-
1
-
-
2042437650
-
Initial sequencing and analysis of the human genome
-
Lander ES, Linton LM, Birren B et al. Initial sequencing and analysis of the human genome. Nature 409, 860-921 (2001).
-
(2001)
Nature
, vol.409
, pp. 860-921
-
-
Lander, E.S.1
Linton, L.M.2
Birren, B.3
-
3
-
-
7244245762
-
Finishing the euchromatic sequence of the human genome
-
Collins FS, Lander ES, Rogers J et al. Finishing the euchromatic sequence of the human genome. Nature 431, 931-945 (2004).
-
(2004)
Nature
, vol.431
, pp. 931-945
-
-
Collins, F.S.1
Lander, E.S.2
Rogers, J.3
-
4
-
-
79951481957
-
Initial impact of the sequencing of the human genome
-
Lander ES. Initial impact of the sequencing of the human genome. Nature 470, 187-197 (2011).
-
(2011)
Nature
, vol.470
, pp. 187-197
-
-
Lander, E.S.1
-
5
-
-
79951475133
-
A decade's perspective on DNA sequencing technology
-
Mardis ER. A decade's perspective on DNA sequencing technology. Nature 470, 198-203 (2011).
-
(2011)
Nature
, vol.470
, pp. 198-203
-
-
Mardis, E.R.1
-
6
-
-
77956838065
-
Advances in understanding cancer genomes through second-generation sequencing
-
Meyerson M, Gabriel S, Getz G. Advances in understanding cancer genomes through second-generation sequencing. Nat. Rev. Genet. 11, 685-696 (2010).
-
(2010)
Nat. Rev. Genet.
, vol.11
, pp. 685-696
-
-
Meyerson, M.1
Gabriel, S.2
Getz, G.3
-
7
-
-
79952610870
-
Making sense of cancer genomic data
-
Chin L, Hahn WC, Getz G, Meyerson M. Making sense of cancer genomic data. Genes Dev. 25, 534-555 (2011).
-
(2011)
Genes Dev.
, vol.25
, pp. 534-555
-
-
Chin, L.1
Hahn, W.C.2
Getz, G.3
Meyerson, M.4
-
8
-
-
84864599271
-
Small-molecule kinase inhibitors: From lab bench to clinic
-
Kenefick K. Small-molecule kinase inhibitors: From lab bench to clinic. Cell Notes 16, 26-29 (2006).
-
(2006)
Cell Notes
, vol.16
, pp. 26-29
-
-
Kenefick, K.1
-
9
-
-
33745489431
-
Oxidative and nitrative damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis
-
Kawanishi S, Hiraku Y, Pinlaor S, Ma N. Oxidative and nitrative damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis. Biol. Chem. 387(4), 365-372 (2006).
-
(2006)
Biol. Chem.
, vol.387
, Issue.4
, pp. 365-372
-
-
Kawanishi, S.1
Hiraku, Y.2
Pinlaor, S.3
Ma, N.4
-
10
-
-
0026021362
-
Production of large amounts of hydrogen peroxide by human tumor cells
-
Szatrowski TP, Nathan CF. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 51, 794-798 (1991).
-
(1991)
Cancer Res.
, vol.51
, pp. 794-798
-
-
Szatrowski, T.P.1
Nathan, C.F.2
-
11
-
-
1442360000
-
Intrinsic oxidative stress in cancer cells: A biochemical basis for therapeutic selectivity
-
Hileman EO, Liu J, Albitar M, Keating MJ, Huang P. Intrinsic oxidative stress in cancer cells: A biochemical basis for therapeutic selectivity. Cancer Chemother. Pharmacol. 53, 209-219 (2004).
-
(2004)
Cancer Chemother. Pharmacol.
, vol.53
, pp. 209-219
-
-
Hileman, E.O.1
Liu, J.2
Albitar, M.3
Keating, M.J.4
Huang, P.5
-
12
-
-
0028900690
-
Persistant oxidative stress in cancer
-
Toyokuni S, Okamoto K, Yodoi J, Hiai H. Persistant oxidative stress in cancer. FEBS Lett. 358, 1-3 (1995).
-
(1995)
FEBS Lett.
, vol.358
, pp. 1-3
-
-
Toyokuni, S.1
Okamoto, K.2
Yodoi, J.3
Hiai, H.4
-
13
-
-
0035826733
-
Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1
-
Arnold RS, Shi J, Murad E et al. Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proc. Natl Acad. Sci. USA 98, 5550-5555 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 5550-5555
-
-
Arnold, R.S.1
Shi, J.2
Murad, E.3
-
14
-
-
43249112094
-
ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis
-
Ishikawa K, Takenaga K, Akimoto M et al ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science 320, 661-664 (2008).
