메뉴 건너뛰기




Volumn 43, Issue 5, 2013, Pages 1173-1184

Efficiently stimulated adult microglia cross-prime naive CD8+ T cells injected in the brain

Author keywords

Adult microglia; Ag cross priming; CNS

Indexed keywords

ANIMAL CELL; ARTICLE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL STIMULATION; CROSS PRESENTATION; IN VIVO STUDY; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 84876874642     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201243040     Document Type: Article
Times cited : (35)

References (68)
  • 2
    • 77953925499 scopus 로고    scopus 로고
    • Site-specific opening of the blood-brain barrier
    • Madsen, S. J. and Hirschberg, H., Site-specific opening of the blood-brain barrier. J. Biophotonics 2010. 3: 356-367.
    • (2010) J. Biophotonics , vol.3 , pp. 356-367
    • Madsen, S.J.1    Hirschberg, H.2
  • 3
    • 77951837763 scopus 로고    scopus 로고
    • Trafficking of immune cells in the central nervous system
    • Wilson, E. H., Weninger, W. and Hunter, C. A., Trafficking of immune cells in the central nervous system. J. Clin. Investig. 2010. 120: 1368-1379.
    • (2010) J. Clin. Investig. , vol.120 , pp. 1368-1379
    • Wilson, E.H.1    Weninger, W.2    Hunter, C.A.3
  • 5
    • 80355143546 scopus 로고    scopus 로고
    • Microglial cell origin and phenotypes in health and disease
    • Saijo, K. and Glass, C. K., Microglial cell origin and phenotypes in health and disease. Nat. Rev. Immunol. 2011. 11: 775-787.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 775-787
    • Saijo, K.1    Glass, C.K.2
  • 7
    • 78650233802 scopus 로고    scopus 로고
    • Microglia in the CNS: immigrants from another world
    • Prinz, M. and Mildner, A., Microglia in the CNS: immigrants from another world. Glia 2011. 59: 177-187.
    • (2011) Glia , vol.59 , pp. 177-187
    • Prinz, M.1    Mildner, A.2
  • 8
    • 0032053391 scopus 로고    scopus 로고
    • Mouse resident microglia: isolation and characterization of immunoregulatory properties with naive CD4+ and CD8+ T-cells
    • Havenith, C. E., Askew, D. and Walker, W. S., Mouse resident microglia: isolation and characterization of immunoregulatory properties with naive CD4+ and CD8+ T-cells. Glia 1998. 22: 348-359.
    • (1998) Glia , vol.22 , pp. 348-359
    • Havenith, C.E.1    Askew, D.2    Walker, W.S.3
  • 9
    • 27344438118 scopus 로고    scopus 로고
    • Identification of new CNS-resident macrophage subpopulation molecular markers for the discrimination with murine systemic macrophages
    • Donnou, S., Fisson, S., Mahe, D., Montoni, A. and Couez, D., Identification of new CNS-resident macrophage subpopulation molecular markers for the discrimination with murine systemic macrophages. J. Neuroimmunol. 2005. 169: 39-49.
    • (2005) J. Neuroimmunol. , vol.169 , pp. 39-49
    • Donnou, S.1    Fisson, S.2    Mahe, D.3    Montoni, A.4    Couez, D.5
  • 11
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: a sensor for pathological events in the CNS
    • Kreutzberg, G. W., Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996. 19: 312-318.
    • (1996) Trends Neurosci. , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 12
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn, A., Kirchhoff, F. and Helmchen, F., Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005. 308: 1314-1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 14
    • 65249157852 scopus 로고    scopus 로고
    • Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals
    • Wake, H., Moorhouse, A. J., Jinno, S., Kohsaka, S. and Nabekura, J., Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J. Neurosci. 2009. 29: 3974-3980.
    • (2009) J. Neurosci. , vol.29 , pp. 3974-3980
    • Wake, H.1    Moorhouse, A.J.2    Jinno, S.3    Kohsaka, S.4    Nabekura, J.5
  • 15
    • 80052315340 scopus 로고    scopus 로고
    • Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential
    • Hanke, M. L. and Kielian, T., Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential. Clin. Sci. 2011. 121: 367-387.
