메뉴 건너뛰기




Volumn 97, Issue , 2007, Pages 247-274

PDGF Receptors as Targets in Tumor Treatment

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CP 673451; FLUOROURACIL; HYDROXYUREA; IMATINIB; ISOPROTEIN; MONOCLONAL ANTIBODY; PACLITAXEL; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; POLYCLONAL ANTIBODY; RECEPTOR BLOCKING AGENT; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG;

EID: 34047127376     PISSN: 0065230X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-230X(06)97011-0     Document Type: Review
Times cited : (189)

References (121)
  • 1
    • 0345798150 scopus 로고    scopus 로고
    • Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors
    • Abramsson A., Lindblom P., and Betsholtz C. Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J. Clin. Invest. 112 (2003) 1142-1151
    • (2003) J. Clin. Invest. , vol.112 , pp. 1142-1151
    • Abramsson, A.1    Lindblom, P.2    Betsholtz, C.3
  • 2
    • 30744477450 scopus 로고    scopus 로고
    • Lymphangiogenesis in development and human disease
    • Alitalo K., Tammela T., and Petrova T.V. Lymphangiogenesis in development and human disease. Nature 438 (2005) 946-953
    • (2005) Nature , vol.438 , pp. 946-953
    • Alitalo, K.1    Tammela, T.2    Petrova, T.V.3
  • 4
    • 1042301958 scopus 로고    scopus 로고
    • Targeting the platelet-derived growth factor receptor in antivascular therapy for human ovarian carcinoma
    • Apte S.M., Fan D., Killion J.J., and Fidler I.J. Targeting the platelet-derived growth factor receptor in antivascular therapy for human ovarian carcinoma. Clin. Cancer Res. 10 (2004) 897-908
    • (2004) Clin. Cancer Res. , vol.10 , pp. 897-908
    • Apte, S.M.1    Fan, D.2    Killion, J.J.3    Fidler, I.J.4
  • 5
    • 0001288948 scopus 로고    scopus 로고
    • Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphatidylinositol 3-kinase
    • Bae Y.S., Sung J.Y., Kim O.S., Kim Y.J., Hur K.C., Kazlauskas A., and Rhee S.G. Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphatidylinositol 3-kinase. J. Biol. Chem. 275 (2000) 10527-10531
    • (2000) J. Biol. Chem. , vol.275 , pp. 10527-10531
    • Bae, Y.S.1    Sung, J.Y.2    Kim, O.S.3    Kim, Y.J.4    Hur, K.C.5    Kazlauskas, A.6    Rhee, S.G.7
  • 8
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G., Song S., Meyer-Morse N., Bergsland E., and Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest. 111 (2003) 1287-1295
    • (2003) J. Clin. Invest. , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 9
    • 2942682933 scopus 로고    scopus 로고
    • Insight into the physiological functions of PDGF through genetic studies in mice
    • Betsholtz C. Insight into the physiological functions of PDGF through genetic studies in mice. Cytokine Growth Factor Rev. 15 (2004) 215-228
    • (2004) Cytokine Growth Factor Rev. , vol.15 , pp. 215-228
    • Betsholtz, C.1
  • 11
    • 0036793520 scopus 로고    scopus 로고
    • Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-αα and -αβ receptors
    • Cao R., Brakenhielm E., Li X., Pietras K., Widenfalk J., Östman A., Eriksson U., and Cao Y. Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-αα and -αβ receptors. FASEB J. 16 (2002) 1575-1583
    • (2002) FASEB J. , vol.16 , pp. 1575-1583
    • Cao, R.1    Brakenhielm, E.2    Li, X.3    Pietras, K.4    Widenfalk, J.5    Östman, A.6    Eriksson, U.7    Cao, Y.8
  • 13
  • 14
    • 0029966854 scopus 로고    scopus 로고
    • The TEL/platelet-derived growth factor β receptor (PDGF β R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF β R kinase-dependent signaling pathways
    • Carroll M., Tomasson M.H., Barker G.F., Golub T.R., and Gilliland D.G. The TEL/platelet-derived growth factor β receptor (PDGF β R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF β R kinase-dependent signaling pathways. Proc. Natl. Acad. Sci. USA 93 (1996) 14845-14850
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14845-14850
    • Carroll, M.1    Tomasson, M.H.2    Barker, G.F.3    Golub, T.R.4    Gilliland, D.G.5
  • 19
    • 0035425048 scopus 로고    scopus 로고
    • PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
    • Dai C., Celestino J.C., Okada Y., Louis D.N., Fuller G.N., and Holland E.C. PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev. 15 (2001) 1913-1925
    • (2001) Genes Dev. , vol.15 , pp. 1913-1925
    • Dai, C.1    Celestino, J.C.2    Okada, Y.3    Louis, D.N.4    Fuller, G.N.5    Holland, E.C.6
  • 21