-
(2008)
Science
, vol.320
, pp. 661-664
-
-
Ishikawa, K.1
Takenaga, K.2
Akimoto, M.3
-
15
-
-
64549096768
-
Reduction of hydrophilic ubiquinones by the flavin in mitochondrial NADH:ubiquinone oxidoreductase (complex I) and production of reactive oxygen species
-
King MS, Sharpley MS, Hirst J. Reduction of hydrophilic ubiquinones by the flavin in mitochondrial NADH:ubiquinone oxidoreductase (complex I) and production of reactive oxygen species. Biochemistry 48, 2053-2062 (2009).
-
(2009)
Biochemistry
, vol.48
, pp. 2053-2062
-
-
King, M.S.1
Sharpley, M.S.2
Hirst, J.3
-
16
-
-
0042705073
-
Reactive oxygen species mediate doxorubicin induced p53-independent apoptosis
-
Tsang WP, Chau SP, Kong SK, Kwok TT. Reactive oxygen species mediate doxorubicin induced p53-independent apoptosis. Life Sci. 73, 2047-2058 (2003).
-
(2003)
Life Sci.
, vol.73
, pp. 2047-2058
-
-
Tsang, W.P.1
Chau, S.P.2
Kong, S.K.3
Kwok, T.T.4
-
17
-
-
0036285034
-
C-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability
-
Vafa O, Wade M, Kern S et al. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability. Mol. Cell 9, 1031-1044 (2002).
-
(2002)
Mol. Cell
, vol.9
, pp. 1031-1044
-
-
Vafa, O.1
Wade, M.2
Kern, S.3
-
18
-
-
79951812916
-
Telomere dysfunction induces metabolic and mitochondrial compromise
-
Sahin E, Colla S, Liesa M et al. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 470, 359-65 (2011).
-
(2011)
Nature
, vol.470
, pp. 359-365
-
-
Sahin, E.1
Colla, S.2
Liesa, M.3
-
19
-
-
84859987864
-
Reactive oxygen species signaling in cancer: Comparison with aging
-
Afanas'ev I. Reactive oxygen species signaling in cancer: Comparison with aging. Aging Dis. 2, 219-230 (2011).
-
(2011)
Aging Dis.
, vol.2
, pp. 219-230
-
-
Afanas'ev, I.1
-
20
-
-
13244277942
-
Cuznsod deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life
-
Elchuri S, Oberley TD, Qi WB et al. CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene 24, 367-380 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 367-380
-
-
Elchuri, S.1
Oberley, T.D.2
Qi, W.B.3
-
21
-
-
79957977169
-
Do reactive oxygen species play a role in myeloid leukemias
-
Hole PS, Darley RL, Tonks A Do reactive oxygen species play a role in myeloid leukemias? Blood 117, 5816-5826 (2011).
-
(2011)
Blood
, vol.117
, pp. 5816-5826
-
-
Hole, P.S.1
Darley, R.L.2
Tonks, A.3
-
22
-
-
0034699513
-
Superoxide dismutase as a target for the selective killing of cancer cells
-
Huang P, Feng L, Oldham EA, Keating MJ, Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature 407, 390-395 (2000).
-
(2000)
Nature
, vol.407
, pp. 390-395
-
-
Huang, P.1
Feng, L.2
Oldham, E.A.3
Keating, M.J.4
Plunkett, W.5
-
23
-
-
33748146888
-
Selective killing of oncogenically transformed cells through a ros-mediated mechanism by beta-phenylethyl isothiocyanate
-
Trachootham D, Zhou Y, Zhang H et al. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 10, 241-252 (2006).
-
(2006)
Cancer Cell
, vol.10
, pp. 241-252
-
-
Trachootham, D.1
Zhou, Y.2
Zhang, H.3
-
24
-
-
3042739537
-
Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry
-
Young TW, Mei FC, Yang G, Thompson- Lanza JA, Liu J, Cheng X. Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry. Cancer Res. 64, 4577-4584 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 4577-4584
-
-
Young, T.W.1
Mei, F.C.2
Yang, G.3
Thompson- Lanza, J.A.4
Liu, J.5
Cheng, X.6
-
25
-
-
20844447150
-
Controlling tumor growth by modulating endogenous production of reactive oxygen species
-
Laurent A, Nicco C, Chéreau C et al. Controlling tumor growth by modulating endogenous production of reactive oxygen species. Cancer Res. 65, 948-956 (2005).
