-
1
-
-
14944385553
-
Global cancer statistics, 2002
-
Parkin, D. M.; Bray, F.; Ferlay, J.; Pisani, P. Global cancer statistics, 2002. CA Cancer J. Clin. 2005, 55, 74-108.
-
(2005)
CA Cancer J. Clin.
, vol.55
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
-
2
-
-
0035888074
-
Estimating the world cancer burden: Globocan 2000
-
Parkin, D. M.; Bray, F.; Ferlay, J.; Pisani P. Estimating the world cancer burden: Globocan 2000. Int. J. Cancer 2001, 94, 153-6.
-
(2001)
Int. J. Cancer
, vol.94
, pp. 153-156
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
-
3
-
-
34250020201
-
Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
-
El-Serag, H. B.; Rudolph, K. L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007, 132, 2557-76.
-
(2007)
Gastroenterology
, vol.132
, pp. 2557-2576
-
-
El-Serag, H.B.1
Rudolph, K.L.2
-
4
-
-
1842426695
-
Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance
-
Sangiovanni, A.; Del Ninno, E.; Fasani, P.; De Fazio, C.; Ronchi, G.; Romeo, R.; Morabito, A.; De Franchis, R.; Colombo, M. Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance. Gastroenterology 2004, 126, 1005-14.
-
(2004)
Gastroenterology
, vol.126
, pp. 1005-1014
-
-
Sangiovanni, A.1
del Ninno, E.2
Fasani, P.3
de Fazio, C.4
Ronchi, G.5
Romeo, R.6
Morabito, A.7
de Franchis, R.8
Colombo, M.9
-
5
-
-
7044272630
-
Hepatocellular carcinoma in cirrhosis: Incidence and risk factors
-
Fattovich, G.; Stroffolini, T.; Zagni, I.; Donato, F. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 2004, 127, S35-S50.
-
(2004)
Gastroenterology
, vol.127
-
-
Fattovich, G.1
Stroffolini, T.2
Zagni, I.3
Donato, F.4
-
6
-
-
7044235603
-
Obesity and hepatocellular carcinoma
-
Caldwell, S. H.; Crespo, D. M.; Kang, H. S.; Al-Osaimi, A. M. Obesity and hepatocellular carcinoma. Gastroenterology 2004, 127, S97-103.
-
(2004)
Gastroenterology
, vol.127
, pp. 97-103
-
-
Caldwell, S.H.1
Crespo, D.M.2
Kang, H.S.3
Al-Osaimi, A.M.4
-
7
-
-
84858658381
-
EASL-EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma
-
European Association for the Study of the Liver, European Organisation for Research and Treatment of Cancer
-
European Association for the Study of the Liver, European Organisation for Research and Treatment of Cancer. EASL-EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma. J. Hepatol. 2012, 56, 908-943.
-
(2012)
J. Hepatol.
, vol.56
, pp. 908-943
-
-
-
8
-
-
0026735844
-
Hepatocellular carcinoma
-
Colombo, M. Hepatocellular carcinoma. J. Hepatol. 1992, 15, 225-236.
-
(1992)
J. Hepatol.
, vol.15
, pp. 225-236
-
-
Colombo, M.1
-
9
-
-
0037129704
-
Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: A randomised controlled trial
-
Barcelona Liver Cancer G
-
Llovet, J. M.; Real, M. I.; Montana, X.; Planas, R.; Coll, S.; Aponte, J.; Ayuso, C.; Sala, M.; Muchart, J.; Sola, R.; Rodes, J.; Bruix, J. Barcelona Liver Cancer G. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet 2002, 359, 1734-1739.
-
(2002)
Lancet
, vol.359
, pp. 1734-1739
-
-
Llovet, J.M.1
Real, M.I.2
Montana, X.3
Planas, R.4
Coll, S.5
Aponte, J.6
Ayuso, C.7
Sala, M.8
Muchart, J.9
Sola, R.10
Rodes, J.11
Bruix, J.12
-
10
-
-
0036237822
-
Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma
-
Lo, C. M.; Ngan, H.; Tso, W. K.; Liu, C. L.; Lam, C. M.; Poon, R. T.; Fan, S. T.; Wong, J. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology 2002, 35, 1164-1171.
-
(2002)
Hepatology
, vol.35
, pp. 1164-1171
-
-
Lo, C.M.1
Ngan, H.2
Tso, W.K.3
Liu, C.L.4
Lam, C.M.5
Poon, R.T.6
Fan, S.T.7
Wong, J.8
-
11
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet, J. M.; Ricci, S.; Mazzaferro, V.; Hilgard, P.; Gane, E.; Blanc, J. F.; de Oliveira, A. C.; Santoro, A.; Raoul, J. L.; Forner, A.; Schwartz, M.; Porta, C.; Zeuzem, S.; Bolondi, L.; Greten, T. F.; Galle, P. R.; Seitz, J. F.; Borbath, I.; Haussinger, D.; Giannaris, T.; Shan, M.; Moscovici, M.; Voliotis, D.; Bruix, J. Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 2008, 359, 378-390.
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
Blanc, J.F.6
de Oliveira, A.C.7
Santoro, A.8
Raoul, J.L.9
Forner, A.10
Schwartz, M.11
Porta, C.12
Zeuzem, S.13
Bolondi, L.14
Greten, T.F.15
Galle, P.R.16
Seitz, J.F.17
Borbath, I.18
Haussinger, D.19
Giannaris, T.20
Shan, M.21
Moscovici, M.22
Voliotis, D.23
Bruix, J.24
more..
-
12
-
-
33747830764
-
Hepatocellular carcinoma pathogenesis: From genes to environment
-
Farazi, P. A.; DePinho, R. A. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer 2006, 6, 674-687.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 674-687
-
-
Farazi, P.A.1
DePinho, R.A.2
-
13
-
-
0031048958
-
Treatment of hepatocellular carcinoma: A systematic review of randomized controlled trials
-
Simonetti, R. G.; Liberati, A.; Angiolini, C.; Pagliaro, L. Treatment of hepatocellular carcinoma: a systematic review of randomized controlled trials. Ann. Oncol. 1997, 8, 117-136.
-
(1997)
Ann. Oncol.
, vol.8
, pp. 117-136
-
-
Simonetti, R.G.1
Liberati, A.2
Angiolini, C.3
Pagliaro, L.4
-
14
-
-
0034100195
-
Expression of Pglycoprotein in hepatocellular carcinoma. A determinant of chemotherapy response
-
Ng, I. O.; Liu, C. L.; Fan, S. T.; Ng, M. Expression of Pglycoprotein in hepatocellular carcinoma. A determinant of chemotherapy response. Am. J. Clin. Pathol. 2000, 113, 355-363.
-
(2000)
Am. J. Clin. Pathol.
, vol.113
, pp. 355-363
-
-
Ng, I.O.1
Liu, C.L.2
Fan, S.T.3
Ng, M.4
-
15
-
-
0024329881
-
The biochemistry of P-glycoproteinmediated multidrug resistance
-
Endicott, J. A.; Ling, V. The biochemistry of P-glycoproteinmediated multidrug resistance. Annu. Rev. Biochem. 1989, 58, 137-171.
-
(1989)
Annu. Rev. Biochem.
, vol.58
, pp. 137-171
-
-
Endicott, J.A.1
Ling, V.2
-
16
-
-
54449083925
-
Molecular targeted therapies in hepatocellular carcinoma
-
Llovet, J. M.; Bruix, J. Molecular targeted therapies in hepatocellular carcinoma. Hepatology 2008, 48, 1312-1327.
-
(2008)
Hepatology
, vol.48
, pp. 1312-1327
-
-
Llovet, J.M.1
Bruix, J.2
-
17
-
-
33847069207
-
Genomics and signaling pathways in hepatocellular carcinoma
-
Villanueva, A.; Newell, P.; Chiang, D. Y.; Friedman, S. L.; Llovet, J. M. Genomics and signaling pathways in hepatocellular carcinoma. Semin. Liver Dis. 2007, 27, 55-76.
-
(2007)
Semin. Liver Dis.
, vol.27
, pp. 55-76
-
-
Villanueva, A.1
Newell, P.2
Chiang, D.Y.3
Friedman, S.L.4
Llovet, J.M.5
-
18
-
-
33745547361
-
New therapies for hepatocellular carcinoma
-
Avila, M. A.; Berasain, C.; Sangro, B.; Prieto, J. New therapies for hepatocellular carcinoma. Oncogene 2006, 25, 3866-3884.
-
(2006)
Oncogene
, vol.25
, pp. 3866-3884
-
-
Avila, M.A.1
Berasain, C.2
Sangro, B.3
Prieto, J.4
-
19
-
-
70349782389
-
An overview of smallmolecule inhibitors of VEGFR signaling
-
Ivy, S. P.; Wick, J. Y.; Kaufman, B. M. An overview of smallmolecule inhibitors of VEGFR signaling. Nat. Rev. Clin. Oncol. 2009, 6, 569-579.
-
(2009)
Nat. Rev. Clin. Oncol.
, vol.6
, pp. 569-579
-
-
Ivy, S.P.1
Wick, J.Y.2
Kaufman, B.M.3
-
20
-
-
0037392444
-
Issues and progress with protein kinase inhibitors for cancer treatment
-
Dancey, J.; Sausville, E. A. Issues and progress with protein kinase inhibitors for cancer treatment. Nat. Rev. Drug Discov. 2003, 2, 296-313.
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 296-313
-
-
Dancey, J.1
Sausville, E.A.2
-
21
-
-
0036984640
-
Role of angiogenesis in tumor growth and metastasis
-
Folkman, J. Role of angiogenesis in tumor growth and metastasis. Semin. Oncol. 2002, 29, 15-18.
-
(2002)
Semin. Oncol.
