Estimation of acute oral toxicity using the No Observed Adverse Effect Level (NOAEL) from the 28 day repeated dose toxicity studies in rats

Regulatory Toxicology and Pharmacology

Volumn 53, Issue 1, 2009, Pages 16-19

  Bulgheroni, Anna ^a   Kinsner Ovaskainen, Agnieszka ^a   Hoffmann, Sebastian ^a   Hartung, Thomas ^a   Prieto, Pilar ^a  

^a JOINT RESEARCH CENTRE   (Italy)

Author keywords

3Rs; Acute oral toxicity; GHS category; NOAEL

Indexed keywords

COSMETIC;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TESTING REDUCTION; ANIMAL TISSUE; ARTICLE; CLASSIFICATION; CONTROLLED STUDY; DATA BASE; DRUG CLASSIFICATION; DRUG INDUSTRY; DRUG MIXTURE; DRUG REEXPOSURE; LD 50; MARKETING; NO OBSERVED ADVERSE EFFECT LEVEL; NONHUMAN; PRIORITY JOURNAL; RAT; REPEATED DRUG DOSE; SAFETY; SCORING SYSTEM; TOXICITY TESTING; TOXICOKINETICS; UNITED NATIONS GLOBALLY HARMONIZED SYSTEM;

ACUTE TOXICITY TESTS; ADMINISTRATION, ORAL; ANIMAL TESTING ALTERNATIVES; ANIMALS; CLINICAL TRIALS AS TOPIC; COSMETICS; DATABASES, FACTUAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG INDUSTRY; EUROPEAN UNION; HUMANS; LETHAL DOSE 50; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RATS;

ANIMALIA; RATTUS;

EID: 58749111973     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2008.10.001     Document Type: Article

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