Collaborating with the enemy: Function of macrophages in the development of neoplastic disease

Mediators of Inflammation

Volumn 2013, Issue , 2013, Pages

  Eljaszewicz, Andrzej ^a   Wiese, Małgorzata ^a   Helmin Basa, Anna ^a   Jankowski, Michal ^a,b   Gackowska, Lidia ^a   Kubiszewska, Izabela ^a   Kaszewski, Wojciech ^a   Michalkiewicz, Jacek ^a,c   Zegarski, Wojciech ^a,b  

^a NICOLAUS COPERNICUS UNIVERSITY   (Poland)

^b Regional Oncology Centre Bydgoszcz   (Poland)

^c CHILDREN'S MEMORIAL HEALTH INSTITUTE   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; CD11B ANTIGEN; CD14 ANTIGEN; CD16 ANTIGEN; CD64 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; FIBROBLAST GROWTH FACTOR 2; GAMMA INTERFERON; GELATINASE B; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 8; MATRIX METALLOPROTEINASE 19; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 3; RANTES; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; ANTINEOPLASTIC AGENT;

BINDING AFFINITY; CANCER PROGNOSIS; CARCINOGENESIS; CELL ACTIVITY; CELL FUNCTION; CYTOKINE RELEASE; DENDRITIC CELL; IMMUNE DEFICIENCY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; MONOCYTE; NEOVASCULARIZATION (PATHOLOGY); PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; REVIEW; T LYMPHOCYTE; TUMOR ASSOCIATED LEUKOCYTE; ANIMAL; HUMAN; IMMUNOLOGY; MACROPHAGE; METABOLISM; NEOPLASM;

ANIMALS; ANTINEOPLASTIC AGENTS; HUMANS; MACROPHAGES; NEOPLASMS;

EID: 84876542348     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2013/831387     Document Type: Review

References (108)

1. Friedberg E. C., DNA damage and repair. Nature 2003 421 6921 436 440 2-s2.0-0037461731 10.1038/nature01408 (Pubitemid 36157951)
2. Bernstein C., Bernstein H., Payne C. M., Garewal H., DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. Mutation Research 2002 511 2 145 178 2-s2.0-0036270993 10.1016/S1383-5742(02)00009-1 (Pubitemid 34621252)
3. Fearon E. R., Vogelstein B., A genetic model for colorectal tumorigenesis. Cell 1990 61 5 759 767 2-s2.0-0025312728 10.1016/0092-8674(90) 90186-I (Pubitemid 20185636)
4. Tanaka T., Bai Z., Srinoulprasert Y., Yang B., Hayasaka H., Miyasaka M., Chemokines in tumor progression and metastasis. Cancer Science 2005 96 6 317 322 2-s2.0-22444444180 10.1111/j.1349-7006.2005.00059.x (Pubitemid 41007465)
5. Luster A. D., Chemokines-chemotactic cytokines that mediate inflammation. The New England Journal of Medicine 1998 338 7 436 445 2-s2.0-0032509889 10.1056/NEJM199802123380706 (Pubitemid 28135672)
6. Bottazzi B., Colotta F., Sica A., Nobili N., Mantovani A., A chemoattractant expressed in human sarcoma cells (tumor-derived chemotactic factor, TDCF) is identical to monocyte chemoattractant protein-1/monocyte chemotactic and activating factor (MCP-1/MCAF). International Journal of Cancer 1990 45 4 795 797 2-s2.0-0025213158 (Pubitemid 20146146)
7. Conti I., Rollins B. J., CCL2 (monocyte chemoattractant protein-1) and cancer. Seminars in Cancer Biology 2004 14 3 149 154 2-s2.0-2342526003 10.1016/j.semcancer.2003.10.009 (Pubitemid 38586739)
8. Amann B., Perabo F. G. E., Wirger A., Hugenschmidt H., Schultze-Seemann W., Urinary levels of monocyte chemo-attractant protein-1 correlate with tumour stage and grade in patients with bladder cancer. British Journal of Urology 1998 82 1 118 121 2-s2.0-0031820554 10.1046/j.1464-410X.1998.00675.x (Pubitemid 28316680)