    • (2011) Clin. Sci. , vol.121 , pp. 367-387
    • Hanke, M.L.1    Kielian, T.2
  • 16
    • 84862804952 scopus 로고    scopus 로고
    • Accessory molecules for Toll-like receptors and their function
    • Lee, C. C., Avalos, A. M. and Ploegh, H. L., Accessory molecules for Toll-like receptors and their function. Nat. Rev. Immunol. 2012. 12: 168-179.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 168-179
    • Lee, C.C.1    Avalos, A.M.2    Ploegh, H.L.3
  • 17
    • 59349112140 scopus 로고    scopus 로고
    • Microglial clearance function in health and disease
    • Napoli, I. and Neumann, H., Microglial clearance function in health and disease. Neuroscience 2009. 158: 1030-1038.
    • (2009) Neuroscience , vol.158 , pp. 1030-1038
    • Napoli, I.1    Neumann, H.2
  • 18
    • 31144457903 scopus 로고    scopus 로고
    • CD40 expression by microglial cells is required for their completion of a two-step activation process during central nervous system autoimmune inflammation
    • Ponomarev, E. D., Shriver, L. P. and Dittel, B. N., CD40 expression by microglial cells is required for their completion of a two-step activation process during central nervous system autoimmune inflammation. J. Immunol. 2006. 176: 1402-1410.
    • (2006) J. Immunol. , vol.176 , pp. 1402-1410
    • Ponomarev, E.D.1    Shriver, L.P.2    Dittel, B.N.3
  • 19
    • 25444484079 scopus 로고    scopus 로고
    • Microglial cell activation and proliferation precedes the onset of CNS autoimmunity
    • Ponomarev, E. D., Shriver, L. P., Maresz, K. and Dittel, B. N., Microglial cell activation and proliferation precedes the onset of CNS autoimmunity. J. Neurosci. Res. 2005. 81: 374-389.
    • (2005) J. Neurosci. Res. , vol.81 , pp. 374-389
    • Ponomarev, E.D.1    Shriver, L.P.2    Maresz, K.3    Dittel, B.N.4
  • 20
    • 0032524997 scopus 로고    scopus 로고
    • Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation
    • Aloisi, F., Ria, F., Penna, G. and Adorini, L., Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation. J. Immunol. 1998. 160: 4671-4680.
    • (1998) J. Immunol. , vol.160 , pp. 4671-4680
    • Aloisi, F.1    Ria, F.2    Penna, G.3    Adorini, L.4
  • 21
    • 0029002659 scopus 로고
    • Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared
    • Ford, A. L., Goodsall, A. L., Hickey, W. F. and Sedgwick, J. D., Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared. J. Immunol. 1995. 154: 4309-4321.
    • (1995) J. Immunol. , vol.154 , pp. 4309-4321
    • Ford, A.L.1    Goodsall, A.L.2    Hickey, W.F.3    Sedgwick, J.D.4
  • 23
    • 0030937833 scopus 로고    scopus 로고
    • Capture and processing of exogenous antigens for presentation on MHC molecules
    • Watts, C., Capture and processing of exogenous antigens for presentation on MHC molecules. Annu. Rev. Immunol. 1997. 15: 821-850.
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 821-850
    • Watts, C.1
  • 24
    • 0033280323 scopus 로고    scopus 로고
    • Mechanisms of viral interference with MHC class I antigen processing and presentation
    • Yewdell, J. W. and Bennink, J. R., Mechanisms of viral interference with MHC class I antigen processing and presentation. Annu. Rev. Cell Dev. Biol. 1999. 15: 579-606.
    • (1999) Annu. Rev. Cell Dev. Biol. , vol.15 , pp. 579-606
    • Yewdell, J.W.1    Bennink, J.R.2
  • 26
    • 30044434147 scopus 로고    scopus 로고
    • Priming of T cells by exogenous antigen cross-presented on MHC class I molecules
    • Shen, L. and Rock, K. L., Priming of T cells by exogenous antigen cross-presented on MHC class I molecules. Curr. Opin. Immunol. 2006. 18: 85-91.
