메뉴 건너뛰기




Volumn 27, Issue 4, 2013, Pages 1347-1356

Comparative analysis of eight cytotoxicity assays evaluated within the ACuteTox Project

Author keywords

Acute toxicity; Concentration response analysis; Correlation analysis; Cytotoxicity; Hierarchical Cluster Analysis; In vitro assays

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; HEXACHLOROBENZENE; LITHIUM SULFATE; METHANOL; NEUROTOXIN; NEUTRAL RED; PROPIDIUM IODIDE;

EID: 84876702225     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.08.015     Document Type: Article
Times cited : (30)

References (42)
  • 1
    • 84931260817 scopus 로고    scopus 로고
    • Anon, Background Review Document (BRD): Validation of Neutral Red Uptake Test Methods NIH/in Vitro Cytotoxicity Test Methods for Estimating Acute Oral Systemic Toxicity.
    • Publication No. 07-4518, November 2006. Available at: <>.
    • Anon, 2006. Background Review Document (BRD): Validation of Neutral Red Uptake Test Methods NIH/in Vitro Cytotoxicity Test Methods for Estimating Acute Oral Systemic Toxicity. Publication No. 07-4518, November 2006. Available at: <>. http://iccvam.niehs.nih.gov/methods/acutetox/inv_nru_brd.htm.
    • (2006)
  • 2
    • 84876743732 scopus 로고    scopus 로고
    • AXLR8, ACuteTox in Alternative Progress Testing Report Strategies 2001.
    • Freie Universität Berlin, Germany
    • AXLR8, 2011. ACuteTox in Alternative Progress Testing Report Strategies 2001. Freie Universität Berlin, Germany, pp. 22-46.
    • (2011) , pp. 22-46
  • 3
    • 0027270211 scopus 로고
    • Characteristation of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-triphenyltetrazolium bromode MTT: subcellular localisation, substrate dependence and involvement of mitochondrial electron transport in MTT reduction
    • Berridge M.A., Tan A.S. Characteristation of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-triphenyltetrazolium bromode MTT: subcellular localisation, substrate dependence and involvement of mitochondrial electron transport in MTT reduction. Archives of Biochemistry and Biophysics 1991, 303:474-482.
    • (1991) Archives of Biochemistry and Biophysics , vol.303 , pp. 474-482
    • Berridge, M.A.1    Tan, A.S.2
  • 5
    • 84876721335 scopus 로고    scopus 로고
    • The integration of kinetic data in the estimation of acute toxicity based on in vitro cytotoxicity measurements.
    • manuscript in preparation
    • Blaauboer, B., Garberg, P., manuscript in preparation, The integration of kinetic data in the estimation of acute toxicity based on in vitro cytotoxicity measurements.
    • Blaauboer, B.1    Garberg, P.2
  • 6
    • 0021990499 scopus 로고
    • Toxicity determined in vitro by morphological alterations and neutral red absorption
    • Borenfreund E., Puerner J.A. Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicology Letters 1985, 24:119-125.
    • (1985) Toxicology Letters , vol.24 , pp. 119-125
    • Borenfreund, E.1    Puerner, J.A.2
  • 8
    • 67449097468 scopus 로고    scopus 로고
    • In vitro sensitivity of granulo-monocytic progenitors as a new toxicological cell system and endpoint in the ACuteTox Project
    • Cerrato L., Valeri A., Bueren J.A., Albella B. In vitro sensitivity of granulo-monocytic progenitors as a new toxicological cell system and endpoint in the ACuteTox Project. Toxicology and Applied Pharmacology 2009, 238(2):111-119.
    • (2009) Toxicology and Applied Pharmacology , vol.238 , Issue.2 , pp. 111-119
    • Cerrato, L.1    Valeri, A.2    Bueren, J.A.3    Albella, B.4
  • 9
    • 2542546742 scopus 로고    scopus 로고
