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Volumn 13, Issue 3, 2013, Pages 300-312

Targeting tyrosine kinase receptors in hepatocellular carcinoma

Author keywords

Cancer; Cell death; Proliferation; Receptors; Tumor

Indexed keywords

ANGIOGENIC FACTOR; BRIVANIB; CEDIRANIB; DOVITINIB; DOXORUBICIN; EPIDERMAL GROWTH FACTOR; ERLOTINIB; FIBROBLAST GROWTH FACTOR 2; FORETINIB; GEFITINIB; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; LAPATINIB; ORANTINIB; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PLATELET DERIVED GROWTH FACTOR; RAPAMYCIN; SOMATOMEDIN; SORAFENIB; STAT3 PROTEIN; SUNITINIB; TIVANTINIB; TRANSFORMING GROWTH FACTOR ALPHA; TYROSINE KINASE RECEPTOR; VANDETANIB; VASCULOTROPIN; VATALANIB;

EID: 84876851311     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/15680096113139990075     Document Type: Review
Times cited : (37)

References (117)
  • 2
    • 0035888074 scopus 로고    scopus 로고
    • Estimating the world cancer burden: Globocan 2000
    • Parkin, D. M.; Bray, F.; Ferlay, J.; Pisani P. Estimating the world cancer burden: Globocan 2000. Int. J. Cancer 2001, 94, 153-6.
    • (2001) Int. J. Cancer , vol.94 , pp. 153-156
    • Parkin, D.M.1    Bray, F.2    Ferlay, J.3    Pisani, P.4
  • 3
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag, H. B.; Rudolph, K. L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007, 132, 2557-76.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 5
    • 7044272630 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in cirrhosis: Incidence and risk factors
    • Fattovich, G.; Stroffolini, T.; Zagni, I.; Donato, F. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 2004, 127, S35-S50.
    • (2004) Gastroenterology , vol.127
    • Fattovich, G.1    Stroffolini, T.2    Zagni, I.3    Donato, F.4
  • 7
    • 84858658381 scopus 로고    scopus 로고
    • EASL-EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma
    • European Association for the Study of the Liver, European Organisation for Research and Treatment of Cancer
    • European Association for the Study of the Liver, European Organisation for Research and Treatment of Cancer. EASL-EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma. J. Hepatol. 2012, 56, 908-943.
    • (2012) J. Hepatol. , vol.56 , pp. 908-943
  • 8
    • 0026735844 scopus 로고
    • Hepatocellular carcinoma
    • Colombo, M. Hepatocellular carcinoma. J. Hepatol. 1992, 15, 225-236.
    • (1992) J. Hepatol. , vol.15 , pp. 225-236
    • Colombo, M.1
  • 9
    • 0037129704 scopus 로고    scopus 로고
    • Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: A randomised controlled trial
    • Barcelona Liver Cancer G
    • Llovet, J. M.; Real, M. I.; Montana, X.; Planas, R.; Coll, S.; Aponte, J.; Ayuso, C.; Sala, M.; Muchart, J.; Sola, R.; Rodes, J.; Bruix, J. Barcelona Liver Cancer G. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet 2002, 359, 1734-1739.
    • (2002) Lancet , vol.359 , pp. 1734-1739
    • Llovet, J.M.1    Real, M.I.2    Montana, X.3    Planas, R.4    Coll, S.5    Aponte, J.6    Ayuso, C.7    Sala, M.8    Muchart, J.9    Sola, R.10    Rodes, J.11    Bruix, J.12
  • 10
    • 0036237822 scopus 로고    scopus 로고
    • Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma
    • Lo, C. M.; Ngan, H.; Tso, W. K.; Liu, C. L.; Lam, C. M.; Poon, R. T.; Fan, S. T.; Wong, J. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology 2002, 35, 1164-1171.
    • (2002) Hepatology , vol.35 , pp. 1164-1171
    • Lo, C.M.1    Ngan, H.2    Tso, W.K.3    Liu, C.L.4    Lam, C.M.5    Poon, R.T.6    Fan, S.T.7    Wong, J.8
  • 12
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: From genes to environment
    • Farazi, P. A.; DePinho, R. A. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer 2006, 6, 674-687.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 13
    • 0031048958 scopus 로고    scopus 로고
    • Treatment of hepatocellular carcinoma: A systematic review of randomized controlled trials
    • Simonetti, R. G.; Liberati, A.; Angiolini, C.; Pagliaro, L. Treatment of hepatocellular carcinoma: a systematic review of randomized controlled trials. Ann. Oncol. 1997, 8, 117-136.
    • (1997) Ann. Oncol. , vol.8 , pp. 117-136
    • Simonetti, R.G.1    Liberati, A.2    Angiolini, C.3    Pagliaro, L.4
  • 14
    • 0034100195 scopus 로고    scopus 로고
    • Expression of Pglycoprotein in hepatocellular carcinoma. A determinant of chemotherapy response
    • Ng, I. O.; Liu, C. L.; Fan, S. T.; Ng, M. Expression of Pglycoprotein in hepatocellular carcinoma. A determinant of chemotherapy response. Am. J. Clin. Pathol. 2000, 113, 355-363.