    • 27144473338 scopus 로고    scopus 로고
    • Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by α platelet-derived growth factor receptor
    • Dolloff N.G., Shulby S.S., Nelson A.V., Stearns M.E., Johannes G.J., Thomas J.D., Meucci O., and Fatatis A. Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by α platelet-derived growth factor receptor. Oncogene 24 (2005) 6848-6854
    • (2005) Oncogene , vol.24 , pp. 6848-6854
    • Dolloff, N.G.1    Shulby, S.S.2    Nelson, A.V.3    Stearns, M.E.4    Johannes, G.J.5    Thomas, J.D.6    Meucci, O.7    Fatatis, A.8
  • 23
    • 26444621412 scopus 로고    scopus 로고
    • Imatinib and hydroxyurea in pretreated progressive glioblastoma multiforme: A patient series
    • Dresemann G. Imatinib and hydroxyurea in pretreated progressive glioblastoma multiforme: A patient series. Ann. Oncol. 16 (2005) 1702-1708
    • (2005) Ann. Oncol. , vol.16 , pp. 1702-1708
    • Dresemann, G.1
  • 24
    • 0037075815 scopus 로고    scopus 로고
    • SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF β-receptor
    • Ekman S., Kallin A., Engström U., Heldin C.-H., and Rönnstrand L. SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF β-receptor. Oncogene 21 (2002) 1870-1875
    • (2002) Oncogene , vol.21 , pp. 1870-1875
    • Ekman, S.1    Kallin, A.2    Engström, U.3    Heldin, C.-H.4    Rönnstrand, L.5
  • 26
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • Erber R., Thurnher A., Katsen A.D., Groth G., Kerger H., Hammes H.P., Menger M.D., Ullrich A., and Vajkoczy P. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J. 18 (2004) 338-340
    • (2004) FASEB J. , vol.18 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3    Groth, G.4    Kerger, H.5    Hammes, H.P.6    Menger, M.D.7    Ullrich, A.8    Vajkoczy, P.9
  • 27
    • 0026583942 scopus 로고
    • PDGF α- and β-receptors activate unique and common signal transduction pathways
    • Eriksson A., Siegbahn A., Westermark B., Heldin C.-H., and Claesson-Welsh L. PDGF α- and β-receptors activate unique and common signal transduction pathways. EMBO J. 11 (1992) 543-550
    • (1992) EMBO J. , vol.11 , pp. 543-550
    • Eriksson, A.1    Siegbahn, A.2    Westermark, B.3    Heldin, C.-H.4    Claesson-Welsh, L.5
  • 28
    • 0026793260 scopus 로고
    • Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors
    • Fleming T.P., Saxena A., Clark W.C., Robertson J.T., Oldfield E.H., Aaronson S.A., and Ali I.U. Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res. 52 (1992) 4550-4553
    • (1992) Cancer Res. , vol.52 , pp. 4550-4553
    • Fleming, T.P.1    Saxena, A.2    Clark, W.C.3    Robertson, J.T.4    Oldfield, E.H.5    Aaronson, S.A.6    Ali, I.U.7
  • 29
    • 0027397240 scopus 로고
    • Platelet-derived growth factor (PDGF) in oncogenesis: Development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB
    • Forsberg K., Valyi-Nagy I., Heldin C.-H., Herlyn M., and Westermark B. Platelet-derived growth factor (PDGF) in oncogenesis: Development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB. Proc. Natl. Acad. Sci. USA 90 (1993) 393-397
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 393-397
    • Forsberg, K.1    Valyi-Nagy, I.2    Heldin, C.-H.3    Herlyn, M.4    Westermark, B.5
  • 30
    • 6344236867 scopus 로고    scopus 로고
    • Tissue plasminogen activator is a potent activator of PDGF-CC
    • Fredriksson L., Li H., Fieber C., Li X., and Eriksson U. Tissue plasminogen activator is a potent activator of PDGF-CC. EMBO J. 23 (2004) 3793-3802
    • (2004) EMBO J. , vol.23 , pp. 3793-3802
    • Fredriksson, L.1    Li, H.2    Fieber, C.3    Li, X.4    Eriksson, U.5
  • 33
    • 33746565515 scopus 로고    scopus 로고
    • Role of Raf kinase in cancer: Therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway
    • Gollob J.A., Wilhelm S., Carter C., and Kelley S.L. Role of Raf kinase in cancer: Therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway. Semin. Oncol. 33 (2006) 392-406
    • (2006) Semin. Oncol. , vol.33 , pp. 392-406
    • Gollob, J.A.1    Wilhelm, S.2    Carter, C.3    Kelley, S.L.4
  • 34
    • 0028224348 scopus 로고
    • Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
    • Golub T.R., Barker G.F., Lovett M., and Gilliland D.G. Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77 (1994) 307-316
    • (1994) Cell , vol.77 , pp. 307-316
    • Golub, T.R.1    Barker, G.F.2    Lovett, M.3    Gilliland, D.G.4
  • 36
    • 0032505090 scopus 로고    scopus 로고