9. Valković T., Lučin K., Krstulja M., Dobi-Babić R., Jonjić N., Expression of monocyte chemotactic protein-1 in human invasive ductal breast cancer. Pathology Research and Practice 1998 194 5 335 340 2-s2.0-0031840907 (Pubitemid 28291370)
10. Tonouchi H., Miki C., Tanaka K., Kusunoki M., Profile of monocyte chemoattractant protein-1 circulating levels in gastric cancer patients. Scandinavian Journal of Gastroenterology 2002 37 7 830 833 2-s2.0-0035988912 (Pubitemid 34836821)
11. Ueno T., Toi M., Saji H., Muta M., Bando H., Kuroi K., Koike M., Inadera H., Matsushima K., Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clinical Cancer Research 2000 6 8 3282 3289 2-s2.0-0033903714 (Pubitemid 30637758)
12. Sica A., Saccani A., Bottazzi B., Bernasconi S., Allavena P., Gaetano B., Fei F., LaRosa G., Scotton C., Balkwill F., Mantovani A., Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma. Journal of Immunology 2000 164 2 733 738 2-s2.0-0034650329 (Pubitemid 30043695)
13. Van Damme J., Proost P., Lenaerts J. P., Opdenakker G., Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. Journal of Experimental Medicine 1992 176 1 59 65 2-s2.0-0026721539 10.1084/jem.176.1.59
14. Luboshits G., Shina S., Kaplan O., Engelberg S., Nass D., Lifshitz-Mercer B., Chaitchik S., Keydar I., Ben-Baruch A., Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma. Cancer Research 1999 59 18 4681 4687 2-s2.0-0033568215 (Pubitemid 29428976)
15. Locati M., Deuschle U., Massardi M. L., Martinez F. O., Sironi M., Sozzani S., Bartfai T., Mantovani A., Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes. Journal of Immunology 2002 168 7 3557 3562 2-s2.0-0036533579 (Pubitemid 34250425)
16. Robinson S. C., Scott K. A., Balkwill F. R., Chemokine stimulation of monocyte matrix metalloproteinase-9 requires endogenous TNF-alpha. European Journal of Immunology 2002 32 404 412 (Pubitemid 34173332)
17. Kim H. K., Song K. S., Park Y. S., Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: possible role of a metastasis predictor. European Journal of Cancer 2003 39 184 191 10.1016/S0959-8049(02)00596-8 (Pubitemid 36057068)
18. Folkman J., Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Medicine 1995 1 1 27 31 2-s2.0-0028929803
19. Folkman J., Watson K., Ingber D., Hanahan D., Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 1989 339 6219 58 61 2-s2.0-0024549349 (Pubitemid 19115892)
20. Folkman J., What is the evidence that tumors are angiogenesis dependent? Journal of the National Cancer Institute 1990 82 1 4 6 2-s2.0-0025141337 (Pubitemid 20020880)
21. Kido S., Kitadai Y., Hattori N., Haruma K., Kido T., Ohta M., Tanaka S., Yoshihara M., Sumii K., Ohmoto Y., Chayama K., Interleukin 8 and vascular endothelial growth factor-prognostic factors in human gastric carcinomas? European Journal of Cancer 2001 37 12 1482 1487 2-s2.0-0034880706 10.1016/S0959-8049(01)00147-2 (Pubitemid 32744677)
22. Toi M., Kondo S., Suzuki H., Quantitative analysis of vascular endothelial growth factor in primary breast cancer. Cancer 1996 77 1101 1106 (Pubitemid 26080900)
23. Fujisaki K., Mitsuyama K., Toyonaga A., Matsuo K., Tanikawa K., Circulating vascular endothelial growth factor in patients with colorectal cancer. American Journal of Gastroenterology 1998 93 2 249 252 2-s2.0-0032008385 10.1111/j.1572-0241.1998.00249.x (Pubitemid 29063978)
