Ligands selective for α4β2 but not α3β4 or α7 nicotinic receptors generalise to the nicotine discriminative stimulus in the rat

Psychopharmacology

Volumn 190, Issue 2, 2007, Pages 157-170

  Smith, Janice W ^a   Mogg, Adrian ^a   Tafi, Elisiana ^a   Peacey, Eleanor ^a   Pullar, Ian A ^a   Szekeres, Philip ^a   Tricklebank, Mark ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

3 4 receptor; 4 2 receptor; 7 receptor; Drug discrimination; Nicotine

Indexed keywords

3 (2 AZETIDINYLMETHOXY)PYRIDINE; 5 (2 AZETIDINYLMETHOXY) 2 CHLOROPYRIDINE; BUNGAROTOXIN RECEPTOR; CYTISINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3BETA4; NICOTINIC RECEPTOR ALPHA4BETA2; RECEPTOR SUBTYPE; TC 2559; UNCLASSIFIED DRUG; VARENICLINE; WO 01 60821A1; WO 03 062224; 5-(2-AZETIDINYLMETHOXY)-2-CHLOROPYRIDINE; ALPHA-BUNGAROTOXIN RECEPTOR; AZETIDINE DERIVATIVE; BENZAZEPINE DERIVATIVE; CYSTINE; NICOTINE; PYRIDINE DERIVATIVE; QUINOXALINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DOPAMINE RELEASE; DRUG DISCRIMINATION; EMBRYO; HUMAN; HUMAN CELL; LIGAND BINDING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SCINTILLATION; ANIMAL; APPETITE; COMPARATIVE STUDY; CORPUS STRIATUM; DISCRIMINATION LEARNING; DOSE RESPONSE; DRUG EFFECT; MOTIVATION; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT STRAIN; TOBACCO DEPENDENCE;

ANIMALS; APPETITIVE BEHAVIOR; AZETIDINES; BENZAZEPINES; CORPUS STRIATUM; CYSTINE; DISCRIMINATION LEARNING; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MOTIVATION; NICOTINE; NICOTINIC AGONISTS; PYRIDINES; QUINOXALINES; RATS; RATS, INBRED STRAINS; RECEPTORS, NICOTINIC; TOBACCO USE DISORDER;

EID: 33845793349     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-006-0596-8     Document Type: Article

References (54)