, vol.29
, pp. 15-18
-
-
Folkman, J.1
-
22
-
-
39749166386
-
Antiangiogenic therapy for cancer: An update
-
Shojaei, F.; Ferrara, N. Antiangiogenic therapy for cancer: an update. Cancer J. 2007, 13, 345-348.
-
(2007)
Cancer J.
, vol.13
, pp. 345-348
-
-
Shojaei, F.1
Ferrara, N.2
-
23
-
-
44149090296
-
Role of platelet-derived growth factors in physiology and medicine
-
Andrae, J.; Gallini, R.; Betsholtz, C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008, 22, 1276-1312.
-
(2008)
Genes Dev.
, vol.22
, pp. 1276-1312
-
-
Andrae, J.1
Gallini, R.2
Betsholtz, C.3
-
24
-
-
78650382003
-
Biologically targeted cancer therapy and marginal benefits: Are we making too much of too little or are we achieving too little by giving too much?
-
Fojo, T.; Parkinson, D. R. Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much? Clin. Cancer Res. 2010, 16, 5972-5980.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 5972-5980
-
-
Fojo, T.1
Parkinson, D.R.2
-
25
-
-
77954218447
-
Molecularly targeted therapy in hepatocellular carcinoma
-
Huynh, H. Molecularly targeted therapy in hepatocellular carcinoma. Biochem. Pharmacol. 2010, 80, 550-560.
-
(2010)
Biochem. Pharmacol.
, vol.80
, pp. 550-560
-
-
Huynh, H.1
-
26
-
-
19144366561
-
Clinical significance of vascular endothelial growth factor and basic fibroblast growth factor gene expression in liver tumor
-
Mise, M.; Arii, S.; Higashituji, H.; Furutani, M.; Niwano, M.; Harada, T.; Ishigami, S.; Toda, Y.; Nakayama, H.; Fukumoto, M.; Fujita, J.; Imamura, M. Clinical significance of vascular endothelial growth factor and basic fibroblast growth factor gene expression in liver tumor. Hepatology 1996, 23, 455-464.
-
(1996)
Hepatology
, vol.23
, pp. 455-464
-
-
Mise, M.1
Arii, S.2
Higashituji, H.3
Furutani, M.4
Niwano, M.5
Harada, T.6
Ishigami, S.7
Toda, Y.8
Nakayama, H.9
Fukumoto, M.10
Fujita, J.11
Imamura, M.12
-
27
-
-
53049086329
-
Focal gains of VEGFA and molecular classification of hepatocellular carcinoma
-
Chiang, D. Y.; Villanueva, A.; Hoshida, Y.; Peix, J.; Newell, P.; Minguez, B.; LeBlanc, A. C.; Donovan, D. J.; Thung, S. N.; Sole, M.; Tovar, V.; Alsinet, C.; Ramos, A. H.; Barretina, J.; Roayaie, S.; Schwartz, M.; Waxman, S.; Bruix, J.; Mazzaferro, V.; Ligon, A. H.; Najfeld, V.; Friedman, S. L.; Sellers, W. R.; Meyerson, M.; Llovet, J. M. Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res. 2008, 68, 6779-6788.
-
(2008)
Cancer Res.
, vol.68
, pp. 6779-6788
-
-
Chiang, D.Y.1
Villanueva, A.2
Hoshida, Y.3
Peix, J.4
Newell, P.5
Minguez, B.6
LeBlanc, A.C.7
Donovan, D.J.8
Thung, S.N.9
Sole, M.10
Tovar, V.11
Alsinet, C.12
Ramos, A.H.13
Barretina, J.14
Roayaie, S.15
Schwartz, M.16
Waxman, S.17
Bruix, J.18
Mazzaferro, V.19
Ligon, A.H.20
Najfeld, V.21
Friedman, S.L.22
Sellers, W.R.23
Meyerson, M.24
Llovet, J.M.25
more..
-
28
-
-
0030723789
-
Increased expression of vascular endothelial growth factor in human hepatocellular carcinoma
-
Miura, H.; Miyazaki, T.; Kuroda, M.; Oka, T.; Machinami, R.; Kodama, T.; Shibuya, M.; Makuuchi, M.; Yazaki, Y.; Ohnishi, S. Increased expression of vascular endothelial growth factor in human hepatocellular carcinoma. J. Hepatol. 1997, 27, 854-861.
-
(1997)
J. Hepatol.
, vol.27
, pp. 854-861
-
-
Miura, H.1
Miyazaki, T.2
Kuroda, M.3
Oka, T.4
McHinami, R.5
Kodama, T.6
Shibuya, M.7
Makuuchi, M.8
Yazaki, Y.9
Ohnishi, S.10
-
29
-
-
0043163428
-
Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery
-
Chao, Y.; Li, C. P.; Chau, G. Y.; Chen, C. P.; King, K. L.; Lui, W. Y.; Yen, S. H.; Chang, F. Y.; Chan, W. K.; Lee, S. D. Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery. Ann. Surg. Oncol. 2003, 10, 355-362.
-
(2003)
Ann. Surg. Oncol.
, vol.10
, pp. 355-362
-
-
Chao, Y.1
Li, C.P.2
Chau, G.Y.3
Chen, C.P.4
King, K.L.5
Lui, W.Y.6
Yen, S.H.7
Chang, F.Y.8
Chan, W.K.9
Lee, S.D.10
-
30
-
-
4944234987
-
Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma
-
Poon, R. T.; Ho, J. W.; Tong, C. S.; Lau, C.; Ng, I. O.; Fan, S. T. Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma. Br. J. Surg. 2004, 91, 1354-1360.
-
(2004)
Br. J. Surg.
, vol.91
, pp. 1354-1360
-
-
Poon, R.T.1
Ho, J.W.2
Tong, C.S.3
Lau, C.4
Ng, I.O.5
Fan, S.T.6
-
31
-
-
29344456631
-
Overexpression of platelet-derived growth factor receptor alpha in endothelial cells of hepatocellular carcinoma associated with high metastatic potential
-
Zhang, T.; Sun, H. C.; Xu, Y.; Zhang, K. Z.; Wang, L.; Qin, L. X.; Wu, W. Z.; Liu, Y. K.; Ye, S. L.; Tang, Z. Y. Overexpression of platelet-derived growth factor receptor alpha in endothelial cells of hepatocellular carcinoma associated with high metastatic potential. Clin. Cancer Res. 2005, 11, 8557-8563.
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 8557-8563
-
-
Zhang, T.1
Sun, H.C.2
Xu, Y.3
Zhang, K.Z.4
Wang, L.5
Qin, L.X.6
Wu, W.Z.7
Liu, Y.K.8
Ye, S.L.9
Tang, Z.Y.10
-
32
-
-
34047127376
-
PDGF receptors as targets in tumor treatment
-
Ostman, A.; Heldin, C. H. PDGF receptors as targets in tumor treatment. Adv. Cancer Res. 2007, 97, 247-274.
-
(2007)
Adv. Cancer Res.
, vol.97
, pp. 247-274
-
-
Ostman, A.1
Heldin, C.H.2
-
33
-
-
58149175849
-
Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma
-
Huynh, H.; Ngo, V. C.; Fargnoli, J.; Ayers, M.; Soo, K. C.; Koong, H. N.; Thng, C. H.; Ong, H. S.; Chung, A.; Chow, P.; Pollock, P.; Byron, S.; Tran, E. Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin. Cancer. Res. 2008, 14, 6146-6153.
-
(2008)
Clin. Cancer. Res.
, vol.14
, pp. 6146-6153
-
-
Huynh, H.1
Ngo, V.C.2
Fargnoli, J.3
Ayers, M.4
Soo, K.C.5
Koong, H.N.6
Thng, C.H.7
Ong, H.S.8
Chung, A.9
Chow, P.10
Pollock, P.11
Byron, S.12
Tran, E.13
-
34
-
-
70349495869
-
Targeting vascular endothelial growth factor receptor-1 and-3 with cediranib (AZD2171): Effects on migration and invasion of gastrointestinal cancer cell lines
-
Morelli, M. P.; Brown, A. M.; Pitts, T. M.; Tentler, J. J.; Ciardiello, F.; Ryan, A.; Jurgensmeier J. M.; Eckhardt, S. G. Targeting vascular endothelial growth factor receptor-1 and-3 with cediranib (AZD2171): effects on migration and invasion of gastrointestinal cancer cell lines. Mol. Cancer Ther. 2009, 8, 2546-2558.
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 2546-2558
-
-
Morelli, M.P.1
Brown, A.M.2
Pitts, T.M.3
Tentler, J.J.4
Ciardiello, F.5
Ryan, A.6
Jurgensmeier, J.M.7
Eckhardt, S.G.8
-
35
-
-
69049090809
-
Cediranib (recentin, AZD2171) reverses ABCB1-and ABCC1-mediated multidrug resistance by inhibition of their transport function
-
Tao, L. Y.; Liang, Y. J.; Wang, F.; Chen, L. M.; Yan, Y. Y.; Dai, C. L.; Fu, L. W. Cediranib (recentin, AZD2171) reverses ABCB1-and ABCC1-mediated multidrug resistance by inhibition of their transport function. Cancer Chemother. Pharmacol. 2009, 64, 961-969.
-
(2009)
Cancer Chemother. Pharmacol.
