Estimation of human blood LC50 values for use in modeling of in vitro-in vivo data of the ACuteTox project

Toxicology in Vitro

Volumn 22, Issue 5, 2008, Pages 1405-1411

  Sjöström, Michael ^a   Kolman, Ada ^b   Clemedson, Cecilia ^b   Clothier, Richard ^c  

^a UMEÅ UNIVERSITY   (Sweden)

^b Expertrådet Environmental Competence AB   (Sweden)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

3T3 NRU; ACuteTox; Human LC50 values; IC50 values; In vitro in vivo modeling

Indexed keywords

2 PROPANOL; ACETYLSALICYLIC ACID; ALCOHOL; AMIODARONE; BENZ[A]ANTHRACENE; BENZENE; CADMIUM CHLORIDE; CAFFEINE; CARBAMAZEPINE; COLCHICINE; CYCLOHEXIMIDE; DIAZEPAM; DIGOXIN; DODECYL SULFATE SODIUM; FLUOROURACIL; LINDANE; MALATHION; MERCURY CHLORIDE; NICOTINE; PARACETAMOL; PENTACHLOROBENZENE; PENTACHLOROPHENOL; PHENANTHRENE; PYRENE; RIFAMPICIN; TERT BUTYL HYDROPEROXIDE; TETRACYCLINE; UNINDEXED DRUG; VALPROIC ACID; VERAPAMIL;

ANALYTIC METHOD; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DATA BASE; HUMAN; INTOXICATION; LC 50; LINEAR REGRESSION ANALYSIS; STATISTICAL ANALYSIS; TOXICITY TESTING;

3T3 CELLS; ACUTE TOXICITY TESTS; ANIMAL TESTING ALTERNATIVES; ANIMALS; ENDPOINT DETERMINATION; EUROPEAN UNION; HUMANS; INHIBITORY CONCENTRATION 50; MICE; PREDICTIVE VALUE OF TESTS; XENOBIOTICS;

ANIMALIA;

EID: 44749094190     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.04.017     Document Type: Article

References (11)

1. Belsley D.A., Kuh E., and Welsch R.E. Regression Diagnostics: Identifying Influential Data and Sources of Collinearity (1980), Wiley, New York
2. Clemedson C., Kolman A., and Forsby A. The integrated Acute Systemic Toxicity Project (ACuteTox) for the optimization and validation of alternative in vitro tests. ATLA 35 (2007) 33-38
3. Clothier R.H. Phototoxicity and acute toxicity studies conducted by the FRAME Alternatives Laboratory: a brief review. ATLA 35 (2007) 515-519
4. Clothier R.H., Hulme L.M., Smith M., and Balls M. Comparison of the in vitro cytotoxicities and acute in vivo toxicities of 59 chemicals. Molecular Toxicology 1 (1987) 571-577
5. Ekwall B., Clemedson C., Crafoord B., Ekwall B., Hallander S., Walum E., and Bondesson I. MEIC evaluation of acute systemic toxicity. Part V. Rodent and human toxicity data for the 50 reference chemicals. ATLA 26 (1998) 571-616
6. Ekwall B., Barile F.A., Castano A., Clemedson C., Clothier R.H., Dierickx P., Ekwall Ba., et al. MEIC evaluation of acute systemic toxicity. Part VI. The prediction of human toxicity by rodent LD50 values and results from 61 in vitro tests. ATLA 26 (1998) 617-658
7. Ekwall B., Ekwall Ba., and Sjöström M. MEIC evaluation of acute systemic toxicity. Part VIII. Multivariate partial least squares evaluation, including the selection of a battery of cell line tests with a good prediction of human acute lethal peak blood concentrations for 50 chemicals. ATLA 28 (2000) 201-234
8. Halle W. The Registry of Cytotoxicity: toxicity testing in cell cultures to predict acute toxicity (LD50) and to reduce testing in animals. ATLA 31 (2003) 89-198
9. Pearson K. Mathematical contributions to the theory of evolution: III. Regression, heredity, and panmixia. Philosophical Transactions of the Royal Society 187 (1896) 253-318
10. Website address: www.acutetox.org.
11. Website address: (accessed 13.08.07).