24. Kiriakidis S., Andreakos E., Monaco C., Foxwell B., Feldmann M., Paleolog E., VEGF expression in human macrophages is NF- B-dependent: studies using adenoviruses expressing the endogenous NF- B inhibitor I B α and a kinase-defective form of the I B kinase 2. Journal of Cell Science 2003 116 4 665 674 2-s2.0-0037442674 10.1242/jcs.00286 (Pubitemid 36231305)
25. Shibuya M., Structure and function of VEGF/VEGF-receptor system involved in angiogenesis. Cell Structure and Function 2001 26 1 25 35 2-s2.0-0035003384 10.1247/csf.26.25 (Pubitemid 32421949)
26. Sawano A., Iwai S., Sakurai Y., Ito M., Shitara K., Nakahata T., Shibuya M., Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans. Blood 2001 97 3 785 791 2-s2.0-0035254646 10.1182/blood.V97.3.785 (Pubitemid 32113414)
27. Hollborn M., Stathopoulos C., Steffen A., Wiedemann P., Kohen L., Bringmann A., Positive feedback regulation between MMP-9 and VEGF in human RPE cells. Investigative Ophthalmology and Visual Science 2007 48 9 4360 4367 2-s2.0-35148897176 10.1167/iovs.06-1234 (Pubitemid 351261070)
28. Hiratsuka S., Nakamura K., Iwai S., Murakami M., Itoh T., Kijima H., Shipley J. M., Senior R. M., Shibuya M., MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell 2002 2 4 289 300 2-s2.0-0036782035 10.1016/S1535-6108(02)00153-8 (Pubitemid 41043963)
29. Bingle L., Brown N. J., Lewis C. E., The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. Journal of Pathology 2002 196 3 254 265 2-s2.0-0036187615 10.1002/path.1027 (Pubitemid 34189413)
30. Dvorak H. F., Brown L. F., Detmar M., Dvorak A. M., Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. American Journal of Pathology 1995 146 5 1029 1039 2-s2.0-0029004025
31. Neufeld G., Cohen T., Gengrinovitch S., Poltorak Z., Vascular endothelial growth factor (VEGF) and its receptors. The FASEB Journal 1999 13 1 9 22 2-s2.0-0032907687 (Pubitemid 29038270)
32. Lissoni P., Malugani F., Bonfanti A., Bucovec R., Secondino S., Brivio F., Ferrari-Bravo A., Ferrante R., Vigore L., Rovelli F., Mandala M., Vivian S., Fumagalli L., Gardani G. S., Abnormally enhanced blood concentrations of vascular endothelial growth factor (VEGF) in metastatic cancer patients and their relation to circulating dendritic cells, IL-12 and endothelin-1. Journal of Biological Regulators and Homeostatic Agents 2001 15 2 140 144 2-s2.0-0034883882 (Pubitemid 32717550)
33. Ferrara N., Hillan K. J., Gerber H. P., Novotny W., Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nature Reviews Drug Discovery 2004 3 5 391 400 2-s2.0-2442621619 (Pubitemid 38618122)
34. Kitadai Y., Angiogenesis and lymphangiogenesis of gastric cancer. Journal of Oncology 2010 2010 8 2-s2.0-77951686858 10.1155/2010/468725 468725
35. Norrby K., Basic fibroblast growth factor and de novo mammalian angiogenesis. Microvascular Research 1994 48 1 96 113 2-s2.0-0027969336 10.1006/mvre.1994.1041
36. Bilgic I., Ozalp N., Tez M., Koc M., Serum bFGF concentrations in gastric cancer patients. Bratislavské Lekárske Listy 2008 109 1 8 9 2-s2.0-44849084488
37. Esposito I., Menicagli M., Funel N., Bergmann F., Boggi U., Mosca F., Bevilacqua G., Campani D., Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma. Journal of Clinical Pathology 2004 57 6 630 636 2-s2.0-2642547301 10.1136/jcp.2003.014498 (Pubitemid 38725766)
38. Lewis C. E., Leek R., Harris A., McGee O. J., Cytokine regulation of angiogenesis in breast cancer: the role of tumor-associated macrophages. Journal of Leukocyte Biology 1995 57 5 747 751 2-s2.0-0029001004