, vol.64
, pp. 961-969
-
-
Tao, L.Y.1
Liang, Y.J.2
Wang, F.3
Chen, L.M.4
Yan, Y.Y.5
Dai, C.L.6
Fu, L.W.7
-
36
-
-
79953325932
-
Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma
-
Park, J. W.; Finn, R. S.; Kim, J. S.; Karwal, M.; Li, R. K.; Ismail, F.; Thomas, M.; Harris, R.; Baudelet, C.; Walters, I.; Raoul, J. L. Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma. Clin. Cancer Res. 2011, 17, 1973-1983.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 1973-1983
-
-
Park, J.W.1
Finn, R.S.2
Kim, J.S.3
Karwal, M.4
Li, R.K.5
Ismail, F.6
Thomas, M.7
Harris, R.8
Baudelet, C.9
Walters, I.10
Raoul, J.L.11
-
37
-
-
84857008164
-
Phase II, openlabel study of brivanib as second-line therapy in patients with advanced hepatocellular carcinoma
-
Finn, R. S.; Kang, Y. K.; Mulcahy, M.; Polite, B. N.; Lim, H. Y.; Walters, I.; Baudelet, C.; Manekas, D.; Park, J. W. Phase II, openlabel study of brivanib as second-line therapy in patients with advanced hepatocellular carcinoma. Clin. Cancer Res. 2012, 18, 2090-2098.
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 2090-2098
-
-
Finn, R.S.1
Kang, Y.K.2
Mulcahy, M.3
Polite, B.N.4
Lim, H.Y.5
Walters, I.6
Baudelet, C.7
Manekas, D.8
Park, J.W.9
-
38
-
-
84859383549
-
Second-line therapies in hepatocellular carcinoma: Emergence of resistance to sorafenib
-
Villanueva, A.; Llovet, J. M. Second-line therapies in hepatocellular carcinoma: emergence of resistance to sorafenib. Clin. Cancer Res. 2012, 18, 1824-1826.
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 1824-1826
-
-
Villanueva, A.1
Llovet, J.M.2
-
39
-
-
34547681379
-
Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors
-
Drevs, J.; Siegert, P.; Medinger, M.; Mross, K.; Strecker, R.; Zirrgiebel, U.; Harder, J.; Blum, H; Robertson, J.; Jurgensmeier, J. M.; Puchalski, T. A.; Young, H.; Saunders, O.; Unger, C. Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors. J. Clin. Oncol. 2007, 25, 3045-3054.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 3045-3054
-
-
Drevs, J.1
Siegert, P.2
Medinger, M.3
Mross, K.4
Strecker, R.5
Zirrgiebel, U.6
Harder, J.7
Blum, H.8
Robertson, J.9
Jurgensmeier, J.M.10
Puchalski, T.A.11
Young, H.12
Saunders, O.13
Unger, C.14
-
40
-
-
84864348077
-
Cediranib (AZD2171) in Patients With Advanced Hepatocellular Carcinoma: A Phase II North Central Cancer Treatment Group Clinical Trial
-
Alberts, S. R.; Fitch, T. R.; Kim, G. P.; Morlan, B. W.; Dakhil, S. R.; Gross, H. M.; Nair, S. Cediranib (AZD2171) in Patients With Advanced Hepatocellular Carcinoma: A Phase II North Central Cancer Treatment Group Clinical Trial. Am. J. Clin. Oncol. 2012, 35, 329-333.
-
(2012)
Am. J. Clin. Oncol.
, vol.35
, pp. 329-333
-
-
Alberts, S.R.1
Fitch, T.R.2
Kim, G.P.3
Morlan, B.W.4
Dakhil, S.R.5
Gross, H.M.6
Nair, S.7
-
41
-
-
44149110127
-
Identification of human liver cytochrome P450 isoforms involved in autoinduced metabolism of the antiangiogenic agent (Z)-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1Hpyrrole-3-pr opanoic acid (TSU-68)
-
Kitamura, R.; Asanoma, H.; Nagayama, S.; Otagiri, M. Identification of human liver cytochrome P450 isoforms involved in autoinduced metabolism of the antiangiogenic agent (Z)-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1Hpyrrole-3-pr opanoic acid (TSU-68). Drug. Metab. Dispos. 2008, 36, 1003-1009.
-
(2008)
Drug. Metab. Dispos.
, vol.36
, pp. 1003-1009
-
-
Kitamura, R.1
Asanoma, H.2
Nagayama, S.3
Otagiri, M.4
-
42
-
-
79953803472
-
A phase I/II trial of the oral antiangiogenic agent TSU-68 in patients with advanced hepatocellular carcinoma
-
Kanai, F.; Yoshida, H.; Tateishi, R.; Sato, S.; Kawabe, T.; Obi, S.; Kondo, Y.; Taniguchi, M.; Tagawa, K.; Ikeda, M.; Morizane, C.; Okusaka, T.; Arioka, H.; Shiina, S.; Omata, M. A phase I/II trial of the oral antiangiogenic agent TSU-68 in patients with advanced hepatocellular carcinoma. Cancer Chemother. Pharmacol. 2011, 67, 315-324.
-
(2011)
Cancer Chemother. Pharmacol.
, vol.67
, pp. 315-324
-
-
Kanai, F.1
Yoshida, H.2
Tateishi, R.3
Sato, S.4
Kawabe, T.5
Obi, S.6
Kondo, Y.7
Taniguchi, M.8
Tagawa, K.9
Ikeda, M.10
Morizane, C.11
Okusaka, T.12
Arioka, H.13
Shiina, S.14
Omata, M.15
-
43
-
-
84859419666
-
Antitumor effect of vascular endothelial growth factor inhibitor sunitinib in preclinical models of hepatocellular carcinoma
-
Bagi, C. M.; Gebhard, D. F.; Andresen, C. J. Antitumor effect of vascular endothelial growth factor inhibitor sunitinib in preclinical models of hepatocellular carcinoma. Eur. J. Gastroenterol. Hepatol. 2012, 24, 563-574.
-
(2012)
Eur. J. Gastroenterol. Hepatol.
, vol.24
, pp. 563-574
-
-
Bagi, C.M.1
Gebhard, D.F.2
Andresen, C.J.3
-
44
-
-
70349158101
-
Sunitinib (SUTENT, SU11248) suppresses tumor growth and induces apoptosis in xenograft models of human hepatocellular carcinoma
-
Huynh, H.; Ngo, V. C.; Choo, S. P.; Poon, D.; Koong, H. N.; Thng, C. H.; Toh, H. C.; Zheng, L.; Ong, L. C.; Jin, Y.; Song, I. C.; Chang, A. P.; Ong, H. S.; Chung, A. Y.; Chow, P. K.; Soo, K. C. Sunitinib (SUTENT, SU11248) suppresses tumor growth and induces apoptosis in xenograft models of human hepatocellular carcinoma. Curr. Cancer Drug Targets 2009, 9, 738-747.
-
(2009)
Curr. Cancer Drug Targets
, vol.9
, pp. 738-747
-
-
Huynh, H.1
Ngo, V.C.2
Choo, S.P.3
Poon, D.4
Koong, H.N.5
Thng, C.H.6
Toh, H.C.7
Zheng, L.8
Ong, L.C.9
Jin, Y.10
Song, I.C.11
Chang, A.P.12
Ong, H.S.13
Chung, A.Y.14
Chow, P.K.15
Soo, K.C.16
-
45
-
-
67649946279
-
Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: A phase II study
-
Zhu, A. X.; Sahani, D. V.; Duda, D. G.; di Tomaso, E.; Ancukiewicz, M.; Catalano, O. A.; Sindhwani, V.; Blaszkowsky, L. S.; Yoon, S. S.; Lahdenranta, J.; Bhargava, P.; Meyerhardt, J.; Clark, J. W.; Kwak, E. L.; Hezel, A. F.; Miksad, R.; Abrams, T. A.; Enzinger, P. C.; Fuchs, C. S.; Ryan, D. P.; Jain, R. K. Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study. J. Clin. Oncol. 2009, 27, 3027-3035.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 3027-3035
-
-
Zhu, A.X.1
Sahani, D.V.2
Duda, D.G.3
Di Tomaso, E.4
Ancukiewicz, M.5
Catalano, O.A.6
Sindhwani, V.7
Blaszkowsky, L.S.8
Yoon, S.S.9
Lahdenranta, J.10
Bhargava, P.11
Meyerhardt, J.12
Clark, J.W.13
Kwak, E.L.14
Hezel, A.F.15
Miksad, R.16
Abrams, T.A.17
Enzinger, P.C.18
Fuchs, C.S.19
Ryan, D.P.20
Jain, R.K.21
more..
-
46
-
-
67651165187
-
Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: An open-label, multicentre, phase II study
-
Faivre, S.; Raymond, E.; Boucher, E; Douillard, J.; Lim, H. Y.; Kim, J. S.; Zappa, M.; Lanzalone S.; Lin, X.; Deprimo, S.; Harmon, C.; Ruiz-Garcia, A.; Lechuga, M. J.; Cheng, A. L. Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study. Lancet Oncol. 2009, 10, 794-800.
-
(2009)
Lancet Oncol.
, vol.10
, pp. 794-800
-
-
Faivre, S.1
Raymond, E.2
Boucher, E.3
Douillard, J.4
Lim, H.Y.5
Kim, J.S.6
Zappa, M.7
Lanzalone, S.8
Lin, X.9
Deprimo, S.10
Harmon, C.11
Ruiz-Garcia, A.12
Lechuga, M.J.13
Cheng, A.L.14
-
47
-
-
73349110120
-
Sunitinib in hepatocellular carcinoma: Redefining appropriate dosing, schedule, and activity end points
-
author reply e251-2
-
Faivre, S. J.; Bouattour, M.; Dreyer, C.; Raymond, E. Sunitinib in hepatocellular carcinoma: redefining appropriate dosing, schedule, and activity end points. J. Clin. Oncol. 2009, 27, e248-50, author reply e251-2.
-
(2009)
J. Clin. Oncol.
, vol.27
-
-
Faivre, S.J.1
Bouattour, M.2
Dreyer, C.3
Raymond, E.4
-
48
-
-
67749089441
-
Sunitinib and the benefits of a negative study
-
Forner, A.; Llovet, J. M.; Bruix, J. Sunitinib and the benefits of a negative study. Lancet Oncol. 2009, 10, 743-744.