    • (2000) Am. J. Clin. Pathol. , vol.113 , pp. 355-363
    • Ng, I.O.1    Liu, C.L.2    Fan, S.T.3    Ng, M.4
  • 15
    • 0024329881 scopus 로고
    • The biochemistry of P-glycoproteinmediated multidrug resistance
    • Endicott, J. A.; Ling, V. The biochemistry of P-glycoproteinmediated multidrug resistance. Annu. Rev. Biochem. 1989, 58, 137-171.
    • (1989) Annu. Rev. Biochem. , vol.58 , pp. 137-171
    • Endicott, J.A.1    Ling, V.2
  • 16
    • 54449083925 scopus 로고    scopus 로고
    • Molecular targeted therapies in hepatocellular carcinoma
    • Llovet, J. M.; Bruix, J. Molecular targeted therapies in hepatocellular carcinoma. Hepatology 2008, 48, 1312-1327.
    • (2008) Hepatology , vol.48 , pp. 1312-1327
    • Llovet, J.M.1    Bruix, J.2
  • 18
    • 33745547361 scopus 로고    scopus 로고
    • New therapies for hepatocellular carcinoma
    • Avila, M. A.; Berasain, C.; Sangro, B.; Prieto, J. New therapies for hepatocellular carcinoma. Oncogene 2006, 25, 3866-3884.
    • (2006) Oncogene , vol.25 , pp. 3866-3884
    • Avila, M.A.1    Berasain, C.2    Sangro, B.3    Prieto, J.4
  • 19
    • 70349782389 scopus 로고    scopus 로고
    • An overview of smallmolecule inhibitors of VEGFR signaling
    • Ivy, S. P.; Wick, J. Y.; Kaufman, B. M. An overview of smallmolecule inhibitors of VEGFR signaling. Nat. Rev. Clin. Oncol. 2009, 6, 569-579.
    • (2009) Nat. Rev. Clin. Oncol. , vol.6 , pp. 569-579
    • Ivy, S.P.1    Wick, J.Y.2    Kaufman, B.M.3
  • 20
    • 0037392444 scopus 로고    scopus 로고
    • Issues and progress with protein kinase inhibitors for cancer treatment
    • Dancey, J.; Sausville, E. A. Issues and progress with protein kinase inhibitors for cancer treatment. Nat. Rev. Drug Discov. 2003, 2, 296-313.
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 296-313
    • Dancey, J.1    Sausville, E.A.2
  • 21
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman, J. Role of angiogenesis in tumor growth and metastasis. Semin. Oncol. 2002, 29, 15-18.
    • (2002) Semin. Oncol. , vol.29 , pp. 15-18
    • Folkman, J.1
  • 22
    • 39749166386 scopus 로고    scopus 로고
    • Antiangiogenic therapy for cancer: An update
    • Shojaei, F.; Ferrara, N. Antiangiogenic therapy for cancer: an update. Cancer J. 2007, 13, 345-348.
    • (2007) Cancer J. , vol.13 , pp. 345-348
    • Shojaei, F.1    Ferrara, N.2
  • 23
    • 44149090296 scopus 로고    scopus 로고
    • Role of platelet-derived growth factors in physiology and medicine
    • Andrae, J.; Gallini, R.; Betsholtz, C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008, 22, 1276-1312.
    • (2008) Genes Dev. , vol.22 , pp. 1276-1312
    • Andrae, J.1    Gallini, R.2    Betsholtz, C.3
  • 24
    • 78650382003 scopus 로고    scopus 로고
    • Biologically targeted cancer therapy and marginal benefits: Are we making too much of too little or are we achieving too little by giving too much?
    • Fojo, T.; Parkinson, D. R. Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much? Clin. Cancer Res. 2010, 16, 5972-5980.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 5972-5980
    • Fojo, T.1    Parkinson, D.R.2
  • 25
    • 77954218447 scopus 로고    scopus 로고
    • Molecularly targeted therapy in hepatocellular carcinoma
    • Huynh, H. Molecularly targeted therapy in hepatocellular carcinoma. Biochem. Pharmacol. 2010, 80, 550-560.
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 550-560
    • Huynh, H.1
  • 29
    • 0043163428 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery
    • Chao, Y.; Li, C. P.; Chau, G. Y.; Chen, C. P.; King, K. L.; Lui, W. Y.; Yen, S. H.; Chang, F. Y.; Chan, W. K.; Lee, S. D. Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery. Ann. Surg. Oncol. 2003, 10, 355-362.
    • (2003) Ann. Surg. Oncol. , vol.10 , pp. 355-362
    • Chao, Y.1    Li, C.P.2    Chau, G.Y.3    Chen, C.P.4    King, K.L.5    Lui, W.Y.6    Yen, S.H.7    Chang, F.Y.8    Chan, W.K.9    Lee, S.D.10
  • 30
    • 4944234987 scopus 로고    scopus 로고
    • Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma
    • Poon, R. T.; Ho, J. W.; Tong, C. S.; Lau, C.; Ng, I. O.; Fan, S. T. Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma. Br. J. Surg. 2004, 91, 1354-1360.
