The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: Results from the European Project ACuteTox

Toxicology in Vitro

Volumn 27, Issue 4, 2013, Pages 1357-1376

  Prieto, P ^a   Kinsner Ovaskainen, A ^a   Stanzel, S ^b   Albella, B ^c   Artursson, P ^d   Campillo, N ^e   Cecchelli, R ^f,g   Cerrato, L ^c   Diaz L ^h   Di Consiglio, E ⁱ   Guerra, A ^e   Gombau, L ^j   Herrera, G ^h   Honegger, P ^k   Landry, C ^f,g   O'Connor, J E ^h   Paez J A ^e   Quintas, G ^j   Svensson, R ^d   Turco, L ⁱ   Zurich, M G ^k   Zurbano, M J ^j   Kopp Schneider, A ^b   more..

^a JOINT RESEARCH CENTRE   (Italy)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c CIEMAT   (Spain)

^d UPPSALA UNIVERSITY   (Sweden)

^e INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^f UNIV LILLE   (France)

^g IUT de Lens   (France)

^h CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

ⁱ ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^j SA   (Spain)

^k UNIVERSITY OF LAUSANNE   (Switzerland)

more..

Author keywords

Acute oral toxicity; Classification and regression trees; Concentration response analysis; In vitro; Random Forests; Testing strategy

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CYTOKINE; NEUTRAL RED; OCTANOL; URIDINE; WATER;

ACUTE TOXICITY; ANIMAL CELL; ARTICLE; ARTIFICIAL NEURAL NETWORK; CELL STRAIN 3T3; COLONY FORMING UNIT GM; COMPUTER MODEL; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY TEST; GENE EXPRESSION; IN VITRO STUDY; INTESTINE ABSORPTION; LD 50; LIVER CELL; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PREDICTIVE VALUE; RAT; TOXICITY TESTING;

ADMINISTRATION, ORAL; ANIMAL TESTING ALTERNATIVES; ANIMALS; BLOOD-BRAIN BARRIER; CELL LINE; CELL SURVIVAL; COLONY-FORMING UNITS ASSAY; COMPUTER SIMULATION; CYTOKINES; HUMANS; INTESTINAL ABSORPTION; LETHAL DOSE 50; MICE; NEURAL NETWORKS (COMPUTER); OXIDATIVE STRESS; RATS; RISK ASSESSMENT; TOXICITY TESTS, ACUTE;

ANIMALIA; RATTUS;

EID: 84876730407     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.07.013     Document Type: Article

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