메뉴 건너뛰기




Volumn 26 SUPPL. 2, Issue , 1998, Pages 617-658

MEIC Evaluation of Acute Systemic Toxicity: Part VI. The Prediction of Human Toxicity by Rodent LD50 Values and Results from 61 In Vitro Methods

Author keywords

[No Author keywords available]

Indexed keywords


EID: 20044374739     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (108)

References (45)
  • 1
    • 0024955695 scopus 로고
    • MEIC. A new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests
    • Bondesson, L, Ekwall, B , Hellberg, S., Romert, L., Stenberg, K & Walum, E. (1989). MEIC. A new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests. Cell Biology and Toxicology 5, 331-347.
    • (1989) Cell Biology and Toxicology , vol.5 , pp. 331-347
    • Bondesson, L.1    Ekwall, B.2    Hellberg, S.3    Romert, L.4    Stenberg, K.5    Walum, E.6
  • 2
    • 0002033758 scopus 로고
    • Cytotoxicity evaluation of the first ten MEIC chemicals: Acute lethal toxicity in man predicted by cytotoxicity in five cellular assays and by oral LD50 tests in rodents
    • Ekwall, B., Bondesson, I., Castell, J.V., Gómez-Lechón, M.J., Hellberg, S., Högberg, J., Jover, R., Ponsoda, X., Romert, L., Stenberg, K. & Walum, E. (1989) Cytotoxicity evaluation of the first ten MEIC chemicals: acute lethal toxicity in man predicted by cytotoxicity in five cellular assays and by oral LD50 tests in rodents. ATLA 17, 83-100.
    • (1989) ATLA , vol.17 , pp. 83-100
    • Ekwall, B.1    Bondesson, I.2    Castell, J.V.3    Gómez-Lechón, M.J.4    Hellberg, S.5    Högberg, J.6    Jover, R.7    Ponsoda, X.8    Romert, L.9    Stenberg, K.10    Walum, E.11
  • 3
    • 0343288742 scopus 로고
    • Features and prospects of the MEIC cytotoxicity evaluation project
    • Ekwall, B. (1992) Features and prospects of the MEIC cytotoxicity evaluation project. AATEX 1, 231-237.
    • (1992) AATEX , vol.1 , pp. 231-237
    • Ekwall, B.1
  • 4
    • 0028125252 scopus 로고
    • Principles for the validation of in vitro toxicology test methods
    • Walum, E., Clemedson, C. & Ekwall, B. (1994). Principles for the validation of in vitro toxicology test methods. Toxicology in Vitro 8, 807-812.
    • (1994) Toxicology in Vitro , vol.8 , pp. 807-812
    • Walum, E.1    Clemedson, C.2    Ekwall, B.3
  • 5
    • 2842560642 scopus 로고    scopus 로고
    • MEIC evaluation of acute systemic toxicity. Part I. Methodology of 68 in vitro toxicity assays used to test the first 30 reference chemicals
    • Clemedson, C. et al. (1996). MEIC evaluation of acute systemic toxicity. Part I. Methodology of 68 in vitro toxicity assays used to test the first 30 reference chemicals. ATLA 24, Suppl. 1, 249-272.
    • (1996) ATLA , vol.24 , Issue.1 SUPPL. , pp. 249-272
    • Clemedson, C.1
  • 6
    • 2842588325 scopus 로고    scopus 로고
    • MEIC evaluation of acute systemic toxicity. Part II. In vitro results from 68 toxicity assays used to test the first 30 reference chemicals and a comparative cytotoxicity analysis
    • Clemedson, C. et al. (1996). MEIC evaluation of acute systemic toxicity. Part II. In vitro results from 68 toxicity assays used to test the first 30 reference chemicals and a comparative cytotoxicity analysis ATLA 24, Suppl. 1, 273-311.