    • (2004) Br. J. Surg. , vol.91 , pp. 1354-1360
    • Poon, R.T.1    Ho, J.W.2    Tong, C.S.3    Lau, C.4    Ng, I.O.5    Fan, S.T.6
  • 31
    • 29344456631 scopus 로고    scopus 로고
    • Overexpression of platelet-derived growth factor receptor alpha in endothelial cells of hepatocellular carcinoma associated with high metastatic potential
    • Zhang, T.; Sun, H. C.; Xu, Y.; Zhang, K. Z.; Wang, L.; Qin, L. X.; Wu, W. Z.; Liu, Y. K.; Ye, S. L.; Tang, Z. Y. Overexpression of platelet-derived growth factor receptor alpha in endothelial cells of hepatocellular carcinoma associated with high metastatic potential. Clin. Cancer Res. 2005, 11, 8557-8563.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 8557-8563
    • Zhang, T.1    Sun, H.C.2    Xu, Y.3    Zhang, K.Z.4    Wang, L.5    Qin, L.X.6    Wu, W.Z.7    Liu, Y.K.8    Ye, S.L.9    Tang, Z.Y.10
  • 32
    • 34047127376 scopus 로고    scopus 로고
    • PDGF receptors as targets in tumor treatment
    • Ostman, A.; Heldin, C. H. PDGF receptors as targets in tumor treatment. Adv. Cancer Res. 2007, 97, 247-274.
    • (2007) Adv. Cancer Res. , vol.97 , pp. 247-274
    • Ostman, A.1    Heldin, C.H.2
  • 33
    • 58149175849 scopus 로고    scopus 로고
    • Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma
    • Huynh, H.; Ngo, V. C.; Fargnoli, J.; Ayers, M.; Soo, K. C.; Koong, H. N.; Thng, C. H.; Ong, H. S.; Chung, A.; Chow, P.; Pollock, P.; Byron, S.; Tran, E. Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin. Cancer. Res. 2008, 14, 6146-6153.
    • (2008) Clin. Cancer. Res. , vol.14 , pp. 6146-6153
    • Huynh, H.1    Ngo, V.C.2    Fargnoli, J.3    Ayers, M.4    Soo, K.C.5    Koong, H.N.6    Thng, C.H.7    Ong, H.S.8    Chung, A.9    Chow, P.10    Pollock, P.11    Byron, S.12    Tran, E.13
  • 34
    • 70349495869 scopus 로고    scopus 로고
    • Targeting vascular endothelial growth factor receptor-1 and-3 with cediranib (AZD2171): Effects on migration and invasion of gastrointestinal cancer cell lines
    • Morelli, M. P.; Brown, A. M.; Pitts, T. M.; Tentler, J. J.; Ciardiello, F.; Ryan, A.; Jurgensmeier J. M.; Eckhardt, S. G. Targeting vascular endothelial growth factor receptor-1 and-3 with cediranib (AZD2171): effects on migration and invasion of gastrointestinal cancer cell lines. Mol. Cancer Ther. 2009, 8, 2546-2558.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 2546-2558
    • Morelli, M.P.1    Brown, A.M.2    Pitts, T.M.3    Tentler, J.J.4    Ciardiello, F.5    Ryan, A.6    Jurgensmeier, J.M.7    Eckhardt, S.G.8
  • 35
    • 69049090809 scopus 로고    scopus 로고
    • Cediranib (recentin, AZD2171) reverses ABCB1-and ABCC1-mediated multidrug resistance by inhibition of their transport function
    • Tao, L. Y.; Liang, Y. J.; Wang, F.; Chen, L. M.; Yan, Y. Y.; Dai, C. L.; Fu, L. W. Cediranib (recentin, AZD2171) reverses ABCB1-and ABCC1-mediated multidrug resistance by inhibition of their transport function. Cancer Chemother. Pharmacol. 2009, 64, 961-969.
    • (2009) Cancer Chemother. Pharmacol. , vol.64 , pp. 961-969
    • Tao, L.Y.1    Liang, Y.J.2    Wang, F.3    Chen, L.M.4    Yan, Y.Y.5    Dai, C.L.6    Fu, L.W.7
  • 38
    • 84859383549 scopus 로고    scopus 로고
    • Second-line therapies in hepatocellular carcinoma: Emergence of resistance to sorafenib
    • Villanueva, A.; Llovet, J. M. Second-line therapies in hepatocellular carcinoma: emergence of resistance to sorafenib. Clin. Cancer Res. 2012, 18, 1824-1826.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 1824-1826
    • Villanueva, A.1    Llovet, J.M.2
  • 40
    • 84864348077 scopus 로고    scopus 로고
    • Cediranib (AZD2171) in Patients With Advanced Hepatocellular Carcinoma: A Phase II North Central Cancer Treatment Group Clinical Trial
    • Alberts, S. R.; Fitch, T. R.; Kim, G. P.; Morlan, B. W.; Dakhil, S. R.; Gross, H. M.; Nair, S. Cediranib (AZD2171) in Patients With Advanced Hepatocellular Carcinoma: A Phase II North Central Cancer Treatment Group Clinical Trial. Am. J. Clin. Oncol. 2012, 35, 329-333.
    • (2012) Am. J. Clin. Oncol. , vol.35 , pp. 329-333
    • Alberts, S.R.1    Fitch, T.R.2    Kim, G.P.3    Morlan, B.W.4    Dakhil, S.R.5    Gross, H.M.6    Nair, S.7
  • 41
    • 44149110127 scopus 로고    scopus 로고
    • Identification of human liver cytochrome P450 isoforms involved in autoinduced metabolism of the antiangiogenic agent (Z)-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1Hpyrrole-3-pr opanoic acid (TSU-68)
    • Kitamura, R.; Asanoma, H.; Nagayama, S.; Otagiri, M. Identification of human liver cytochrome P450 isoforms involved in autoinduced metabolism of the antiangiogenic agent (Z)-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1Hpyrrole-3-pr opanoic acid (TSU-68). Drug. Metab. Dispos. 2008, 36, 1003-1009.
