A conservative, single-amino acid substitution in the second cytoplasmic domain of the human serotonin2C receptor alters both ligand-dependent and -independent receptor signaling

Journal of Pharmacology and Experimental Therapeutics

Volumn 324, Issue 3, 2008, Pages 1084-1092

  Berg, Kelly A ^a,c   Dunlop, John ^b   Sanchez, Teresa ^a   Silva, Michelle ^a   Clarke, William P ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; 2 (6 CHLORO 5 FLUORO 1 INDOLYL) 1 METHYLETHYLAMINE; 2,5 DIMETHOXY 4 METHYLAMPHETAMINE; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 8,9 DICHLORO 2,3,4 4A TETRAHYDRO 1H PYRAZINO[1,2 A]QUINOXALIN 5(6H) ONE; BUFOTENINE; ISOLEUCINE; LYSERGIDE; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; QUIPAZINE; SEROTONIN 2C AGONIST; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG; VALINE; WAY 161503;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOPLASM; DRUG EFFECT; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; ISOMER; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; THERMOSTABILITY;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; CYTOPLASM; HUMANS; LIGANDS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, SEROTONIN, 5-HT2C; SIGNAL TRANSDUCTION;

EID: 40849102720     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.131524     Document Type: Article

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