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Volumn 10, Issue 13, 2000, Pages 1405-1408

Antifungal rapamycin analogues with reduced immunosuppressive activity

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; CARBAMIC ACID DERIVATIVE; IMMUNOSUPPRESSIVE AGENT; RAPAMYCIN;

EID: 0034601227     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00184-0     Document Type: Article
Times cited : (15)

References (29)
  • 2
    • 0028568541 scopus 로고
    • (b)
    • (b) Sternberg, S. Science 1994, 266, 1632.
    • (1994) Science , vol.266 , pp. 1632
    • Sternberg, S.1
  • 25
    • 0343657610 scopus 로고    scopus 로고
    • US 5,672,605 and references cited therein
    • Or, Y. S.; Luly, J. R.; Wagner, R. US 5,672,605 and references cited therein.
    • Or, Y.S.1    Luly, J.R.2    Wagner, R.3
  • 26
    • 0342787390 scopus 로고    scopus 로고
    • Holt, D. A. Keenan, T. P.; Clackson, T. P.; Rozamus, L.; Yang, W.; Gilman, M. Z. WO9802441-A2
    • Holt, D. A. Keenan, T. P.; Clackson, T. P.; Rozamus, L.; Yang, W.; Gilman, M. Z. WO9802441-A2.
  • 27
    • 0343221936 scopus 로고    scopus 로고
    • Note
    • 13b The epimeric products were purfied by preparative HPLC (acetone:hexane gradient from 1:10 to 20:1 ratios). Compounds 13, 14 and 15 were synthesized from 1 and acetyl hydroxamic acid and N-hydroxyurea. Substituted N-hydroxycarbamates and N-hydroxyureas were prepared by reaction of the corresponding chloroformates in a stirred biphasic water-dichloromethane solution in the presence of 2.0 equiv of hydroxylamine-HCl and 3.0 equiv sodium bicarbonate 12 h; the aqueous layer was acidified with phosphoric acid and the organic layer was concentrated to yield the N-hydroxycarbamate. Compounds 23 and 25, were prepared by reaction of N-carbonylphenoxy-hydroxylamine with piperidine and morpholine, respectively. Compound 24 was formed as a side product when water was present in the Lewis-acid catalyzed reaction mixture. All compounds were characterized by NMR and HRMS.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.