-
1
-
-
0344441259
-
Distinct recruitment of E2F family members to specific E2F-binding sites mediates activation and repression of the E2F1 promoter
-
Araki K, Nakajima Y, Eto K, Ikeda MA. (2003). Distinct recruitment of E2F family members to specific E2F-binding sites mediates activation and repression of the E2F1 promoter. Oncogene 22: 7632-7641.
-
(2003)
Oncogene
, vol.22
, pp. 7632-7641
-
-
Araki, K.1
Nakajima, Y.2
Eto, K.3
Ikeda, M.A.4
-
2
-
-
0041966056
-
Reversal of human cellular senescence: Roles of the p53 and p16 pathways
-
Beausejour CM, Krtolica A, Galimi F, Narita M, Lowe SW, Yaswen P et al. (2003). Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 22: 4212-4222.
-
(2003)
EMBO J
, vol.22
, pp. 4212-4222
-
-
Beausejour, C.M.1
Krtolica, A.2
Galimi, F.3
Narita, M.4
Lowe, S.W.5
Yaswen, P.6
-
3
-
-
23244461708
-
Oncogene-induced senescence as an initial barrier in lymphoma development
-
Braig M, Lee S, Loddenkemper C, Rudolph C, Peters AH, Schlegelberger B et al. (2005). Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436: 660-665.
-
(2005)
Nature
, vol.436
, pp. 660-665
-
-
Braig, M.1
Lee, S.2
Loddenkemper, C.3
Rudolph, C.4
Peters, A.H.5
Schlegelberger, B.6
-
4
-
-
0030609861
-
Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human .broblasts
-
Brown JP, Wei W, Sedivy JM. (1997). Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human .broblasts. Science 277: 831-834.
-
(1997)
Science
, vol.277
, pp. 831-834
-
-
Brown, J.P.1
Wei, W.2
Sedivy, J.M.3
-
5
-
-
0032553485
-
Requirement for p53 and p21 to sustain G2 arrest after DNA damage
-
Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP et al. (1998). Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282: 1497-1501.
-
(1998)
Science
, vol.282
, pp. 1497-1501
-
-
Bunz, F.1
Dutriaux, A.2
Lengauer, C.3
Waldman, T.4
Zhou, S.5
Brown, J.P.6
-
6
-
-
17444388849
-
A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents
-
Chang BD, Broude EV, Dokmanovic M, Zhu H, Ruth A, Xuan Y et al. (1999). A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res 59: 3761-3767.
-
(1999)
Cancer Res
, vol.59
, pp. 3761-3767
-
-
Chang, B.D.1
Broude, E.V.2
Dokmanovic, M.3
Zhu, H.4
Ruth, A.5
Xuan, Y.6
-
7
-
-
0034689774
-
P21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells
-
Chang BD, Broude EV, Fang J, Kalinichenko TV, Abdryashitov R, Poole JC et al. (2000). p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene 19: 2165-2170.
-
(2000)
Oncogene
, vol.19
, pp. 2165-2170
-
-
Chang, B.D.1
Broude, E.V.2
Fang, J.3
Kalinichenko, T.V.4
Abdryashitov, R.5
Poole, J.C.6
-
8
-
-
23244460597
-
Crucial role of p53-dependent cellular senescence in suppression of Pten-de.cient tumorigenesis
-
Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M et al. (2005). Crucial role of p53-dependent cellular senescence in suppression of Pten-de.cient tumorigenesis. Nature 436: 725-730.
-
(2005)
Nature
, vol.436
, pp. 725-730
-
-
Chen, Z.1
Trotman, L.C.2
Shaffer, D.3
Lin, H.K.4
Dotan, Z.A.5
Niki, M.6
-
9
-
-
26944443541
-
Tumor-specific exon 1 mutations could be the 0hit event0 predisposing Rb2/p130 gene to epigenetic silencing in lung cancer
-
Cinti C, Macaluso M, Giordano A. (2005). Tumor-specific exon 1 mutations could be the 0hit event0 predisposing Rb2/p130 gene to epigenetic silencing in lung cancer. Oncogene 24: 5821-5826.
-
(2005)
Oncogene
, vol.24
, pp. 5821-5826
-
-
Cinti, C.1
MacAluso, M.2
Giordano, A.3
-
10
-
-
0028143074
-
P130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107
-
Claudio PP, Howard CM, Baldi A, De Luca A, Fu Y, Condorelli G et al. (1994). p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res 54: 5556-5560.