    • (2006) Curr. Opin. Immunol. , vol.18 , pp. 85-91
    • Shen, L.1    Rock, K.L.2
  • 28
    • 0030852624 scopus 로고    scopus 로고
    • Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells
    • Kurts, C., Kosaka, H., Carbone, F. R., Miller, J. F. and Heath, W. R., Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells. J. Exp. Med. 1997. 186: 239-245.
    • (1997) J. Exp. Med. , vol.186 , pp. 239-245
    • Kurts, C.1    Kosaka, H.2    Carbone, F.R.3    Miller, J.F.4    Heath, W.R.5
  • 29
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau, J. and Steinman, R. M., Dendritic cells and the control of immunity. Nature 1998. 392: 245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 30
    • 0025991258 scopus 로고
    • Macrophages as accessory cells for class I MHC-restricted immune responses
    • Debrick, J. E., Campbell, P. A. and Staerz, U. D., Macrophages as accessory cells for class I MHC-restricted immune responses. J. Immunol. 1991. 147: 2846-2851.
    • (1991) J. Immunol. , vol.147 , pp. 2846-2851
    • Debrick, J.E.1    Campbell, P.A.2    Staerz, U.D.3
  • 31
    • 39149113772 scopus 로고    scopus 로고
    • Antigen presentation by monocytes and monocyte-derived cells
    • Randolph, G. J., Jakubzick, C. and Qu, C., Antigen presentation by monocytes and monocyte-derived cells. Curr. Opin. Immunol. 2008. 20: 52-60.
    • (2008) Curr. Opin. Immunol. , vol.20 , pp. 52-60
    • Randolph, G.J.1    Jakubzick, C.2    Qu, C.3
  • 32
    • 17844363748 scopus 로고    scopus 로고
    • B lymphocytes participate in cross-presentation of antigen following gene gun vaccination
    • Hon, H., Oran, A., Brocker, T. and Jacob, J., B lymphocytes participate in cross-presentation of antigen following gene gun vaccination. J. Immunol. 2005. 174: 5233-5242.
    • (2005) J. Immunol. , vol.174 , pp. 5233-5242
    • Hon, H.1    Oran, A.2    Brocker, T.3    Jacob, J.4
  • 35
    • 0034665112 scopus 로고    scopus 로고
    • The brain parenchyma is permissive for full antitumor CTL effector function, even in the absence of CD4 T cells
    • Walker, P. R., Calzascia, T., Schnuriger, V., Scamuffa, N., Saas, P., de Tribolet, N. and Dietrich, P. Y., The brain parenchyma is permissive for full antitumor CTL effector function, even in the absence of CD4 T cells. J. Immunol. 2000. 165: 3128-3135.
    • (2000) J. Immunol. , vol.165 , pp. 3128-3135
    • Walker, P.R.1    Calzascia, T.2    Schnuriger, V.3    Scamuffa, N.4    Saas, P.5    de Tribolet, N.6    Dietrich, P.Y.7
  • 36
    • 77953537495 scopus 로고    scopus 로고
    • Activated microglial cells acquire an immature dendritic cell phenotype and may terminate the immune response in an acute model of EAE
    • Almolda, B., Gonzalez, B. and Castellano, B., Activated microglial cells acquire an immature dendritic cell phenotype and may terminate the immune response in an acute model of EAE. J. Neuroimmunol. 2010. 223: 39-54.
    • (2010) J. Neuroimmunol. , vol.223 , pp. 39-54
    • Almolda, B.1    Gonzalez, B.2    Castellano, B.3
  • 37
    • 0035865406 scopus 로고    scopus 로고
    • Brain dendritic cells and macrophages/microglia in central nervous system inflammation
    • Fischer, H. G. and Reichmann, G., Brain dendritic cells and macrophages/microglia in central nervous system inflammation. J. Immunol. 2001. 166: 2717-2726.
    • (2001) J. Immunol. , vol.166 , pp. 2717-2726
    • Fischer, H.G.1    Reichmann, G.2
  • 38
    • 0036347321 scopus 로고    scopus 로고
    • Dendritic cells and dendritic-like microglia in focal cortical ischemia of the mouse brain
    • Reichmann, G., Schroeter, M., Jander, S. and Fischer, H. G., Dendritic cells and dendritic-like microglia in focal cortical ischemia of the mouse brain. J. Neuroimmunol. 2002. 129: 125-132.