-
(2005)
Cancer Res.
, vol.65
, pp. 948-956
-
-
Laurent, A.1
Nicco, C.2
Chéreau, C.3
-
26
-
-
18044364401
-
Differential modulation of normal and tumor cell proliferation by reactive oxygen species
-
Nicco C, Laurent A, Chereau C, Weill B, Batteux F. Differential modulation of normal and tumor cell proliferation by reactive oxygen species. Biomed Pharmacother. 59, 169-74 (2005).
-
(2005)
Biomed Pharmacother.
, vol.59
, pp. 169-174
-
-
Nicco, C.1
Laurent, A.2
Chereau, C.3
Weill, B.4
Batteux, F.5
-
27
-
-
0342327329
-
Adaptation to oxidative stress: Quinone-mediated protection of signaling in rat lung epithelial L2 cells
-
Choi J, Liu RM, Forman HJ. Adaptation to oxidative stress: Quinone-mediated protection of signaling in rat lung epithelial L2 cells. Biochem. Pharmacol. 53, 987-993 (1997).
-
(1997)
Iochem. Pharmacol.
, vol.53
, pp. 987-993
-
-
Choi, J.1
Liu, R.M.2
Forman, H.J.3
-
28
-
-
33750616552
-
Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: A review
-
Kim GJ, Chandrasekaran K, Morgan WF. Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: A review. Mutagenesis 21, 361-367 (2006).
-
(2006)
Mutagenesis
, vol.21
, pp. 361-367
-
-
Kim, G.J.1
Chandrasekaran, K.2
Morgan, W.F.3
-
29
-
-
58749084282
-
Nuclear oxidative damage correlates with poor survival in colorectal cancer
-
Sheridan J, Wang LM, Tosetto M et al. Nuclear oxidative damage correlates with poor survival in colorectal cancer. Br. J. Cancer 100, 381-388 (2009
-
(2009)
Br. J. Cancer
, vol.100
, pp. 381-388
-
-
Sheridan, J.1
Wang, L.M.2
Tosetto, M.3
-
30
-
-
0343776197
-
Role of reactive oxygen species in apoptosis: Implications for cancer therapy
-
Mates JM, Sanchez-Jimenez FM. Role of reactive oxygen species in apoptosis: Implications for cancer therapy. Int. J. Biochem. Cell. Biol. 32, 157-170 (2000).
-
(2000)
Int. J. Biochem. Cell. Biol.
, vol.32
, pp. 157-170
-
-
Mates, J.M.1
Sanchez-Jimenez, F.M.2
-
31
-
-
34447093423
-
Superoxide anion: Oncogenic reactive oxygen species
-
Pervaiz S, Clement MV. Superoxide anion: Oncogenic reactive oxygen species? Int. J. Biochem. Cell. Biol. 39, 1297-1304 (2007).
-
(2007)
Int. Biochem. Cell. Biol.
, vol.39
, pp. 1297-1304
-
-
Pervaiz, S.1
Clement, M.V.2
-
32
-
-
25444523184
-
Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity
-
Kong D, Park EJ, Stephen AG et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 65, 9047-9055 (2005).
-
(2005)
Cancer Res.
, vol.65
, pp. 9047-9055
-
-
Kong, D.1
Park, E.J.2
Stephen, A.G.3
-
33
-
-
79959955993
-
Cancer therapeutic agents targeting hypoxia-inducible factor-1
-
Wang R, Zhou S, Li S. Cancer therapeutic agents targeting hypoxia-inducible factor-1. Curr. Med. Chem. 18, 3168-3189 (2011).
-
(2011)
Curr. Med. Chem.
, vol.18
, pp. 3168-3189
-
-
Wang, R.1
Zhou, S.2
Li, S.3
-
34
-
-
79952532412
-
Cancer epigenetics: Linking basic biology to clinical medicine
-
Tsai HC, Baylin SB. Cancer epigenetics: Linking basic biology to clinical medicine. Cell Res. 21, 502-517 (2011).
-
(2011)
Cell Res.
, vol.21
, pp. 502-517
-
-
Tsai, H.C.1
Baylin, S.B.2
-
35
-
-
81255162523
-
Oxidative damage targets complexes containing DNA methyltransferases SIRT1 and polycomb members to promoter CpG Islands
-
O'Hagan HM, Wang W, Sen S et al. Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands. Cancer Cell. 20, 606-619 (2011).