    • (2008) Drug. Metab. Dispos. , vol.36 , pp. 1003-1009
    • Kitamura, R.1    Asanoma, H.2    Nagayama, S.3    Otagiri, M.4
  • 43
    • 84859419666 scopus 로고    scopus 로고
    • Antitumor effect of vascular endothelial growth factor inhibitor sunitinib in preclinical models of hepatocellular carcinoma
    • Bagi, C. M.; Gebhard, D. F.; Andresen, C. J. Antitumor effect of vascular endothelial growth factor inhibitor sunitinib in preclinical models of hepatocellular carcinoma. Eur. J. Gastroenterol. Hepatol. 2012, 24, 563-574.
    • (2012) Eur. J. Gastroenterol. Hepatol. , vol.24 , pp. 563-574
    • Bagi, C.M.1    Gebhard, D.F.2    Andresen, C.J.3
  • 47
    • 73349110120 scopus 로고    scopus 로고
    • Sunitinib in hepatocellular carcinoma: Redefining appropriate dosing, schedule, and activity end points
    • author reply e251-2
    • Faivre, S. J.; Bouattour, M.; Dreyer, C.; Raymond, E. Sunitinib in hepatocellular carcinoma: redefining appropriate dosing, schedule, and activity end points. J. Clin. Oncol. 2009, 27, e248-50, author reply e251-2.
    • (2009) J. Clin. Oncol. , vol.27
    • Faivre, S.J.1    Bouattour, M.2    Dreyer, C.3    Raymond, E.4
  • 48
    • 67749089441 scopus 로고    scopus 로고
    • Sunitinib and the benefits of a negative study
    • Forner, A.; Llovet, J. M.; Bruix, J. Sunitinib and the benefits of a negative study. Lancet Oncol. 2009, 10, 743-744.
    • (2009) Lancet Oncol. , vol.10 , pp. 743-744
    • Forner, A.1    Llovet, J.M.2    Bruix, J.3
  • 49
    • 84857357820 scopus 로고    scopus 로고
    • Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma
    • Huynh, H.; Chow, P. K.; Tai, W. M.; Choo, S. P.; Chung, A. Y.; Ong, H. S.; Soo, K. C.; Ong, R.; Linnartz, R.; Shi, M. M. Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma. J. Hepatol. 2012, 56, 595-601.
    • (2012) J. Hepatol. , vol.56 , pp. 595-601
    • Huynh, H.1    Chow, P.K.2    Tai, W.M.3    Choo, S.P.4    Chung, A.Y.5    Ong, H.S.6    Soo, K.C.7    Ong, R.8    Linnartz, R.9    Shi, M.M.10
  • 50
    • 84984586832 scopus 로고    scopus 로고
    • Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3
    • Tai, W. T.; Cheng, A. L.; Shiau, C. W.; Liu, C. Y.; Ko, C. H.; Lin, M. W.; Chen, P. J.; Chen, K. F. Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3. Mol. Cancer Ther. 2012, 11, 452-463.
    • (2012) Mol. Cancer Ther. , vol.11 , pp. 452-463
    • Tai, W.T.1    Cheng, A.L.2    Shiau, C.W.3    Liu, C.Y.4    Ko, C.H.5    Lin, M.W.6    Chen, P.J.7    Chen, K.F.8
  • 52
    • 18144401256 scopus 로고    scopus 로고
    • Both antiangiogenesis-and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584
    • Liu, Y.; Poon, R. T.; Li, Q.; Kok, T. W.; Lau, C.; Fan, S. T. Both antiangiogenesis-and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584. Cancer Res. 2005, 65, 3691-3699.
    • (2005) Cancer Res. , vol.65 , pp. 3691-3699
    • Liu, Y.1    Poon, R.T.2    Li, Q.3    Kok, T.W.4    Lau, C.5    Fan, S.T.6
  • 54
    • 78249288161 scopus 로고    scopus 로고
    • Phase 1-2 trial of PTK787/ZK222584 combined with intravenous doxorubicin for treatment of patients with advanced hepatocellular carcinoma: Implication for antiangiogenic approach to hepatocellular carcinoma
    • Yau, T.; Chan, P.; Pang, R.; Ng, K.; Fan, S. T.; Poon, R. T. Phase 1-2 trial of PTK787/ZK222584 combined with intravenous doxorubicin for treatment of patients with advanced hepatocellular carcinoma: implication for antiangiogenic approach to hepatocellular carcinoma. Cancer 2010, 116, 5022-5029.
    • (2010) Cancer , vol.116 , pp. 5022-5029
    • Yau, T.1    Chan, P.2    Pang, R.3    Ng, K.4    Fan, S.T.5    Poon, R.T.6
  • 56
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    • Liu, L.; Cao, Y.; Chen, C.; Zhang, X.; McNabola, A.; Wilkie, D.; Wilhelm, S.; Lynch, M.; Carter, C. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res. 2006, 66, 11851-11858.
    • (2006) Cancer Res. , vol.66 , pp. 11851-11858
    • Liu, L.1    Cao, Y.2    Chen, C.3    Zhang, X.4    McNabola, A.5    Wilkie, D.6    Wilhelm, S.7    Lynch, M.8    Carter, C.9
  • 58
    • 84984589185 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma
    • Tai, W. T.; Cheng, A. L.; Shiau, C. W.; Huang, H. P.; Huang, J. W.; Chen, P. J.; Chen, K. F. Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma. J. Hepatol. 2011, 55, 1041-1048.
