메뉴 건너뛰기




Volumn 17, Issue 9, 2010, Pages 1448-1462

Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation

Author keywords

Akt1; apoptosis; dephosphorylation; differentiation; PP 1

Indexed keywords

PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B;

EID: 77955711839     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2010.16     Document Type: Article
Times cited : (85)

References (63)
  • 2
    • 70350745708 scopus 로고    scopus 로고
    • Protein serine/threonine phosphatases in the nerve system
    • Binder, Hirokawa, Windhorst (eds) Springer: Heidelberg
    • Yan Q, Mao Y-W, Li DW. Protein serine/threonine phosphatases in the nerve system. In: Binder, Hirokawa, Windhorst (eds). Encyclopedia of Neuroscience. Springer: Heidelberg, 2009, pp 3325-3329.
    • (2009) Encyclopedia of Neuroscience , pp. 3325-3329
    • Yan, Q.1    Mao, Y.-W.2    Li, D.W.3
  • 3
    • 0024397415 scopus 로고
    • The structure and regulation of protein phosphatases
    • Cohen P. The structure and regulation of protein phosphatases. Annu Rev Biochem 1989; 58: 453-508.
    • (1989) Annu Rev Biochem , vol.58 , pp. 453-508
    • Cohen, P.1
  • 4
    • 0027143725 scopus 로고
    • Protein serine/threonine phosphatases: Structure, regulation, and functions in cell growth
    • Mumby MC, Walter G. Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth. Physiol Rev 1993; 73: 673-699.
    • (1993) Physiol Rev , vol.73 , pp. 673-699
    • Mumby, M.C.1    Walter, G.2
  • 5
    • 33646889064 scopus 로고    scopus 로고
    • Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities
    • Li DW-C, Liu J-P, Schmid PC, Schelosser R, Feng H, Liu W-B et al. Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities. Oncogene 2006; 25: 3006-3022.
    • (2006) Oncogene , vol.25 , pp. 3006-3022
    • Dw-C, L.1    Liu, J.-P.2    Schmid, P.C.3    Schelosser, R.4    Feng, H.5    Liu, W.-B.6
  • 6
    • 42949170340 scopus 로고    scopus 로고
    • Protein phosphatase-2A is a target of epigallocatechin-3-gallate and regulates p53-Bak apoptotic pathway
    • Qin J-C, Chen H-J, Yan Q, Deng M, Liu J-P, Doerge S et al. Protein phosphatase-2A is a target of epigallocatechin-3-gallate and regulates p53-Bak apoptotic pathway. Cancer Res 2008; 68: 4150-4162.
    • (2008) Cancer Res , vol.68 , pp. 4150-4162
    • Qin, J.-C.1    Chen, H.-J.2    Yan, Q.3    Deng, M.4    Liu, J.-P.5    Doerge, S.6
  • 7
    • 0942301178 scopus 로고    scopus 로고
    • Phosphorylation of p53 at Serine 37 is important for transcriptional activity and regulation in response to DNA damage
    • Dohoney KM, Guillerm C, Whiteford C, Elbi C, Lambert PF, Hager GL et al. Phosphorylation of p53 at Serine 37 is important for transcriptional activity and regulation in response to DNA damage. Oncogene 2004; 23: 49-57.
    • (2004) Oncogene , vol.23 , pp. 49-57
    • Dohoney, K.M.1    Guillerm, C.2    Whiteford, C.3    Elbi, C.4    Lambert, P.F.5    Hager, G.L.6
  • 8
    • 0035489468 scopus 로고    scopus 로고
    • PKB/AKT: Functional insights from genetic models
    • Scheid MP, Woodgett JR. PKB/AKT: functional insights from genetic models. Nat Rev Mol Cell Biol 2001; 2: 760-768.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 760-768
    • Scheid, M.P.1    Woodgett, J.R.2
  • 9
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev 1999; 13: 2905-2927.
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 10
    • 0030907987 scopus 로고    scopus 로고
    • PI3K: Downstream AKTion blocks apoptosis
    • Franke TF, Kaplan DR, Cantley LC. PI3K: downstream AKTion blocks apoptosis. Cell 1997; 88: 435-437.