-
(2011)
Cancer Cell.
, vol.20
, pp. 606-619
-
-
O'Hagan, H.M.1
Wang, W.2
Sen, S.3
-
36
-
-
79953870540
-
Targeting hif1a eliminates cancer stem cells in hematological malignancies
-
Wang Y, Liu Y, Malek SN, Zheng P, Liu Y. Targeting HIF1a eliminates cancer stem cells in hematological malignancies. Cell Stem Cell. 8, 399-411 (2011).
-
(2011)
Cell Stem. Cell.
, vol.8
, pp. 399-411
-
-
Wang, Y.1
Liu, Y.2
Malek, S.N.3
Zheng, P.4
Liu, Y.5
-
37
-
-
35448982386
-
Dual effect of echinomycin on hypoxia-inducible factor-1 activity under normoxic and hypoxic conditions
-
Vlaminck B, Toffoli S, Ghislain B, Demazy C, Raes M, Michiels C. Dual effect of echinomycin on hypoxia-inducible factor-1 activity under normoxic and hypoxic conditions. FEBS J. 274, 5533-5542 (2007).
-
(2007)
Febs J.
, vol.274
, pp. 5533-5542
-
-
Vlaminck, B.1
Toffoli, S.2
Ghislain, B.3
Demazy, C.4
Raes, M.5
Michiels, C.6
-
38
-
-
0026718484
-
Echinomycin (NSC 526417) in recurrent and metastatic nonsquamous cell carcinoma of the cervix. A Phase II trial of the gynecologic oncology group
-
Muss HB, Blessing JA, Hanjani P, Malfetano JH, Kemp GM, Webster K. Echinomycin (NSC 526417) in recurrent and metastatic nonsquamous cell carcinoma of the cervix. A Phase II trial of the gynecologic oncology group. Am. J. Clin. Oncol. 15, 363-364 (1992).
-
(1992)
Am. J. Clin. Oncol.
, vol.15
, pp. 363-364
-
-
Muss, H.B.1
Blessing, J.A.2
Hanjani, P.3
Malfetano, J.H.4
Kemp, G.M.5
Webster, K.6
-
39
-
-
0027132564
-
Echinomycin in recurrent and metastatic endometrial carcinoma
-
A Phase II trial of the Gynecologic Oncology Group
-
Muss HB, Blessing JA, DuBeshter B. Echinomycin in recurrent and metastatic endometrial carcinoma. A Phase II trial of the Gynecologic Oncology Group. Am. J. Clin. Oncol. 16, 492-493 (1993).
-
(1993)
Am. J. Clin. Oncol.
, vol.16
, pp. 492-493
-
-
Muss, H.B.1
Blessing, J.A.2
DuBeshter, B.3
-
40
-
-
2942590732
-
Exploiting tumor hypoxia in cancer treatment
-
Brown JM, Wilson WR. Exploiting tumor hypoxia in cancer treatment. Nat. Rev. Cancer 4, 437-447 (2004).
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 437-447
-
-
Brown, J.M.1
Wilson, W.R.2
-
41
-
-
80051628334
-
Pronounced hypoxia in models of murine and human leukemia: High efficacy of hypoxia-activated prodrug PR-104
-
Benito J, Shi Y, Szymanska B et al. Pronounced hypoxia in models of murine and human leukemia: High efficacy of hypoxia-activated prodrug PR-104. PloS ONE 6, e23108 (2011).
-
(2011)
Plos One
, vol.6
-
-
Benito, J.1
Shi, Y.2
Szymanska, B.3
-
42
-
-
34447122556
-
Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104
-
Patterson AV, Ferry DM, Edmunds SJ et al. Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104. Clin. Cancer Res. 13, 3922-3932 (2007)
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 3922-3932
-
-
Patterson, A.V.1
Ferry, D.M.2
Edmunds, S.J.3
-
43
-
-
58149105356
-
Cancer cell killing via ROS: To increase or decrease, that is the question
-
Wang J, Yi J. Cancer cell killing via ROS:T o increase or decrease, that is the question. Cancer Biol. Ther. 7, 1875-1884 (2008).
-
(2008)
Cancer Biol. Ther.
, vol.7
, pp. 1875-1884
-
-
Wang, J.1
Yi, J.2
-
44
-
-
33144488485
-
Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir
-
Alexandre J, Nicco C, Chéreau C. Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir. J. Natl Cancer Inst. 98, 236-244 (2006).