    • Transforming activity of the chimeric sequence formed by the fusion of collagen gene COL1A1 and the platelet derived growth factor b-chain gene in dermatofibrosarcoma protuberans
    • Greco A., Fusetti L., Villa R., Sozzi G., Minoletti F., Mauri P., and Pierotti M.A. Transforming activity of the chimeric sequence formed by the fusion of collagen gene COL1A1 and the platelet derived growth factor b-chain gene in dermatofibrosarcoma protuberans. Oncogene 17 (1998) 1313-1319
    • (1998) Oncogene , vol.17 , pp. 1313-1319
    • Greco, A.1    Fusetti, L.2    Villa, R.3    Sozzi, G.4    Minoletti, F.5    Mauri, P.6    Pierotti, M.A.7
  • 37
    • 0344837389 scopus 로고    scopus 로고
    • Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment
    • Guo P., Hu B., Gu W., Xu L., Wang D., Huang H.J., Cavenee W.K., and Cheng S.Y. Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment. Am. J. Pathol. 162 (2003) 1083-1093
    • (2003) Am. J. Pathol. , vol.162 , pp. 1083-1093
    • Guo, P.1    Hu, B.2    Gu, W.3    Xu, L.4    Wang, D.5    Huang, H.J.6    Cavenee, W.K.7    Cheng, S.Y.8
  • 39
    • 0028812442 scopus 로고
    • β PDGFR-IgG chimera demonstrates that human β PDGFR Ig-like domains 1 to 3 are sufficient for high affinity PDGF BB binding
    • Heidaran M.A., Mahadevan D., and Larochelle W.J. β PDGFR-IgG chimera demonstrates that human β PDGFR Ig-like domains 1 to 3 are sufficient for high affinity PDGF BB binding. FASEB J. 9 (1995) 140-145
    • (1995) FASEB J. , vol.9 , pp. 140-145
    • Heidaran, M.A.1    Mahadevan, D.2    Larochelle, W.J.3
  • 42
    • 0032875460 scopus 로고    scopus 로고
    • Mechanism of action and in vivo role of platelet-derived growth factor
    • Heldin C.-H., and Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev. 79 (1999) 1283-1316
    • (1999) Physiol. Rev. , vol.79 , pp. 1283-1316
    • Heldin, C.-H.1    Westermark, B.2
  • 43
    • 0032547385 scopus 로고    scopus 로고
    • Signal transduction via platelet-derived growth factor receptors
    • Heldin C.-H., Östman A., and Rönnstrand L. Signal transduction via platelet-derived growth factor receptors. Biochim. Biophys. Acta 1378 (1998) F79-F113
    • (1998) Biochim. Biophys. Acta , vol.1378
    • Heldin, C.-H.1    Östman, A.2    Rönnstrand, L.3
  • 44
    • 0037085234 scopus 로고    scopus 로고
    • New members of the platelet-derived growth factor family of mitogens
    • Heldin C.-H., Eriksson U., and Östman A. New members of the platelet-derived growth factor family of mitogens. Arch. Biochem. Biophys. 398 (2002) 284-290
    • (2002) Arch. Biochem. Biophys. , vol.398 , pp. 284-290
    • Heldin, C.-H.1    Eriksson, U.2    Östman, A.3
  • 45
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure-an obstacle in cancer therapy
    • Heldin C.-H., Rubin K., Pietras K., and Östman A. High interstitial fluid pressure-an obstacle in cancer therapy. Nat. Rev. Cancer 4 (2004) 806-813
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 806-813
    • Heldin, C.-H.1    Rubin, K.2    Pietras, K.3    Östman, A.4
  • 46
    • 0026772431 scopus 로고
    • Platelet-derived growth factor and its receptors in human glioma tissue: Expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops
    • Hermanson M., Funa K., Hartman M., Claesson-Welsh L., Heldin C.-H., Westermark B., and Nistér M. Platelet-derived growth factor and its receptors in human glioma tissue: Expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res. 52 (1992) 3213-3219
    • (1992) Cancer Res. , vol.52 , pp. 3213-3219
    • Hermanson, M.1    Funa, K.2    Hartman, M.3    Claesson-Welsh, L.4    Heldin, C.-H.5    Westermark, B.6    Nistér, M.7
  • 47
    • 0042591478 scopus 로고    scopus 로고
    • Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model
    • Hesselager G., Uhrbom L., Westermark B., and Nistér M. Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model. Cancer Res. 63 (2003) 4305-4309
    • (2003) Cancer Res. , vol.63 , pp. 4305-4309
    • Hesselager, G.1    Uhrbom, L.2    Westermark, B.3    Nistér, M.4
  • 49
    • 0346333243 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model
    • Hwang R.F., Yokoi K., Bucana C.D., Tsan R., Killion J.J., Evans D.B., and Fidler I.J. Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model. Clin. Cancer Res. 9 (2003) 6534-6544
    • (2003) Clin. Cancer Res. , vol.9 , pp. 6534-6544
    • Hwang, R.F.1    Yokoi, K.2    Bucana, C.D.3    Tsan, R.4    Killion, J.J.5    Evans, D.B.6    Fidler, I.J.7