    • (1997) Cell , vol.88 , pp. 435-437
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3
  • 11
    • 0034168037 scopus 로고    scopus 로고
    • Protein kinase C-mediated regulation of the cell cycle
    • Black JD. Protein kinase C-mediated regulation of the cell cycle. Front Biosci 2000; 5: D406-D423.
    • (2000) Front Biosci , vol.5
    • Black, J.D.1
  • 12
    • 0034845958 scopus 로고    scopus 로고
    • PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?
    • Lawlor MA, Alessi DR. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 2001; 114: 2903-2910.
    • (2001) J Cell Sci , vol.114 , pp. 2903-2910
    • Lawlor, M.A.1    Alessi, D.R.2
  • 13
    • 0036185848 scopus 로고    scopus 로고
    • The protein kinase B/Akt signalling pathway in human malignancy
    • Nicholson KM, Anderson NG. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 2002; 14: 381-395.
    • (2002) Cell Signal , vol.14 , pp. 381-395
    • Nicholson, K.M.1    Anderson, N.G.2
  • 14
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 15
    • 33644840939 scopus 로고    scopus 로고
    • Prime time for JNK-mediated Akt reactivation in hypoxia-reoxygenation
    • Shaw J, Kirshenbaum JA. Prime time for JNK-mediated Akt reactivation in hypoxia-reoxygenation. Circ Res 2006; 98: 7-9.
    • (2006) Circ Res , vol.98 , pp. 7-9
    • Shaw, J.1    Kirshenbaum, J.A.2
  • 16
    • 33644841906 scopus 로고    scopus 로고
    • C-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo
    • Shao Z, Bhattacharya K, Hsich E, Park L, Walters B, Germann U et al. c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo. Circ Res 2006; 98: 111-118.
    • (2006) Circ Res , vol.98 , pp. 111-118
    • Shao, Z.1    Bhattacharya, K.2    Hsich, E.3    Park, L.4    Walters, B.5    Germann, U.6
  • 18
    • 0032578999 scopus 로고    scopus 로고
    • Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
    • Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB et al. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 1998; 279: 710-714.
    • (1998) Science , vol.279 , pp. 710-714
    • Stephens, L.1    Anderson, K.2    Stokoe, D.3    Erdjument-Bromage, H.4    Painter, G.F.5    Holmes, A.B.6
  • 19
    • 0033565608 scopus 로고    scopus 로고
    • The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation
    • Behn-Krappa A, Newton AC. The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation. Curr Biol 1999; 9: 728-737.
    • (1999) Curr Biol , vol.9 , pp. 728-737
    • Behn-Krappa, A.1    Newton, A.C.2
  • 20
    • 0034708482 scopus 로고    scopus 로고
    • Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site
    • Toker A, Newton AC. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J Biol Chem 2000; 275: 8271-8274.
    • (2000) J Biol Chem , vol.275 , pp. 8271-8274
    • Toker, A.1    Newton, A.C.2
  • 21
    • 0035413599 scopus 로고    scopus 로고
    • Phosphoinositide-regulated kinases and phosphoinositide phosphatases
    • Leslie NR, Biondi RM, Alessi DR. Phosphoinositide-regulated kinases and phosphoinositide phosphatases. Chem Rev 2001; 101: 2365-2380.
    • (2001) Chem Rev , vol.101 , pp. 2365-2380
    • Leslie, N.R.1    Biondi, R.M.2    Alessi, D.R.3
  • 22
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307: 1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 23
    • 33749076673 scopus 로고    scopus 로고
    • SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    • Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY et al. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006; 127: 125-137.
    • (2006) Cell , vol.127 , pp. 125-137
    • Jacinto, E.1    Facchinetti, V.2    Liu, D.3    Soto, N.4    Wei, S.5    Jung, S.Y.6
  • 24
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998; 273: 13375-13378.
    • (1998) J Biol Chem , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 25
    • 0036899518 scopus 로고    scopus 로고
    • PTEN and myotubularin phosphatases: From 3-phosphoinositide dephosphorylation to disease
    • Wishart MJ, Dixon JE. PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. Trends Cell Biol 2002; 12: 579-585.
