Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect

Age

Volumn 34, Issue 2, 2012, Pages 281-293

  Zanichelli, Fulvia ^b   Capasso, Stefania ^b   Cipollaro, Marilena ^b   Pagnotta, Eleonora ^d   Cartenì, Maria ^b   Casale, Fiorina ^b   Iori, Renato ^d   Galderisi, Umberto ^a,b,c  

^a TEMPLE UNIVERSITY   (United States)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c Human Health Foundation   (Italy)

^d ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

Author keywords

Apoptosis; Cell cycle; Differentiation; Histone deacetylase; Isothiocyanate; Marrow stromal stem cells; Senescence

Indexed keywords

HISTONE DEACETYLASE; ISOTHIOCYANIC ACID DERIVATIVE; SULFORAPHANE 1 ISOTHIOCYANATO 4 (METHYLSULFINYL)BUTANE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG CYTOTOXICITY; ENZYME INHIBITION; HEMATOPOIESIS; HOMEOSTASIS; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; SENESCENCE;

AGING; ANTICARCINOGENIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL CYCLE CHECKPOINTS; CELL LINE; CELL PROLIFERATION; CHILD; DIETARY SUPPLEMENTS; HUMANS; ISOTHIOCYANATES; MESENCHYMAL STEM CELLS; THIOCYANATES;

EID: 84857919108     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-011-9231-7     Document Type: Article

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