  • 50
    • 0035291243 scopus 로고    scopus 로고
    • Delivery of molecular and cellular medicine to solid tumors
    • Jain R.K. Delivery of molecular and cellular medicine to solid tumors. Adv. Drug Deliv. Rev. 46 (2001) 149-168
    • (2001) Adv. Drug Deliv. Rev. , vol.46 , pp. 149-168
    • Jain, R.K.1
  • 51
  • 53
    • 12144261476 scopus 로고    scopus 로고
    • Oncogenic derivatives of platelet-derived growth factor receptors
    • Jones A.V., and Cross N.C. Oncogenic derivatives of platelet-derived growth factor receptors. Cell. Mol. Life Sci. 61 (2004) 2912-2923
    • (2004) Cell. Mol. Life Sci. , vol.61 , pp. 2912-2923
    • Jones, A.V.1    Cross, N.C.2
  • 54
    • 17144463437 scopus 로고    scopus 로고
    • A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR β oncoprotein
    • Jousset C., Carron C., Boureux A., Quang C.T., Oury C., Dusanter-Fourt I., Charon M., Levin J., Bernard O., and Ghysdael J. A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR β oncoprotein. EMBO J. 16 (1997) 69-82
    • (1997) EMBO J. , vol.16 , pp. 69-82
    • Jousset, C.1    Carron, C.2    Boureux, A.3    Quang, C.T.4    Oury, C.5    Dusanter-Fourt, I.6    Charon, M.7    Levin, J.8    Bernard, O.9    Ghysdael, J.10
  • 55
    • 0033832891 scopus 로고    scopus 로고
    • Abnormal gastrointestinal development in PDGF-A and PDGFR-(α) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis
    • Karlsson L., Lindahl P., Heath J.K., and Betsholtz C. Abnormal gastrointestinal development in PDGF-A and PDGFR-(α) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development 127 (2000) 3457-3466
    • (2000) Development , vol.127 , pp. 3457-3466
    • Karlsson, L.1    Lindahl, P.2    Heath, J.K.3    Betsholtz, C.4
  • 56
    • 0034665138 scopus 로고    scopus 로고
    • Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class
    • Kilic T., Alberta J.A., Zdunek P.R., Acar M., Iannarelli P., O'Reilly T., Buchdunger E., Black P.M., and Stiles C.D. Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class. Cancer Res. 60 (2000) 5143-5150
    • (2000) Cancer Res. , vol.60 , pp. 5143-5150
    • Kilic, T.1    Alberta, J.A.2    Zdunek, P.R.3    Acar, M.4    Iannarelli, P.5    O'Reilly, T.6    Buchdunger, E.7    Black, P.M.8    Stiles, C.D.9
  • 58
    • 20044363847 scopus 로고    scopus 로고
    • Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-β
    • Kiyan J., Kiyan R., Haller H., and Dumler I. Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-β. EMBO J. 24 (2005) 1787-1797
    • (2005) EMBO J. , vol.24 , pp. 1787-1797
    • Kiyan, J.1    Kiyan, R.2    Haller, H.3    Dumler, I.4
  • 59
    • 0029085194 scopus 로고
    • Identification of a putative Syp substrate, the PDGF β receptor
    • Klinghoffer R.A., and Kazlauskas A. Identification of a putative Syp substrate, the PDGF β receptor. J. Biol. Chem. 270 (1995) 22208-22217
    • (1995) J. Biol. Chem. , vol.270 , pp. 22208-22217
    • Klinghoffer, R.A.1    Kazlauskas, A.2
  • 60
    • 0035106689 scopus 로고    scopus 로고
    • The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions
    • Klinghoffer R.A., Mueting-Nelsen P.F., Faerman A., Shani M., and Soriano P. The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. Mol. Cell 7 (2001) 343-354
    • (2001) Mol. Cell , vol.7 , pp. 343-354
    • Klinghoffer, R.A.1    Mueting-Nelsen, P.F.2    Faerman, A.3    Shani, M.4    Soriano, P.5
  • 62
    • 0034717163 scopus 로고    scopus 로고
    • Site-selective dephosphorylation of the platelet-derived growth factor β-receptor by the receptor-like protein-tyrosine phosphatase DEP-1
    • Kovalenko M., Denner K., Sandström J., Persson C., Gross S., Jandt E., Vilella R., Böhmer F., and Östman A. Site-selective dephosphorylation of the platelet-derived growth factor β-receptor by the receptor-like protein-tyrosine phosphatase DEP-1. J. Biol. Chem. 275 (2000) 16219-16226
    • (2000) J. Biol. Chem. , vol.275 , pp. 16219-16226
    • Kovalenko, M.1    Denner, K.2    Sandström, J.3    Persson, C.4    Gross, S.5    Jandt, E.6    Vilella, R.7    Böhmer, F.8    Östman, A.9
  • 63
    • 0040182907 scopus 로고    scopus 로고
    • Predimerization of recombinant platelet-derived growth factor receptor extracellular domains increases antagonistic potency
    • Leppänen O., Miyazawa K., Bäckström G., Pietras K., Sjöblom T., Heldin C.-H., and Östman A. Predimerization of recombinant platelet-derived growth factor receptor extracellular domains increases antagonistic potency. Biochemistry 39 (2000) 2370-2375