-
(2006)
J. Natl Cancer Inst.
, vol.98
, pp. 236-244
-
-
Alexandre, J.1
Nicco, C.2
Chéreau, C.3
-
45
-
-
0141509869
-
Inhibition of mitochondrial respiration: A novel strategy to enhance drug-induced apoptosis in human cells by a reactive oxygen species-mediated mechanism
-
Pelicano H, Feng L, Zhou Y et al. Inhibition of mitochondrial respiration: A novel strategy to enhance drug-induced apoptosis in human cells by a reactive oxygen species-mediated mechanism. J. Biol. Chem. 278, 37832-37839 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 37832-37839
-
-
Pelicano, H.1
Feng, L.2
Zhou, Y.3
-
46
-
-
67650071137
-
Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic appoach
-
Trachootham, D, Alexandre J, Huang P. Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic appoach? Nat. Rev. Drug. Discov. 8, 579-591 (2009).
-
(2009)
Nat. Rev. Drug. Discov.
, vol.8
, pp. 579-591
-
-
Trachootham, D.1
Alexandre, J.2
Huang, P.3
-
47
-
-
2942593991
-
Ros stress in cancer cells and the therapeutic implications
-
Pelicano H, Carney D, Huang P. ROS stress in cancer cells and the therapeutic implications. Drug Resist. Update 7, 97-110 (2004).
-
(2004)
Drug Resist. Update
, vol.7
, pp. 97-110
-
-
Pelicano, H.1
Carney, D.2
Huang, P.3
-
48
-
-
34248396033
-
Dual role of hydrogen peroxide in cancer: Possible relevance to cancer chemoprevention and therapy
-
Lopez-Lazaro M. Dual role of hydrogen peroxide in cancer: Possible relevance to cancer chemoprevention and therapy. Cancer Lett. 252, 1-8 (2007).
-
(2007)
Cancer Lett.
, vol.252
, pp. 1-8
-
-
Lopez-Lazaro, M.1
-
49
-
-
64149087422
-
Therapeutic strategies by modulating oxygen stress in cancer and inflammation
-
Fang J, Seki T, Maeda H. Therapeutic strategies by modulating oxygen stress in cancer and inflammation. Adv. Drug Deliv. Rev. 61, 290-302 (2009).
-
(2009)
Adv. Drug Deliv. Rev.
, vol.61
, pp. 290-302
-
-
Fang, J.1
Seki, T.2
Maeda, H.3
-
50
-
-
33748165596
-
Reactive oxygen species in cancer cells: Live by the sword die by the sword
-
Schumacker PT. Reactive oxygen species in cancer cells: Live by the sword, die by the sword. Cancer Cell. 10, 175-176 (2006).
-
(2006)
Cancer Cell.
, vol.10
, pp. 175-176
-
-
Schumacker, P.T.1
-
51
-
-
0033568238
-
Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway
-
Jing Y, Dai J, Chalmers-Redman RM, Tatton WG, Waxman S. Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Blood 94, 2102-2111 (1999).
-
(1999)
Blood
, vol.94
, pp. 2102-2111
-
-
Jing, Y.1
Dai, J.2
Chalmers-Redman, R.M.3
Tatton, W.G.4
Waxman, S.5
-
52
-
-
0031011174
-
Role of reactive oxygen species in cis-diclorodiammineplatinum-induced cytotoxicity on bladder cancer cells
-
Miyajima A, Nakashima J, Yoshioka K, Tachibana M, Tazaki H, Murai M. Role of reactive oxygen species in cis-diclorodiammineplatinum-induced cytotoxicity on bladder cancer cells. Br. J. Cancer 76, 206-210 (1997).
-
(1997)
Br. J. Cancer
, vol.76
, pp. 206-210
-
-
Miyajima, A.1
Nakashima, J.2
Yoshioka, K.3
Tachibana, M.4
Tazaki, H.5
Murai, M.6
-
53
-
-
82755166890
-
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
-
Anastasious D, Poulogiannis G, Asara JM et al. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 334, 1278-1283 (2011).
-
(2011)
Science
, vol.334
, pp. 1278-1283
-
-
Anastasious, D.1
Poulogiannis, G.2
Asara, J.M.3
-
54
-
-
0035874967
-
Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins
-
Lee SH, Oe T, Blair IA. Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins. Science 292, 2083-2086 (2001).