    • (2002) J. Neuroimmunol. , vol.129 , pp. 125-132
    • Reichmann, G.1    Schroeter, M.2    Jander, S.3    Fischer, H.G.4
  • 39
    • 7644232963 scopus 로고    scopus 로고
    • Damaging and protective cell signalling in the untargeted effects of ionizing radiation
    • Coates, P. J., Lorimore, S. A. and Wright, E. G., Damaging and protective cell signalling in the untargeted effects of ionizing radiation. Mutat. Res. 2004. 568: 5-20.
    • (2004) Mutat. Res. , vol.568 , pp. 5-20
    • Coates, P.J.1    Lorimore, S.A.2    Wright, E.G.3
  • 40
    • 84862783824 scopus 로고    scopus 로고
    • Response patterns of cytokines/chemokines in two murine strains after irradiation
    • Zhang, M., Yin, L., Zhang, K., Sun, W., Yang, S., Zhang, B., Salzman, P. et al., Response patterns of cytokines/chemokines in two murine strains after irradiation. Cytokine 2012. 58: 169-177.
    • (2012) Cytokine , vol.58 , pp. 169-177
    • Zhang, M.1    Yin, L.2    Zhang, K.3    Sun, W.4    Yang, S.5    Zhang, B.6    Salzman, P.7
  • 41
    • 77955486302 scopus 로고    scopus 로고
    • Exploring the roles of CD8(+) T lymphocytes in the pathogenesis of autoimmune demyelination
    • Johnson, T. A., Jirik, F. R. and Fournier, S., Exploring the roles of CD8(+) T lymphocytes in the pathogenesis of autoimmune demyelination. Semin. Immunopathol. 2010. 32: 197-209.
    • (2010) Semin. Immunopathol. , vol.32 , pp. 197-209
    • Johnson, T.A.1    Jirik, F.R.2    Fournier, S.3
  • 42
    • 12344280009 scopus 로고    scopus 로고
    • Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitis
    • Ford, M. L. and Evavold, B. D., Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitis. Eur. J. Immunol. 2005. 35: 76-85.
    • (2005) Eur. J. Immunol. , vol.35 , pp. 76-85
    • Ford, M.L.1    Evavold, B.D.2
  • 44
    • 0031149344 scopus 로고    scopus 로고
    • Transient suppression of macrophage functions by liposome-encapsulated drugs
    • van Rooijen, N., Bakker, J. and Sanders, A., Transient suppression of macrophage functions by liposome-encapsulated drugs. Trends Biotechnol. 1997. 15: 178-185.
    • (1997) Trends Biotechnol. , vol.15 , pp. 178-185
    • van Rooijen, N.1    Bakker, J.2    Sanders, A.3
  • 45
    • 77950479716 scopus 로고    scopus 로고
    • Liposomes for specific depletion of macrophages from organs and tissues
    • van Rooijen, N. and Hendrikx, E., Liposomes for specific depletion of macrophages from organs and tissues. Methods Mol. Biol. 2010. 605: 189-203.
    • (2010) Methods Mol. Biol. , vol.605 , pp. 189-203
    • van Rooijen, N.1    Hendrikx, E.2
  • 47
  • 49
    • 79952354608 scopus 로고    scopus 로고
    • Microglia-insights into immune system structure, function, and reactivity in the central nervous system
    • Wirenfeldt, M., Babcock, A. A. and Vinters, H. V., Microglia-insights into immune system structure, function, and reactivity in the central nervous system. Histol. Histopathol. 2011. 26: 519-530.
    • (2011) Histol. Histopathol. , vol.26 , pp. 519-530
    • Wirenfeldt, M.1    Babcock, A.A.2    Vinters, H.V.3
  • 50
    • 0037623350 scopus 로고    scopus 로고
    • Establishment of modified chimeric mice using GFP bone marrow as a model for neurological disorders
    • Furuya, T., Tanaka, R., Urabe, T., Hayakawa, J., Migita, M., Shimada, T., Mizuno, Y. et al., Establishment of modified chimeric mice using GFP bone marrow as a model for neurological disorders. Neuroreport 2003. 14: 629-631.