39. Jo M. J., Lee J. H., Nam B. H., Kook M. C., Ryu K. W., Choi I. J., Kim Y. W., Bae J. M., Preoperative serum angiopoietin-2 levels correlate with lymph node status in patients with early gastric cancer. Annals of Surgical Oncology 2009 16 7 2052 2057 2-s2.0-67649202230 10.1245/s10434-009-0474-9
40. Wang J., Wu K., Zhang D., Tang H., Xie H., Hong L., Pan Y., Lan M., Hu S., Ning X., Fan D., Expressions and clinical significances of angiopoietin-1, -2 and Tie2 in human gastric cancer. Biochemical and Biophysical Research Communications 2005 337 1 386 393 2-s2.0-25844444603 10.1016/j.bbrc.2005.09.051 (Pubitemid 41393807)
41. Hangai M., Murata T., Miyawaki N., Spee C., Lim J. I., He S., Hinton D. R., Ryan S. J., Angiopoietin-1 upregulation by vascular endothelial growth factor in human retinal pigment epithelial cells. Investigative Ophthalmology and Visual Science 2001 42 7 1617 1625 2-s2.0-0035009998 (Pubitemid 32520756)
42. Niedźwiecki S., Stepień T., Kopeć K., Kuzdak K., Komorowski J., Krupiński R., Stepień H., Angiopoietin 1 (Ang-1), angiopoietin 2 (Ang-2) and Tie-2 (a receptor tyrosine kinase) concentrations in peripheral blood of patients with thyroid cancers. Cytokine 2006 36 5-6 291 295 2-s2.0-34047093338 10.1016/j.cyto.2007.02.008 (Pubitemid 46529482)
43. Murdoch C., Tazzyman S., Webster S., Lewis C. E., Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. Journal of Immunology 2007 178 11 7405 7411 2-s2.0-34249791475 (Pubitemid 46847468)
44. Szkaradkiewicz A., Karpiński T. M., Drews M., Borejsza-Wysocki M., Majewski P., Andrzejewska E., Natural killer cell cytotoxicity and immunosuppressive cytokines (IL-10, TGF- β 1) in patients with gastric cancer. Journal of Biomedicine and Biotechnology 2010 2010 7 2-s2.0-77952519772 10.1155/2010/901564 901564
45. Groux H., Bigler M., De Vries J. E., Roncarolo M. G., Inhibitory and stimulatory effects of IL-10 on Human CD8+ T cells. Journal of Immunology 1998 160 7 3188 3193 2-s2.0-0032055224 (Pubitemid 28164707)
46. Yano S., Sone S., Nishioka Y., Mukaida N., Matsushima K., Ogura T., Differential effects of anti-inflammatory cytokines (IL-4, IL-10 and IL-13) on tumoricidal and chemotactic properties of human monocytes induced by monocyte chemotactic and activating factor. Journal of Leukocyte Biology 1995 57 2 303 309 2-s2.0-0028859171
47. Becker J. C., Czerny C., Brocker E. B., Maintenance of clonal anergy by endogenously produced IL-10. International Immunology 1994 6 10 1605 1612 2-s2.0-0027960758 (Pubitemid 24317870)
48. Kim R., Emi M., Tanabe K., Arihiro K., Tumor-driven evolution of immunosuppressive networks during malignant progression. Cancer Research 2006 66 11 5527 5536 2-s2.0-33745258657 10.1158/0008-5472.CAN-05-4128 (Pubitemid 43927099)
49. Chouaib S., Asselin-Paturel C., Mami-Chouaib F., Caignard A., Blay J. Y., The host-tumor immune conflict: from immunosuppression to resistance and destruction. Immunology Today 1997 18 10 493 497 2-s2.0-0030981706 10.1016/S0167-5699(97)01115-8 (Pubitemid 27441593)
50. Chen C., Shen Y., Qu Q. X., Chen X. Q., Zhang X. G., Huang J. A., Induced expression of B7-H3 on the lung cancer cells and macrophages suppresses T-cell mediating anti-tumor immune response. Experimental Cell Research 2013 319 1 96 102
51. Gordon S., Taylor P. R., Monocyte and macrophage heterogeneity. Nature Reviews Immunology 2005 5 12 953 964 2-s2.0-28544446111 10.1038/nri1733 (Pubitemid 41746764)