-
(2001)
Science
, vol.292
, pp. 2083-2086
-
-
Lee, S.H.1
Oe, T.2
Blair, I.A.3
-
55
-
-
33845472110
-
Preventive effects of vitamin c on carcinogenesis
-
Lee KW, Lee HJ, Kang KS, Lee CY. Preventive effects of vitamin C on carcinogenesis. Lancet 359, 172 (2002).
-
(2002)
Lancet
, vol.359
, pp. 172
-
-
Lee, K.W.1
Lee, H.J.2
Kang, K.S.3
Lee, C.Y.4
-
56
-
-
19344368071
-
Chemopreventive and therapeutic effects of curcumin
-
Duvoix A, Blasius R, Delhalle S et al. Chemopreventive and therapeutic effects of curcumin. Cancer Lett. 223, 181-190 (2005).
-
(2005)
Cancer Lett.
, vol.223
, pp. 181-190
-
-
Duvoix, A.1
Blasius, R.2
Delhalle, S.3
-
57
-
-
0034176645
-
The antioxidant paradox
-
Halliwell B. The antioxidant paradox. Lancet 355, 1179-1180 (2000).
-
(2000)
Lancet
, vol.355
, pp. 1179-1180
-
-
Halliwell, B.1
-
58
-
-
33646517942
-
Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo
-
Alexandre J, Batteux F, Nicco C et al. Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo. Int. J. Cancer 119, 41-48 (2006).
-
(2006)
Int. J. Cancer
, vol.119
, pp. 41-48
-
-
Alexandre, J.1
Batteux, F.2
Nicco, C.3
-
59
-
-
37849018320
-
Antioxidants block proteasome inhibitor function in endometrial carcinoma cells
-
Llobet D, Eritja N, Encinas M et al. Antioxidants block proteasome inhibitor function in endometrial carcinoma cells. Anticancer Drugs 19, 115-124 (2008).
-
(2008)
Anticancer Drugs
, vol.19
, pp. 115-124
-
-
Llobet, D.1
Eritja, N.2
Encinas, M.3
-
60
-
-
33144466181
-
Redox modulation of chemotherapy-induced tumor cell killing and normal tissue toxicity
-
Doroshow JH. Redox modulation of chemotherapy-induced tumor cell killing and normal tissue toxicity. J. Natl. Cancer Inst. 98, 223-225 (2006).
-
(2006)
J. Natl. Cancer Inst.
, vol.98
, pp. 223-225
-
-
Doroshow, J.H.1
-
61
-
-
0035415493
-
Prodrugs strategies in cancer therapy
-
Denny WA. Prodrugs strategies in cancer therapy. Eur. J. Med. Chem. 36, 577-595 (2001).
-
(2001)
Eur. J. Med. Chem.
, vol.36
, pp. 577-595
-
-
Denny, W.A.1
-
62
-
-
79960427057
-
Selective killing of cancer cells by a small molecule targeting the stress response to ros
-
Raj L, Ide T, Gurkar AU et al. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature 475, 231-234.
-
Nature
, vol.475
, pp. 231-234
-
-
Raj, L.1
Ide, T.2
Gurkar, A.U.3
-
63
-
-
77957903553
-
Synthesis and selective anticancer activity of organochalcogen based redox catalysts
-
Doering M, Ba LA, Lilienthal N et al. Synthesis and selective anticancer activity of organochalcogen based redox catalysts. J. Med. Chem. 53, 6954-6963 (2010).
-
(2010)
J. Med. Chem.
, vol.53
, pp. 6954-6963
-
-
Doering, M.1
Ba, L.A.2
Lilienthal, N.3
-
64
-
-
77951081423
-
Chemistry and biology of deoxynyboquinone, a potent inducer of cancer cell death
-
Bair JS, Palchaudhuri R, Hergenrother PJ. Chemistry and biology of deoxynyboquinone, a potent inducer of cancer cell death, J. Am. Chem. Soc. 132, 5469-5478 (2010).
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 5469-5478
-
-
Bair, J.S.1
Palchaudhuri, R.2
Hergenrother, P.J.3
-
65
-
-
77956598957
-
Hydrogen peroxide activated matrix metalloproteinase inhibitors: A prodrug approach
-
Major Jourden JL, Cohen SM. Hydrogen peroxide activated matrix metalloproteinase inhibitors: A prodrug approach. Angew. Chem. Int. Ed. 49, 6795-6797 (2010).
-
(2010)
Angew. Chem. Int. Ed.