    • (2000) Biochemistry , vol.39 , pp. 2370-2375
    • Leppänen, O.1    Miyazawa, K.2    Bäckström, G.3    Pietras, K.4    Sjöblom, T.5    Heldin, C.-H.6    Östman, A.7
  • 64
    • 11344264600 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor receptor signaling restricts the growth of human breast cancer in the bone of nude mice
    • Lev D.C., Kim S.J., Onn A., Stone V., Nam D.H., Yazici S., Fidler I.J., and Price J.E. Inhibition of platelet-derived growth factor receptor signaling restricts the growth of human breast cancer in the bone of nude mice. Clin. Cancer Res. 11 (2005) 306-314
    • (2005) Clin. Cancer Res. , vol.11 , pp. 306-314
    • Lev, D.C.1    Kim, S.J.2    Onn, A.3    Stone, V.4    Nam, D.H.5    Yazici, S.6    Fidler, I.J.7    Price, J.E.8
  • 65
    • 0027936261 scopus 로고
    • Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities
    • Leveen P., Pekny M., Gebre-Medhin S., Swolin B., Larsson E., and Betsholtz C. Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes Dev. 8 (1994) 1875-1887
    • (1994) Genes Dev. , vol.8 , pp. 1875-1887
    • Leveen, P.1    Pekny, M.2    Gebre-Medhin, S.3    Swolin, B.4    Larsson, E.5    Betsholtz, C.6
  • 66
    • 33748751207 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor-BB-induced receptor activation and fibroblast migration by hyaluronan activation of CD44
    • Li L., Heldin C.-H., and Heldin P. Inhibition of platelet-derived growth factor-BB-induced receptor activation and fibroblast migration by hyaluronan activation of CD44. J. Biol. Chem. 281 (2006) 26512-26519
    • (2006) J. Biol. Chem. , vol.281 , pp. 26512-26519
    • Li, L.1    Heldin, C.-H.2    Heldin, P.3
  • 67
    • 0037380709 scopus 로고    scopus 로고
    • Novel PDGF family members: PDGF-C and PDGF-D
    • Li X., and Eriksson U. Novel PDGF family members: PDGF-C and PDGF-D. Cytokine Growth Factor Rev. 14 (2003) 91-98
    • (2003) Cytokine Growth Factor Rev. , vol.14 , pp. 91-98
    • Li, X.1    Eriksson, U.2
  • 69
    • 33645296886 scopus 로고    scopus 로고
    • Platelet-derived growth factor BB-mediated normalization of dermal interstitial fluid pressure after mast cell degranulation depends on beta3 but not beta1 integrins
    • Liden A., Berg A., Nedrebo T., Reed R.K., and Rubin K. Platelet-derived growth factor BB-mediated normalization of dermal interstitial fluid pressure after mast cell degranulation depends on beta3 but not beta1 integrins. Circ. Res. 98 (2006) 635-641
    • (2006) Circ. Res. , vol.98 , pp. 635-641
    • Liden, A.1    Berg, A.2    Nedrebo, T.3    Reed, R.K.4    Rubin, K.5
  • 71
    • 20144389471 scopus 로고    scopus 로고
    • Targeting the platelet-derived growth factor receptor α with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: Implications as a potential therapeutic target
    • Loizos N., Xu Y., Huber J., Liu M., Lu D., Finnerty B., Rolser R., Malikzay A., Persaud A., Corcoran E., Deevi D.S., Balderes P., et al. Targeting the platelet-derived growth factor receptor α with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: Implications as a potential therapeutic target. Mol. Cancer Ther. 4 (2005) 369-379
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 369-379
    • Loizos, N.1    Xu, Y.2    Huber, J.3    Liu, M.4    Lu, D.5    Finnerty, B.6    Rolser, R.7    Malikzay, A.8    Persaud, A.9    Corcoran, E.10    Deevi, D.S.11    Balderes, P.12
  • 72
    • 0842311601 scopus 로고    scopus 로고
    • Imatinib mesylate (Gleevec) inhibits ovarian cancer cell growth through a mechanism dependent on platelet-derived growth factor receptor α and Akt inactivation
    • Matei D., Chang D.D., and Jeng M.H. Imatinib mesylate (Gleevec) inhibits ovarian cancer cell growth through a mechanism dependent on platelet-derived growth factor receptor α and Akt inactivation. Clin. Cancer Res. 10 (2004) 681-690
    • (2004) Clin. Cancer Res. , vol.10 , pp. 681-690
    • Matei, D.1    Chang, D.D.2    Jeng, M.H.3
  • 73
    • 33748068096 scopus 로고    scopus 로고
    • Dermatofibrosarcoma protuberans: A surgical disease with a molecular savior
    • McArthur G.A. Dermatofibrosarcoma protuberans: A surgical disease with a molecular savior. Curr. Opin. Oncol. 18 (2006) 341-346
    • (2006) Curr. Opin. Oncol. , vol.18 , pp. 341-346
    • McArthur, G.A.1
  • 75
    • 33646448005 scopus 로고    scopus 로고