    • MEIC evaluation of acute systemic toxicity. Part IV. In vitro results from 67 toxicity assays used to test reference chemicals 31-50 and a comparative cytotoxicity analysis
    • Clemedson C., et al. MEIC evaluation of acute systemic toxicity. Part IV. In vitro results from 67 toxicity assays used to test reference chemicals 31-50 and a comparative cytotoxicity analysis. ATLA 1998, 26:131-183.
    • (1998) ATLA , vol.26 , pp. 131-183
    • Clemedson, C.1
  • 10
    • 49149091978 scopus 로고    scopus 로고
    • The European ACuteTox Project: a modern integrative in vitro approach to better prediction of acute toxicity
    • Clemedson C. The European ACuteTox Project: a modern integrative in vitro approach to better prediction of acute toxicity. Clinical Pharmacology and Therapeutics 2008, 84(2):200-202.
    • (2008) Clinical Pharmacology and Therapeutics , vol.84 , Issue.2 , pp. 200-202
    • Clemedson, C.1
  • 11
    • 34247163663 scopus 로고    scopus 로고
    • The integrated Acute Systemic Toxicity Project (ACuteTox) for the optimisation and validation of alternative in vitro tests
    • Clemedson C., Kolman A., Forsby A. The integrated Acute Systemic Toxicity Project (ACuteTox) for the optimisation and validation of alternative in vitro tests. ATLA 2007, 35:33-38.
    • (2007) ATLA , vol.35 , pp. 33-38
    • Clemedson, C.1    Kolman, A.2    Forsby, A.3
  • 12
    • 0032891414 scopus 로고    scopus 로고
    • The use of human keratinocytes in the EU/COLIPA international in vitro phototoxicity test validation study and the ECVAM/COLIPA study on UV filter chemicals
    • Clothier R., Willshaw A., Cox H., Garle M., Bowler H., Combes R. The use of human keratinocytes in the EU/COLIPA international in vitro phototoxicity test validation study and the ECVAM/COLIPA study on UV filter chemicals. ATLA 1999, 27:247-259.
    • (1999) ATLA , vol.27 , pp. 247-259
    • Clothier, R.1    Willshaw, A.2    Cox, H.3    Garle, M.4    Bowler, H.5    Combes, R.6
  • 15
    • 84876738467 scopus 로고    scopus 로고
    • DB-ALM, ECVAM database service on alternative methods to animal experimentation.
    • Available at:
    • DB-ALM, ECVAM database service on alternative methods to animal experimentation. Available at: <>. http://ihcp.jrc.ec.europa.eu/our_databases/db-alm.
  • 17
    • 0009663357 scopus 로고
    • A multiple comparison procedure for comparing several treatments with a control
    • Dunnett C.W. A multiple comparison procedure for comparing several treatments with a control. Journal of the American Statistical Association 1955, 50:1096-1121.
    • (1955) Journal of the American Statistical Association , vol.50 , pp. 1096-1121
    • Dunnett, C.W.1
  • 18
    • 20044374739 scopus 로고    scopus 로고
    • MEIC evaluation of acute systemic toxicity. Part VI. The prediction of human toxicity by rodent LD50 values and results from 61 in vitro tests
    • Ekwall B., Barile F.A., Castano A., Clemedson C., Clothier R.H., Dierickx P., Ekwall Balls, et al. MEIC evaluation of acute systemic toxicity. Part VI. The prediction of human toxicity by rodent LD50 values and results from 61 in vitro tests. ATLA 1998, 26:617-658.
    • (1998) ATLA , vol.26 , pp. 617-658
    • Ekwall, B.1    Barile, F.A.2    Castano, A.3    Clemedson, C.4    Clothier, R.H.5    Dierickx, P.6    Ekwall, B.7
  • 21
    • 73649094450 scopus 로고    scopus 로고
    • GABAA receptor and cell membrane potential as functional endpoints in cultured neurons to evaluate chemicals for human acute toxicity
