Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells

Cellular and Molecular Life Sciences

Volumn 70, Issue 9, 2013, Pages 1637-1651

  Alessio, Nicola ^a   Bohn, Wolfgang ^b   Rauchberger, Verena ^b   Rizzolio, Flavio ^c   Cipollaro, Marilena ^a   Rosemann, Michael ^d   Irmler, Martin ^d   Beckers, Johannes ^d,e   Giordano, Antonio ^c,f,g   Galderisi, Umberto ^a,c,f  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^c TEMPLE UNIVERSITY   (United States)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f Human Health Foundation   (Italy)

^g UNIVERSITY OF SIENA   (Italy)

Author keywords

Apoptosis; Cell cycle; Differentiation; DNA damage; Marrow stromal stem cells; Retinoblastoma gene family; Senescence

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; DNA; PROTEIN P107; PROTEIN P130; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ADIPOGENESIS; APOPTOSIS; ARTICLE; BONE DEVELOPMENT; CELL AGING; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL RENEWAL; CHONDROGENESIS; CLONOGENESIS; CONTROLLED STUDY; DNA DAMAGE; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCHYMAL STEM CELL; NUCLEOTIDE SEQUENCE; P107 GENE; P130 GENE; PHENOTYPE; RB1 GENE; RB2 GENE; RNA INTERFERENCE; TUMOR SUPPRESSOR GENE;

APOPTOSIS; CELL AGING; CELL CYCLE; CELL DIFFERENTIATION; CELLS, CULTURED; DNA DAMAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MESENCHYMAL STROMAL CELLS; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P130; RNA INTERFERENCE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84876686535     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1224-x     Document Type: Article

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