52. Ohno S., Inagawa H., Dhar D. K., Fujii T., Ueda S., Tachibana M., Suzuki N., Inoue M., Soma G. I., Nagasue N., The degree of macrophage infiltration into the cancer cell nest is a significant predictor of survival in gastric cancer patients. Anticancer Research 2003 23 6 5015 5022 2-s2.0-10744224063 (Pubitemid 38182119)
53. Leek R. D., Lewis C. E., Whitehouse R., Greenall M., Clarke J., Harris A. L., Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Research 1996 56 20 4625 4629 2-s2.0-0029816609 (Pubitemid 26338061)
54. Shimura S., Yang G., Ebara S., Wheeler T. M., Frolov A., Thompson T. C., Reduced infiltration of tumor-associated macrophages in human prostate cancer: association with cancer progression. Cancer Research 2000 60 20 5857 5861 2-s2.0-0034667386
55. Maliszewski D. J. T., Drucis K., Kopacz A., Czynniki prognostyczne w raku jelita grubego-co możemy dodaćdo standardu? Współ czesna Onkologia 2008 12 212 216
56. Ziegler-Heitbrock L., Ancuta P., Crowe S., Dalod M., Grau V., Hart D. N., Leenen P. J. M., Liu Y. J., MacPherson G., Randolph G. J., Scherberich J., Schmitz J., Shortman K., Sozzani S., Strobl H., Zembala M., Austyn J. M., Lutz M. B., Nomenclature of monocytes and dendritic cells in blood. Blood 2010 116 16 e74 e80 2-s2.0-77958185103 10.1182/blood-2010-02-258558
57. Ziegler-Heitbrock H. W. L., Heterogeneity of human blood monocytes: the CD14+CD16+ subpopulation. Immunology Today 1996 17 9 424 428 2-s2.0-0030250093 10.1016/0167-5699(96)10029-3 (Pubitemid 26278368)
58. Grage-Griebenow E., Flad H. D., Ernst M., Heterogeneity of human peripheral blood monocyte subsets. Journal of Leukocyte Biology 2001 69 1 11 20 2-s2.0-0035155787 (Pubitemid 32095112)
59. Skrzeczyńska-Moncznik J., Bzowska M., Loseke S., Grage-Griebenow E., Zembala M., Pryjma J., Peripheral blood CD14high CD16+ monocytes are main producers of IL-10. Scandinavian Journal of Immunology 2008 67 2 152 159 2-s2.0-38149044069 10.1111/j.1365-3083.2007.02051.x
60. Nockher W. A., Scherberich J. E., Expanded CD14+ CD16+ Monocyte subpopulation in patients with acute and chronic infections undergoing hemodialysis. Infection and Immunity 1998 66 6 2782 2790 2-s2.0-0031838141 (Pubitemid 28261784)
61. Katayama K., Matsubara T., Fujiwara M., Koga M., Furukawa S., CD14+CD16+ monocyte subpopulation in Kawasaki disease. Clinical and Experimental Immunology 2000 121 3 566 570 2-s2.0-0033856807 10.1046/j.1365-2249.2000.01321.x
62. Fingerle G., Pforte A., Passlick B., Blumenstein M., Strobel M., Ziegler- Heitbrock H. W. L., The novel subset of CD14+/CD16+ blood monocytes is expanded in sepsis patients. Blood 1993 82 10 3170 3176 2-s2.0-0027365645 (Pubitemid 23334947)
63. Feng A. L., Zhu J. K., Sun J. T., Yang M. X., Neckenig M. R., Wang X. W., Shao Q. Q., Song B. F., Yang Q. F., Kong B. H., Qu X., CD16+ monocytes in breast cancer patients: expanded by monocyte chemoattractant protein-1 and may be useful for early diagnosis. Clinical and Experimental Immunology 2011 164 1 57 65 2-s2.0-79952517840 10.1111/j.1365-2249.2011.04321.x
64. Saleh M. N., Goldman S. J., LoBuglio A. F., Beall A. C., Sabio H., McCord M. C., Minasian L., Alpaugh R. K., Weiner L. M., Munn D. H., CD16+ monocytes in patients with cancer: spontaneous elevation and pharmacologic induction by recombinant human macrophage colony-stimulating factor. Blood 1995 85 10 2910 2917 2-s2.0-0029029368