    • (2003) Neuroreport , vol.14 , pp. 629-631
    • Furuya, T.1    Tanaka, R.2    Urabe, T.3    Hayakawa, J.4    Migita, M.5    Shimada, T.6    Mizuno, Y.7
  • 51
    • 6944234040 scopus 로고    scopus 로고
    • Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia
    • Simard, A. R. and Rivest, S., Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. FASEB J. 2004. 18: 998-1000.
    • (2004) FASEB J. , vol.18 , pp. 998-1000
    • Simard, A.R.1    Rivest, S.2
  • 53
    • 0030006799 scopus 로고    scopus 로고
    • Early events of the inflammatory reaction induced in rat brain by lipopolysaccharide intracerebral injection: relative contribution of peripheral monocytes and activated microglia
    • Montero-Menei, C. N., Sindji, L., Garcion, E., Mege, M., Couez, D., Gamelin, E. and Darcy, F., Early events of the inflammatory reaction induced in rat brain by lipopolysaccharide intracerebral injection: relative contribution of peripheral monocytes and activated microglia. Brain. Res. 1996. 724: 55-66.
    • (1996) Brain. Res. , vol.724 , pp. 55-66
    • Montero-Menei, C.N.1    Sindji, L.2    Garcion, E.3    Mege, M.4    Couez, D.5    Gamelin, E.6    Darcy, F.7
  • 54
    • 0025331842 scopus 로고
    • An animal model of prophylactic cranial irradiation: histologic effects at acute, early and delayed stages
    • Mildenberger, M., Beach, T. G., McGeer, E. G. and Ludgate, C. M., An animal model of prophylactic cranial irradiation: histologic effects at acute, early and delayed stages. Int. J. Radiat. Oncol. Biol. Phys. 1990. 18: 1051-1060.
    • (1990) Int. J. Radiat. Oncol. Biol. Phys. , vol.18 , pp. 1051-1060
    • Mildenberger, M.1    Beach, T.G.2    McGeer, E.G.3    Ludgate, C.M.4
  • 55
    • 0036735783 scopus 로고    scopus 로고
    • Irradiation induces neural precursor-cell dysfunction
    • Monje, M. L., Mizumatsu, S., Fike, J. R. and Palmer, T. D., Irradiation induces neural precursor-cell dysfunction. Nat. Med. 2002. 8: 955-962.
    • (2002) Nat. Med. , vol.8 , pp. 955-962
    • Monje, M.L.1    Mizumatsu, S.2    Fike, J.R.3    Palmer, T.D.4
  • 56
    • 20144372362 scopus 로고    scopus 로고
    • CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide
    • Townsend, K. P., Town, T., Mori, T., Lue, L. F., Shytle, D., Sanberg, P. R., Morgan, D. et al., CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide. Eur. J. Immunol. 2005. 35: 901-910.
    • (2005) Eur. J. Immunol. , vol.35 , pp. 901-910
    • Townsend, K.P.1    Town, T.2    Mori, T.3    Lue, L.F.4    Shytle, D.5    Sanberg, P.R.6    Morgan, D.7
  • 57
    • 0035152836 scopus 로고    scopus 로고
    • Immune function of microglia
    • Aloisi, F., Immune function of microglia. Glia 2001. 36: 165-179.
    • (2001) Glia , vol.36 , pp. 165-179
    • Aloisi, F.1
  • 58
    • 0036721843 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation
    • Re, F., Belyanskaya, S. L., Riese, R. J., Cipriani, B., Fischer, F. R., Granucci, F., Ricciardi-Castagnoli, P. et al., Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation. J. Immunol. 2002. 169: 2264-2273.