-
(1994)
Cancer Res
, vol.54
, pp. 5556-5560
-
-
Claudio, P.P.1
Howard, C.M.2
Baldi, A.3
De Luca, A.4
Fu, Y.5
Condorelli, G.6
-
11
-
-
0027140404
-
Cell cycle-specific association of E2F with the p130 E1A-binding protein
-
Cobrinik D, Whyte P, Peeper DS, Jacks T, Weinberg RA. (1993). Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev 7: 2392-2404.
-
(1993)
Genes Dev
, vol.7
, pp. 2392-2404
-
-
Cobrinik, D.1
Whyte, P.2
Peeper, D.S.3
Jacks, T.4
Weinberg, R.A.5
-
12
-
-
23244447893
-
Tumour biology: Senescence in premalignant tumours
-
Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher AJ, Barradas M et al. (2005). Tumour biology: senescence in premalignant tumours. Nature 436: 642.
-
(2005)
Nature
, vol.436
, pp. 642
-
-
Collado, M.1
Gil, J.2
Efeyan, A.3
Guerra, C.4
Schuhmacher, A.J.5
Barradas, M.6
-
13
-
-
33845269825
-
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
-
Di Micco R, Fumagalli M, Cicalese A, Piccinin S, Gasparini P, Luise C et al. (2006). Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444: 638-642.
-
(2006)
Nature
, vol.444
, pp. 638-642
-
-
Di Micco, R.1
Fumagalli, M.2
Cicalese, A.3
Piccinin, S.4
Gasparini, P.5
Luise, C.6
-
14
-
-
0029047362
-
A biomarker that identi.es senescent human cells in culture and in aging skin in vivo
-
Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C et al. (1995). A biomarker that identi.es senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
-
15
-
-
0031935827
-
Reinitiation of DNA synthesis and cell division in senescent human .broblasts by microinjection of anti-p53 antibodies
-
Gire V, Wynford-Thomas D. (1998). Reinitiation of DNA synthesis and cell division in senescent human .broblasts by microinjection of anti-p53 antibodies. Mol Cell Biol 18: 1611-1621.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 1611-1621
-
-
Gire, V.1
Wynford-Thomas, D.2
-
16
-
-
33748080443
-
Regulation of cellular senescence by Rb2/p130
-
Helmbold H, Deppert W, Bohn W. (2006). Regulation of cellular senescence by Rb2/p130. Oncogene 25: 5257-5262.
-
(2006)
Oncogene
, vol.25
, pp. 5257-5262
-
-
Helmbold, H.1
Deppert, W.2
Bohn, W.3
-
17
-
-
33645219500
-
Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells
-
Jackson JG, Pereira-Smith OM. (2006). Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells. Mol Cell Biol 26: 2501-2510.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2501-2510
-
-
Jackson, J.G.1
Pereira-Smith, O.M.2
-
18
-
-
30844459708
-
Cooperation between p53 and p130(Rb2) in induction of cellular senescence
-
Kapic A, Helmbold H, Reimer R, Klotzsche O, Deppert W, Bohn W. (2006). Cooperation between p53 and p130(Rb2) in induction of cellular senescence. Cell Death Differ 13: 324-334.
-
(2006)
Cell Death Differ
, vol.13
, pp. 324-334
-
-
Kapic, A.1
Helmbold, H.2
Reimer, R.3
Klotzsche, O.4
Deppert, W.5
Bohn, W.6
-
19
-
-
0034679076
-
Cancer risk and the ATM gene: A continuing debate
-
Khanna KK. (2000). Cancer risk and the ATM gene: a continuing debate. J Natl Cancer Inst 92: 795-802.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 795-802
-
-
Khanna, K.K.1
-
20
-
-
0030970366
-
Identi.cation of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes
-
Lacy S, Whyte P. (1997). Identi.cation of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes. Oncogene 14: 2395-2406.
-
(1997)
Oncogene
, vol.14
, pp. 2395-2406
-
-
Lacy, S.1
Whyte, P.2
-
21
-
-
13244279609
-
Expression of Rb2/p130 protein correlates with the degree of malignancy in gliomas
-
Li Q, Sakurai Y, Ryu T, Azuma K, Yoshimura K, Yamanouchi Y et al. (2004). Expression of Rb2/p130 protein correlates with the degree of malignancy in gliomas. Brain Tumor Pathol 21: 121-125.