    • (1996) ATLA , vol.24 , Issue.1 SUPPL. , pp. 273-311
    • Clemedson, C.1
  • 7
    • 2542620018 scopus 로고    scopus 로고
    • MEIC evaluation of acute systemic toxicity Part III. In vitro results from 16 additional methods used to test the first 30 reference chemicals and a comparative cytotoxicity analysis
    • Clemedson, C et al (1998) MEIC evaluation of acute systemic toxicity Part III. In vitro results from 16 additional methods used to test the first 30 reference chemicals and a comparative cytotoxicity analysis ATLA 26, Suppl. 1, 93-129.
    • (1998) ATLA , vol.26 , Issue.1 SUPPL. , pp. 93-129
    • Clemedson, C.1
  • 8
    • 2542546742 scopus 로고    scopus 로고
    • MEIC evaluation of acute systemic toxicity Part IV. In vitro results from 67 toxicity assays used to test reference chemicals 31-50 and a comparative cytotoxicity analysis
    • Clemedson, C. et al. (1998). MEIC evaluation of acute systemic toxicity Part IV. In vitro results from 67 toxicity assays used to test reference chemicals 31-50 and a comparative cytotoxicity analysis ATLA 26, Suppl. 1, 131-183
    • (1998) ATLA , vol.26 , Issue.1 SUPPL. , pp. 131-183
    • Clemedson, C.1
  • 9
    • 20944432074 scopus 로고    scopus 로고
    • MEIC evaluation of acute systemic toxicity Part V. Rodent and human toxicity data for the 50 reference chemicals
    • Ekwall, B., Clemedson, C , Crafoord, B , Ekwall, B, Hallander, S , Walum, E. & Bondesson, I. (1998) MEIC evaluation of acute systemic toxicity Part V. Rodent and human toxicity data for the 50 reference chemicals. ATLA 26, Suppl. 2, 571-616
    • (1998) ATLA , vol.26 , Issue.2 SUPPL. , pp. 571-616
    • Ekwall, B.1    Clemedson, C.2    Crafoord, B.3    Ekwall, B.4    Hallander, S.5    Walum, E.6    Bondesson, I.7
  • 10
    • 0020644295 scopus 로고
    • Screening of toxic compounds in mammalian cell cultures
    • ed G M Williams, V C Dunkel & V A Ray, New York. The New York Academy of Sciences
    • Ekwall, B (1983) Screening of toxic compounds in mammalian cell cultures In Annals of the New York Academy of Sciences, Vol 407, Cellular Systems for Toxicity Testing (ed G M Williams, V C Dunkel & V A Ray), pp 64-77 New York. The New York Academy of Sciences
    • (1983) Annals of the New York Academy of Sciences, Vol 407, Cellular Systems for Toxicity Testing , vol.407 , pp. 64-77
    • Ekwall, B.1
  • 13
    • 0018878743 scopus 로고
    • Preliminary studies on the validity of in vitro measurement of drug toxicity using HeLa cells III Lethal action to man of 43 drugs related to the HeLa cell toxicity of the lethal drug concentrations
    • Ekwall, B (1980) Preliminary studies on the validity of in vitro measurement of drug toxicity using HeLa cells III Lethal action to man of 43 drugs related to the HeLa cell toxicity of the lethal drug concentrations Toxicology Letters 5, 319-331
    • (1980) Toxicology Letters , vol.5 , pp. 319-331
    • Ekwall, B.1
  • 15
    • 2542540366 scopus 로고
    • First CFN Symposium on LD50 and Possible Alternatives
    • Lindquist, N ed, (1983). First CFN Symposium on LD50 and Possible Alternatives. Acta Pharmacologica et Toxicologica 52, Suppl 2
    • (1983) Acta Pharmacologica et Toxicologica , vol.52 , Issue.2 SUPPL.
    • Lindquist, N.1
  • 16
    • 2542637741 scopus 로고
    • Toxic effects of chemicals: Difficulties in extrapolating data from animals to man
    • Garattim, S. (1985). Toxic effects of chemicals: difficulties in extrapolating data from animals to man. Critical Reviews in Toxicology 4, 711-720.
    • (1985) Critical Reviews in Toxicology , vol.4 , pp. 711-720
    • Garattim, S.1
  • 17
    • 0019391510 scopus 로고
    • Significance of the LD50 test for the toxicological evaluation of chemical substances
    • Zbmden, G. & Flury-Roversi, M (1981). Significance of the LD50 test for the toxicological evaluation of chemical substances. Archives of Toxicology 47, 77-99.