    • Sunitinib malate for the treatment of solid tumours: A review of current clinical data
    • Motzer R.J., Hoosen S., Bello C.L., and Christensen J.G. Sunitinib malate for the treatment of solid tumours: A review of current clinical data. Expert Opin. Investig. Drugs 15 (2006) 553-561
    • (2006) Expert Opin. Investig. Drugs , vol.15 , pp. 553-561
    • Motzer, R.J.1    Hoosen, S.2    Bello, C.L.3    Christensen, J.G.4
  • 76
    • 28944432768 scopus 로고    scopus 로고
    • Imatinib mesylate as a novel treatment option for hypereosinophilic syndrome: Two case reports and a comprehensive review of the literature
    • Muller A.M., Martens U.M., Hofmann S.C., Bruckner-Tuderman L., Mertelsmann R., and Lubbert M. Imatinib mesylate as a novel treatment option for hypereosinophilic syndrome: Two case reports and a comprehensive review of the literature. Ann. Hematol. 85 (2006) 1-16
    • (2006) Ann. Hematol. , vol.85 , pp. 1-16
    • Muller, A.M.1    Martens, U.M.2    Hofmann, S.C.3    Bruckner-Tuderman, L.4    Mertelsmann, R.5    Lubbert, M.6
  • 77
    • 13444270334 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: The incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era-a population-based study in western Sweden
    • Nilsson B., Bumming P., Meis-Kindblom J.M., Oden A., Dortok A., Gustavsson B., Sablinska K., and Kindblom L.G. Gastrointestinal stromal tumors: The incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era-a population-based study in western Sweden. Cancer 103 (2005) 821-829
    • (2005) Cancer , vol.103 , pp. 821-829
    • Nilsson, B.1    Bumming, P.2    Meis-Kindblom, J.M.3    Oden, A.4    Dortok, A.5    Gustavsson, B.6    Sablinska, K.7    Kindblom, L.G.8
  • 78
    • 2942670180 scopus 로고    scopus 로고
    • PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma
    • Östman A. PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. Cytokine Growth Factor Rev. 15 (2004) 275-286
    • (2004) Cytokine Growth Factor Rev. , vol.15 , pp. 275-286
    • Östman, A.1
  • 79
    • 0033763567 scopus 로고    scopus 로고
    • Involvement of platelet-derived growth factor in disease: Development of specific antagonists
    • Östman A., and Heldin C.-H. Involvement of platelet-derived growth factor in disease: Development of specific antagonists. Adv. Cancer Res. 80 (2001) 1-38
    • (2001) Adv. Cancer Res. , vol.80 , pp. 1-38
    • Östman, A.1    Heldin, C.-H.2
  • 82
    • 14644446018 scopus 로고    scopus 로고
    • A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
    • Pietras K., and Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J. Clin. Oncol. 23 (2005) 939-952
    • (2005) J. Clin. Oncol. , vol.23 , pp. 939-952
    • Pietras, K.1    Hanahan, D.2
  • 83
    • 0035297541 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors
    • Pietras K., Östman A., Sjöquist M., Buchdunger E., Reed R.K., Heldin C.-H., and Rubin K. Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res. 61 (2001) 2929-2934
    • (2001) Cancer Res. , vol.61 , pp. 2929-2934
    • Pietras, K.1    Östman, A.2    Sjöquist, M.3    Buchdunger, E.4    Reed, R.K.5    Heldin, C.-H.6    Rubin, K.7
  • 90
    • 0026595966 scopus 로고
    • Platelet-derived growth factor BB for the treatment of chronic pressure ulcers
    • Robson M.C., Phillips L.G., Thomason A., Robson L.E., and Pierce G.F. Platelet-derived growth factor BB for the treatment of chronic pressure ulcers. Lancet 339 (1992) 23-25
    • (1992) Lancet , vol.339 , pp. 23-25
    • Robson, M.C.1    Phillips, L.G.2    Thomason, A.3    Robson, L.E.4    Pierce, G.F.5
  • 91
    • 0029824569 scopus 로고    scopus 로고
    • A novel physiological function for platelet-derived growth factor-BB in rat dermis
    • Rodt S.A., Ahlén K., Berg A., Rubin K., and Reed R.K. A novel physiological function for platelet-derived growth factor-BB in rat dermis. J. Physiol. 495 Pt. 1 (1996) 193-200
    • (1996) J. Physiol. , vol.495 , Issue.PART 1 , pp. 193-200
    • Rodt, S.A.1    Ahlén, K.2    Berg, A.3    Rubin, K.4    Reed, R.K.5
  • 93
    • 33646152550 scopus 로고    scopus 로고
    • Identification of a novel imatinib responsive KIF5B-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia
    • Score J., Curtis C., Waghorn K., Stalder M., Jotterand M., Grand F.H., and Cross N.C. Identification of a novel imatinib responsive KIF5B-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia. Leukemia 20 (2006) 827-832
    • (2006) Leukemia , vol.20 , pp. 827-832
