Overview of the final MEIC results: I. The in vitro--in vitro evaluation

Toxicology in Vitro

Volumn 13, Issue 4-5, 1999, Pages 657-663

  Clemedson, C ^a   Ekwall, B ^a  

^a CTLU   (Sweden)

Author keywords

Acute toxicity; Alternatives; Basal cytotoxicity; Cell tests; Chemicals; ecotoxicology; Evaluation; Principal components analysis; Toxicity testing

Indexed keywords

1,1,1 TRICHLOROETHANE; 2 PROPANOL; 2,4 DICHLOROPHENOXYACETIC ACID; ACETYLSALICYLIC ACID; ALCOHOL; AMITRIPTYLINE; DEXTROPROPOXYPHENE; DIAZEPAM; DIGOXIN; ETHYLENE GLYCOL; FERROUS SULFATE; FLUORIDE SODIUM; LITHIUM SULFATE; MALATHION; METHANOL; NICOTINE; PARACETAMOL; PHENOBARBITAL; PHENOL; POTASSIUM CYANIDE; PROPRANOLOL; SODIUM CHLORIDE; THEOPHYLLINE; UNINDEXED DRUG; XYLENE;

CELL LINE; CONFERENCE PAPER; CYTOTOXICITY; DIAGNOSTIC TEST; ECOTOXICOLOGY; EVALUATION; HUMAN; IN VITRO STUDY; MEASUREMENT; NONHUMAN; STANDARDIZATION; TOXICITY;

EID: 0032865119     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(99)00060-0     Document Type: Conference Paper

References (6)

1. Clemedson C., McFarlane-Abdulla E., Andersson M., Barile F.A., Calleja M.C., Chesné C., Clothier R., Cottin M., Curren R., Daniel-Szolgay E., Dierickx P., Ferro M., Fiskesjö G., Garza-Ocanas L., Gómez-Lechón M.J., Gülden M., Isomaa B., Janus J., Judge P., Kahru A., Kemp R.B., Kerszman G., Kristen U., Kunimoto M., Kärenlampi S., Lavrijsen K., Lewan L., Lilius H., Ohno T., Persoone G., Roguet R., Romert L., Sawyer T., Seibert H., Shrivastava R., Stammati A., Tanaka N., Torres Alanis O., Voss J-U., Wakuri S., Walum E., Wang X., Zucco F., Ekwall B. MEIC evaluation of acute systemic toxicity. Part I. Methodology of 68 in vitro toxicity assays used to test the first 30 reference chemicals. ATLA. 24:(Suppl. 1):1996;249-272.
2. Clemedson C., McFarlane-Abdulla E., Andersson M., Barile F.A., Calleja M.C., Chesné C., Clothier R., Cottin M., Curren R., Dierickx P., Ferro M., Fiskesjö G., Garza-Ocanas L., Gómez-Lechón M.J., Gülden M., Isomaa B., Janus J., Judge P., Kahru A., Kemp R.B., Kerszman G., Kristen U., Kunimoto M., Kärenlampi S., Lavrijsen K., Lewan L., Lilius H., Malmsten A., Ohno T., Persoone G., Pettersson R., Roguet R., Romert L., Sandberg M., Sawyer T., Seibert H., Shrivastava R., Sjöström M., Stammati A., Tanaka N., Torres Alanis O., Voss J-U., Wakuri S., Walum E., Wang X., Zucco F., Ekwall B. MEIC evaluation of acute systemic toxicity. Part II. In vitro results from 68 toxicity assays used to test the first 30 reference chemicals and a comparative cytotoxicity analysis. ATLA. 24:(Suppl. 1):1996;273-311.
3. Clemedson C., Barile F.A., Ekwall B., Gómez-Lechón M.J., Hall T., Imai K., Kahru A., Logemann P., Monaco F., Ohno T., Segner H., Sjöström M., Valentino M., Walum E., Wang X., Ekwall B. MEIC evaluation of acute systemic toxicity: Part III. In vitro results from 16 additional methods used to test the first 30 reference chemicals and a comparative cytotoxicity analysis. ATLA. 26:(Suppl. 1):1998;93-129.
4. Clemedson C., Aoki Y., Andersson M., Barile F.A., Bassi A.M., Calleja M.C., Castano A., Clothier R.H., Dierickx P., Ekwall Ba, Ferro M., Fiskesjö G., Garza-Ocanas L., Gómez-Lechón M.J., Gülden M., Hall T., Imai K., Isomaa B., Kahru A., Kerszman G., Kjellstrand P., Kristen U., Kunimoto M., Kärenlampi S., Lewan L., Lilius H., Loukianov A., Monaco F., Ohno T., Persoone G., Romert L., Sawyer T.W., Shrivastava R., Segner H., Seibert H., Sjöström M., Stammati A., Tanaka N., Thuvander A., Torres-Alanis O., Valentino M., Wakuri S., Walum E., Wieslander A., Wang X., Zucco F., Ekwall B. MEIC evaluation of acute systemic toxicity. Part IV. In vitro results from 67 toxicity assays used to test reference chemicals 31-50 and a comparative cytotoxicity analysis. ATLA. 26:(Suppl. 1):1998;131-183.
5. Ekwall B. (1995) The basal cytotoxicity concept. In Alternative Methods in Toxicology and the Life Sciences, Vol. 11, The World Congress on Alternatives and Animal Use in the Life Sciences; Education, Research, Testing. Edited by A. M. Goldberg and L. F. M. van Zupthen, pp. 721-725. Mary Ann Liebert, New York.
6. Ekwall B. Overview of the Final MEIC Results: II. The in vitro-in vivo evaluation, including a selection of a practical battery of cell tests for prediction of acute lethal blood concentrations in humans. Toxicology in Vitro. 13:1999;665-673.