1. Bannon AW, Decker MW, Kim DJB, Campbell JE, Arneric SP (1998) ABT-594, a novel cholinergic channel modulator, is efficacious in nerve ligation and diabetic neuropathy models of neuropathic pain. Brain Res 801:158-163
2. Brioni JD, Kim DJB, O'Neill AB (1996) Nicotine cue: lack of effect of the alpha7 nicotinic receptor antagonist methyllycaconitine. Eur J Pharmacol 301:1-5
3. Buckley MJ, Surowy C, Meyer M, Curzon P (2004) Mechanism of action of A-85380 in an animal model of depression. Prog Neuropsychopharmacol Biol Psychiatry 28:723-730
4. Cao YJ, Surowy CS, Puttfarcken PS (2005) Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release. Neuropharmacology 48:72-79
5. Chandler CJ, Stolerman IP (1997) Discriminative stimulus properties of the nicotinic agonist cytisine. Psychopharmacology 129:257-264
6. Chen Y, Sharples TJW, Phillips KG, Benedetti G, Broad LM, Zwart R, Sher E (2003) The nicotinic alpha4beta2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices. Neuropharmacology 45:334-344
7. Cheng YC, Prusoff WH (1973) Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108
8. Coe JW, Brooks PR, Wirtz MC, Bashore CG, Bianco KE, Vetelino MG, Arnold EP, Lebel LA, Fox CB, Tingley FD 3rd, Schulz DW, Davis TI, Sands SB, Mansbach RS, Rollema H, O'Neill BT (2005) 3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation. Bioorg Med Chem Lett 15:4889-4897
9. Cooper E, Couturier S, Ballivet M (1991) Pentameric structure and subunit stoichiometry of a neuronal acetylcholine receptor. Nature 350:235-238
10. Corrigall WA, Franklin KBJ, Coen KM, Clarke PBS (1992) The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine. Psychopharmacology 107:285-289
11. Corrigall WA, Coen KM, Adamson KL (1994) Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area. Brain Res 653:278-284
12. Corringer PJ, Le Novere N, Changeux J-P (2000) Nicotinic receptors at the amino acid level. Annu Rev Pharmacol Toxicol 40:431-458
13. Couturier S, Bertrand D, Matter JM, Hernandez MC, Bertrand S, Millar N, Valera S, Barkas T, Ballivet M (1990) A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homo-oligomeric channel blocked by alpha-BTX. Neuron 5:847-856
14. Cunningham CS, Polston JE, Jany JR, Segert IL, Miller DK (2006) Interaction of lobeline and nicotinic receptor ligands with the discriminative stimulus properties of cocaine and amphetamine. Drug Alcohol Depend 84:211-222
15. De Biasi M (2002) Nicotinic mechanisms in the autonomic control of organ systems. J Neurobiol 53:568-579
16. Di Chiara G (2000) Role of dopamine in the behavioural actions of nicotine related to addiction. Eur J Pharmacol 393:295-314
17. Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85:5274-5278
18. Donnelly-Roberts D, Puttfarcken PS, Kuntzweiler TA, Briggs CA, Anderson DJ, Campbell JE, Piattoni-Kaplan M, McKenna DG, Wasicak JT, Holladay MW, Williams M, Arneric SP (1998) ABT-594 [(R)-5-(2-azetidinylmethoxy)-2- chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterisation. J Pharmacol Exp Ther 285:777-786
19. Fu Y, Matta SG, Sharp BM (1999) Local alpha-bungarotoxin-sensitive nicotinic receptors modulate hippocampal norepinephrine release by systemic nicotine. J Pharmacol Exp Ther 289:133-139
20. Garcha HS, Giardini V, Pratt JA, Stolerman IP (1983) Investigation of the effects of ganglion-blocking drugs and methergoline on the nicotine cue in rats. Br J Pharmacol 78:9P
21. Gommans J, Stolerman IP, Shoaib M (2000) Antagonism of the discriminative and aversive stimulus properties of nicotine in C57BL/6J mice. Neuropharmacology 39:2840-2847
22. Grady SR, Meinerz NM, Cao J, Reynolds AM, Picciotto MR, Changeux J-P, McIntosh JM, Marks MJ, Collins AC (2001) Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum. J Neurochem 76:258-268
23. Hirschhorn ID, Rosecrans JA (1974) Studies on the time course and the effect of cholinergic and adrenergic receptor blockers on the stimulus effect of nicotine. Psychopharmacologia 40:109-120
24. Kallman WM, Rosecrans JA, Kallman MJ, Harry GJ, Woodson PT (1982) Nicotine as a discriminative stimulus in human subjects. Psychopharmacology 76:A8
25. Kumar R, Reavill C, Stolerman IP (1987) Nicotine cue in rats: effects of central administration of ganglion-blocking drugs. Br J Pharmacol 90:239-246
26. Lambe EK, Picciotto MR, Aghajanian GK (2003) Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex. Neuropsychopharmacology 28:216-225
27. Le Novere N, Corringer P-J, Changeux J-P (2002) The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences. J Neurobiol 53:447-456
28. Leslie FM, Gallardo KA, Park MK (2002) Nicotinic acetylcholine receptor-mediated release of [3H]norepinephrine from developing and adult rat hippocampus: direct and indirect mechanisms. Neuropharmacology 42:653-661
29. Luo S, Kulak JM, Cartier GE, Jacobsen RB, Yoshikami D, Olivera BM, McIntosh JM (1998) alpha-conotoxin AuIB selectively blocks alpha3 beta4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release. J Neurosci 18:8571-8579