    • (1981) Archives of Toxicology , vol.47 , pp. 77-99
    • Zbmden, G.1    Flury-Roversi, M.2
  • 18
    • 0026515929 scopus 로고
    • Evaluation of the cytotoxicity of ten chemicals on cultured human hepatocytes. predictability of human toxicity and comparisons with rodent cell culture systems
    • Jover, R., Ponsoda, X, Castell, J.V & Gómez-Lechón, M.J. (1992) Evaluation of the cytotoxicity of ten chemicals on cultured human hepatocytes. predictability of human toxicity and comparisons with rodent cell culture systems. Toxicology In Vitro 6, 47-52.
    • (1992) Toxicology in Vitro , vol.6 , pp. 47-52
    • Jover, R.1    Ponsoda, X.2    Castell, J.V.3    Gómez-Lechón, M.J.4
  • 19
    • 0030219867 scopus 로고    scopus 로고
    • Cytotoxic and non-cytotoxic effects of the MEIC reference chemicals on spontaneously contracting primary cultured rat skeletal muscle cells
    • Gülden, M. & Seibert, H. (1996) Cytotoxic and non-cytotoxic effects of the MEIC reference chemicals on spontaneously contracting primary cultured rat skeletal muscle cells Toxicology in Vitro 10, 395-406.
    • (1996) Toxicology in Vitro , vol.10 , pp. 395-406
    • Gülden, M.1    Seibert, H.2
  • 21
    • 0000095031 scopus 로고
    • Of bacteria and men: Toxicity of 30 MEIC chemicals to bacteria and humans
    • Kerszman, G. (1993). Of bacteria and men: toxicity of 30 MEIC chemicals to bacteria and humans. AT.LA 21, 233-238.
    • (1993) ATLA , vol.21 , pp. 233-238
    • Kerszman, G.1
  • 22
    • 0009869946 scopus 로고    scopus 로고
    • Main features of basal cytotoxicity: Sites of toxic action and interaction in the pollen tube cell
    • Kristen, U. (1996) Main features of basal cytotoxicity: sites of toxic action and interaction in the pollen tube cell ATLA 24, 429-434
    • (1996) ATLA , vol.24 , pp. 429-434
    • Kristen, U.1
  • 23
    • 0030967272 scopus 로고    scopus 로고
    • Use of higher plants as screens for toxicity assessment
    • Kristen, U (1997) Use of higher plants as screens for toxicity assessment Toxicology in Vitro 11, 181-191.
    • (1997) Toxicology in Vitro , vol.11 , pp. 181-191
    • Kristen, U.1
  • 24
    • 0344141231 scopus 로고
    • Relationship between cytotoxicity in vitro and whole animal toxicity
    • Smith, C.G., Grady J.E. & Northam, J.I. (1963). Relationship between cytotoxicity in vitro and whole animal toxicity Cancer Chemotherapy Reports 30, 9-12
    • (1963) Cancer Chemotherapy Reports , vol.30 , pp. 9-12
    • Smith, C.G.1    Grady, J.E.2    Northam, J.I.3
  • 25
    • 0018892845 scopus 로고
    • Preliminary studies on the validity of in vitro measurement of drug toxicity using HeLa cells. II. Drug toxicity in the MIT-24 system compared with mouse and human lethal dosage of 52 drugs
    • Ekwall, B (1980). Preliminary studies on the validity of in vitro measurement of drug toxicity using HeLa cells. II. Drug toxicity in the MIT-24 system compared with mouse and human lethal dosage of 52 drugs Toxicology Letters 5, 309-317.