    • (2002) Trends Cell Biol , vol.12 , pp. 579-585
    • Wishart, M.J.1    Dixon, J.E.2
  • 26
    • 15944406764 scopus 로고    scopus 로고
    • PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
    • Gao T, Furnari F, Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 2005; 18: 13-24.
    • (2005) Mol Cell , vol.18 , pp. 13-24
    • Gao, T.1    Furnari, F.2    Newton, A.C.3
  • 27
    • 33947203621 scopus 로고    scopus 로고
    • PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
    • Brognard J, Sierecki E, Gao T, Newton AC. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell 2007; 25: 917-931.
    • (2007) Mol Cell , vol.25 , pp. 917-931
    • Brognard, J.1    Sierecki, E.2    Gao, T.3    Newton, A.C.4
  • 28
    • 0029942186 scopus 로고    scopus 로고
    • Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors
    • Andjelkovic M, Jakubowicz T, Cron P, Ming XF, Han JW, Hemmings BA. Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci USA 1996; 93: 5699-5704.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5699-5704
    • Andjelkovic, M.1    Jakubowicz, T.2    Cron, P.3    Ming, X.F.4    Han, J.W.5    Hemmings, B.A.6
  • 29
    • 38349190654 scopus 로고    scopus 로고
    • Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt
    • Kuo Y-C, Huang K-Y, Yang C-H, Yang Y-S, Lee W-Y, Chiang C-W. Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt. J Biol Chem 2008; 283: 1882-1892.
    • (2008) J Biol Chem , vol.283 , pp. 1882-1892
    • Kuo, Y.-C.1    Huang, K.-Y.2    Yang, C.-H.3    Yang, Y.-S.4    Lee, W.-Y.5    Chiang, C.-W.6
  • 30
    • 0034931503 scopus 로고    scopus 로고
    • Yang L et al. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
    • Han Z, Boyle DL, Chang L, Bennett B, Karin M, Yang L et al. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest 2001; 108: 73-81.
    • (2001) J Clin Invest , vol.108 , pp. 73-81
    • Han, Z.1    Boyle, D.L.2    Chang, L.3    Bennett, B.4    Karin, M.5
  • 31
    • 33750006297 scopus 로고    scopus 로고
    • Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins
    • Xing Y, Xu Y, Chen Y, Jeffrey PD, Chao Y, Zheng L et al. Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. Cell 2006; 127: 341-352.
    • (2006) Cell , vol.127 , pp. 341-352
    • Xing, Y.1    Xu, Y.2    Chen, Y.3    Jeffrey, P.D.4    Chao, Y.5    Zheng, L.6
  • 32
    • 4444281383 scopus 로고    scopus 로고
    • Human alphaA-and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathways
    • Liu JP, Schlosser R, Ma WY, Dong Z, Feng H, Lui L et al. Human alphaA-and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathways. Exp Eye Res 2004; 79: 393-403.
    • (2004) Exp Eye Res , vol.79 , pp. 393-403
    • Liu, J.P.1    Schlosser, R.2    Ma, W.Y.3    Dong, Z.4    Feng, H.5    Lui, L.6
  • 33
    • 0034651983 scopus 로고    scopus 로고
    • Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart
    • Fujio Y, Nguyen T, Wencker D, Kitsis RN, Walsh K. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 2000; 101: 660-667.
    • (2000) Circulation , vol.101 , pp. 660-667
    • Fujio, Y.1    Nguyen, T.2    Wencker, D.3    Kitsis, R.N.4    Walsh, K.5
  • 34
    • 0035902451 scopus 로고    scopus 로고
    • Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo
    • Matsui T, Tao J, del Monte F, Lee KH, Li L, Picard MH et al. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation 2001; 104: 330-335.
    • (2001) Circulation , vol.104 , pp. 330-335
    • Matsui, T.1    Tao, J.2    Del Monte, F.3    Lee, K.H.4    Li, L.5    Picard, M.H.6
  • 36
    • 0032699449 scopus 로고    scopus 로고
    • Which factors stimulate lens fiber cell differentiation in vivo?