65. Belge K. U., Dayyani F., Horelt A., Siedlar M., Frankenberger M., Frankenberger B., Espevik T., Ziegler-Heitbrock L., The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF. Journal of Immunology 2002 168 7 3536 3542 2-s2.0-0036533648 (Pubitemid 34250422)
66. Ziegler-Heitbrock L., The CD14+ CD16+ blood monocytes: their role in infection and inflammation. Journal of Leukocyte Biology 2007 81 3 584 592 2-s2.0-33847789122 10.1189/jlb.0806510 (Pubitemid 46393535)
67. Rivier A., Pene J., Rabesandratana H., Chanez P., Bousquet J., Campbell A. M., Blood monocytes of untreated asthmatics exhibit some features of tissue macrophages. Clinical and Experimental Immunology 1995 100 2 314 318 2-s2.0-0029021843
68. Skrzeczyñska J., Kobylarz K., Hartwich Z., Zembala M., Pryjma J., CD14+CD16+ monocytes in the course of sepsis in neonates and small children: monitoring and functional studies. Scandinavian Journal of Immunology 2002 55 6 629 638 2-s2.0-0036093574 10.1046/j.1365-3083.2002.01092.x (Pubitemid 34535555)
69. Eljaszewicz A., Jankowski M., Gackowska L., Gastric cancer increase the percentage of intermediate (CD14++CD16+) and nonclassical (CD14+CD16+) monocytes. Central European Journal of Immunology 2012 37 355 361
70. Rothe G., Gabriel H., Kovacs E., Klucken J., Stöhr J., Kindermann W., Schmitz G., Peripheral blood mononuclear phagocyte subpopulations as cellular markers in hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology 1996 16 12 1437 1447 2-s2.0-0030467734 (Pubitemid 26427596)
71. Szaflarska A., Baj-Krzyworzeka M., Siedlar M., Wglarczyk K., Ruggiero I., Hajto B., Zembala M., Antitumor response of CD14+/CD16+ monocyte subpopulation. Experimental Hematology 2004 32 8 748 755 2-s2.0-4143145320 10.1016/j.exphem.2004.05.027 (Pubitemid 39092740)
72. Colombo M. P., Trinchieri G., Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine and Growth Factor Reviews 2002 13 2 155 168 2-s2.0-0036005890 10.1016/S1359-6101(01)00032-6 (Pubitemid 34229390)
73. Ha S. J., Lee C. H., Lee S. B., Kim C. M., Jang K. L., Shin H. S., Sung Y. C., Sung Y. C., A novel function of IL-12p40 as a chemotactic molecule for macrophages. Journal of Immunology 1999 163 5 2902 2908 2-s2.0-0000155803 (Pubitemid 29399221)
74. Nakayama H., Kitayama J., Muto T., Nagawa H., Characterization of intracellular cytokine profile of CD4(+) T cells in peripheral blood and tumor-draining lymph nodes of patients with gastrointestinal cancer. Japanese Journal of Clinical Oncology 2000 30 7 301 305 2-s2.0-0033814460
75. Augustin H. G., Young Koh G., Thurston G., Alitalo K., Control of vascular morphogenesis and homeostasis through the angiopoietin-tie system. Nature Reviews Molecular Cell Biology 2009 10 3 165 177 2-s2.0-60749096085 10.1038/nrm2639
76. Venneri M. A., De Palma M., Ponzoni M., Pucci F., Scielzo C., Zonari E., Mazzieri R., Doglioni C., Naldini L., Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer. Blood 2007 109 12 5276 5285 2-s2.0-34249979533 10.1182/blood-2006-10-053504 (Pubitemid 46890548)
77. De Palma M., Venneri M. A., Roca C., Naldini L., Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells. Nature Medicine 2003 9 6 789 795 2-s2.0-0038644403 10.1038/nm871 (Pubitemid 36749231)
78. Benoit M., Ghigo E., Capo C., Raoult D., Mege J. L., The uptake of apoptotic cells drives Coxiella burnetii replication and macrophage polarization: a model for Q fever endocarditis. PLoS Pathogens 2008 4 5 2-s2.0-44949223453 10.1371/journal.ppat.1000066 e1000066 (Pubitemid 351811526)