    • (2002) J. Immunol. , vol.169 , pp. 2264-2273
    • Re, F.1    Belyanskaya, S.L.2    Riese, R.J.3    Cipriani, B.4    Fischer, F.R.5    Granucci, F.6    Ricciardi-Castagnoli, P.7
  • 59
    • 73949110091 scopus 로고    scopus 로고
    • Acute in vivo exposure to interferon-gamma enables resident brain dendritic cells to become effective antigen presenting cells
    • Gottfried-Blackmore, A., Kaunzner, U. W., Idoyaga, J., Felger, J. C., McEwen, B. S. and Bulloch, K., Acute in vivo exposure to interferon-gamma enables resident brain dendritic cells to become effective antigen presenting cells. Proc. Natl. Acad. Sci. USA 2009. 106: 20918-20923.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 20918-20923
    • Gottfried-Blackmore, A.1    Kaunzner, U.W.2    Idoyaga, J.3    Felger, J.C.4    McEwen, B.S.5    Bulloch, K.6
  • 60
    • 79953675959 scopus 로고    scopus 로고
    • CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system
    • Prodinger, C., Bunse, J., Kruger, M., Schiefenhovel, F., Brandt, C., Laman, J. D., Greter, M. et al., CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system. Acta Neuropathol. 2011. 121: 445-458.
    • (2011) Acta Neuropathol. , vol.121 , pp. 445-458
    • Prodinger, C.1    Bunse, J.2    Kruger, M.3    Schiefenhovel, F.4    Brandt, C.5    Laman, J.D.6    Greter, M.7
  • 62
    • 0033802454 scopus 로고    scopus 로고
    • In situ tolerance within the central nervous system as a mechanism for preventing autoimmunity
    • Brabb, T., von Dassow, P., Ordonez, N., Schnabel, B., Duke, B. and Goverman, J., In situ tolerance within the central nervous system as a mechanism for preventing autoimmunity. J. Exp. Med. 2000. 192: 871-880.
    • (2000) J. Exp. Med. , vol.192 , pp. 871-880
    • Brabb, T.1    von Dassow, P.2    Ordonez, N.3    Schnabel, B.4    Duke, B.5    Goverman, J.6
  • 63
    • 33745370610 scopus 로고    scopus 로고
    • Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway
    • Cose, S., Brammer, C., Khanna, K. M., Masopust, D. and Lefrancois, L., Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway. Eur. J. Immunol. 2006. 36: 1423-1433.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 1423-1433
    • Cose, S.1    Brammer, C.2    Khanna, K.M.3    Masopust, D.4    Lefrancois, L.5
  • 64
    • 23744475685 scopus 로고    scopus 로고
    • The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms
    • Engelhardt, B. and Ransohoff, R. M., The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. Trends Immunol. 2005. 26: 485-495.
    • (2005) Trends Immunol. , vol.26 , pp. 485-495
    • Engelhardt, B.1    Ransohoff, R.M.2
  • 65
    • 0034004454 scopus 로고    scopus 로고
    • Naive T lymphocytes traffic to inflamed central nervous system, but require antigen recognition for activation
    • Krakowski, M. L. and Owens, T., Naive T lymphocytes traffic to inflamed central nervous system, but require antigen recognition for activation. Eur. J. Immunol. 2000. 30: 1002-1009.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1002-1009
    • Krakowski, M.L.1    Owens, T.2
  • 66
    • 16244417773 scopus 로고    scopus 로고
    • Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis
    • McMahon, E. J., Bailey, S. L., Castenada, C. V., Waldner, H. and Miller, S. D., Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat. Med. 2005. 11: 335-339.
    • (2005) Nat. Med. , vol.11 , pp. 335-339
    • McMahon, E.J.1    Bailey, S.L.2    Castenada, C.V.3    Waldner, H.4    Miller, S.D.5
  • 67
    • 0029149603 scopus 로고
    • Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis
    • Reise eSousa, C. and Germain, R. N., Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis. J. Exp. Med. 1995. 182: 841-851.
    • (1995) J. Exp. Med. , vol.182 , pp. 841-851
    • Reise eSousa, C.1    Germain, R.N.2
  • 68
    • 0032525023 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species
    • Yi, A. K., Tuetken, R., Redford, T., Waldschmidt, M., Kirsch, J. and Krieg, A. M., CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J. Immunol. 1998. 160: 4755-4761.
    • (1998) J. Immunol. , vol.160 , pp. 4755-4761
    • Yi, A.K.1    Tuetken, R.2    Redford, T.3    Waldschmidt, M.4    Kirsch, J.5    Krieg, A.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.