    • (2011) J. Hepatol. , vol.55 , pp. 1041-1048
    • Tai, W.T.1    Cheng, A.L.2    Shiau, C.W.3    Huang, H.P.4    Huang, J.W.5    Chen, P.J.6    Chen, K.F.7
  • 61
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas, O.; Hicklin, D. J.; Bergers, G.; Hanahan, D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005, 8, 299-309.
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 63
    • 78149336711 scopus 로고    scopus 로고
    • Sunitinib in patients with advanced hepatocellular carcinoma after progression under sorafenib treatment
    • Worns, M. A.; Schuchmann, M.; Duber, C.; Otto, G.; Galle, P. R.; Weinmann, A. Sunitinib in patients with advanced hepatocellular carcinoma after progression under sorafenib treatment. Oncology 2010, 79, 85-92.
    • (2010) Oncology , vol.79 , pp. 85-92
    • Worns, M.A.1    Schuchmann, M.2    Duber, C.3    Otto, G.4    Galle, P.R.5    Weinmann, A.6
  • 64
    • 44449127592 scopus 로고    scopus 로고
    • The epidermal growth factor receptor family: Biology driving targeted therapeutics
    • Wieduwilt, M. J.; Moasser, M. M. The epidermal growth factor receptor family: biology driving targeted therapeutics. Cell Mol. Life Sci. 2008, 65, 1566-1584.
    • (2008) Cell Mol. Life Sci. , vol.65 , pp. 1566-1584
    • Wieduwilt, M.J.1    Moasser, M.M.2
  • 65
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
    • Burgering, B. M.; Coffer, P. J. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 1995, 376, 599-602.
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 66
    • 33749316418 scopus 로고    scopus 로고
    • The epidermal growth factor receptor pathway: A model for targeted therapy
    • Scaltriti, M.; Baselga, J. The epidermal growth factor receptor pathway: a model for targeted therapy. Clin. Cancer Res. 2006, 12, 5268-5272.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 5268-5272
    • Scaltriti, M.1    Baselga, J.2
  • 68
    • 33645844566 scopus 로고    scopus 로고
    • CD24 expression is a prognostic factor in intrahepatic cholangiocarcinoma
    • Su, M. C.; Hsu, C.; Kao, H. L.; Jeng, Y. M. CD24 expression is a prognostic factor in intrahepatic cholangiocarcinoma. Cancer Lett. 2006, 235, 34-39.
    • (2006) Cancer Lett. , vol.235 , pp. 34-39
    • Su, M.C.1    Hsu, C.2    Kao, H.L.3    Jeng, Y.M.4
  • 69
    • 0023102903 scopus 로고
    • Elevation of transforming growth factor alpha and its relationship to the epidermal growth factor and alphafetoprotein levels in patients with hepatocellular carcinoma
    • Yeh, Y. C.; Tsai, J. F.; Chuang, L. Y.; Yeh, H. W.; Tsai, J. H.; Florine, D. L.; Tam, J. P. Elevation of transforming growth factor alpha and its relationship to the epidermal growth factor and alphafetoprotein levels in patients with hepatocellular carcinoma. Cancer Res. 1987, 47, 896-901.
    • (1987) Cancer Res. , vol.47 , pp. 896-901
    • Yeh, Y.C.1    Tsai, J.F.2    Chuang, L.Y.3    Yeh, H.W.4    Tsai, J.H.5    Florine, D.L.6    Tam, J.P.7
  • 70
    • 1642375342 scopus 로고    scopus 로고
    • Early molecular and genetic determinants of primary liver malignancy
    • Feitelson, M. A.; Pan, J.; Lian, Z. Early molecular and genetic determinants of primary liver malignancy. Surg. Clin. North Am. 2004, 84, 339-354.
    • (2004) Surg. Clin. North Am. , vol.84 , pp. 339-354
    • Feitelson, M.A.1    Pan, J.2    Lian, Z.3
  • 75
    • 9644255742 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma
    • Hopfner, M.; Sutter, A. P.; Huether, A.; Schuppan, D.; Zeitz, M.; Scherubl, H. Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma. J. Hepatol. 2004, 41, 1008-1016.
    • (2004) J. Hepatol. , vol.41 , pp. 1008-1016
    • Hopfner, M.1    Sutter, A.P.2    Huether, A.3    Schuppan, D.4    Zeitz, M.5    Scherubl, H.6
  • 76
    • 0027965569 scopus 로고
    • Expression of insulin-like growth factor II in hepatitis B, cirrhosis and hepatocellular carcinoma: Its relationship with hepatitis B virus antigen expression
    • Su, Q.; Liu, Y. F.; Zhang, J. F.; Zhang, S. X.; Li, D. F.; Yang, J. J. Expression of insulin-like growth factor II in hepatitis B, cirrhosis and hepatocellular carcinoma: its relationship with hepatitis B virus antigen expression. Hepatology 1994, 20, 788-799.