    • Lang RA. Which factors stimulate lens fiber cell differentiation in vivo? Invest Ophthalmol Vis Sci 1999; 40: 3075-3078.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 3075-3078
    • Lang, R.A.1
  • 37
    • 0034992107 scopus 로고    scopus 로고
    • Secreted FGFR3, but not FGFR1, inhibits lens fiber differentiation
    • Govindarajan V, Overbeek PA. Secreted FGFR3, but not FGFR1, inhibits lens fiber differentiation. Development 2001; 128: 1617-1627.
    • (2001) Development , vol.128 , pp. 1617-1627
    • Govindarajan, V.1    Overbeek, P.A.2
  • 38
    • 0035691974 scopus 로고    scopus 로고
    • FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signalling
    • Lovicu FJ, McAvoy JW. FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signalling. Development 2001; 128: 5075-5084.
    • (2001) Development , vol.128 , pp. 5075-5084
    • Lovicu, F.J.1    McAvoy, J.W.2
  • 39
    • 0035833256 scopus 로고    scopus 로고
    • A novel role for FGF and extracellular signal-regulated kinase in gap junction-mediated intercellular communication in the lens
    • Le AC, Musil LS. A novel role for FGF and extracellular signal-regulated kinase in gap junction-mediated intercellular communication in the lens. J Cell Biol 2001; 154: 197-216.
    • (2001) J Cell Biol , vol.154 , pp. 197-216
    • Le, A.C.1    Musil, L.S.2
  • 40
    • 0037414828 scopus 로고    scopus 로고
    • The stability of the lens-specific Maf protein is regulated by fibroblast growth factor (FGF)/ERK signaling in lens fiber differentiation
    • Ochi H, Ogino H, Kageyama Y, Yasuda K. The stability of the lens-specific Maf protein is regulated by fibroblast growth factor (FGF)/ERK signaling in lens fiber differentiation. J Biol Chem 2003; 278: 537-544.
    • (2003) J Biol Chem , vol.278 , pp. 537-544
    • Ochi, H.1    Ogino, H.2    Kageyama, Y.3    Yasuda, K.4
  • 41
    • 0034997845 scopus 로고    scopus 로고
    • Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
    • Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 2001; 22: 153-183.
    • (2001) Endocr Rev , vol.22 , pp. 153-183
    • Pearson, G.1    Robinson, F.2    Beers Gibson, T.3    Xu, B.E.4    Karandikar, M.5    Berman, K.6
  • 42
    • 4644254018 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase (PI-3K)/Akt but not PI-3K/p70 S6 kinase signaling mediates IGF-1-promoted lens epithelial cell survival
    • Chandrasekher G, Sailaja D. Phosphatidylinositol 3-kinase (PI-3K)/Akt but not PI-3K/p70 S6 kinase signaling mediates IGF-1-promoted lens epithelial cell survival. Invest Ophthalmol Vis Sci 2004; 45: 3577-3588.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 3577-3588
    • Chandrasekher, G.1    Sailaja, D.2
  • 43
    • 10344231494 scopus 로고    scopus 로고
    • Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina
    • Gotoh N, Ito M, Yamamoto S, Yoshino I, Song N, Wang Y et al. Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina. Proc Natl Acad Sci USA 2004; 101: 17144-17149.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 17144-17149
    • Gotoh, N.1    Ito, M.2    Yamamoto, S.3    Yoshino, I.4    Song, N.5    Wang, Y.6
  • 44
    • 16244401977 scopus 로고    scopus 로고
    • Characterization and functional activity of thrombin receptors in the human lens
    • James C, Collison DJ, Duncan G. Characterization and functional activity of thrombin receptors in the human lens. Invest Ophthalmol Vis Sci 2005; 46: 925-932.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 925-932
    • James, C.1    Collison, D.J.2    Duncan, G.3
  • 45
    • 33745128008 scopus 로고    scopus 로고
    • Aqueous humour-and growth factor-induced lens cell proliferation is dependent on MAPK/ERK1/2 and Akt/PI3-K signalling
    • Iyengar L, Patkunanathan B, Lynch OT, McAvoy JW, Rasko JE, Lovicu FJ. Aqueous humour-and growth factor-induced lens cell proliferation is dependent on MAPK/ERK1/2 and Akt/PI3-K signalling. Exp Eye Res 2008; 83: 667-678.