-
(2009)
Lancet Oncol.
, vol.10
, pp. 743-744
-
-
Forner, A.1
Llovet, J.M.2
Bruix, J.3
-
49
-
-
84857357820
-
Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma
-
Huynh, H.; Chow, P. K.; Tai, W. M.; Choo, S. P.; Chung, A. Y.; Ong, H. S.; Soo, K. C.; Ong, R.; Linnartz, R.; Shi, M. M. Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma. J. Hepatol. 2012, 56, 595-601.
-
(2012)
J. Hepatol.
, vol.56
, pp. 595-601
-
-
Huynh, H.1
Chow, P.K.2
Tai, W.M.3
Choo, S.P.4
Chung, A.Y.5
Ong, H.S.6
Soo, K.C.7
Ong, R.8
Linnartz, R.9
Shi, M.M.10
-
50
-
-
84984586832
-
Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3
-
Tai, W. T.; Cheng, A. L.; Shiau, C. W.; Liu, C. Y.; Ko, C. H.; Lin, M. W.; Chen, P. J.; Chen, K. F. Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3. Mol. Cancer Ther. 2012, 11, 452-463.
-
(2012)
Mol. Cancer Ther.
, vol.11
, pp. 452-463
-
-
Tai, W.T.1
Cheng, A.L.2
Shiau, C.W.3
Liu, C.Y.4
Ko, C.H.5
Lin, M.W.6
Chen, P.J.7
Chen, K.F.8
-
51
-
-
42249087301
-
A phase I pharmacokinetic and pharmacodynamic study of TKI258, an oral, multitargeted receptor tyrosine kinase inhibitor in patients with advanced solid tumors
-
Sarker, D.; Molife, R.; Evans, T. R.; Hardie, M.; Marriott, C.; Butzberger-Zimmerli, P.; Morrison, R.; Fox, J. A.; Heise, C.; Louie, S.; Aziz, N.; Garzon, F.; Michelson, G.; Judson, I. R.; Jadayel, D.; Braendle, E.; de Bono, J. S. A phase I pharmacokinetic and pharmacodynamic study of TKI258, an oral, multitargeted receptor tyrosine kinase inhibitor in patients with advanced solid tumors. Clin. Cancer Res. 2008, 14, 2075-2081.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 2075-2081
-
-
Sarker, D.1
Molife, R.2
Evans, T.R.3
Hardie, M.4
Marriott, C.5
Butzberger-Zimmerli, P.6
Morrison, R.7
Fox, J.A.8
Heise, C.9
Louie, S.10
Aziz, N.11
Garzon, F.12
Michelson, G.13
Judson, I.R.14
Jadayel, D.15
Braendle, E.16
de Bono, J.S.17
-
52
-
-
18144401256
-
Both antiangiogenesis-and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584
-
Liu, Y.; Poon, R. T.; Li, Q.; Kok, T. W.; Lau, C.; Fan, S. T. Both antiangiogenesis-and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584. Cancer Res. 2005, 65, 3691-3699.
-
(2005)
Cancer Res.
, vol.65
, pp. 3691-3699
-
-
Liu, Y.1
Poon, R.T.2
Li, Q.3
Kok, T.W.4
Lau, C.5
Fan, S.T.6
-
53
-
-
79951558136
-
Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferonalpha/ 5-fluorouracil therapy for hepatocellular carcinoma cells
-
Murakami, M.; Kobayashi, S.; Marubashi, S.; Tomimaru, Y.; Noda, T.; Wada, H.; Eguchi, H.; Takeda, Y.; Tanemura, M.; Umeshita, K.; Doki, Y.; Mori, M.; Nagano, H. Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferonalpha/ 5-fluorouracil therapy for hepatocellular carcinoma cells. Ann. Surg. Oncol. 2011, 18, 589-596.
-
(2011)
Ann. Surg. Oncol.
, vol.18
, pp. 589-596
-
-
Murakami, M.1
Kobayashi, S.2
Marubashi, S.3
Tomimaru, Y.4
Noda, T.5
Wada, H.6
Eguchi, H.7
Takeda, Y.8
Tanemura, M.9
Umeshita, K.10
Doki, Y.11
Mori, M.12
Nagano, H.13
-
54
-
-
78249288161
-
Phase 1-2 trial of PTK787/ZK222584 combined with intravenous doxorubicin for treatment of patients with advanced hepatocellular carcinoma: Implication for antiangiogenic approach to hepatocellular carcinoma
-
Yau, T.; Chan, P.; Pang, R.; Ng, K.; Fan, S. T.; Poon, R. T. Phase 1-2 trial of PTK787/ZK222584 combined with intravenous doxorubicin for treatment of patients with advanced hepatocellular carcinoma: implication for antiangiogenic approach to hepatocellular carcinoma. Cancer 2010, 116, 5022-5029.
-
(2010)
Cancer
, vol.116
, pp. 5022-5029
-
-
Yau, T.1
Chan, P.2
Pang, R.3
Ng, K.4
Fan, S.T.5
Poon, R.T.6
-
55
-
-
79955401037
-
Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma
-
Villanueva, A.; Hoshida, Y.; Battiston, C.; Tovar, V.; Sia, D.; Alsinet, C.; Cornella, H.; Liberzon, A.; Kobayashi, M.; Kumada, H.; Thung, S. N.; Bruix, J.; Newell, P.; April, C.; Fan, J. B.; Roayaie, S.; Mazzaferro, V.; Schwartz, M. E.; Llovet, J. M. Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma. Gastroenterology 2011, 140, 1501-1512 e2.
-
(2011)
Gastroenterology
, vol.140
-
-
Villanueva, A.1
Hoshida, Y.2
Battiston, C.3
Tovar, V.4
Sia, D.5
Alsinet, C.6
Cornella, H.7
Liberzon, A.8
Kobayashi, M.9
Kumada, H.10
Thung, S.N.11
Bruix, J.12
Newell, P.13
April, C.14
Fan, J.B.15
Roayaie, S.16
Mazzaferro, V.17
Schwartz, M.E.18
Llovet, J.M.19
-
56
-
-
33846212284
-
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
-
Liu, L.; Cao, Y.; Chen, C.; Zhang, X.; McNabola, A.; Wilkie, D.; Wilhelm, S.; Lynch, M.; Carter, C. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res. 2006, 66, 11851-11858.
-
(2006)
Cancer Res.
, vol.66
, pp. 11851-11858
-
-
Liu, L.1
Cao, Y.2
Chen, C.3
Zhang, X.4
McNabola, A.5
Wilkie, D.6
Wilhelm, S.7
Lynch, M.8
Carter, C.9
-
57
-
-
84984559474
-
Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3
-
Chen, K. F.; Tai, W. T.; Liu, T. H.; Huang, H. P.; Lin, Y. C.; Shiau, C. W.; Li, P. K.; Chen, P. J.; Cheng, A. L. Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3. Clin. Cancer Res. 2010, 16, 5189-5199.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 5189-5199
-
-
Chen, K.F.1
Tai, W.T.2
Liu, T.H.3
Huang, H.P.4
Lin, Y.C.5
Shiau, C.W.6
Li, P.K.7
Chen, P.J.8
Cheng, A.L.9
-
58
-
-
84984589185
-
Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma
-
Tai, W. T.; Cheng, A. L.; Shiau, C. W.; Huang, H. P.; Huang, J. W.; Chen, P. J.; Chen, K. F. Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma. J. Hepatol. 2011, 55, 1041-1048.
-
(2011)
J. Hepatol.
, vol.55
, pp. 1041-1048
-
-
Tai, W.T.1
Cheng, A.L.2
Shiau, C.W.3
Huang, H.P.4
Huang, J.W.5
Chen, P.J.6
Chen, K.F.7
-
59
-
-
69949129964
-
Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo
-
Newell, P.; Toffanin, S.; Villanueva, A.; Chiang, D. Y.; Minguez, B.; Cabellos, L.; Savic, R.; Hoshida, Y.; Lim, K. H.; Melgar-Lesmes, P.; Yea, S.; Peix, J.; Deniz, K.; Fiel, M. I.; Thung, S.; Alsinet, C.; Tovar, V.; Mazzaferro, V.; Bruix, J.; Roayaie, S.; Schwartz, M.; Friedman, S. L.; Llovet, J. M. Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo. J. Hepatol. 2009, 51, 725-733.
-
(2009)
J. Hepatol.
, vol.51
, pp. 725-733
-
-
Newell, P.1
Toffanin, S.2
Villanueva, A.3
Chiang, D.Y.4
Minguez, B.5
Cabellos, L.6
Savic, R.7
Hoshida, Y.8
Lim, K.H.9
Melgar-Lesmes, P.10
Yea, S.11
Peix, J.12
Deniz, K.13
Fiel, M.I.14
Thung, S.15
Alsinet, C.16
Tovar, V.17
Mazzaferro, V.18
Bruix, J.19
Roayaie, S.20
Schwartz, M.21
Friedman, S.L.22
Llovet, J.M.23
more..
-
60
-
-
33749017926
-
Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
-
Abou-Alfa, G. K.; Schwartz, L.; Ricci, S.; Amadori, D.; Santoro, A.; Figer, A.; De Greve, J.; Douillard, J. Y.; Lathia, C.; Schwartz, B.; Taylor, I.; Moscovici, M.; Saltz, L. B. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J. Clin. Oncol. 2006, 24, 4293-4300.
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 4293-4300
-
-
Abou-Alfa, G.K.1
Schwartz, L.2
Ricci, S.3
Amadori, D.4
Santoro, A.5
Figer, A.6
de Greve, J.7
Douillard, J.Y.8
Lathia, C.9
Schwartz, B.10
Taylor, I.11
Moscovici, M.12
Saltz, L.B.13
-
61
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
Casanovas, O.; Hicklin, D. J.; Bergers, G.; Hanahan, D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005, 8, 299-309.