    • (1980) Toxicology Letters , vol.5 , pp. 309-317
    • Ekwall, B.1
  • 26
    • 0020956006 scopus 로고
    • Correlation between cytotoxicity in vitro and LD50 values
    • Ekwall, B (1983). Correlation between cytotoxicity in vitro and LD50 values Acta Pharmacologica et Toxicologica 52, Suppl 2, 80-99
    • (1983) Acta Pharmacologica et Toxicologica , vol.52 , Issue.2 SUPPL. , pp. 80-99
    • Ekwall, B.1
  • 27
    • 0021157768 scopus 로고
    • On the application of cultured neuroblastoma cells in chemical toxicity screening
    • Walum, E & Peterson, A. (1984) On the application of cultured neuroblastoma cells in chemical toxicity screening, Journal of Toxicology and Environmental Health 13, 511-520
    • (1984) Journal of Toxicology and Environmental Health , vol.13 , pp. 511-520
    • Walum, E.1    Peterson, A.2
  • 28
    • 0023402386 scopus 로고
    • Comparison of the in vitro cytotoxicities and acute in vivo toxicities of 59 chemicals
    • Clothier, R.H , Hulme, L M , Smith, M & Balls, M (1987.) Comparison of the in vitro cytotoxicities and acute in vivo toxicities of 59 chemicals. Molecular Toxicology 1, 571-577
    • (1987) Molecular Toxicology , vol.1 , pp. 571-577
    • Clothier, R.H.1    Hulme, L.M.2    Smith, M.3    Balls, M.4
  • 29
    • 0023485253 scopus 로고
    • Besitzt die Vorhersage der LD50 mit Hilfe der Zellkultur Allmeingultigkeit?
    • Halle, W, Gores, E & Baeger I (1987) Besitzt die Vorhersage der LD50 mit Hilfe der Zellkultur Allmeingultigkeit? (Can the results from the prediction of LD50 by cell cultures be generalised?) Farmazie 42, 848-850
    • (1987) Farmazie , vol.42 , pp. 848-850
    • Halle, W.1    Gores, E.2    Baeger, I.3
  • 30
    • 0003490357 scopus 로고
    • Hepatocytes in primary culture. an alternative to LD50 testing? Validation of a predictive model by multivariate analysis
    • Peloux. A-F , Fédérici, C , Bichet. N , Gouy, D & Cano, J-P (1992) Hepatocytes in primary culture. an alternative to LD50 testing? Validation of a predictive model by multivariate analysis ATLA 20, 8-26.
    • (1992) ATLA , vol.20 , pp. 8-26
    • Peloux, A.-F.1    Fédérici, C.2    Bichet, N.3    Gouy, D.4    Cano, J.-P.5
  • 31
    • 0000952337 scopus 로고
    • The use of basal cytotoxicity and target organ toxicity tests in hazard identification and risk assessment
    • Balls, M & Fentem, J.H. (1992) The use of basal cytotoxicity and target organ toxicity tests in hazard identification and risk assessment. ATLA 20, 368-388.
    • (1992) ATLA , vol.20 , pp. 368-388
    • Balls, M.1    Fentem, J.H.2
  • 32
    • 2542551017 scopus 로고    scopus 로고
    • Reduktion der Tierzahlen fur die akute orale Toxizität
    • Halle, W , Liebsch, M., Traue, D. & Spielmann, H. (1997). Reduktion der Tierzahlen fur die akute orale Toxizität (Reduction in the number of animals used for the classification of the acute oral toxicity of chemicals by taking into account cytotoxicity data from the Registry of Cytotoxicity). ALTEX 14, 8-15.
    • (1997) ALTEX , vol.14 , pp. 8-15
    • Halle, W.1    Liebsch, M.2    Traue, D.3    Spielmann, H.4
  • 34
    • 0027433375 scopus 로고
    • Cytotoxicity of the MEIC test chemicals in primary neurone cultures
    • Weiss, M T & Sawyer, T.W. (1993). Cytotoxicity of the MEIC test chemicals in primary neurone cultures. Toxicology in Vitro 7, 653-667.