    • (2008) Exp Eye Res , vol.83 , pp. 667-678
    • Iyengar, L.1    Patkunanathan, B.2    Lynch, O.T.3    McAvoy, J.W.4    Rasko, J.E.5    Lovicu, F.J.6
  • 46
    • 69249202259 scopus 로고    scopus 로고
    • Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions
    • Jiang Y, Luo W, Howe PH. Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions. Oncogene 2009; 28: 2999-3007.
    • (2009) Oncogene , vol.28 , pp. 2999-3007
    • Jiang, Y.1    Luo, W.2    Howe, P.H.3
  • 47
    • 1642539976 scopus 로고    scopus 로고
    • GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type i receptor
    • Shi W, Sun C, He B, Xiong W, Shi X, Yao D et al. GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor. J Cell Biol 2004; 164: 291-300.
    • (2004) J Cell Biol , vol.164 , pp. 291-300
    • Shi, W.1    Sun, C.2    He, B.3    Xiong, W.4    Shi, X.5    Yao, D.6
  • 48
    • 42449137850 scopus 로고    scopus 로고
    • Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1
    • Li HY, Liu H, Wang CH, Zhang JY, Man JH, Gao YF et al. Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1. Nat Immunol 2008; 9: 533-541.
    • (2008) Nat Immunol , vol.9 , pp. 533-541
    • Li, H.Y.1    Liu, H.2    Wang, C.H.3    Zhang, J.Y.4    Man, J.H.5    Gao, Y.F.6
  • 49
    • 0035947778 scopus 로고    scopus 로고
    • Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
    • Novoa I, Zeng H, Harding HP, Ron D. Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. J Cell Biol 2001; 53: 1011-1022.
    • (2001) J Cell Biol , vol.53 , pp. 1011-1022
    • Novoa, I.1    Zeng, H.2    Harding, H.P.3    Ron, D.4
  • 50
    • 0345599024 scopus 로고    scopus 로고
    • Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells
    • Jousse C, Oyadomari S, Novoa I, Lu P, Zhang Y, Harding HP et al. Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells. J Cell Biol 2003; 163: 767-775.
    • (2003) J Cell Biol , vol.163 , pp. 767-775
    • Jousse, C.1    Oyadomari, S.2    Novoa, I.3    Lu, P.4    Zhang, Y.5    Harding, H.P.6
  • 51
    • 0034808081 scopus 로고    scopus 로고
    • Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1
    • Connor JH, Weiser DC, Li S, Hallenbeck JM, Shenolikar S. Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. Mol Cell Biol 2001; 21: 6841-6850.
    • (2001) Mol Cell Biol , vol.21 , pp. 6841-6850
    • Connor, J.H.1    Weiser, D.C.2    Li, S.3    Hallenbeck, J.M.4    Shenolikar, S.5
  • 52
    • 65449141379 scopus 로고    scopus 로고
    • An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation
    • Lee YY, Cevallos RC, Jan E. An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation. J Biol Chem 2009; 284: 6661-6673.
    • (2009) J Biol Chem , vol.284 , pp. 6661-6673
    • Lee, Y.Y.1    Cevallos, R.C.2    Jan, E.3
  • 53
    • 0037096159 scopus 로고    scopus 로고
    • Involvement of protein phosphatase-1-mediated MARCKS translocation in myogenic differentiation of embryonic muscle cells
    • Kim SS, Kim JH, Lee SH, Chung SS, Bang OS, Park D et al. Involvement of protein phosphatase-1-mediated MARCKS translocation in myogenic differentiation of embryonic muscle cells. J Cell Sci 2002; 115 (Pt 12): 2465-2473.
    • (2002) J Cell Sci , vol.115 , Issue.PART 12 , pp. 2465-2473
    • Kim, S.S.1    Kim, J.H.2    Lee, S.H.3    Chung, S.S.4    Bang, O.S.5    Park, D.6
  • 54
    • 34347240393 scopus 로고    scopus 로고
    • Protein phosphatase-1 dephosphorylates Pax-6, a transcription factor controlling brain and eye development
    • Yan Q, Liu W-B, Qin J, Liu J-P, Chen H-G, Huang X et al. Protein phosphatase-1 dephosphorylates Pax-6, a transcription factor controlling brain and eye development. J Biol Chem 2007; 282: 13954-13965.
