, Y.P., Chen, W., Liang, Y., Li, E. & Stashenko, P. Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat. Genet. 23, 447-451 (1999).
13. Takami, M., Woo, J.T. & Nagai, K. Osteoblastic cells induce fusion and activation of osteoclasts through a mechanism independent of macrophage-colony-stimulating factor production. Cell Tissue Res. 298, 327-334 (1999).
14. Chen, E.H. & Olson, E.N. Unveiling the mechanisms of cell-cell fusion. Science 308, 369-373 (2005).
15. Verrier, S., Hogan, A., McKie, N. & Horton, M. ADAM gene expression and regulation during human osteoclast formation. Bone 35, 34-46 (2004).
16. Abe, E., Mocharla, H., Yamate, T., Taguchi, Y. & Manolagas, S.C. Meltrin-alpha, a fusion protein involved in multinucleated giant cell and osteoclast formation. Calcif. Tissue Int. 64, 508-515 (1999).
17. Choi, S.J., Han, J.H. & Roodman, G.D. ADAM8: a novel osteoclast stimulating factor. J. Bone Miner. Res. 16, 814-822 (2001).
18. Martin, T.J. & Sims, N.A. Osteoclast-derived activity in the coupling of bone formation to resoption. Trends Mol. Med. 11, 76-81 (2005).
19. Rho, J., Gong, S., Kim, N. & Choi, Y. TDAG51 is not essential for Fas/CD95 regulation and apoptosis in vivo. Mol. Cell. Biol. 21, 8365-8370 (2001).
20. Lee, S.K. et al. Interleukin-7 influences osteoclast function in vivo but is not a critical factor in ovariectomy-induced bone loss. J. Bone Miner. Res. 21, 695-702 (2006).
21. Montero, A. et al. Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation. J. Clin. Invest. 105, 1085-1093 (2000).
22. Jacquin, C., Gran, D.E., Lee, S.K., Lorenzo, J.A. & Aguila, H.L. Identification of multiple osteoclast precursor populations in murine bone marrow. J. Bone Miner. Res. 21, 67-77 (2006).