    • Score, J.1    Curtis, C.2    Waghorn, K.3    Stalder, M.4    Jotterand, M.5    Grand, F.H.6    Cross, N.C.7
  • 94
    • 0034618408 scopus 로고    scopus 로고
    • Human breast carcinoma desmoplasia is PDGF initiated
    • Shao Z.M., Nguyen M., and Barsky S.H. Human breast carcinoma desmoplasia is PDGF initiated. Oncogene 19 (2000) 4337-4345
    • (2000) Oncogene , vol.19 , pp. 4337-4345
    • Shao, Z.M.1    Nguyen, M.2    Barsky, S.H.3
  • 95
    • 0033178762 scopus 로고    scopus 로고
    • The dermatofibrosarcoma protuberans-associated collagen type Iα1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB
    • Shimizu A., O'Brien K.P., Sjöblom T., Pietras K., Buchdunger E., Collins V.P., Heldin C.-H., Dumanski J.P., and Östman A. The dermatofibrosarcoma protuberans-associated collagen type Iα1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB. Cancer Res. 59 (1999) 3719-3723
    • (1999) Cancer Res. , vol.59 , pp. 3719-3723
    • Shimizu, A.1    O'Brien, K.P.2    Sjöblom, T.3    Pietras, K.4    Buchdunger, E.5    Collins, V.P.6    Heldin, C.-H.7    Dumanski, J.P.8    Östman, A.9
  • 98
    • 0033604460 scopus 로고    scopus 로고
    • Characterization of the chronic myelomonocytic leukemia associated TEL-PDGF β R fusion protein
    • Sjöblom T., Boureux A., Rönnstrand L., Heldin C.-H., Ghysdael J., and Östman A. Characterization of the chronic myelomonocytic leukemia associated TEL-PDGF β R fusion protein. Oncogene 18 (1999) 7055-7062
    • (1999) Oncogene , vol.18 , pp. 7055-7062
    • Sjöblom, T.1    Boureux, A.2    Rönnstrand, L.3    Heldin, C.-H.4    Ghysdael, J.5    Östman, A.6
  • 99
    • 0035421175 scopus 로고    scopus 로고
    • Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis
    • Sjöblom T., Shimizu A., O'Brien K.P., Pietras K., Dal Cin P., Buchdunger E., Dumanski J.P., Östman A., and Heldin C.-H. Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis. Cancer Res. 61 (2001) 5778-5783
    • (2001) Cancer Res. , vol.61 , pp. 5778-5783
    • Sjöblom, T.1    Shimizu, A.2    O'Brien, K.P.3    Pietras, K.4    Dal Cin, P.5    Buchdunger, E.6    Dumanski, J.P.7    Östman, A.8    Heldin, C.-H.9
  • 100
    • 0032477806 scopus 로고    scopus 로고
    • Tumorigenic conversion of immortal human keratinocytes through stromal cell activation
    • Skobe M., and Fusenig N.E. Tumorigenic conversion of immortal human keratinocytes through stromal cell activation. Proc. Natl. Acad. Sci. USA 95 (1998) 1050-1055
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 1050-1055
    • Skobe, M.1    Fusenig, N.E.2
  • 101
    • 26944437515 scopus 로고    scopus 로고
    • PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
    • Song S., Ewald A.J., Stallcup W., Werb Z., and Bergers G. PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat. Cell Biol. 7 (2005) 870-879
    • (2005) Nat. Cell Biol. , vol.7 , pp. 870-879
    • Song, S.1    Ewald, A.J.2    Stallcup, W.3    Werb, Z.4    Bergers, G.5
  • 102
    • 0028059309 scopus 로고
    • Abnormal kidney development and hematological disorders in PDGF β-receptor mutant mice
    • Soriano P. Abnormal kidney development and hematological disorders in PDGF β-receptor mutant mice. Genes Dev. 8 (1994) 1888-1896
    • (1994) Genes Dev. , vol.8 , pp. 1888-1896
    • Soriano, P.1
  • 103
    • 0030808324 scopus 로고    scopus 로고
    • The PDGF α receptor is required for neural crest cell development and for normal patterning of the somites
    • Soriano P. The PDGF α receptor is required for neural crest cell development and for normal patterning of the somites. Development 124 (1997) 2691-2700
    • (1997) Development , vol.124 , pp. 2691-2700
    • Soriano, P.1
  • 104
    • 0028973482 scopus 로고
    • Requirement for generation of H2O2 for platelet-derived growth factor signal transduction
    • Sundaresan M., Yu Z.X., Ferrans V.J., Irani K., and Finkel T. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270 (1995) 296-299
    • (1995) Science , vol.270 , pp. 296-299
    • Sundaresan, M.1    Yu, Z.X.2    Ferrans, V.J.3    Irani, K.4    Finkel, T.5
  • 105
    • 0027744498 scopus 로고
    • Microvascular pericytes express platelet-derived growth factor-β receptors in human healing wounds and colorectal adenocarcinoma
    • Sundberg C., Ljungström M., Lindmark G., Gerdin B., and Rubin K. Microvascular pericytes express platelet-derived growth factor-β receptors in human healing wounds and colorectal adenocarcinoma. Am. J. Pathol. 143 (1993) 1377-1388