    • (1994) Hepatology , vol.20 , pp. 788-799
    • Su, Q.1    Liu, Y.F.2    Zhang, J.F.3    Zhang, S.X.4    Li, D.F.5    Yang, J.J.6
  • 78
    • 0036251946 scopus 로고    scopus 로고
    • A possible role for insulin-like growth factor-binding protein-3 autocrine/paracrine loops in controlling hepatocellular carcinoma cell proliferation
    • Huynh, H.; Chow, P. K.; Ooi, L. L.; Soo, K. C. A possible role for insulin-like growth factor-binding protein-3 autocrine/paracrine loops in controlling hepatocellular carcinoma cell proliferation. Cell Growth Differ. 2002, 13, 115-122.
    • (2002) Cell Growth Differ. , vol.13 , pp. 115-122
    • Huynh, H.1    Chow, P.K.2    Ooi, L.L.3    Soo, K.C.4
  • 79
    • 33745552897 scopus 로고    scopus 로고
    • Dysregulation of growth factor signaling in human hepatocellular carcinoma
    • Breuhahn, K.; Longerich, T.; Schirmacher, P. Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene 2006, 25, 3787-3800.
    • (2006) Oncogene , vol.25 , pp. 3787-3800
    • Breuhahn, K.1    Longerich, T.2    Schirmacher, P.3
  • 80
    • 33645333133 scopus 로고    scopus 로고
    • Gefitinib and the modulation of the signaling pathways downstream of epidermal growth factor receptor in human liver cancer cells
    • Okano, J.; Matsumoto, K.; Nagahara, T.; Murawaki, Y. Gefitinib and the modulation of the signaling pathways downstream of epidermal growth factor receptor in human liver cancer cells. J. Gastroenterol. 2006, 41, 166-176.
    • (2006) J. Gastroenterol. , vol.41 , pp. 166-176
    • Okano, J.1    Matsumoto, K.2    Nagahara, T.3    Murawaki, Y.4
  • 81
    • 24344489502 scopus 로고    scopus 로고
    • Erlotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances chemosensitivity towards cytostatics
    • Huether, A.; Hopfner, M.; Sutter, A. P.; Schuppan, D.; Scherubl, H. Erlotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances chemosensitivity towards cytostatics. J. Hepatol. 2005, 43, 661-669.
    • (2005) J. Hepatol. , vol.43 , pp. 661-669
    • Huether, A.1    Hopfner, M.2    Sutter, A.P.3    Schuppan, D.4    Scherubl, H.5
  • 82
    • 33748544630 scopus 로고    scopus 로고
    • Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancer
    • Huether, A.; Hopfner, M.; Sutter, A. P.; Baradari, V.; Schuppan, D.; Scherubl, H. Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancer. World J. Gastroenterol. 2006, 12, 5160-5167.
    • (2006) World J. Gastroenterol. , vol.12 , pp. 5160-5167
    • Huether, A.1    Hopfner, M.2    Sutter, A.P.3    Baradari, V.4    Schuppan, D.5    Scherubl, H.6
  • 83
    • 0142024593 scopus 로고    scopus 로고
    • ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, shows antimetastatic activity using a hepatocellular carcinoma model
    • Matsuo, M.; Sakurai, H.; Saiki, I. ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, shows antimetastatic activity using a hepatocellular carcinoma model. Mol. Cancer Ther. 2003, 2, 557-561.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 557-561
    • Matsuo, M.1    Sakurai, H.2    Saiki, I.3
  • 84
    • 15844431836 scopus 로고    scopus 로고
    • Antitumor effect of Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, combined with cytotoxic agent on murine hepatocellular carcinoma
    • Zhu, B. D.; Yuan, S. J.; Zhao, Q. C.; Li, X.; Li, Y.; Lu, Q. Y. Antitumor effect of Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, combined with cytotoxic agent on murine hepatocellular carcinoma. World J. Gastroenterol. 2005, 11, 1382-1386.
    • (2005) World J. Gastroenterol. , vol.11 , pp. 1382-1386
    • Zhu, B.D.1    Yuan, S.J.2    Zhao, Q.C.3    Li, X.4    Li, Y.5    Lu, Q.Y.6
  • 85
    • 33744903661 scopus 로고    scopus 로고
    • PTEN/Akt signaling through epidermal growth factor receptor is prerequisite for angiogenesis by hepatocellular carcinoma cells that is susceptible to inhibition by gefitinib
    • Ueda, S.; Basaki, Y.; Yoshie, M.; Ogawa, K.; Sakisaka, S.; Kuwano, M.; Ono, M. PTEN/Akt signaling through epidermal growth factor receptor is prerequisite for angiogenesis by hepatocellular carcinoma cells that is susceptible to inhibition by gefitinib. Cancer Res. 2006, 66, 5346-5353.
    • (2006) Cancer Res. , vol.66 , pp. 5346-5353
    • Ueda, S.1    Basaki, Y.2    Yoshie, M.3    Ogawa, K.4    Sakisaka, S.5    Kuwano, M.6    Ono, M.7
  • 87
    • 77956627711 scopus 로고    scopus 로고
    • The role of signaling pathways in the development and treatment of hepatocellular carcinoma
    • Whittaker, S.; Marais, R.; Zhu, A. X. The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 2010, 29, 4989-5005.
    • (2010) Oncogene , vol.29 , pp. 4989-5005
    • Whittaker, S.1    Marais, R.2    Zhu, A.X.3
  • 88
    • 0035553174 scopus 로고    scopus 로고
    • The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo
    • Rusnak, D. W.; Lackey, K.; Affleck, K.; Wood, E. R.; Alligood, K. J.; Rhodes, N.; Keith, B. R.; Murray, D. M.; Knight, W. B.; Mullin, R. J.; Gilmer, T. M. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol. Cancer Ther. 2001, 1, 85-94.
