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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 10, 2013, Pages 2951-2954

Novel ROS-activated agents utilize a tethered amine to selectively target acute myeloid leukemia

(7) Bell Horwath, Tiffany R a Vadukoot, Anish K a Thowfeik, Fathima Shazna a Li, Guorui a Wunderlich, Mark a Mulloy, James C b Merino, Edward J a

a UNIVERSITY OF CINCINNATI (United States)

b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER (United States)

Author keywords

DNA modifying agent Acute myeloid leukemia 2 Deoxyguanosine Reactive oxygen species Structure activity

Indexed keywords

ANTINEOPLASTIC AGENT; CD4 ANTIGEN; CHLORAMBUCIL; CISPLATIN; CYTARABINE; DOXORUBICIN; REACTIVE OXYGEN ACTIVATED DNA MODIFYING AGENT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DNA MODIFICATION; DRUG POTENCY; HUMAN; HUMAN CELL; IC 50; STEM CELL;

AMINES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MOLECULAR STRUCTURE; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84876692575 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.03.048 Document Type: Article

Times cited : (14)

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