30. Malin DH, Lake JR, Schopen CK, Kirk JW, Sailer EE, Lawless BA, Upchurch TP, Shenoi M, Rajan N (1997) Nicotine abstinence syndrome precipitated by central but not peripheral hexamethonium. Pharmacol Biochem Behav 58:695-699
31. Marks MJ, Pauly JR, Gross SD, Deneris ES, Hermans-Borgmeyer I, Heinemann SF, Collins AC (1992) Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J Neurosci 12:2765-2784
32. Miyata H, Ando K, Yanagita T (1999) Medial prefrontal cortex is involved in the discriminative stimulus effects of nicotine in rats. Psychopharmacology 145:234-236
33. Miyata H, Ando K, Yanagita T (2002) Brain regions mediating the discriminative stimulus effects of nicotine in rats. Ann N Y Acad Sci 965:354-363
34. Ohashi K, Osuga J-I, Tozawa R, Kitamine T, Yagyu H, Sekiya M, Tomita S, Okazaki H, Tamura Y, Yahagi N, Iizuka Y, Harada K, Gotoda T, Shimano H, Yamada N, Ishibashi S (2003) Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene. J Biol Chem 278:42936-42941
35. Picciotto MR, Zoli M, Rimondini R, Lena C, Marubio LM, Pich EM, Fuxe K, Changeux J-P (1998) Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine. Nature 391:173-177
36. Pratt JA, Stolerman IP, Garcha HS, Giardini V, Feyerabend C (1983) Discriminative stimulus properties of nicotine: further evidence for mediation at a cholinergic receptor. Psychopharmacology 81:54-60
37. Salas R, Orr-Urtreger A, Broide RS, Beaudet A, Paylor R, De Biasi M (2003) The nicotinic acetylcholine receptor subunit a5 mediates short-term effects of nicotine in vivo. Mol Pharmacol 63:1059-1066
38. Salas R, Cook KD, Bassetto L, De Biasi M (2004) The a3 and b4 nicotinic acetylcholine receptor subunits are necessary for nicotine-induced seizures and hypolocomotion. Neuropharmacology 47:401-407
39. Schechter MD (1995) Scopolamine-physostigmine combination does not substitute for nicotine. Prog Neuropsychopharmacol Biol Psychiatry 19:499-508
40. Shoaib M, Stolerman IP (1996) Brain sites mediating the discriminative stimulus effects of nicotine in rats. Behav Brain Res 78:183-188
41. Shoaib M, Zubaran C, Stolerman IP (2000) Antagonism of stimulus properties of nicotine by dihydro-b-erythroidine (DHbE) in rats. Psychopharmacology 149:140-146
42. Shoaib M, Gommans J, Morley A, Stolerman IP, Grailhe R, Changeux J (2002) The role of nicotinic receptor beta-2 subunits in nicotine discrimination and conditioned taste aversion. Neuropharmacology 42:530-539
43. Stolerman IP, Garcha HS, Pratt JA, Kumar R (1984) Role of training dose in discrimination of nicotine and related compounds by rats. Psychopharmacology 84:413-419
44. Stolerman IP, Chandler CJ, Garcha HS, Newton JM (1997) Selective antagonism of behavioural effects of nicotine by dihydro-beta-erythroidine in rats. Psychopharmacology 129:390-397
45. Stolerman IP, Chamberlain S, Bizarro L, Fernandes C, Schalkwyk L (2004) The role of nicotinic receptor alpha7 subunits in nicotine discrimination. Neuropharmacology 46:363-371
46. Sullivan JP, Donnelly-Roberts D, Briggs CA, Anderson DJ, Gopalakrishnan M, Piattoni-Kaplan M, Campbell JE, McKenna DG, Molinari E, Hettinger A-M, Garvey DS, Wasicak JT, Holladay MW, Williams M, Arneric SP (1998) A-85380 [3-(2 (S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha4beta2 nicotinic acetylcholine receptor ligand. Neuropharmacology 35:725-734
47. Unwin N (2003) Structure and action of the nicotinic acetylcholine receptor explored by electron microscopy. FEBS Lett 555:91-95
48. Watkins SS, Epping-Jordan MP, Koob GF, Markou A (1999) Blockade of nicotine self-administration with nicotinic antagonists in rats. Pharmacol Biochem Behav 62:743-751
49. Wiley JL, James JR, Rosecrans JA (1996) Discriminative stimulus properties of nicotine: approaches to evaluating potential nicotinic receptor agonists and antagonists. Drug Dev Res 38:222-230
50. Wu J, George AA, Schroeder KM, Xu L, Marxer-Miller S, Lucero L, Lukas RJ (2004) Electrophysiological, pharmacological and molecular evidence for α7-nicotinic acetylcholine receptors in rat midbrain dopamine neurons. J Pharmacol Exp Ther 311:80-91
51. Xu W, Orr-Urtreger A, Nigro F, Gelber S, Sutcliffe CB, Armstrong D, Patrick JW, Role LW, Beaudet AL, De Biasi M (1999a) Multiorgan autonomic dysfunction in mice lacking the beta2 and the beta4 subunits of neuronal nicotinic acetylcholine receptors. J Neurosci 19:9298-9305
52. Xu W, Gelber S, Orr-Urtreger A, Armstrong D, Lewis RA, Ou C, Patrick J, Role L, De Biasi M, Beaudet AL (1999b) Megacystis, mydriasis, and ion channel defect in mice lacking the alpha3 neuronal nicotinic acetylcholine receptor. Proc Natl Acad Sci USA 96:5746-5751
53. Zhu PJ, Chiappinelli VA (2002) Nicotinic receptors mediate increased GABA release in brain through a tetrodotoxin-insensitive mechanism during prolonged exposure to nicotine. Neuroscience 115:137-144
54. Zoli M, Lena C, Picciotto MR, Changeux JP (1998) Identification of four classes of brain nicotinic receptors using beta2 mutant mice. J Neurosci 18:4461-4472