-
(2005)
Cancer Cell
, vol.8
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
62
-
-
79952497178
-
Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening
-
Sawey, E. T.; Chanrion, M.; Cai, C.; Wu, G.; Zhang, J.; Zender, L.; Zhao, A.; Busuttil, R. W.; Yee, H.; Stein, L.; French, D. M.; Finn, R. S.; Lowe, S. W.; Powers, S. Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening. Cancer Cell 2011, 19, 347-358.
-
(2011)
Cancer Cell
, vol.19
, pp. 347-358
-
-
Sawey, E.T.1
Chanrion, M.2
Cai, C.3
Wu, G.4
Zhang, J.5
Zender, L.6
Zhao, A.7
Busuttil, R.W.8
Yee, H.9
Stein, L.10
French, D.M.11
Finn, R.S.12
Lowe, S.W.13
Powers, S.14
-
63
-
-
78149336711
-
Sunitinib in patients with advanced hepatocellular carcinoma after progression under sorafenib treatment
-
Worns, M. A.; Schuchmann, M.; Duber, C.; Otto, G.; Galle, P. R.; Weinmann, A. Sunitinib in patients with advanced hepatocellular carcinoma after progression under sorafenib treatment. Oncology 2010, 79, 85-92.
-
(2010)
Oncology
, vol.79
, pp. 85-92
-
-
Worns, M.A.1
Schuchmann, M.2
Duber, C.3
Otto, G.4
Galle, P.R.5
Weinmann, A.6
-
64
-
-
44449127592
-
The epidermal growth factor receptor family: Biology driving targeted therapeutics
-
Wieduwilt, M. J.; Moasser, M. M. The epidermal growth factor receptor family: biology driving targeted therapeutics. Cell Mol. Life Sci. 2008, 65, 1566-1584.
-
(2008)
Cell Mol. Life Sci.
, vol.65
, pp. 1566-1584
-
-
Wieduwilt, M.J.1
Moasser, M.M.2
-
65
-
-
0029160069
-
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
-
Burgering, B. M.; Coffer, P. J. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 1995, 376, 599-602.
-
(1995)
Nature
, vol.376
, pp. 599-602
-
-
Burgering, B.M.1
Coffer, P.J.2
-
66
-
-
33749316418
-
The epidermal growth factor receptor pathway: A model for targeted therapy
-
Scaltriti, M.; Baselga, J. The epidermal growth factor receptor pathway: a model for targeted therapy. Clin. Cancer Res. 2006, 12, 5268-5272.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 5268-5272
-
-
Scaltriti, M.1
Baselga, J.2
-
67
-
-
32044464123
-
Epidermal growth factor receptor (EGFR) signaling in cancer
-
Normanno, N.; De Luca, A.; Bianco, C.; Strizzi, L.; Mancino, M.; Maiello, M. R.; Carotenuto, A.; De Feo, G.; Caponigro, F.; Salomon, D. S. Epidermal growth factor receptor (EGFR) signaling in cancer. Gene 2006, 366, 2-16.
-
(2006)
Gene
, vol.366
, pp. 2-16
-
-
Normanno, N.1
de Luca, A.2
Bianco, C.3
Strizzi, L.4
Mancino, M.5
Maiello, M.R.6
Carotenuto, A.7
de Feo, G.8
Caponigro, F.9
Salomon, D.S.10
-
68
-
-
33645844566
-
CD24 expression is a prognostic factor in intrahepatic cholangiocarcinoma
-
Su, M. C.; Hsu, C.; Kao, H. L.; Jeng, Y. M. CD24 expression is a prognostic factor in intrahepatic cholangiocarcinoma. Cancer Lett. 2006, 235, 34-39.
-
(2006)
Cancer Lett.
, vol.235
, pp. 34-39
-
-
Su, M.C.1
Hsu, C.2
Kao, H.L.3
Jeng, Y.M.4
-
69
-
-
0023102903
-
Elevation of transforming growth factor alpha and its relationship to the epidermal growth factor and alphafetoprotein levels in patients with hepatocellular carcinoma
-
Yeh, Y. C.; Tsai, J. F.; Chuang, L. Y.; Yeh, H. W.; Tsai, J. H.; Florine, D. L.; Tam, J. P. Elevation of transforming growth factor alpha and its relationship to the epidermal growth factor and alphafetoprotein levels in patients with hepatocellular carcinoma. Cancer Res. 1987, 47, 896-901.
-
(1987)
Cancer Res.
, vol.47
, pp. 896-901
-
-
Yeh, Y.C.1
Tsai, J.F.2
Chuang, L.Y.3
Yeh, H.W.4
Tsai, J.H.5
Florine, D.L.6
Tam, J.P.7
-
70
-
-
1642375342
-
Early molecular and genetic determinants of primary liver malignancy
-
Feitelson, M. A.; Pan, J.; Lian, Z. Early molecular and genetic determinants of primary liver malignancy. Surg. Clin. North Am. 2004, 84, 339-354.
-
(2004)
Surg. Clin. North Am.
, vol.84
, pp. 339-354
-
-
Feitelson, M.A.1
Pan, J.2
Lian, Z.3
-
71
-
-
33745714256
-
Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells
-
Castillo, J.; Erroba, E.; Perugorria, M. J.; Santamaria, M.; Lee, D. C.; Prieto, J.; Avila, M. A.; Berasain, C. Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells. Cancer Res. 2006, 66, 6129-6138.
-
(2006)
Cancer Res.
, vol.66
, pp. 6129-6138
-
-
Castillo, J.1
Erroba, E.2
Perugorria, M.J.3
Santamaria, M.4
Lee, D.C.5
Prieto, J.6
Avila, M.A.7
Berasain, C.8
-
72
-
-
33750605628
-
Impact of IGF-1R/EGFR cross-talks on hepatoma cell sensitivity to gefitinib
-
Desbois-Mouthon, C.; Cacheux, W.; Blivet-Van Eggelpoel, M. J.; Barbu, V.; Fartoux, L.; Poupon, R.; Housset, C.; Rosmorduc, O. Impact of IGF-1R/EGFR cross-talks on hepatoma cell sensitivity to gefitinib. Int. J. Cancer 2006, 119, 2557-2566.
-
(2006)
Int. J. Cancer
, vol.119
, pp. 2557-2566
-
-
Desbois-Mouthon, C.1
Cacheux, W.2
Blivet-van Eggelpoel, M.J.3
Barbu, V.4
Fartoux, L.5
Poupon, R.6
Housset, C.7
Rosmorduc, O.8
-
73
-
-
57349090407
-
Gene expression in fixed tissues and outcome in hepatocellular carcinoma
-
Hoshida, Y.; Villanueva, A.; Kobayashi, M.; Peix, J.; Chiang, D. Y.; Camargo, A.; Gupta, S.; Moore, J.; Wrobel, M. J.; Lerner, J.; Reich, M.; Chan, J. A.; Glickman, J. N.; Ikeda, K.; Hashimoto, M.; Watanabe, G.; Daidone, M. G.; Roayaie, S.; Schwartz, M.; Thung, S.; Salvesen, H. B.; Gabriel, S.; Mazzaferro, V.; Bruix, J.; Friedman, S. L.; Kumada, H.; Llovet, J. M.; Golub, T. R. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N. Engl. J. Med. 2008, 359, 1995-2004.
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 1995-2004
-
-
Hoshida, Y.1
Villanueva, A.2
Kobayashi, M.3
Peix, J.4
Chiang, D.Y.5
Camargo, A.6
Gupta, S.7
Moore, J.8
Wrobel, M.J.9
Lerner, J.10
Reich, M.11
Chan, J.A.12
Glickman, J.N.13
Ikeda, K.14
Hashimoto, M.15
Watanabe, G.16
Daidone, M.G.17
Roayaie, S.18
Schwartz, M.19
Thung, S.20
Salvesen, H.B.21
Gabriel, S.22
Mazzaferro, V.23
Bruix, J.24
Friedman, S.L.25
Kumada, H.26
Llovet, J.M.27
Golub, T.R.28
more..
-
74
-
-
17044450254
-
Induction of apoptosis in rat hepatocarcinoma cells by expression of IGF-I antisense c-DNA
-
Ellouk-Achard, S.; Djenabi, S.; De Oliveira, G. A.; Desauty, G.; Duc, H. T.; Zohair, M.; Trojan, J.; Claude, J. R.; Sarasin, A.; Lafarge-Frayssinet, C. Induction of apoptosis in rat hepatocarcinoma cells by expression of IGF-I antisense c-DNA. J. Hepatol. 1998, 29, 807-818.
-
(1998)
J. Hepatol.
, vol.29
, pp. 807-818
-
-
Ellouk-Achard, S.1
Djenabi, S.2
de Oliveira, G.A.3
Desauty, G.4
Duc, H.T.5
Zohair, M.6
Trojan, J.7
Claude, J.R.8
Sarasin, A.9
Lafarge-Frayssinet, C.10
-
75
-
-
9644255742
-
Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma
-
Hopfner, M.; Sutter, A. P.; Huether, A.; Schuppan, D.; Zeitz, M.; Scherubl, H. Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma. J. Hepatol. 2004, 41, 1008-1016.
-
(2004)
J. Hepatol.
, vol.41
, pp. 1008-1016
-
-
Hopfner, M.1
Sutter, A.P.2
Huether, A.3
Schuppan, D.4
Zeitz, M.5
Scherubl, H.6
-
76
-
-
0027965569
-
Expression of insulin-like growth factor II in hepatitis B, cirrhosis and hepatocellular carcinoma: Its relationship with hepatitis B virus antigen expression
-
Su, Q.; Liu, Y. F.; Zhang, J. F.; Zhang, S. X.; Li, D. F.; Yang, J. J. Expression of insulin-like growth factor II in hepatitis B, cirrhosis and hepatocellular carcinoma: its relationship with hepatitis B virus antigen expression. Hepatology 1994, 20, 788-799.
