Cross-sector review of drivers and available 3Rs approaches for acute systemic toxicity testing

Toxicological Sciences

Volumn 116, Issue 2, 2010, Pages 382-396

  Seidle, Troy ^a,b   Robinson, Sally ^c   Holmes, Tom ^d,i   Creton, Stuart ^e   Prieto, Pilar ^f   Scheel, Julia ^g   Chlebus, Magda ^h  

^a Humane Society International   (Belgium)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c ASTRAZENECA   (United Kingdom)

^d UK   (United Kingdom)

^e National Centre for the Replacement   (United Kingdom)

^f JOINT RESEARCH CENTRE   (Italy)

^g HENKEL KGAA   (Germany)

^h CEE Region Affairs and Animal Welfare   (Belgium)

ⁱ Agchem Project Consulting   (United Kingdom)

Author keywords

3Rs; Acute toxicity; Harmonization; Hazard labeling; Limit dose; Redundancy; Regulatory classification; Systemic toxicity

Indexed keywords

AGRICULTURAL CHEMICAL; BIOCIDE; COSMETIC;

ACUTE TOXICITY; CROSS-SECTIONAL STUDY; DRIVER; DRUG INDUSTRY; HUMAN; NONHUMAN; OCCUPATIONAL EXPOSURE; OCCUPATIONAL TOXICOLOGY; QUESTIONNAIRE; REVIEW; TOXICITY TESTING; ANIMAL; ANIMAL TESTING ALTERNATIVE; BIOASSAY; LD 50; PRACTICE GUIDELINE; PROCEDURES;

ANIMAL TESTING ALTERNATIVES; ANIMALS; ENDPOINT DETERMINATION; GUIDELINES AS TOPIC; HUMANS; LETHAL DOSE 50; TOXICITY TESTS, ACUTE;

EID: 77955168444     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq143     Document Type: Review

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