Mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of spinocerebellar ataxia type 12 (SCA12)

Journal of Biological Chemistry

Volumn 286, Issue 24, 2011, Pages 21742-21754

  Wang, Yu Chun ^a   Lee, Chi Mei ^a   Lee, Li Ching ^a   Tung, Li Chu ^a   Hsieh Li, Hsiu Mei ^a   Lee Chen, Guey Jen ^a   Su, Ming Tsan ^a  

^a NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT TREATMENT; AUTOPHAGOSOMES; CASPASE-3; CEREBELLAR ATAXIA; CYTOCHROME C; CYTOSOLIC; DROSOPHILA HOMOLOG; ECTOPIC EXPRESSIONS; LIFE SPAN; MITOCHONDRIAL DYSFUNCTION; NEURODEGENERATION; OVER-EXPRESSION; OXIDATIVE INJURY; PHARMACOLOGICAL TREATMENT; REACTIVE OXYGEN SPECIES; THERAPEUTIC INTERVENTION; TRANSGENICS;

CELL DEATH; ENZYME INHIBITION; TRANSMISSION ELECTRON MICROSCOPY;

MITOCHONDRIA;

CASPASE 3; CYTOCHROME C; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL PROTEIN; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; CONTROLLED STUDY; CYTOSOL; DISEASE COURSE; DISEASE PREDISPOSITION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DROSOPHILA; ENZYME ACTIVITY; GENE OVEREXPRESSION; LIFESPAN; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PHOTORECEPTOR; PPP2R2B GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINOCEREBELLAR ATAXIA TYPE 12; SPINOCEREBELLAR DEGENERATION; TWS GENE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; AUTOPHAGY; CASPASE 3; CYTOCHROMES C; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; GENE EXPRESSION REGULATION; HUMANS; MITOCHONDRIA; NERVE TISSUE PROTEINS; OXIDATIVE STRESS; PROTEIN PHOSPHATASE 2; REACTIVE OXYGEN SPECIES; RNA, DOUBLE-STRANDED; SPINOCEREBELLAR ATAXIAS;

EID: 79958723738     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.160697     Document Type: Article

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