-
(1994)
Hepatology
, vol.20
, pp. 788-799
-
-
Su, Q.1
Liu, Y.F.2
Zhang, J.F.3
Zhang, S.X.4
Li, D.F.5
Yang, J.J.6
-
77
-
-
24044536590
-
Overexpression of insulin receptor substrate-2 in human and murine hepatocellular carcinoma
-
Boissan, M.; Beurel, E.; Wendum, D.; Rey, C.; Lecluse, Y.; Housset, C.; Lacombe, M. L.; Desbois-Mouthon, C. Overexpression of insulin receptor substrate-2 in human and murine hepatocellular carcinoma. Am. J. Pathol. 2005, 167, 869-877.
-
(2005)
Am. J. Pathol.
, vol.167
, pp. 869-877
-
-
Boissan, M.1
Beurel, E.2
Wendum, D.3
Rey, C.4
Lecluse, Y.5
Housset, C.6
Lacombe, M.L.7
Desbois-Mouthon, C.8
-
78
-
-
0036251946
-
A possible role for insulin-like growth factor-binding protein-3 autocrine/paracrine loops in controlling hepatocellular carcinoma cell proliferation
-
Huynh, H.; Chow, P. K.; Ooi, L. L.; Soo, K. C. A possible role for insulin-like growth factor-binding protein-3 autocrine/paracrine loops in controlling hepatocellular carcinoma cell proliferation. Cell Growth Differ. 2002, 13, 115-122.
-
(2002)
Cell Growth Differ.
, vol.13
, pp. 115-122
-
-
Huynh, H.1
Chow, P.K.2
Ooi, L.L.3
Soo, K.C.4
-
79
-
-
33745552897
-
Dysregulation of growth factor signaling in human hepatocellular carcinoma
-
Breuhahn, K.; Longerich, T.; Schirmacher, P. Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene 2006, 25, 3787-3800.
-
(2006)
Oncogene
, vol.25
, pp. 3787-3800
-
-
Breuhahn, K.1
Longerich, T.2
Schirmacher, P.3
-
80
-
-
33645333133
-
Gefitinib and the modulation of the signaling pathways downstream of epidermal growth factor receptor in human liver cancer cells
-
Okano, J.; Matsumoto, K.; Nagahara, T.; Murawaki, Y. Gefitinib and the modulation of the signaling pathways downstream of epidermal growth factor receptor in human liver cancer cells. J. Gastroenterol. 2006, 41, 166-176.
-
(2006)
J. Gastroenterol.
, vol.41
, pp. 166-176
-
-
Okano, J.1
Matsumoto, K.2
Nagahara, T.3
Murawaki, Y.4
-
81
-
-
24344489502
-
Erlotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances chemosensitivity towards cytostatics
-
Huether, A.; Hopfner, M.; Sutter, A. P.; Schuppan, D.; Scherubl, H. Erlotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances chemosensitivity towards cytostatics. J. Hepatol. 2005, 43, 661-669.
-
(2005)
J. Hepatol.
, vol.43
, pp. 661-669
-
-
Huether, A.1
Hopfner, M.2
Sutter, A.P.3
Schuppan, D.4
Scherubl, H.5
-
82
-
-
33748544630
-
Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancer
-
Huether, A.; Hopfner, M.; Sutter, A. P.; Baradari, V.; Schuppan, D.; Scherubl, H. Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancer. World J. Gastroenterol. 2006, 12, 5160-5167.
-
(2006)
World J. Gastroenterol.
, vol.12
, pp. 5160-5167
-
-
Huether, A.1
Hopfner, M.2
Sutter, A.P.3
Baradari, V.4
Schuppan, D.5
Scherubl, H.6
-
83
-
-
0142024593
-
ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, shows antimetastatic activity using a hepatocellular carcinoma model
-
Matsuo, M.; Sakurai, H.; Saiki, I. ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, shows antimetastatic activity using a hepatocellular carcinoma model. Mol. Cancer Ther. 2003, 2, 557-561.
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 557-561
-
-
Matsuo, M.1
Sakurai, H.2
Saiki, I.3
-
84
-
-
15844431836
-
Antitumor effect of Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, combined with cytotoxic agent on murine hepatocellular carcinoma
-
Zhu, B. D.; Yuan, S. J.; Zhao, Q. C.; Li, X.; Li, Y.; Lu, Q. Y. Antitumor effect of Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, combined with cytotoxic agent on murine hepatocellular carcinoma. World J. Gastroenterol. 2005, 11, 1382-1386.
-
(2005)
World J. Gastroenterol.
, vol.11
, pp. 1382-1386
-
-
Zhu, B.D.1
Yuan, S.J.2
Zhao, Q.C.3
Li, X.4
Li, Y.5
Lu, Q.Y.6
-
85
-
-
33744903661
-
PTEN/Akt signaling through epidermal growth factor receptor is prerequisite for angiogenesis by hepatocellular carcinoma cells that is susceptible to inhibition by gefitinib
-
Ueda, S.; Basaki, Y.; Yoshie, M.; Ogawa, K.; Sakisaka, S.; Kuwano, M.; Ono, M. PTEN/Akt signaling through epidermal growth factor receptor is prerequisite for angiogenesis by hepatocellular carcinoma cells that is susceptible to inhibition by gefitinib. Cancer Res. 2006, 66, 5346-5353.
-
(2006)
Cancer Res.
, vol.66
, pp. 5346-5353
-
-
Ueda, S.1
Basaki, Y.2
Yoshie, M.3
Ogawa, K.4
Sakisaka, S.5
Kuwano, M.6
Ono, M.7
-
86
-
-
27244447373
-
Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer
-
Philip, P.A.; Mahoney, M. R.; Allmer, C.; Thomas, J.; Pitot, H. C.; Kim, G.; Donehower, R. C.; Fitch, T.; Picus, J.; Erlichman, C. Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer. J. Clin. Oncol. 2005, 23, 6657-6663.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 6657-6663
-
-
Philip, P.A.1
Mahoney, M.R.2
Allmer, C.3
Thomas, J.4
Pitot, H.C.5
Kim, G.6
Donehower, R.C.7
Fitch, T.8
Picus, J.9
Erlichman, C.10
-
87
-
-
77956627711
-
The role of signaling pathways in the development and treatment of hepatocellular carcinoma
-
Whittaker, S.; Marais, R.; Zhu, A. X. The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 2010, 29, 4989-5005.
-
(2010)
Oncogene
, vol.29
, pp. 4989-5005
-
-
Whittaker, S.1
Marais, R.2
Zhu, A.X.3
-
88
-
-
0035553174
-
The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo
-
Rusnak, D. W.; Lackey, K.; Affleck, K.; Wood, E. R.; Alligood, K. J.; Rhodes, N.; Keith, B. R.; Murray, D. M.; Knight, W. B.; Mullin, R. J.; Gilmer, T. M. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol. Cancer Ther. 2001, 1, 85-94.
-
(2001)
Mol. Cancer Ther.
, vol.1
, pp. 85-94
-
-
Rusnak, D.W.1
Lackey, K.2
Affleck, K.3
Wood, E.R.4
Alligood, K.J.5
Rhodes, N.6
Keith, B.R.7
Murray, D.M.8
Knight, W.B.9
Mullin, R.J.10
Gilmer, T.M.11
-
89
-
-
77955553428
-
Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study
-
El-Azab, A.S.; Al-Omar, M. A.; Abdel-Aziz, A. A.; Abdel-Aziz, N. I.; el-Sayed, M. A.; Aleisa, A. M.; Sayed-Ahmed, M. M.; Abdel-Hamide, S. G. Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: molecular docking study. Eur. J. Med. Chem. 2010, 45, 4188-4198.
-
(2010)
Eur. J. Med. Chem.
, vol.45
, pp. 4188-4198
-
-
El-Azab, A.S.1
Al-Omar, M.A.2
Abdel-Aziz, A.A.3
Abdel-Aziz, N.I.4
El-Sayed, M.A.5
Aleisa, A.M.6
Sayed-Ahmed, M.M.7
Abdel-Hamide, S.G.8
-
90
-
-
70349443677
-
A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas
-
Bekaii-Saab, T.; Markowitz, J.; Prescott, N.; Sadee, W.; Heerema, N.; Wei, L.; Dai, Z.; Papp, A.; Campbell, A.; Culler, K.; Balint, C.; O'Neil, B.; Lee, R. M.; Zalupski, M.; Dancey, J.; Chen, H.; Grever, M.; Eng, C.; Villalona-Calero, M. A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas. Clin. Cancer Res. 2009, 15, 5895-5901.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 5895-5901
-
-
Bekaii-Saab, T.1
Markowitz, J.2
Prescott, N.3
Sadee, W.4
Heerema, N.5
Wei, L.6
Dai, Z.7
Papp, A.8
Campbell, A.9
Culler, K.10
Balint, C.11
O'Neil, B.12
Lee, R.M.13
Zalupski, M.14
Dancey, J.15
Chen, H.16
Grever, M.17
Eng, C.18
Villalona-Calero, M.19
-
91
-
-
79956051199
-
Vandetanib inhibits both VEGFR-2 and EGFR signalling at clinically relevant drug levels in preclinical models of human cancer
-
Brave, S. R.; Odedra, R.; James, N. H.; Smith, N. R.; Marshall, G. B.; Acheson, K. L.; Baker, D.; Howard, Z.; Jackson, L.; Ratcliffe, K.; Wainwright, A.; Lovick, S. C.; Hickinson, D. M.; Wilkinson, R. W.; Barry, S. T.; Speake, G.; Ryan, A. J. Vandetanib inhibits both VEGFR-2 and EGFR signalling at clinically relevant drug levels in preclinical models of human cancer. Int. J. Oncol. 2011, 39, 271-278.