79. Mantovani A., Sica A., Sozzani S., Allavena P., Vecchi A., Locati M., The chemokine system in diverse forms of macrophage activation and polarization. Trends in Immunology 2004 25 12 677 686 2-s2.0-7644231561 10.1016/j.it.2004.09. 015 (Pubitemid 39457982)
80. Ohri C. M., Shikotra A., Green R. H., Waller D. A., Bradding P., Macrophages within NSCLC tumour islets are predominantly of a cytotoxic M1 phenotype associated with extended survival. European Respiratory Journal 2009 33 1 118 126 2-s2.0-58849166142 10.1183/09031936.00065708
81. Ohmori Y., Hamilton T. A., Requirement for STAT1 in LPS-induced gene expression in macrophages. Journal of Leukocyte Biology 2001 69 4 598 604 2-s2.0-0035067108 (Pubitemid 32294845)
82. Akira S., Toll-like receptor signaling. Journal of Biological Chemistry 2003 278 40 38105 38108 2-s2.0-0141532262 10.1074/jbc.R300028200 (Pubitemid 37221695)
83. Ito S., Ansari P., Sakatsume M., Dickensheets H., Vazquez N., Donnelly R. P., Larner A. C., Finbloom D. S., Interleukin-10 inhibits expression of both interferon α-and interferon γ -induced genes by suppressing tyrosine phosphorylation of STAT1. Blood 1999 93 5 1456 1463 2-s2.0-0033104946 (Pubitemid 29102470)
84. Coffelt S. B., Hughes R., Lewis C. E., Tumor-associated macrophages: effectors of angiogenesis and tumor progression. Biochimica et Biophysica Acta 2009 1796 1 11 18 2-s2.0-68949114117 10.1016/j.bbcan.2009.02.004
85. Mantovani A., Sozzani S., Locati M., Allavena P., Sica A., Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends in Immunology 2002 23 11 549 555 2-s2.0-0036839143 10.1016/S1471-4906(02)02302-5 (Pubitemid 35223554)
86. Solinas G., Germano G., Mantovani A., Allavena P., Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. Journal of Leukocyte Biology 2009 86 5 1065 1073 2-s2.0-70350728931 10.1189/jlb.0609385
87. Hagemann T., Lawrence T., McNeish I., Charles K. A., Kulbe H., Thompson R. G., Robinson S. C., Balkwill F. R., 'Re-educating' tumor-associated macrophages by targeting NF- B. Journal of Experimental Medicine 2008 205 6 1261 1268 2-s2.0-45149134605 10.1084/jem.20080108 (Pubitemid 351831483)
88. Germann T., Rude E., Interleukin-12. International Archives of Allergy and Immunology 1995 108 2 103 112 2-s2.0-0029153226
89. Al-Sarireh B., Eremin O., Tumour-associated macrophages (TAMS): disordered function, immune suppression and progressive tumour growth. Journal of the Royal College of Surgeons of Edinburgh 2000 45 1 1 16 2-s2.0-0034143110 (Pubitemid 35385843)
90. Sikora J., Dworacki G., Giersz R., Zeromski J., The role of monocytes/macrophages in TCR- ζ chain downregulation and apoptosis of T lymphocytes in malignant pleural effusions. Journal of Biological Regulators and Homeostatic Agents 2004 18 1 26 32 2-s2.0-4444339448 (Pubitemid 39193426)
91. Guo S. J., Lin D. M., Li J., Liu R. Z., Zhou C. X., Wang D. M., Ma W. B., Zhang Y. H., Zhang S. R., Tumor-associated macrophages and CD3- ζ expression of tumor-infiltrating lymphocytes in human esophageal squamous-cell carcinoma. Diseases of the Esophagus 2007 20 2 107 116 2-s2.0-34147128107 10.1111/j.1442-2050.2007.00655.x (Pubitemid 46562848)
92. Mulder W. M. C., Bloemena E., Stukart M. J., Kummer J. A., Wagstaff J., Scheper R. J., T cell receptor- ζ and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma. Gut 1997 40 1 113 119 2-s2.0-0031043487 (Pubitemid 27079762)