-
(2004)
Brain Tumor Pathol
, vol.21
, pp. 121-125
-
-
Li, Q.1
Sakurai, Y.2
Ryu, T.3
Azuma, K.4
Yoshimura, K.5
Yamanouchi, Y.6
-
22
-
-
34548211521
-
The DNA damage signaling pathway connects oncogenic stress to cellular senescence
-
Mallette FA, Ferbeyre G. (2007). The DNA damage signaling pathway connects oncogenic stress to cellular senescence. Cell Cycle 6: 1831-1836. (Pubitemid 47327900)
-
(2007)
Cell Cycle
, vol.6
, Issue.15
, pp. 1831-1836
-
-
Mallette, F.A.1
Ferbeyre, G.2
-
23
-
-
0035754080
-
To cycle or not to cycle: A critical decision in cancer
-
Malumbres M, Barbacid M. (2001). To cycle or not to cycle: a critical decision in cancer. Nat Rev Cancer 1: 222-231.
-
(2001)
Nat Rev Cancer
, vol.1
, pp. 222-231
-
-
Malumbres, M.1
Barbacid, M.2
-
24
-
-
0037667702
-
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
-
Narita M, Nunez S, Heard E, Narita M, Lin AW, Hearn SA et al. (2003). Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113: 703-716.
-
(2003)
Cell
, vol.113
, pp. 703-716
-
-
Narita, M.1
Nunez, S.2
Heard, E.3
Narita, M.4
Lin, A.W.5
Hearn, S.A.6
-
25
-
-
0036258111
-
The IARC TP53 database: New online mutation analysis and recommendations to users
-
Olivier M, Eeles R, Hollstein M, Khan MA, Harris CC, Hainaut P. (2002). The IARC TP53 database: new online mutation analysis and recommendations to users. Hum Mutat 19: 607-614.
-
(2002)
Hum Mutat
, vol.19
, pp. 607-614
-
-
Olivier, M.1
Eeles, R.2
Hollstein, M.3
Khan, M.A.4
Harris, C.C.5
Hainaut, P.6
-
26
-
-
0003418645
-
A restriction point for control of normal animal cell proliferation
-
Pardee AB. (1974). A restriction point for control of normal animal cell proliferation. Proc Natl Acad Sci USA 71: 1286-1290.
-
(1974)
Proc Natl Acad Sci USA
, vol.71
, pp. 1286-1290
-
-
Pardee, A.B.1
-
27
-
-
2342478606
-
Role of the Retinoblastoma Pathway in Senescence Triggered by Repression of the Human Papillomavirus E7 Protein in Cervical Carcinoma Cells
-
DOI 10.1158/0008-5472.CAN-03-3739
-
Psyrri A, DeFilippis RA, Edwards AP, Yates KE, Manuelidis L, DiMaio D. (2004). Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells. Cancer Res 64: 3079-3086. (Pubitemid 38581407)
-
(2004)
Cancer Research
, vol.64
, Issue.9
, pp. 3079-3086
-
-
Psyrri, A.1
DeFilippis, R.A.2
Edwards, A.P.B.3
Yates, K.E.4
Manuelidis, L.5
DiMaio, D.6
-
28
-
-
0037080483
-
E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints
-
Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA et al. (2002). E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev 16: 245-256.
-
(2002)
Genes Dev
, vol.16
, pp. 245-256
-
-
Ren, B.1
Cam, H.2
Takahashi, Y.3
Volkert, T.4
Terragni, J.5
Young, R.A.6
-
29
-
-
0037013154
-
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
-
Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM et al. (2002). A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 109: 335-346.
-
(2002)
Cell
, vol.109
, pp. 335-346
-
-
Schmitt, C.A.1
Fridman, J.S.2
Yang, M.3
Lee, S.4
Baranov, E.5
Hoffman, R.M.6
-
30
-
-
0028144410
-
The transcription factor E2F-1 mediates the autoregulation of RB gene expression
-
Shan B, Chang CY, Jones D, Lee WH. (1994). The transcription factor E2F-1 mediates the autoregulation of RB gene expression. Mol Cell Biol 14: 299-309.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 299-309
-
-
Shan, B.1
Chang, C.Y.2
Jones, D.3
Lee, W.H.4
-
31
-
-
0035038192
-
Expression of the retinoblastoma-related gene Rb2/ p130 is downregulated in atypical endometrial hyperplasia and adenocarcinoma
-
Susini T, Massi D, Paglierani M, Masciullo V, Scambia G, Giordano A et al. (2001). Expression of the retinoblastoma-related gene Rb2/ p130 is downregulated in atypical endometrial hyperplasia and adenocarcinoma. Hum Pathol 32: 360-367.