    • (2001) Mol. Cancer Ther. , vol.1 , pp. 85-94
    • Rusnak, D.W.1    Lackey, K.2    Affleck, K.3    Wood, E.R.4    Alligood, K.J.5    Rhodes, N.6    Keith, B.R.7    Murray, D.M.8    Knight, W.B.9    Mullin, R.J.10    Gilmer, T.M.11
  • 92
    • 84863977102 scopus 로고    scopus 로고
    • Vandetanib, an Inhibitor of VEGF Receptor-2 and EGF Receptor, Suppresses Tumor Development and Improves Prognosis of Liver Cancer in Mice
    • Inoue, K.; Torimura, T.; Nakamura, T.; Iwamoto, H.; Masuda, H.; Abe, M.; Hashimoto, O.; Koga, H.; Ueno, T.; Yano, H.; Sata, M. Vandetanib, an Inhibitor of VEGF Receptor-2 and EGF Receptor, Suppresses Tumor Development and Improves Prognosis of Liver Cancer in Mice. Clin. Cancer Res. 2012, 18, 3924-3933.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 3924-3933
    • Inoue, K.1    Torimura, T.2    Nakamura, T.3    Iwamoto, H.4    Masuda, H.5    Abe, M.6    Hashimoto, O.7    Koga, H.8    Ueno, T.9    Yano, H.10    Sata, M.11
  • 93
    • 84862832278 scopus 로고    scopus 로고
    • Vandetanib in patients with inoperable hepatocellular carcinoma: A phase II, randomized, double-blind, placebocontrolled study
    • Hsu, C.; Yang, T. S.; Huo, T. I.; Hsieh, R. K.; Yu, C. W.; Hwang, W. S.; Hsieh, T. Y.; Huang, W. T.; Chao, Y.; Meng, R.; Cheng, A. L. Vandetanib in patients with inoperable hepatocellular carcinoma: a phase II, randomized, double-blind, placebocontrolled study. J. Hepatol. 2012, 56, 1097-1103.
    • (2012) J. Hepatol. , vol.56 , pp. 1097-1103
    • Hsu, C.1    Yang, T.S.2    Huo, T.I.3    Hsieh, R.K.4    Yu, C.W.5    Hwang, W.S.6    Hsieh, T.Y.7    Huang, W.T.8    Chao, Y.9    Meng, R.10    Cheng, A.L.11
  • 94
    • 0037008761 scopus 로고    scopus 로고
    • Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor
    • Gilmore, A. P.; Valentijn, A. J.; Wang, P.; Ranger, A. M.; Bundred, N.; O'Hare, M. J.; Wakeling, A.; Korsmeyer, S. J.; Streuli, C. H. Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor. J. Biol. Chem. 2002, 277, 27643-27650.
    • (2002) J. Biol. Chem. , vol.277 , pp. 27643-27650
    • Gilmore, A.P.1    Valentijn, A.J.2    Wang, P.3    Ranger, A.M.4    Bundred, N.5    O'Hare, M.J.6    Wakeling, A.7    Korsmeyer, S.J.8    Streuli, C.H.9
  • 95
    • 33646040417 scopus 로고    scopus 로고
    • Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells
    • Hopfner, M.; Huether, A.; Sutter, A. P.; Baradari, V.; Schuppan, D.; Scherubl, H. Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells. Biochem. Pharmacol. 2006, 71, 1435-1448.
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 1435-1448
    • Hopfner, M.1    Huether, A.2    Sutter, A.P.3    Baradari, V.4    Schuppan, D.5    Scherubl, H.6
  • 96
    • 69949106121 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: Rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma
    • Desbois-Mouthon, C.; Baron, A.; Blivet-Van Eggelpoel, M. J.; Fartoux, L.; Venot, C.; Bladt, F.; Housset, C.; Rosmorduc, O. Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma. Clin. Cancer Res. 2009, 15, 5445-5456.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5445-5456
    • Desbois-Mouthon, C.1    Baron, A.2    Blivet-van Eggelpoel, M.J.3    Fartoux, L.4    Venot, C.5    Bladt, F.6    Housset, C.7    Rosmorduc, O.8
  • 97
    • 65549158055 scopus 로고    scopus 로고
    • High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter disease-free survival in resected non-small-cell lung cancer patients
    • Ludovini, V.; Bellezza, G.; Pistola, L.; Bianconi, F.; Di Carlo, L.; Sidoni, A.; Semeraro, A.; Del Sordo, R.; Tofanetti, F. R.; Mameli, M. G.; Daddi, G.; Cavaliere, A.; Tonato, M.; Crino, L. High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter disease-free survival in resected non-small-cell lung cancer patients. Ann. Oncol. 2009, 20, 842-849.