-
(2011)
Int. J. Oncol.
, vol.39
, pp. 271-278
-
-
Brave, S.R.1
Odedra, R.2
James, N.H.3
Smith, N.R.4
Marshall, G.B.5
Acheson, K.L.6
Baker, D.7
Howard, Z.8
Jackson, L.9
Ratcliffe, K.10
Wainwright, A.11
Lovick, S.C.12
Hickinson, D.M.13
Wilkinson, R.W.14
Barry, S.T.15
Speake, G.16
Ryan, A.J.17
-
92
-
-
84863977102
-
Vandetanib, an Inhibitor of VEGF Receptor-2 and EGF Receptor, Suppresses Tumor Development and Improves Prognosis of Liver Cancer in Mice
-
Inoue, K.; Torimura, T.; Nakamura, T.; Iwamoto, H.; Masuda, H.; Abe, M.; Hashimoto, O.; Koga, H.; Ueno, T.; Yano, H.; Sata, M. Vandetanib, an Inhibitor of VEGF Receptor-2 and EGF Receptor, Suppresses Tumor Development and Improves Prognosis of Liver Cancer in Mice. Clin. Cancer Res. 2012, 18, 3924-3933.
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 3924-3933
-
-
Inoue, K.1
Torimura, T.2
Nakamura, T.3
Iwamoto, H.4
Masuda, H.5
Abe, M.6
Hashimoto, O.7
Koga, H.8
Ueno, T.9
Yano, H.10
Sata, M.11
-
93
-
-
84862832278
-
Vandetanib in patients with inoperable hepatocellular carcinoma: A phase II, randomized, double-blind, placebocontrolled study
-
Hsu, C.; Yang, T. S.; Huo, T. I.; Hsieh, R. K.; Yu, C. W.; Hwang, W. S.; Hsieh, T. Y.; Huang, W. T.; Chao, Y.; Meng, R.; Cheng, A. L. Vandetanib in patients with inoperable hepatocellular carcinoma: a phase II, randomized, double-blind, placebocontrolled study. J. Hepatol. 2012, 56, 1097-1103.
-
(2012)
J. Hepatol.
, vol.56
, pp. 1097-1103
-
-
Hsu, C.1
Yang, T.S.2
Huo, T.I.3
Hsieh, R.K.4
Yu, C.W.5
Hwang, W.S.6
Hsieh, T.Y.7
Huang, W.T.8
Chao, Y.9
Meng, R.10
Cheng, A.L.11
-
94
-
-
0037008761
-
Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor
-
Gilmore, A. P.; Valentijn, A. J.; Wang, P.; Ranger, A. M.; Bundred, N.; O'Hare, M. J.; Wakeling, A.; Korsmeyer, S. J.; Streuli, C. H. Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor. J. Biol. Chem. 2002, 277, 27643-27650.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 27643-27650
-
-
Gilmore, A.P.1
Valentijn, A.J.2
Wang, P.3
Ranger, A.M.4
Bundred, N.5
O'Hare, M.J.6
Wakeling, A.7
Korsmeyer, S.J.8
Streuli, C.H.9
-
95
-
-
33646040417
-
Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells
-
Hopfner, M.; Huether, A.; Sutter, A. P.; Baradari, V.; Schuppan, D.; Scherubl, H. Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells. Biochem. Pharmacol. 2006, 71, 1435-1448.
-
(2006)
Biochem. Pharmacol.
, vol.71
, pp. 1435-1448
-
-
Hopfner, M.1
Huether, A.2
Sutter, A.P.3
Baradari, V.4
Schuppan, D.5
Scherubl, H.6
-
96
-
-
69949106121
-
Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: Rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma
-
Desbois-Mouthon, C.; Baron, A.; Blivet-Van Eggelpoel, M. J.; Fartoux, L.; Venot, C.; Bladt, F.; Housset, C.; Rosmorduc, O. Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma. Clin. Cancer Res. 2009, 15, 5445-5456.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 5445-5456
-
-
Desbois-Mouthon, C.1
Baron, A.2
Blivet-van Eggelpoel, M.J.3
Fartoux, L.4
Venot, C.5
Bladt, F.6
Housset, C.7
Rosmorduc, O.8
-
97
-
-
65549158055
-
High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter disease-free survival in resected non-small-cell lung cancer patients
-
Ludovini, V.; Bellezza, G.; Pistola, L.; Bianconi, F.; Di Carlo, L.; Sidoni, A.; Semeraro, A.; Del Sordo, R.; Tofanetti, F. R.; Mameli, M. G.; Daddi, G.; Cavaliere, A.; Tonato, M.; Crino, L. High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter disease-free survival in resected non-small-cell lung cancer patients. Ann. Oncol. 2009, 20, 842-849.
-
(2009)
Ann. Oncol.
, vol.20
, pp. 842-849
-
-
Ludovini, V.1
Bellezza, G.2
Pistola, L.3
Bianconi, F.4
Di Carlo, L.5
Sidoni, A.6
Semeraro, A.7
del Sordo, R.8
Tofanetti, F.R.9
Mameli, M.G.10
Daddi, G.11
Cavaliere, A.12
Tonato, M.13
Crino, L.14
-
98
-
-
77953078857
-
Combined inhibition of IGFR enhances the effects of gefitinib in H1650: A lung cancer cell line with EGFR mutation and primary resistance to EGFR-TK inhibitors
-
Choi, Y. J.; Rho, J. K.; Jeon, B. S.; Choi, S. J.; Park, S. C.; Lee, S. S.; Kim, H. R.; Kim, C. H.; Lee, J. C. Combined inhibition of IGFR enhances the effects of gefitinib in H1650: a lung cancer cell line with EGFR mutation and primary resistance to EGFR-TK inhibitors. Cancer Chemother. Pharmacol. 2010, 66, 381-388.
-
(2010)
Cancer Chemother. Pharmacol.
, vol.66
, pp. 381-388
-
-
Choi, Y.J.1
Rho, J.K.2
Jeon, B.S.3
Choi, S.J.4
Park, S.C.5
Lee, S.S.6
Kim, H.R.7
Kim, C.H.8
Lee, J.C.9
-
99
-
-
4644293033
-
Effects of human hepatocyte growth factor on the proliferation of human hepatocytes and hepatocellular carcinoma cell lines
-
Efimova, E. A.; Glanemann, M.; Liu, L.; Schumacher, G.; Settmacher, U.; Jonas, S.; Langrehr, J. M.; Neuhaus, P.; Nussler, A. K. Effects of human hepatocyte growth factor on the proliferation of human hepatocytes and hepatocellular carcinoma cell lines. Eur. Surg. Res. 2004, 36, 300-307.
-
(2004)
Eur. Surg. Res.
, vol.36
, pp. 300-307
-
-
Efimova, E.A.1
Glanemann, M.2
Liu, L.3
Schumacher, G.4
Settmacher, U.5
Jonas, S.6
Langrehr, J.M.7
Neuhaus, P.8
Nussler, A.K.9
-
100
-
-
0345601083
-
Met, metastasis, motility and more
-
Birchmeier, C.; Birchmeier, W.; Gherardi, E.; Vande Woude, G. F. Met, metastasis, motility and more. Nat. Rev. Mol. Cell Biol. 2003, 4, 915-925.
-
(2003)
Nat. Rev. Mol. Cell Biol.
, vol.4
, pp. 915-925
-
-
Birchmeier, C.1
Birchmeier, W.2
Gherardi, E.3
Vande Woude, G.F.4
-
101
-
-
3142512610
-
Targeting the tumor and its microenvironment by a dual-function decoy Met receptor
-
Michieli, P.; Mazzone, M.; Basilico, C.; Cavassa, S.; Sottile, A.; Naldini, L.; Comoglio, P. M. Targeting the tumor and its microenvironment by a dual-function decoy Met receptor. Cancer Cell 2004, 6, 61-73.
-
(2004)
Cancer Cell
, vol.6
, pp. 61-73
-
-
Michieli, P.1
Mazzone, M.2
Basilico, C.3
Cavassa, S.4
Sottile, A.5
Naldini, L.6
Comoglio, P.M.7
-
102
-
-
0038115223
-
HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro
-
Ding, S.; Merkulova-Rainon, T.; Han, Z. C.; Tobelem, G. HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro. Blood 2003, 101, 4816-22.
-
(2003)
Blood
, vol.101
, pp. 4816-4822
-
-
Ding, S.1
Merkulova-Rainon, T.2
Han, Z.C.3
Tobelem, G.4
-
103
-
-
0027954225
-
c-met mRNA overexpression in human hepatocellular carcinoma
-
Boix, L.; Rosa, J. L.; Ventura, F.; Castells, A.; Bruix, J.; Rodes, J.; Bartrons, R. c-met mRNA overexpression in human hepatocellular carcinoma. Hepatology 1994, 19, 88-91.
-
(1994)
Hepatology
, vol.19
, pp. 88-91
-
-
Boix, L.1
Rosa, J.L.2
Ventura, F.3
Castells, A.4
Bruix, J.5
Rodes, J.6
Bartrons, R.7
-
104
-
-
0028071919
-
Expression of hepatocyte growth factor mRNA, and c-met mRNA (hepatocyte growth factor receptor) in human liver tumours
-
Selden, C.; Farnaud, S.; Ding, S. F.; Habib, N.; Foster, C.; Hodgson, H. J. Expression of hepatocyte growth factor mRNA, and c-met mRNA (hepatocyte growth factor receptor) in human liver tumours. J. Hepatol. 1994, 21, 227-234.
