Induced expression of B7-H3 on the lung cancer cells and macrophages suppresses T-cell mediating anti-tumor immune response

Experimental Cell Research

Volumn 319, Issue 1, 2013, Pages 96-102

  Chen, Cheng ^a   Shen, Yu ^a   Qu, Qiu Xia ^a   Chen, Xu Qin ^b   Zhang, Xue Guang ^a,b   Huang, Jian An ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

B7 H3; Lung cancer; T cell; Tumor associated macrophage

Indexed keywords

ANTIGEN; B7 H3 ANTIGEN; INTERLEUKIN 10; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL INTERACTION; CELL ISOLATION; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; IMMUNOREGULATION; LUNG CANCER; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL;

EID: 84869080530     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2012.09.006     Document Type: Article

References (24)

1. Mahipal A., Terai M., Berd D., Chervoneva I., Patel K., Mastrangelo M.J., Sato T. Tumor-derived interleukin-10 as a prognostic factor in stage III patients undergoing adjuvant treatment with an autologous melanoma cell vaccine. Cancer Immunol. Immunother. 2011, 7:1039-1045.
2. Dong H., Chen L. B7-H1 pathway and its role in the evasion of tumor immunity. J. Mol. Med. 2003, 81:281-287.
3. Lu B., Chen L., Liu L., Zhu Y., Wu C., Jiang J., Zhang X. T-cell-mediated tumor immune surveillance and expression of B7 co-inhibitory molecules in cancers of the upper gastrointestinal tract. Immunol. Res. 2011, 50:269-275.
4. Solinas G., Germano G., Mantovani A., Allavena P. Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J. Leukoc. Biol. 2009, 86:1-9.
5. Mantovani A., Schioppa T., Porta C., Allavena P., Sica A. Role of tumor-associated macrophages in tumor progression and invasion. Cancer Metastasis Rev. 2006, 25:315-322.
6. Mantovani A., Sica A., Allavena P., Garlanda C., Locati M. Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation. Hum. Immunol. 2009, 70:325-330.
7. Chapoval A.I., Ni J., Lau J.S., Wilcox R.A., Flies D.B., Liu D., Dong H., Sica G.L., Zhu G., Tamada K., Chen L. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol. 2001, 2:269-274.
8. Sun X., Vale M., Leung E., Kanwar J.R., Gupta R., Krissansen G.W. Mouse B7-H3 induces antitumor immunity. Gene Ther. 2003, 10:1728-1734.
9. Luo L., Chapoval A.I., Flies D.B., Zhu G., Hirano F., Wang S., Lau J.S., Dong H., Tamada K., Flies A.S., Liu Y., Chen L. B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells. J. Immunol. 2004, 173:5445-5450.
10. Lupu C.M., Eisenbach C., Kuefner M.A., Schmidt J., Lupu A.D., Stremmel W., Encke J. An orthotopic colon cancer model for studying the B7-H3 antitumor effect in vivo. J. Gastrointest. Surg. 2006, 10:635-645.
11. Ling V., Wu P.W., Spaulding V., Kieleczawa J., Luxenberg D., Carreno B.M., Collins M. Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss. Genomics 2003, 82:365-377.
12. Prasad D.V., Nguyen T., Li Z., Yang Y., Duong J., Wang Y., Dong C. Murine B7-H3 is a negative regulator of T cells. J. Immunol. 2004, 173:2500-2506.
13. Suh W.K., Gajewska B.U., Okada H., Gronski M.A., Bertram E.M., Dawicki W., Duncan G.S., Bukczynski J., Plyte S., Elia A., Wakeham A., Itie A., Chung S., Da Costa J., Arya S., Horan T., Campbell P., Gaida K., Ohashi P.S., Watts T.H., Yoshinaga S.K., Bray M.R., Jordana M., Mak T.W. The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat. Immunol. 2003, 4:899-906.
14. Leitner J., Kuschei W., Grabmeier-Pfistershammer K., Woitek R., Kriehuber E., Majdic O., Zlabinger G., Pickl W.F., Steinberger P. T cell stimulator cells, an efficient and versatile cellular system to assess the role of costimulatory ligands in the activation of human T cells. J. Immunol. Methods 2010, 362:131-141.
15. Fassbender M., Gerlitzki B., Ullrich N., Lupp C., Klein M., Radsak M.P., Schmitt E., Bopp T., Schild H. Cyclic adenosine monophosphate and IL-10 coordinately contribute to nTreg cell-mediated suppression of dendritic cell activation. Cell Immunol. 2010, 265:91-96.
16. Schneider T., Hoffmann H., Dienemann H., Schnabel P.A., Enk A.H., Ring S., Mahnke K. Non-small cell lung cancer induces an immunosuppressive phenotype of dendritic cells in tumor microenvironment by upregulating B7-H3. J. Thorac. Oncol. 2011, 6:1162-1168.
17. Heusinkveld M., de Vos van Steenwijk P.J., Goedemans R., Ramwadhdoebe T.H., Gorter A., Welters M.J., van Hall T., van der Burg S.H. M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+Th1 cells. J. Immunol. 2011, 187:1157-1165.
18. Adam W.M., Rita M., Young I. Myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) produce CCL22 which selectively recruits regulatory T-cells (Tregs) to the tumor microenvironment. FASEB J. 2008, 22:1078-1079.
19. Yamato I., Sho M., Nomi T., Akahori T., Shimada K., Hotta K., Kanehiro H., Konishi N., Yagita H., Nakajima Y. Clinical importance of B7-H3 expression in human pancreatic cancer. Br. J. Cancer 2009, 101:1709-1716.
20. Chavin G., Sheinin Y., Crispen P.L., Boorjian S.A., Roth T.J., Rangel L., Blute M.L., Sebo T.J., Tindall D.J., Kwon E.D., Karnes R.J. Expression of immunosuppresive B7-H3 ligand by hormone-treated prostate cancer tumors and metastases. Clin. Cancer Res. 2009, 15:2174-2180.
21. Zang X., Thompson R.H., Al-Ahmadie H.A., Serio A.M., Reuter V.E., Eastham J.A., Scardino P.T., Sharma P., Allison J.P. B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome. Proc. Natl. Acad. Sci. USA 2007, 104:19458-19463.
22. Roth T.J., Sheinin Y., Lohse C.M., Kuntz S.M., Frigola X., Inman B.A., Krambeck A.E., McKenney M.E., Karnes R.J., Blute M.L., Cheville J.C., Sebo T.J., Kwon E.D. B7-H3 ligand expression by prostate cancer: a novel marker of prognosis and potential target for therapy. Cancer Res. 2007, 67:7893-7900.
23. Sun Y., Wang Y., Zhao J., Gu M., Giscombe R., Lefvert A.K., Wang X. B7-H3 and B7-H4 expression in non-small-cell lung cancer. Lung Cancer 2006, 53:143-151.
24. Sun J., Chen L.J., Zhang G.B., Jiang J.T., Zhu M., Tan Y., Wang H.T., Lu B.F., Zhang X.G. Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma. Cancer Immunol. Immunother. 2010, 59:1163-1171.