93. Kersh E. N., Shaw A. S., Allen P. M., Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation. Science 1998 281 5376 572 575 2-s2.0-0032563231 10.1126/science.281.5376.572 (Pubitemid 28357374)
94. Leivonen S. K., Kähäri V. M., Transforming growth factor- β signaling in cancer invasion and metastasis. International Journal of Cancer 2007 121 10 2119 2124 2-s2.0-35348847256 10.1002/ijc.23113 (Pubitemid 47585589)
95. Lamagna C., Aurrand-Lions M., Imhof B. A., Dual role of macrophages in tumor growth and angiogenesis. Journal of Leukocyte Biology 2006 80 4 705 713 2-s2.0-33751551172 10.1189/jlb.1105656 (Pubitemid 44835885)
96. Shih J.-Y., Yuan A., Chen J. J. W., Yang P. C., Tumor-associated macrophage: its role in cancer invasion and metastasis. Journal of Cancer Molecules 2006 2 101 106
97. Hildenbrand R., Wolf G., Böhme B., Bleyl U., Steinborn A., Urokinase plasminogen activator receptor (CD87) expression of tumor- associated macrophages in ductal carcinoma in situ, breast cancer, and resident macrophages of normal breast tissue. Journal of Leukocyte Biology 1999 66 1 40 49 2-s2.0-0032990269 (Pubitemid 29321368)
98. Lin E. Y., Nguyen A. V., Russell R. G., Pollard J. W., Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. Journal of Experimental Medicine 2001 193 6 727 739 2-s2.0-0035911221 10.1084/jem.193.6.727 (Pubitemid 32524466)
99. Wyckoff J., Wang W., Lin E. Y., Wang Y., Pixley F., Stanley E. R., Graf T., Pollard J. W., Segall J., Condeelis J., A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Research 2004 64 19 7022 7029 2-s2.0-4944229701 10.1158/0008-5472.CAN-04-1449 (Pubitemid 39331012)
100. Goswami S., Sahai E., Wyckoff J. B., Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Research 2005 65 5278 5283 10.1158/0008-5472.CAN-04-1853 (Pubitemid 40827339)
101. DeNardo D. G., Barreto J. B., Andreu P., Vasquez L., Tawfik D., Kolhatkar N., Coussens L. M., CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 2009 16 2 91 102 2-s2.0-67651160649 10.1016/j.ccr.2009.06.018
102. Gocheva V., Wang H. W., Gadea B. B., Shree T., Hunter K. E., Garfall A. L., Berman T., Joyce J. A., IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes and Development 2010 24 3 241 255 2-s2.0-76149146398 10.1101/gad.1874010
103. Hagemann T., Wilson J., Kulbe H., Li N. F., Leinster D. A., Charles K., Klemm F., Pukrop T., Binder C., Balkwill F. R., Macrophages induce invasiveness of epithelial cancer cells via NF- B and JNK. Journal of Immunology 2005 175 2 1197 1205 2-s2.0-23244451640 (Pubitemid 41095008)
104. Li Q., Verma I. M., NF-kappaB regulation in the immune system. Nature Reviews Immunology 2002 2 725 734
105. Bonizzi G., Karin M., The two NF- B activation pathways and their role in innate and adaptive immunity. Trends in Immunology 2004 25 6 280 288 2-s2.0-2342464085 10.1016/j.it.2004.03.008 (Pubitemid 38610351)
106. Wyckoff J. B., Wang Y., Lin E. Y., Li J. F., Goswami S., Stanley E. R., Segall J. E., Pollard J. W., Condeelis J., Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Research 2007 67 6 2649 2656 2-s2.0-34047246527 10.1158/0008-5472.CAN-06-1823 (Pubitemid 46548952)
107. Ingman W. V., Wyckoff J., Gouon-Evans V., Condeelis J., Pollard J. W., Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland. Developmental Dynamics 2006 235 12 3222 3229 2-s2.0-33845354896 10.1002/dvdy.20972 (Pubitemid 44888188)
108. Choi J., Kim H. Y., Ju E. J., Use of macrophages to deliver therapeutic and imaging contrast agents to tumors. Biomaterials 2012 33 4195 4203