    • (1993) Toxicology in Vitro , vol.7 , pp. 653-667
    • Weiss, M.T.1    Sawyer, T.W.2
  • 35
    • 0028231276 scopus 로고
    • The cytotoxicity of 50 chemicals from the MEIC study determined by growth inhibition of ascites sarcoma BP8 cells: A comparison with acute toxicity data in man and rodents
    • Romert, L., Jansson, T. & Jenssen, D. (1994). The cytotoxicity of 50 chemicals from the MEIC study determined by growth inhibition of ascites sarcoma BP8 cells: a comparison with acute toxicity data in man and rodents Toxicology Letters 71, 39-46
    • (1994) Toxicology Letters , vol.71 , pp. 39-46
    • Romert, L.1    Jansson, T.2    Jenssen, D.3
  • 36
    • 0028345560 scopus 로고
    • Human acute toxicity prediction of the first 50 MEIC chemicals by a battery of ecotoxicological tests and physicochemical properties
    • Calleja, M.C., Persoone, G. & Geladi, P. (1994). Human acute toxicity prediction of the first 50 MEIC chemicals by a battery of ecotoxicological tests and physicochemical properties. Food and Chemical Toxicology 32, 173-187.
    • (1994) Food and Chemical Toxicology , vol.32 , pp. 173-187
    • Calleja, M.C.1    Persoone, G.2    Geladi, P.3
  • 38
    • 0027942071 scopus 로고
    • The use of cultured skeletal muscle cells in testing for acute systemic toxicity
    • Gulden, M , Seibert, H & Voss, J-U (1994) The use of cultured skeletal muscle cells in testing for acute systemic toxicity. Toxicology in Vitro 8, 779-782.
    • (1994) Toxicology in Vitro , vol.8 , pp. 779-782
    • Gulden, M.1    Seibert, H.2    Voss, J.-U.3
  • 40
    • 0028146664 scopus 로고
    • In vitro cytotoxicity testing for prediction of acute human toxicity
    • Barile, F A , Dierickx P J & Kristen U. (1994) In vitro cytotoxicity testing for prediction of acute human toxicity Cell Biology and Toxicology 10, 155-162
    • (1994) Cell Biology and Toxicology , vol.10 , pp. 155-162
    • Barile, F.A.1    Dierickx, P.J.2    Kristen, U.3
  • 41
    • 0001162024 scopus 로고
    • Potential of human lung cells for predicting acute toxicity
    • Barile, F.A . Alexander, D & Sookhoo, A (1995). Potential of human lung cells for predicting acute toxicity ATLA 23, 461-468
    • (1995) ATLA , vol.23 , pp. 461-468
    • Barile, F.A.1    Alexander, D.2    Sookhoo, A.3
  • 42
    • 2542562878 scopus 로고    scopus 로고
    • Evaluation of the cytotoxic effects of MEIC chemicals 31-50 on primary cultures of rat hepatocytes and hepatic and nonhepatic cell lines
    • Ponsoda, X , Núnez, C , Castell J V. & Gómez-Lechón, M J (1997) Evaluation of the cytotoxic effects of MEIC chemicals 31-50 on primary cultures of rat hepatocytes and hepatic and nonhepatic cell lines ATLA 25, 423-436
    • (1997) ATLA , vol.25 , pp. 423-436
    • Ponsoda, X.1    Núnez, C.2    Castell, J.V.3    Gómez-Lechón, M.J.4
  • 43
    • 0001044613 scopus 로고    scopus 로고
    • Dynamic qualities of validation and the evolution of new in vitro toxicological tests
    • Walum, E , Forsby, A , Clemedson, C & Ekwall, B (1996) Dynamic qualities of validation and the evolution of new in vitro toxicological tests. ATLA 24, 333-338
    • (1996) ATLA , vol.24 , pp. 333-338
    • Walum, E.1    Forsby, A.2    Clemedson, C.3    Ekwall, B.4
  • 44
    • 2542573862 scopus 로고    scopus 로고
    • Nar, Sweden. CTLU
    • Ekwall. B (1997) The EDIT programme. Web site http wwv.ctlu se Nar, Sweden. CTLU
    • (1997) The EDIT Programme
    • Ekwall, B.1
  • 45
    • 2542525594 scopus 로고    scopus 로고
    • An animal protection sponsor's view of MEIC
    • Thurston, E. (1997). An animal protection sponsor's view of MEIC ATLA 25, 343-345
    • (1997) ATLA , vol.25 , pp. 343-345
    • Thurston, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.