-
(2001)
Hum Pathol
, vol.32
, pp. 360-367
-
-
Susini, T.1
Massi, D.2
Paglierani, M.3
Masciullo, V.4
Scambia, G.5
Giordano, A.6
-
32
-
-
33750510904
-
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence
-
Takahashi A, Ohtani N, Yamakoshi K, Iida S, Tahara H, Nakayama K et al. (2006). Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol 8: 1291-1297.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1291-1297
-
-
Takahashi, A.1
Ohtani, N.2
Yamakoshi, K.3
Iida, S.4
Tahara, H.5
Nakayama, K.6
-
33
-
-
0034175616
-
Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression
-
Takahashi Y, Rayman JB, Dynlacht BD. (2000). Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev 14: 804-816.
-
(2000)
Genes Dev
, vol.14
, pp. 804-816
-
-
Takahashi, Y.1
Rayman, J.B.2
Dynlacht, B.D.3
-
34
-
-
0037086268
-
DNA damage is able to induce senescence in tumor cells in vitro and in vivo
-
te Poele RH, Okorokov AL, Jardine L, Cummings J, Joel SP. (2002). DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res 62: 1876-1883.
-
(2002)
Cancer Res
, vol.62
, pp. 1876-1883
-
-
Te Poele, R.H.1
Okorokov, A.L.2
Jardine, L.3
Cummings, J.4
Joel, S.P.5
-
35
-
-
70349662698
-
-
Tosi GM, Trimarchi C, Macaluso M, La Sala D, Ciccodicola A, Lazzi S et al. (2005). Genetic and epigenetic alterations of RB2/p130
-
(2005)
Genetic and Epigenetic Alterations of RB2/p130
-
-
Tosi, G.M.1
Trimarchi, C.2
MacAluso, M.3
La Sala, D.4
Ciccodicola, A.5
Lazzi, S.6
-
36
-
-
70349681241
-
Tumor suppressor gene in human sporadic retinoblastoma: Implications for pathogenesis and therapeutic approach
-
tumor suppressor gene in human sporadic retinoblastoma: implications for pathogenesis and therapeutic approach. Oncogene 24: 5827-5836.
-
Oncogene
, vol.24
, pp. 5827-5836
-
-
-
37
-
-
0030011128
-
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
-
Waldman T, Lengauer C, Kinzler KW, Vogelstein B. (1996). Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381: 713-716.
-
(1996)
Nature
, vol.381
, pp. 713-716
-
-
Waldman, T.1
Lengauer, C.2
Kinzler, K.W.3
Vogelstein, B.4
-
38
-
-
0029091312
-
Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation
-
Zalvide J, DeCaprio JA. (1995). Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation. Mol Cell Biol 15: 5800-5810.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 5800-5810
-
-
Zalvide, J.1
Decaprio, J.A.2
-
39
-
-
31044437418
-
The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradation
-
Zhang B, Chen W, Roman A. (2006). The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradation. Proc Natl Acad Sci USA 103: 437-442.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 437-442
-
-
Zhang, B.1
Chen, W.2
Roman, A.3
-
40
-
-
0034737290
-
Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and RbhSWI/ SNF
-
Zhang HS, Gavin M, Dahiya A, Postigo AA, Ma D, Luo RX et al. (2000). Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and RbhSWI/ SNF. Cell 101: 79-89.
-
(2000)
Cell
, vol.101
, pp. 79-89
-
-
Zhang, H.S.1
Gavin, M.2
Dahiya, A.3
Postigo, A.A.4
Ma, D.5
Luo, R.X.6
-
41
-
-
0027313470
-
Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein
-
Zhu L, van den Heuvel S, Helin K, Fattaey A, Ewen M, Livingston D et al. (1993). Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev 7: 1111-1125.
-
(1993)
Genes Dev
, vol.7
, pp. 1111-1125
-
-
Zhu, L.1
Van Den Heuvel, S.2
Helin, K.3
Fattaey, A.4
Ewen, M.5
Livingston, D.6
|