    • Galofré M., Babot Z., García D.A., Iraola S., Rodríguez-Farré E., Forsby A., Suñol C. GABAA receptor and cell membrane potential as functional endpoints in cultured neurons to evaluate chemicals for human acute toxicity. Neurotoxicology and Teratology 2010, 32(1):52-61.
    • (2010) Neurotoxicology and Teratology , vol.32 , Issue.1 , pp. 52-61
    • Galofré, M.1    Babot, Z.2    García, D.A.3    Iraola, S.4    Rodríguez-Farré, E.5    Forsby, A.6    Suñol, C.7
  • 24
    • 79959511702 scopus 로고    scopus 로고
    • Acute oral toxicity: variability, reliability, relevance and interspecies comparison of rodent LD50 data from literature surveyed for the ACuteTox Project
    • Hoffmann S., Kinsner-Ovaskainen A., Prieto P., Mangelsdorf I., Bieler C., Cole T. Acute oral toxicity: variability, reliability, relevance and interspecies comparison of rodent LD50 data from literature surveyed for the ACuteTox Project. Regulatory Toxicology and Pharmacology 2010, 58(3):395-407.
    • (2010) Regulatory Toxicology and Pharmacology , vol.58 , Issue.3 , pp. 395-407
    • Hoffmann, S.1    Kinsner-Ovaskainen, A.2    Prieto, P.3    Mangelsdorf, I.4    Bieler, C.5    Cole, T.6
  • 25
    • 77950676999 scopus 로고    scopus 로고
    • Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria
    • Jones D.P., Lemasters J.J., Han D., Boelsterli U.A., Kaplowitz N. Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria. Mol Interv 2010, 10:98-111.
    • (2010) Mol Interv , vol.10 , pp. 98-111
    • Jones, D.P.1    Lemasters, J.J.2    Han, D.3    Boelsterli, U.A.4    Kaplowitz, N.5
  • 28
    • 84876716058 scopus 로고    scopus 로고
    • Selection of in vitro and in silico assays to be included in a tiered testing strategy to predict acute oral toxicity: an approach based on extended statistical analysis of data obtained in phase 1 of the ACuteTox Project
    • Kinsner-Ovaskainen A., Prieto P., Stanzel S., Kopp-Schneider A. Selection of in vitro and in silico assays to be included in a tiered testing strategy to predict acute oral toxicity: an approach based on extended statistical analysis of data obtained in phase 1 of the ACuteTox Project. Toxicology In Vitro 2013, 27(4):1377-1394.
    • (2013) Toxicology In Vitro , vol.27 , Issue.4 , pp. 1377-1394
    • Kinsner-Ovaskainen, A.1    Prieto, P.2    Stanzel, S.3    Kopp-Schneider, A.4
  • 29
    • 77956177747 scopus 로고    scopus 로고
    • Inhibition of in vitro cytokine production by human peripheral blood mononuclear cells treated with xenobiotics: implications for the prediction of general toxicity and immunotoxicity
    • Kooijman R., Devos S., Hooghe-Peters E. Inhibition of in vitro cytokine production by human peripheral blood mononuclear cells treated with xenobiotics: implications for the prediction of general toxicity and immunotoxicity. Toxicology In Vitro 2010, 24(6):1782-1789.
    • (2010) Toxicology In Vitro , vol.24 , Issue.6 , pp. 1782-1789
    • Kooijman, R.1    Devos, S.2    Hooghe-Peters, E.3
  • 30
    • 34548789044 scopus 로고    scopus 로고
    • Influence of albumin on sorption kinetics in solid-phase microextraction: consequences for chemical analyses and uptake processes
    • Kramer N.I., van Eijkeren J.C.H., Hermens J.L.M. Influence of albumin on sorption kinetics in solid-phase microextraction: consequences for chemical analyses and uptake processes. Analytical Chemistry 2007, 79:6941-6948.
    • (2007) Analytical Chemistry , vol.79 , pp. 6941-6948
    • Kramer, N.I.1    van Eijkeren, J.C.H.2    Hermens, J.L.M.3
  • 31
    • 84857963032 scopus 로고    scopus 로고