    • (2009) Ann. Oncol. , vol.20 , pp. 842-849
    • Ludovini, V.1    Bellezza, G.2    Pistola, L.3    Bianconi, F.4    Di Carlo, L.5    Sidoni, A.6    Semeraro, A.7    del Sordo, R.8    Tofanetti, F.R.9    Mameli, M.G.10    Daddi, G.11    Cavaliere, A.12    Tonato, M.13    Crino, L.14
  • 98
    • 77953078857 scopus 로고    scopus 로고
    • Combined inhibition of IGFR enhances the effects of gefitinib in H1650: A lung cancer cell line with EGFR mutation and primary resistance to EGFR-TK inhibitors
    • Choi, Y. J.; Rho, J. K.; Jeon, B. S.; Choi, S. J.; Park, S. C.; Lee, S. S.; Kim, H. R.; Kim, C. H.; Lee, J. C. Combined inhibition of IGFR enhances the effects of gefitinib in H1650: a lung cancer cell line with EGFR mutation and primary resistance to EGFR-TK inhibitors. Cancer Chemother. Pharmacol. 2010, 66, 381-388.
    • (2010) Cancer Chemother. Pharmacol. , vol.66 , pp. 381-388
    • Choi, Y.J.1    Rho, J.K.2    Jeon, B.S.3    Choi, S.J.4    Park, S.C.5    Lee, S.S.6    Kim, H.R.7    Kim, C.H.8    Lee, J.C.9
  • 102
    • 0038115223 scopus 로고    scopus 로고
    • HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro
    • Ding, S.; Merkulova-Rainon, T.; Han, Z. C.; Tobelem, G. HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro. Blood 2003, 101, 4816-22.
    • (2003) Blood , vol.101 , pp. 4816-4822
    • Ding, S.1    Merkulova-Rainon, T.2    Han, Z.C.3    Tobelem, G.4
  • 104
    • 0028071919 scopus 로고
    • Expression of hepatocyte growth factor mRNA, and c-met mRNA (hepatocyte growth factor receptor) in human liver tumours
    • Selden, C.; Farnaud, S.; Ding, S. F.; Habib, N.; Foster, C.; Hodgson, H. J. Expression of hepatocyte growth factor mRNA, and c-met mRNA (hepatocyte growth factor receptor) in human liver tumours. J. Hepatol. 1994, 21, 227-234.
    • (1994) J. Hepatol. , vol.21 , pp. 227-234
    • Selden, C.1    Farnaud, S.2    Ding, S.F.3    Habib, N.4    Foster, C.5    Hodgson, H.J.6
  • 106
    • 84856020870 scopus 로고    scopus 로고
    • Targeting c-Met as a promising strategy for the treatment of hepatocellular carcinoma
    • Gao, J.; Inagaki, Y.; Song, P.; Qu, X.; Kokudo, N.; Tang, W. Targeting c-Met as a promising strategy for the treatment of hepatocellular carcinoma. Pharmacol. Res. 2012, 65, 23-30.
    • (2012) Pharmacol. Res. , vol.65 , pp. 23-30
    • Gao, J.1    Inagaki, Y.2    Song, P.3    Qu, X.4    Kokudo, N.5    Tang, W.6
  • 108
    • 44349155339 scopus 로고    scopus 로고
    • Clinical significance of serum HGF and c-Met expression in tumor tissue for evaluation of properties and treatment of hepatocellular carcinoma
    • Osada, S.; Kanematsu, M.; Imai, H.; Goshima, S. Clinical significance of serum HGF and c-Met expression in tumor tissue for evaluation of properties and treatment of hepatocellular carcinoma. Hepatogastroenterology 2008, 55, 544-549.
    • (2008) Hepatogastroenterology , vol.55 , pp. 544-549
    • Osada, S.1    Kanematsu, M.2    Imai, H.3    Goshima, S.4
  • 110
    • 35148864569 scopus 로고    scopus 로고
    • In vitro c-met inhibition by antisense RNA and plasmidbased RNAi down-modulates migration and invasion of hepatocellular carcinoma cells
    • Salvi, A.; Arici, B.; Portolani, N.; Giulini, S. M.; De Petro, G.; Barlati, S. In vitro c-met inhibition by antisense RNA and plasmidbased RNAi down-modulates migration and invasion of hepatocellular carcinoma cells. Int. J. Oncol. 2007, 31, 451-460.
    • (2007) Int. J. Oncol. , vol.31 , pp. 451-460
    • Salvi, A.1    Arici, B.2    Portolani, N.3    Giulini, S.M.4    de Petro, G.5    Barlati, S.6
  • 111
    • 80052033164 scopus 로고    scopus 로고
    • c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma
    • You, H.; Ding, W.; Dang, H.; Jiang, Y.; Rountree, C. B. c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma. Hepatology 2011, 54, 879-889.
    • (2011) Hepatology , vol.54 , pp. 879-889
    • You, H.1    Ding, W.2    Dang, H.3    Jiang, Y.4    Rountree, C.B.5
  • 115
    • 84861535274 scopus 로고    scopus 로고
    • Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma
    • Huynh, H.; Ong, R.; Soo, K. C. Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma. Angiogenesis 2012, 15, 59-70.
    • (2012) Angiogenesis , vol.15 , pp. 59-70
    • Huynh, H.1    Ong, R.2    Soo, K.C.3
  • 117
    • 84857020475 scopus 로고    scopus 로고
    • Targeted systemic therapies for hepatocellular carcinoma: Clinical perspectives, challenges and implications
    • Frenette, C.; Gish, R. Targeted systemic therapies for hepatocellular carcinoma: clinical perspectives, challenges and implications. World J. Gastroenterol. 2012, 18, 498-506.
    • (2012) World J. Gastroenterol. , vol.18 , pp. 498-506
    • Frenette, C.1    Gish, R.2


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