Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells

Cell Death and Disease

Volumn 4, Issue 4, 2013, Pages

  Song, X ^a   Kim, S Y ^a   Zhou, Z ^b   Lagasse, E ^b   Kwon, Y T ^c,d   Lee, Y J ^a,b  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c Seoul National University   (South Korea)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

C FLIPL; Hyperthermia; Mapatumumab; Mitochondria independent pathway; Ubiquitination

Indexed keywords

ARGININE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; DEATH RECEPTOR; FLICE INHIBITORY PROTEIN; LYSINE; MAPATUMUMAB; MESSENGER RNA; PROTEASOME; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLLEUCYL LEUCYL LEUCINE ALDEHYDE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; LEUPEPTIN; MONOCLONAL ANTIBODY; PROTEASOME INHIBITOR; UBIQUITIN;

APOPTOSIS; ARTICLE; CANCER CELL; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; GENE SILENCING; HEAT TREATMENT; HUMAN; HUMAN CELL; HYPERTHERMIC THERAPY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN STABILITY; UBIQUITINATION; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HEAT; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HOT TEMPERATURE; HUMANS; LEUPEPTINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PROTEOLYSIS; SIGNAL TRANSDUCTION; UBIQUITIN;

EID: 84876908739     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.104     Document Type: Article

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