    • Evaluation of drugs with specific organ toxicities in organ-specific cell lines
    • Lin Z., Will Y. Evaluation of drugs with specific organ toxicities in organ-specific cell lines. Toxicological Sciences 2012, 126(1):114-127.
    • (2012) Toxicological Sciences , vol.126 , Issue.1 , pp. 114-127
    • Lin, Z.1    Will, Y.2
  • 32
    • 0021061819 scopus 로고
    • Rapid colourmetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay
    • Mossman T. Rapid colourmetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay. Journal of Immunological Methods 1983, 6:55-63.
    • (1983) Journal of Immunological Methods , vol.6 , pp. 55-63
    • Mossman, T.1
  • 34
    • 78650761734 scopus 로고    scopus 로고
    • Trends in safety pharmacology: posters presented at the annual meetings of the Safety Pharmacology Society 2001-2010
    • Redfern W.S., Valentin J.P. Trends in safety pharmacology: posters presented at the annual meetings of the Safety Pharmacology Society 2001-2010. Journal of Pharmacological and Toxicological Methods 2011, 64(1):102-110.
    • (2011) Journal of Pharmacological and Toxicological Methods , vol.64 , Issue.1 , pp. 102-110
    • Redfern, W.S.1    Valentin, J.P.2
  • 36
    • 84876742840 scopus 로고    scopus 로고
    • Array technology as a useful tool to identify alerts for neurotoxicity.
    • manuscript in preparation
    • Rimbau, V., Pallàs, M., Forsby, A., Sureda, F., Camins, A., Folch, J., manuscript in preparation. Array technology as a useful tool to identify alerts for neurotoxicity.
    • Rimbau, V.1    Pallàs, M.2    Forsby, A.3    Sureda, F.4    Camins, A.5    Folch, J.6
  • 37
    • 44749094190 scopus 로고    scopus 로고
    • Estimation of human blood LC50 values for use in modeling of in vitro-in vivo data of the ACuteTox Project
    • Sjöström M., Kolman A., Clemedson C., Clothier R. Estimation of human blood LC50 values for use in modeling of in vitro-in vivo data of the ACuteTox Project. Toxicology in Vitro 2008, 22:1405-1411.
    • (2008) Toxicology in Vitro , vol.22 , pp. 1405-1411
    • Sjöström, M.1    Kolman, A.2    Clemedson, C.3    Clothier, R.4
  • 39
    • 57349163499 scopus 로고    scopus 로고
    • Neutral red uptake cytotoxicity tests for estimating starting doses for acute oral toxicity tests
    • Stokes W.S., Casati S., Strickland J., Paris M. Neutral red uptake cytotoxicity tests for estimating starting doses for acute oral toxicity tests. Current Protocols in Toxicology Unit 2008, 20(4):1-20.
    • (2008) Current Protocols in Toxicology Unit , vol.20 , Issue.4 , pp. 1-20
    • Stokes, W.S.1    Casati, S.2    Strickland, J.3    Paris, M.4
  • 41
    • 0028114498 scopus 로고
    • In vitro alternatives for the detection of photoirritant chemicals: the EEC/COLIPA trial
    • Willshaw A., Moore L.J., Balls M. In vitro alternatives for the detection of photoirritant chemicals: the EEC/COLIPA trial. Toxicology in Vitro 1994, 8:723-725.
    • (1994) Toxicology in Vitro , vol.8 , pp. 723-725
    • Willshaw, A.1    Moore, L.J.2    Balls, M.3
  • 42
    • 84876726626 scopus 로고    scopus 로고
    • Use of aggregating brain cell cultures for the detection of organ-specific toxicity
    • Zurich M.G., Stanzel S., Kopp-Schneider A., Honegger P. Use of aggregating brain cell cultures for the detection of organ-specific toxicity. Toxicology In Vitro 2013, 27(4):1416-1424.
    • (2013) Toxicology In Vitro , vol.27 , Issue.4 , pp. 1416-1424
    • Zurich, M.G.1    Stanzel, S.2    Kopp-Schneider, A.3    Honegger, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.