, vol.49
, pp. 6795-6797
-
-
Major Jourden, J.L.1
Cohen, S.M.2
-
66
-
-
82555170608
-
Peroxide inducible DNA cross-linking agents:T argeted anticancer prodrugs
-
Kuang Y, Balakrishnan K, Gandhi V, Peng X. Hydrogen peroxide inducible DNA cross-linking agents:T argeted anticancer prodrugs. J. Am. Chem. Soc. 133, 19278-19231 (2011).
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 19278-19231
-
-
Kuang, Y.1
Balakrishnan, K.2
Gandhi, V.3
Peng, X.4
-
67
-
-
84856400292
-
Aminoferrocene-based prodrugs activated by reactive oxygen species
-
Hagen H, Marzenell P, Jentzsch E et al. Aminoferrocene-based prodrugs activated by reactive oxygen species. J. Med. Chem. 55(2), 924-934 (2012).
-
(2012)
J. Med. Chem.
, vol.55
, Issue.2
, pp. 924-934
-
-
Hagen, H.1
Marzenell, P.2
Jentzsch, E.3
-
68
-
-
79955034398
-
Oxidatively activated DNA-modifying agents for selective cytotoxicity
-
Li G, Bell T, Merino EJ. Oxidatively activated DNA-modifying agents for selective cytotoxicity. Chem. Med. Chem. 6, 869-875 (2011).
-
(2011)
Chem. Med. Chem.
, vol.6
, pp. 869-875
-
-
Li, G.1
Bell, T.2
Merino, E.J.3
-
69
-
-
29544436942
-
Ferrocene-mediated proton-coupled electron transfer in a series of ferrocifen-typed breast cancer drug candidates
-
Hillard E, Vessieres A, Thouin L, Jaouen G, Amatore C. Ferrocene-mediated proton-coupled electron transfer in a series of ferrocifen-typed breast cancer drug candidates. Angew. Chem. Int. Ed. 45, 285-290 (2006).
-
(2006)
Angew. Chem. Int. Ed.
, vol.45
, pp. 285-290
-
-
Hillard, E.1
Vessieres, A.2
Thouin, L.3
Jaouen, G.4
Amatore, C.5
-
70
-
-
20444389353
-
Modification of the estrogenic properties of diphenols by the incorporation of ferrocene generation of antiproliferative effects in vitro
-
Vessieres A, Top S, Pigeon P et al. Modification of the estrogenic properties of diphenols by the incorporation of ferrocene. Generation of antiproliferative effects in vitro. J. Med. Chem. 48, 3937-3940 (2005).
-
(2005)
J. Med. Chem.
, vol.48
, pp. 3937-3940
-
-
Vessieres, A.1
Top, S.2
Pigeon, P.3
-
71
-
-
70449555098
-
Ferrocenyl quinone methides as strong antipfoliferative agents: Formation by metabolic and chemical oxidation of ferrocenyl phenols. Angew
-
Hamels D, Dansette PM, Hillard EA et al. Ferrocenyl quinone methides as strong antipfoliferative agents: Formation by metabolic and chemical oxidation of ferrocenyl phenols. Angew. Chem. Int. Ed. 48, 9124-9126 (2009).
-
(2009)
Chem. Int. Ed.
, vol.48
, pp. 9124-9126
-
-
Hamels, D.1
Dansette, P.M.2
Hillard, E.A.3
-
72
-
-
84861159405
-
Deciphering the activation sequence of ferrociphenol anticancer drug candidates. Chem
-
Messina P, Labbe E, Buriez O et al. Deciphering the activation sequence of ferrociphenol anticancer drug candidates. Chem. Eur. J. 18(21), 6581-6587 (2012).
-
(2012)
Eur. J.
, vol.18
, Issue.21
, pp. 6581-6587
-
-
Messina, P.1
Labbe, E.2
Buriez, O.3
-
73
-
-
0037724313
-
Electrophilic displacement reactions. IX Effects of substituents on rates of reactions between hydrogen peroxide and benzeneboronic acid
-
Kuivila HG, Armour AG. Electrophilic displacement reactions. IX. Effects of substituents on rates of reactions between hydrogen peroxide and benzeneboronic acid. J. Am. Chem. Soc. 79, 5659-5662 (1957).
-
(1957)
J. Am. Chem. Soc.
, vol.79
, pp. 5659-5662
-
-
Kuivila, H.G.1
Armour, A.G.2
-
74
-
-
85157234778
-
-
Boronic Acids Hall DG (Ed.), Weinheim, Germany
-
Yang WQ, Gao X, Wang BH. Boronic Acids Hall DG (Ed.). Wiley-VCH, Weinheim, Germany, 481-512 (2005).