-
(1994)
J. Hepatol.
, vol.21
, pp. 227-234
-
-
Selden, C.1
Farnaud, S.2
Ding, S.F.3
Habib, N.4
Foster, C.5
Hodgson, H.J.6
-
105
-
-
0345722740
-
Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas
-
Park, W. S.; Dong, S. M.; Kim, S. Y.; Na, E. Y.; Shin, M. S.; Pi, J. H.; Kim, B. J.; Bae, J. H.; Hong, Y. K.; Lee, K. S.; Lee, S. H.; Yoo, N. J.; Jang, J. J.; Pack, S.; Zhuang, Z.; Schmidt, L.; Zbar, B.; Lee, J. Y. Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas. Cancer Res. 1999, 59, 307-310.
-
(1999)
Cancer Res.
, vol.59
, pp. 307-310
-
-
Park, W.S.1
Dong, S.M.2
Kim, S.Y.3
Na, E.Y.4
Shin, M.S.5
Pi, J.H.6
Kim, B.J.7
Bae, J.H.8
Hong, Y.K.9
Lee, K.S.10
Lee, S.H.11
Yoo, N.J.12
Jang, J.J.13
Pack, S.14
Zhuang, Z.15
Schmidt, L.16
Zbar, B.17
Lee, J.Y.18
-
106
-
-
84856020870
-
Targeting c-Met as a promising strategy for the treatment of hepatocellular carcinoma
-
Gao, J.; Inagaki, Y.; Song, P.; Qu, X.; Kokudo, N.; Tang, W. Targeting c-Met as a promising strategy for the treatment of hepatocellular carcinoma. Pharmacol. Res. 2012, 65, 23-30.
-
(2012)
Pharmacol. Res.
, vol.65
, pp. 23-30
-
-
Gao, J.1
Inagaki, Y.2
Song, P.3
Qu, X.4
Kokudo, N.5
Tang, W.6
-
107
-
-
80052841535
-
Gene signatures derived from a c-MET-driven liver cancer mouse model predict survival of patients with hepatocellular carcinoma
-
Ivanovska, I.; Zhang, C.; Liu, A. M.; Wong, K. F.; Lee, N. P.; Lewis, P.; Philippar, U.; Bansal, D.; Buser, C.; Scott, M.; Mao, M.; Poon, R. T.; Fan, S. T.; Cleary, M. A.; Luk, J. M.; Dai, H. Gene signatures derived from a c-MET-driven liver cancer mouse model predict survival of patients with hepatocellular carcinoma. PLoS One 2011, 6, e24582.
-
(2011)
PLoS One
, vol.6
-
-
Ivanovska, I.1
Zhang, C.2
Liu, A.M.3
Wong, K.F.4
Lee, N.P.5
Lewis, P.6
Philippar, U.7
Bansal, D.8
Buser, C.9
Scott, M.10
Mao, M.11
Poon, R.T.12
Fan, S.T.13
Cleary, M.A.14
Luk, J.M.15
Dai, H.16
-
108
-
-
44349155339
-
Clinical significance of serum HGF and c-Met expression in tumor tissue for evaluation of properties and treatment of hepatocellular carcinoma
-
Osada, S.; Kanematsu, M.; Imai, H.; Goshima, S. Clinical significance of serum HGF and c-Met expression in tumor tissue for evaluation of properties and treatment of hepatocellular carcinoma. Hepatogastroenterology 2008, 55, 544-549.
-
(2008)
Hepatogastroenterology
, vol.55
, pp. 544-549
-
-
Osada, S.1
Kanematsu, M.2
Imai, H.3
Goshima, S.4
-
109
-
-
78650339354
-
HGF/c-Met acts as an alternative angiogenic pathway in sunitinib-resistant tumors
-
Shojaei, F.; Lee, J. H.; Simmons, B. H.; Wong, A.; Esparza, C. O.; Plumlee, P. A.; Feng, J.; Stewart, A. E.; Hu-Lowe, D. D.; Christensen, J. G. HGF/c-Met acts as an alternative angiogenic pathway in sunitinib-resistant tumors. Cancer. Res. 2010, 70, 10090-11100.
-
(2010)
Cancer. Res.
, vol.70
, pp. 10090-11100
-
-
Shojaei, F.1
Lee, J.H.2
Simmons, B.H.3
Wong, A.4
Esparza, C.O.5
Plumlee, P.A.6
Feng, J.7
Stewart, A.E.8
Hu-Lowe, D.D.9
Christensen, J.G.10
-
110
-
-
35148864569
-
In vitro c-met inhibition by antisense RNA and plasmidbased RNAi down-modulates migration and invasion of hepatocellular carcinoma cells
-
Salvi, A.; Arici, B.; Portolani, N.; Giulini, S. M.; De Petro, G.; Barlati, S. In vitro c-met inhibition by antisense RNA and plasmidbased RNAi down-modulates migration and invasion of hepatocellular carcinoma cells. Int. J. Oncol. 2007, 31, 451-460.
-
(2007)
Int. J. Oncol.
, vol.31
, pp. 451-460
-
-
Salvi, A.1
Arici, B.2
Portolani, N.3
Giulini, S.M.4
de Petro, G.5
Barlati, S.6
-
111
-
-
80052033164
-
c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma
-
You, H.; Ding, W.; Dang, H.; Jiang, Y.; Rountree, C. B. c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma. Hepatology 2011, 54, 879-889.
-
(2011)
Hepatology
, vol.54
, pp. 879-889
-
-
You, H.1
Ding, W.2
Dang, H.3
Jiang, Y.4
Rountree, C.B.5
-
112
-
-
82255179972
-
Effect of c-Met inhibitor SU11274 on hepatocellular carcinoma cell growth
-
Inagaki, Y.; Qi, F.; Gao, J.; Qu, X.; Hasegawa, K.; Sugawara, Y.; Tang, W.; Kokudo, N. Effect of c-Met inhibitor SU11274 on hepatocellular carcinoma cell growth. Biosci. Trends. 2011, 5, 52-56.
-
(2011)
Biosci. Trends.
, vol.5
, pp. 52-56
-
-
Inagaki, Y.1
Qi, F.2
Gao, J.3
Qu, X.4
Hasegawa, K.5
Sugawara, Y.6
Tang, W.7
Kokudo, N.8
-
113
-
-
70249123081
-
Met receptor tyrosine kinase transactivation is involved in proteinase-activated receptor-2-mediated hepatocellular carcinoma cell invasion
-
Kaufmann, R.; Oettel, C.; Horn, A.; Halbhuber, K. J.; Eitner, A.; Krieg, R.; Katenkamp, K.; Henklein, P.; Westermann, M.; Bohmer, F. D.; Ramachandran, R.; Saifeddine, M.; Hollenberg, M. D.; Settmacher, U. Met receptor tyrosine kinase transactivation is involved in proteinase-activated receptor-2-mediated hepatocellular carcinoma cell invasion. Carcinogenesis 2009, 30, 1487-1496.
-
(2009)
Carcinogenesis
, vol.30
, pp. 1487-1496
-
-
Kaufmann, R.1
Oettel, C.2
Horn, A.3
Halbhuber, K.J.4
Eitner, A.5
Krieg, R.6
Katenkamp, K.7
Henklein, P.8
Westermann, M.9
Bohmer, F.D.10
Ramachandran, R.11
Saifeddine, M.12
Hollenberg, M.D.13
Settmacher, U.14
-
114
-
-
70350230210
-
Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases
-
Qian, F.; Engst, S.; Yamaguchi, K.; Yu, P.; Won, K. A.; Mock, L.; Lou, T.; Tan, J.; Li, C.; Tam, D.; Lougheed, J.; Yakes, F. M.; Bentzien, F.; Xu, W.; Zaks, T.; Wooster, R.; Greshock, J.; Joly, A. H. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res. 2009, 69, 8009-8016.
-
(2009)
Cancer Res.
, vol.69
, pp. 8009-8016
-
-
Qian, F.1
Engst, S.2
Yamaguchi, K.3
Yu, P.4
Won, K.A.5
Mock, L.6
Lou, T.7
Tan, J.8
Li, C.9
Tam, D.10
Lougheed, J.11
Yakes, F.M.12
Bentzien, F.13
Xu, W.14
Zaks, T.15
Wooster, R.16
Greshock, J.17
Joly, A.H.18
-
115
-
-
84861535274
-
Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma
-
Huynh, H.; Ong, R.; Soo, K. C. Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma. Angiogenesis 2012, 15, 59-70.
-
(2012)
Angiogenesis
, vol.15
, pp. 59-70
-
-
Huynh, H.1
Ong, R.2
Soo, K.C.3
-
116
-
-
77954236265
-
A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2
-
Eder, J. P.; Shapiro, G. I.; Appleman, L. J.; Zhu, A. X.; Miles, D.; Keer, H.; Cancilla, B.; Chu, F.; Hitchcock-Bryan, S.; Sherman, L.; McCallum, S.; Heath, E. I.; Boerner, S. A.; LoRusso, P. M. A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2. Clin. Cancer Res. 2010, 16, 3507-3516.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 3507-3516
-
-
Eder, J.P.1
Shapiro, G.I.2
Appleman, L.J.3
Zhu, A.X.4
Miles, D.5
Keer, H.6
Cancilla, B.7
Chu, F.8
Hitchcock-Bryan, S.9
Sherman, L.10
McCallum, S.11
Heath, E.I.12
Boerner, S.A.13
LoRusso, P.M.14
-
117
-
-
84857020475
-
Targeted systemic therapies for hepatocellular carcinoma: Clinical perspectives, challenges and implications
-
Frenette, C.; Gish, R. Targeted systemic therapies for hepatocellular carcinoma: clinical perspectives, challenges and implications. World J. Gastroenterol. 2012, 18, 498-506.
-
(2012)
World J. Gastroenterol.
, vol.18
, pp. 498-506
-
-
Frenette, C.1
Gish, R.2
|