    • (1993) Am. J. Pathol. , vol.143 , pp. 1377-1388
    • Sundberg, C.1    Ljungström, M.2    Lindmark, G.3    Gerdin, B.4    Rubin, K.5
  • 106
    • 33644504867 scopus 로고    scopus 로고
    • PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling
    • Takahashi Y., Morales F.C., Kreimann E.L., and Georgescu M.M. PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. EMBO J. 25 (2006) 910-920
    • (2006) EMBO J. , vol.25 , pp. 910-920
    • Takahashi, Y.1    Morales, F.C.2    Kreimann, E.L.3    Georgescu, M.M.4
  • 108
    • 0035282956 scopus 로고    scopus 로고
    • Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony-stimulating factor or interleukin-3
    • Tomasson M.H., Williams I.R., Li S., Kutok J., Cain D., Gillessen S., Dranoff G., Van Etten R.A., and Gilliland D.G. Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony-stimulating factor or interleukin-3. Blood 97 (2001) 1435-1441
    • (2001) Blood , vol.97 , pp. 1435-1441
    • Tomasson, M.H.1    Williams, I.R.2    Li, S.3    Kutok, J.4    Cain, D.5    Gillessen, S.6    Dranoff, G.7    Van Etten, R.A.8    Gilliland, D.G.9
  • 109
    • 0041335547 scopus 로고    scopus 로고
    • Chronic myeloproliferative disorders with rearrangement of the platelet-derived growth factor α receptor: A new clinical target for STI571/Glivec
    • Trempat P., Villalva C., Laurent G., Armstrong F., Delsol G., Dastugue N., and Brousset P. Chronic myeloproliferative disorders with rearrangement of the platelet-derived growth factor α receptor: A new clinical target for STI571/Glivec. Oncogene 22 (2003) 5702-5706
    • (2003) Oncogene , vol.22 , pp. 5702-5706
    • Trempat, P.1    Villalva, C.2    Laurent, G.3    Armstrong, F.4    Delsol, G.5    Dastugue, N.6    Brousset, P.7
  • 110
    • 0033986415 scopus 로고    scopus 로고
    • Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells
    • Uhrbom L., Hesselager G., Östman A., Nistér M., and Westermark B. Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells. Int. J. Cancer 85 (2000) 398-406
    • (2000) Int. J. Cancer , vol.85 , pp. 398-406
    • Uhrbom, L.1    Hesselager, G.2    Östman, A.3    Nistér, M.4    Westermark, B.5
  • 111
    • 21744439110 scopus 로고    scopus 로고
    • Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells
    • Ustach C.V., and Kim H.R. Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells. Mol. Cell. Biol. 25 (2005) 6279-6288
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 6279-6288
    • Ustach, C.V.1    Kim, H.R.2
  • 114
    • 0027952893 scopus 로고
    • Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line
    • Vassbotn F.S., Östman A., Langeland N., Holmsen H., Westermark B., Heldin C.-H., and Nistér M. Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line. J. Cell. Physiol. 158 (1994) 381-389
    • (1994) J. Cell. Physiol. , vol.158 , pp. 381-389
    • Vassbotn, F.S.1    Östman, A.2    Langeland, N.3    Holmsen, H.4    Westermark, B.5    Heldin, C.-H.6    Nistér, M.7
  • 118
    • 21344435054 scopus 로고    scopus 로고
    • Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model
    • Xu L., Tong R., Cochran D.M., and Jain R.K. Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model. Cancer Res. 65 (2005) 5711-5719
    • (2005) Cancer Res. , vol.65 , pp. 5711-5719
    • Xu, L.1    Tong, R.2    Cochran, D.M.3    Jain, R.K.4
  • 119
    • 0036468926 scopus 로고    scopus 로고
    • Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer
    • Yi B., Williams P.J., Niewolna M., Wang Y., and Yoneda T. Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer. Cancer Res. 62 (2002) 917-923
    • (2002) Cancer Res. , vol.62 , pp. 917-923
    • Yi, B.1    Williams, P.J.2    Niewolna, M.3    Wang, Y.4    Yoneda, T.5
  • 120
    • 0035242001 scopus 로고    scopus 로고
    • PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors
    • Zwerner J.P., and May W.A. PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors. Oncogene 20 (2001) 626-633
    • (2001) Oncogene , vol.20 , pp. 626-633
    • Zwerner, J.P.1    May, W.A.2
  • 121
    • 0037198637 scopus 로고    scopus 로고
    • Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines
    • Zwerner J.P., and May W.A. Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines. Oncogene 21 (2002) 3847-3854
    • (2002) Oncogene , vol.21 , pp. 3847-3854
    • Zwerner, J.P.1    May, W.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.