-
(2005)
Wiley-VCH
, pp. 481-512
-
-
Yang, W.Q.1
Gao, X.2
Wang, B.H.3
-
75
-
-
48249118740
-
A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells. J
-
Dickinson BC, Chang CJ. A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells. J. Am. Chem. Soc. 130, 9638-9639 (2008).
-
(2008)
Am. Chem. Soc.
, vol.130
, pp. 9638-9639
-
-
Dickinson, B.C.1
Chang, C.J.2
-
76
-
-
28444495141
-
Boronate-based fluorescent probes for imaging cellular hydrogen peroxide. J
-
Miller EW, Albers AE, Pralle A, Isacoff EY, Chang CJ. Boronate-based fluorescent probes for imaging cellular hydrogen peroxide. J. Am. Chem. Soc. 127, 16652-16659 (2005).
-
(2005)
Am. Chem. Soc.
, vol.127
, pp. 16652-16659
-
-
Miller, E.W.1
Albers, A.E.2
Pralle, A.3
Isacoff, E.Y.4
Chang, C.J.5
-
77
-
-
34247255302
-
Moleaular imaging of hydrogen peroxide produced for cell signalling. Nat
-
Miller EW, Tulyathan O, Isacoff EY, Chang CJ. Moleaular imaging of hydrogen peroxide produced for cell signalling. Nat. Chem. Biol. 3, 263-267 (2007).
-
(2007)
Chem. Biol.
, vol.3
, pp. 263-267
-
-
Miller, E.W.1
Tulyathan, O.2
Isacoff, E.Y.3
Chang, C.J.4
-
78
-
-
41849149664
-
An ICT-based approach to ratiometric fluorescence imaging of hydrogen peroxide produced in living cells
-
Srikun D, Miller EW, Domaille DW, Chang CJ. An ICT-based approach to ratiometric fluorescence imaging of hydrogen peroxide produced in living cells. J. Am. Chem. Soc. 130, 4596-4597 (2008).
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 4596-4597
-
-
Srikun, D.1
Miller, E.W.2
Domaille, D.W.3
Chang, C.J.4
-
79
-
-
23844551612
-
Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu-Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung cancer
-
Kaynar H, Meral M, Turhanb H, Kelesc M, Celikb G, Akcayb F. Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu-Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung cancer. Cancer Lett. 227, 133-139 (2005).
-
(2005)
Cancer Lett.
, vol.227
, pp. 133-139
-
-
Kaynar, H.1
Meral, M.2
Turhanb, H.3
Kelesc, M.4
Celikb, G.5
Akcayb, F.6
-
80
-
-
41849113037
-
Measurement of oxidative stress and antioxidant status in acute lymphoblastic leukemia patients
-
Battisti V, Maders LDK, Bagatini MD et al. Measurement of oxidative stress and antioxidant status in acute lymphoblastic leukemia patients. Clin. Biochem. 41, 511-518 (2008).
-
(2008)
Clin. Biochem.
, vol.41
, pp. 511-518
-
-
Battisti, V.1
Maders, L.D.K.2
Bagatini, M.D.3
-
81
-
-
84862806824
-
Status of oxidative stress in patients with renal cell carcinoma
-
Ganesamoni R, Bhattacharyya S, Kumar S et al. Status of oxidative stress in patients with renal cell carcinoma. J. Urol. 187, 1172-1176 (2012).
-
(2012)
J. Urol.
, vol.187
, pp. 1172-1176
-
-
Ganesamoni, R.1
Bhattacharyya, S.2
Kumar, S.3
-
82
-
-
0037926836
-
Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents
-
Zhou Y, Hileman EO, Plunkett W, Keating MJ, Huang P. Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents. Blood 101, 4098-4104 (2003).
-
(2003)
Blood
, vol.101
, pp. 4098-4104
-
-
Zhou, Y.1
Hileman, E.O.2
Plunkett, W.3
Keating, M.J.4
Huang, P.5
-
83
-
-
84858958604
-
ROS-inducible DNA cross-linking agent as a new anticancer prodrug building block
-
Cao S, Wang Y, Peng X. ROS-inducible DNA cross-linking agent as a new anticancer prodrug building block. Chem. Eur. J. 18, 3850-3854 (2012).
-
(2012)
Chem. Eur. J.
, vol.18
, pp. 3850-3854
-
-
Cao, S.1
Wang, Y.2
Peng, X.3
|