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Angewandte Chemie - International Edition

Volumn 49, Issue 38, 2010, Pages 6795-6797

Hydrogen peroxide activated matrix metalloproteinase inhibitors: A prodrug approach

(2) Major Jourden, Jody L a Cohen, Seth M a

a UNIVERSITY OF CALIFORNIA (United States)

Author keywords

Hydrogen peroxide; Matrix metalloproteinases; Proinhibitors; Self immolative protecting groups; Stroke

Indexed keywords

BLOOD-BRAIN BARRIER; MATRIX METALLOPROTEINASES; METALLOPROTEINASES; PRODRUGS; PROINHIBITORS; PROTECTING GROUP; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; SINGLE COMPOUND; STROKE;

ENZYME INHIBITION; HYDROGEN; HYDROGEN PEROXIDE; OXIDATION; OXYGEN;

BLOOD VESSELS;

1,2 HOPO 2 CPD; 1,2-HOPO-2 CPD; ENZYME INHIBITOR; GELATINASE B; HYDROGEN PEROXIDE; MACROPHAGE ELASTASE; MATRIX METALLOPROTEINASE; PRODRUG; PYRIDONE DERIVATIVE; REACTIVE OXYGEN METABOLITE;

ARTICLE; BLOOD BRAIN BARRIER; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; SYNTHESIS;

BLOOD-BRAIN BARRIER; ENZYME INHIBITORS; HYDROGEN PEROXIDE; MATRIX METALLOPROTEINASE 12; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; PRODRUGS; PYRIDONES; REACTIVE OXYGEN SPECIES;

EID: 77956598957 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201003819 Document Type: Article

Times cited : (104)

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