    • (2007) J Biol Chem , vol.282 , pp. 13954-13965
    • Yan, Q.1    Liu, W.-B.2    Qin, J.3    Liu, J.-P.4    Chen, H.-G.5    Huang, X.6
  • 55
    • 0028335717 scopus 로고
    • Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
    • Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 1994; 9: 1799-1805.
    • (1994) Oncogene , vol.9 , pp. 1799-1805
    • Miyashita, T.1    Krajewski, S.2    Krajewska, M.3    Wang, H.G.4    Lin, H.K.5    Liebermann, D.A.6
  • 57
    • 2342553892 scopus 로고    scopus 로고
    • Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
    • Leu JI, Dumont P, Hafey M, Murphy ME, George DL. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol 2004; 6: 443-450.
    • (2004) Nat Cell Biol , vol.6 , pp. 443-450
    • Leu, J.I.1    Dumont, P.2    Hafey, M.3    Murphy, M.E.4    George, D.L.5
  • 58
    • 4944255743 scopus 로고    scopus 로고
    • Post-translational modification of p53 in tumorigenesis
    • Bode AM, Dong ZG. Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer 2004; 4: 793-805.
    • (2004) Nat Rev Cancer , vol.4 , pp. 793-805
    • Bode, A.M.1    Dong, Z.G.2
  • 59
    • 34347232361 scopus 로고    scopus 로고
    • Phactr4 regulates neural tube and optic fissure closure by controlling PP1-,Rb-, and E2F1-regulated cell-cycle progression
    • Kim TH, Goodman J, Anderson KV, Niswander L. Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression. Dev Cell 2007; 13: 87-102.
    • (2007) Dev Cell , vol.13 , pp. 87-102
    • Kim, T.H.1    Goodman, J.2    Anderson, K.V.3    Niswander, L.4
  • 60
    • 0037161961 scopus 로고    scopus 로고
    • Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating RB/E2F pathway
    • Xiang H, Wang J, Mao Y, Liu M, Reddy VN, Li DW. Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating RB/E2F pathway. Oncogene 2002; 21: 3784-3791.
    • (2002) Oncogene , vol.21 , pp. 3784-3791
    • Xiang, H.1    Wang, J.2    Mao, Y.3    Liu, M.4    Reddy, V.N.5    Li, D.W.6
  • 61
    • 2442681777 scopus 로고    scopus 로고
    • Human alphaA-and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis
    • Mao YW, Liu JP, Xiang H, Li DW. Human alphaA-and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine- induced apoptosis. Cell Death Differ 2004; 11: 512-526.
    • (2004) Cell Death Differ , vol.11 , pp. 512-526
    • Mao, Y.W.1    Liu, J.P.2    Xiang, H.3    Li, D.W.4
  • 62
    • 70349198164 scopus 로고    scopus 로고
    • Transcriptional regulation of PP2A-Aa is mediated by multiple factors including AP-2a, CREB, ETS, and SP-1
    • Chen H-G, Han W-J, Deng M, Qin J-C, Yuan D, Liu J-P et al. Transcriptional regulation of PP2A-Aa is mediated by multiple factors including AP-2a, CREB, ETS, and SP-1. PLoS ONE 2009; 4: e7019.
    • (2009) PLoS ONE , vol.4
    • Chen, H.-G.1    Han, W.-J.2    Deng, M.3    Qin, J.-C.4    Yuan, D.5    Liu, J.-P.6
  • 63
    • 24344508124 scopus 로고    scopus 로고
    • Calcium-activated RAF/MEK/ERK pathway mediates p53-dependent apoptosis and is abrogated by aB-crystallin through inhibition of Ras activation
    • Li DW-C, Liu J-P, Mao YW, Xiang H, Wang J, Ma W-Y. et al. Calcium-activated RAF/MEK/ERK pathway mediates p53-dependent apoptosis and is abrogated by aB-crystallin through inhibition of Ras activation. Mol Biol Cell 2005; 16: 4437-4453.
    • (2005) Mol Biol Cell , vol.16 , pp. 4437-4453
    • Dw-C, L.1    Liu, J.-P.2    Mao, Y.W.3    Xiang, H.4    Wang, J.5    Ma, W.-Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.