Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation

Journal of Immunology

Volumn 169, Issue 5, 2002, Pages 2264-2273

  Re, Fabio ^a   Belyanskaya, Svetlana L ^a   Riese, Richiard J ^a   Cipriani, Barbara ^a   Fischer, Falko R ^a   Granucci, Francesca ^a   Ricciardi Castagnoli, Paola ^a   Brosnan, Celia ^a   Stern, Lawrence J ^a   Strominger, Jack L ^a   Santambrogio, Laura ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; GENE PRODUCT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; IMMUNITY; MICROGLIA; MORPHOLOGY; MOUSE; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

EID: 0036721843     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.5.2264     Document Type: Article

References (56)

1. The origin and nature of ramified and amoeboid microglia: A historical review and current concepts
2. Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells
3. Microglia: A sensor to threats in the nervous system?
4. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
5. Central nervous system perivascular cells are immunoregulatory cells that connect the CNS with the peripheral immune system
6. Microglial ramification requires nondiffusible factors derived from astrocytes
7. Neuronal control of MHC class II inducibility in rat astrocytes and microglia
8. Neurotrophins inhibit major histocompatibility class II inducibility of microglia: Involvement of the p75 neurotrophin receptor
9. Signal transduction pathways induced by GM-CSF in microglia: Significance in the control of proliferation
10. Separate precursor cells for macrophages and microglia in mouse brain: Immunophenotypic and immunoregulatory properties of the progeny
11. Functional dichotomy of mouse microglia developed in vitro: Differential effects of macrophage and granulocyte/macrophage colony-stimulating factor on cytokine secretion and antitoxoplasmic activity
12. Effects of colony stimulating factors on isolated microglia in vitro
13. Developmental plasticity of CNS microglia
14. Brain dendritic cells and macrophages/microglia in central nervous system inflammation
15. Macrophage colony-stimulating factor augments β-amyloid-induced interleukin-1, interleukin-6, and nitric oxide production by microglial cells
16. Regulation of microglial activation by TGF-β, IL-10, and CSF-1
17. Differentiation driven by granulocyte-macrophage colonystimulating factor endows microglia with interferon-γ-independent antigen presentation function
18. Microglia induce myelin basic protein-specific T cell anergy or T cell activation, according to their state of activation
19. Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colony-stimulating factor and interaction with Th1 cells
20. Production of hemopoietic colony-stimulating factors by astrocytes
21. The distribution of granulocyte-macrophage colony-stimulating factor and its receptor in the developing human fetus
22. Murine T helper cell clones secrete granulocyte-macrophage colony-stimulating factor (GmCSF) by both interleukin-2-dependent and interleukin-2-independent pathways
23. Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis
24. GM-CSF promotes proliferation of human fetal and adult microglia in primary cultures
25. Abundant empty class II MHC molecules on the surface of immature dendritic cells
26. The multi-domain structure of extracellular matrix molecules: Implications for nervous system regeneration
27. Regeneration in the adult mammalian CNS: Guided by development
28. Haemopoietic biglycan produced by brain cells stimulates growth of microglial cells
29. Nerve growth factor signaling, neuroprotection, and neural repair
30. Cultured astrocytes express mRNA for peptidylglycine-α-amidating monooxygenase, a neuropeptide processing enzyme
31. Regulation of neuropeptide-processing enzymes by nitric oxide in cultured astrocytes
32. Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: Potential involvement of glial-derived factors
33. Astrocyte differentiation of fetal neuroepithelial cells by interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor, STAT3
34. Heat-stable antigen is a costimulatory molecule for CD4 T cell growth
35. The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis
36. Excitotoxin-induced neuronal death is associated with response of a unique intracellular aspartic proteinase, cathepsin E
37. Possible involvement of matrix metalloproteinase-9 in Langerhans cell migration and maturation
38. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases define the migratory characteristics of human monocyte-derived dendritic cells
39. Matrix metalloproteinases: Multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis
40. Migration of multiple sclerosis lymphocytes through brain endothelium
41. Antigen presentation mediated by recycling of surface HLA-DR molecules
42. Activation changes the spectrum but not the diversity of genes expressed by T cells
43. The plasticity of dendritic cell responses to pathogens and their components
44. Microglia in colony-stimulating factor 1-deficient op/op mice
45. Identification of macrophages and dendritic cells in the osteopetrotic (op/op) mouse
46. GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1
47. Cloning of the low-affinity murine granulocyte-macrophage colony-stimulating factor receptor and reconstitution of a high-affinity receptor complex
48. Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): Evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor
49. Cytoplasmic domains of the human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor β chain (hβc) responsible for human GM-CSF-induced myeloid cell differentiation
50. Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blasts
51. Nectadrin, the heat-stable antigen, is a cell adhesion molecule
52. Distinct costimulatory molecules are required for the induction of effector and memory cytotoxic T lymphocytes
53. Cathepsin L: Critical role in Ii degradation and CD4 T cell selection in the thymus
54. Cathepsin S required for normal MHC class II peptide loading and germinal center development
55. Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages
56. Neurotrophic factors regulate cathepsin S in macrophages and microglia: A role in the degradation of myelin basic protein and amyloid β peptide