The serotonin2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination

Psychopharmacology

Volumn 193, Issue 3, 2007, Pages 391-402

  Quarta, Davide ^a,b   Naylor, Christopher G ^a   Stolerman, Ian P ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GSK   (Italy)

Author keywords

Attention; Drug discrimination; Nicotine; Pentobarbitone; Rats; Ro 60 0175; Serotonin receptors

Indexed keywords

2 (6 CHLORO 5 FLUORO 1 INDOLYL) 1 METHYLETHYLAMINE; NICOTINE; SEROTONIN 2C AGONIST;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; ATTENTION; CONTROLLED STUDY; DOSE RESPONSE; FOOD; MALE; NONHUMAN; PERCEPTIVE DISCRIMINATION; PRIORITY JOURNAL; RAT; REACTION TIME; REINFORCEMENT; SEDATION; TASK PERFORMANCE; TRAINING;

ANIMALS; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLAMINES; GANGLIONIC STIMULANTS; HYPNOTICS AND SEDATIVES; INDOLES; MALE; NICOTINE; PENTOBARBITAL; RATS; REACTION TIME; RECEPTOR, SEROTONIN, 5-HT2C;

EID: 34447298639     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-007-0802-3     Document Type: Article

References (65)

1. Ator NA, Griffiths RR (2003) Principles of drug abuse liability assessment in laboratory animals. Drug Alcohol Depend 70 (Suppl 1):S55-S72
2. Balfour DJK, Benwell MEM, Birrell CE, Keely RJ, Al-Aloul M (1998) Sensitization of the mesoaccumbens dopamine response to nicotine. Pharmacol Biochem Behav 59:1021-1030
3. Barnes NM, Sharp T (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38:1083-1152
4. 2A/2C receptor agonists. Psychopharmacology (Berl) 179:393-401
5. 2 receptor subtypes: a family re-united? Trends Pharmacol Sci 16:105-110
6. Benwell ME, Balfour DJK (1979) Effects of nicotine administration and its withdrawal on plasma corticosterone and brain 5-hydroxyindoles. Psychopharmacology (Berl) 63:7-11
7. Bizarro L, Stolerman IP (2003) Attentional effects of nicotine and amphetamine in rats at different levels of motivation. Psychopharmacology (Berl) 170:271-277
8. Dalley JW, Theobald DE, Eagle DM, Passetti F, Robbins TW (2002) Deficits in impulse control associated with tonically elevated serotonergic function in rat prefrontal cortex. Neuropsychopharmacology 26:716-728
9. De Deurwaerdere P, Navailles S, Berg KA, Clarke WP, Spampinato U (2004) Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens. J Neurosci 24:3235-3241
10. Desai RI, Barber DJ, Terry P (2003) Dopaminergic and cholinergic involvement in the discriminative stimulus effects of nicotine and cocaine in rats. Psychopharmacology (Berl) 167:335-343
11. 2C/2B receptors enhances dopamine release in the rat nucleus accumbens. Neuropharmacology 37:265-272
12. Di Matteo V, Pierucci M, Esposito E (2004) Selective stimulation of serotonin2c receptors blocks the enhancement of striatal and accumbal dopamine release induced by nicotine administration. J Neurochem 89:418-429
13. Eberle-Wang K, Mikeladze Z, Uryu K, Chesselet MF (1997) Pattern of expression of the serotonin2C receptor messenger RNA in the basal ganglia of adult rats. J Comp Neurol 384:233-247
14. 2C receptor agonist Ro60-0175 into the ventral tegmental area reduces cocaine-induced locomotor activity and cocaine self-administration. Neuropsychopharmacology 29:308-318
15. Gasior M, Shoaib M, Yasar S, Jaszyna M, Goldberg SR (1999) Acquisition of nicotine discrimination and discriminative stimulus effects of nicotine in rats chronically exposed to caffeine. J Pharmacol Exp Ther 288:1053-1073
16. Gioanni Y, Rougeot C, Clarke PB, Lepouse C, Thierry AM, Vidal C (1999) Nicotinic receptors in the rat prefrontal cortex: increase in glutamate release and facilitation of mediodorsal thalamo-cortical transmission. Eur J Neurosci 11:18-30
17. Granon S, Passetti F, Thomas KL, Dalley JW, Everitt BJ, Robbins TW (2000) Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex. J Neurosci 20:1208-1215
18. Grottick AJ, Fletcher PJ, Higgins GA (2000) Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior. J Pharmacol Exp Ther 295:1183-1191
19. Grottick AJ, Corrigall WA, Higgins GA (2001) Activation of 5-HT(2C) receptors reduces the locomotor and rewarding effects of nicotine. Psychopharmacology (Berl) 157:292-298
20. Hahn B, Stolerman IP (2002) Nicotine-induced attentional enhancement in rats: effects of chronic exposure to nicotine. Neuropsychopharmacology 27:712-722
21. Hahn B, Shoaib M, Stolerman IP (2002a) Nicotine-induced enhancement of attention in the five-choice serial reaction time task: the influence of task-demands. Psychopharmacology (Berl) 162:129-137
22. Hahn B, Shoaib M, Stolerman IP (2002b) Effects of dopamine receptor antagonists on nicotine-induced attentional enhancement. Behav Pharmacol 13:621-632
23. Hahn B, Shoaib M, Stolerman IP (2003) Involvement of the prefrontal cortex but not the dorsal hippocampus in the attention-enhancing effects of nicotine in rats. Psychopharmacology (Berl) 168:271-279
24. Harrison AA, Everitt BJ, Robbins TW (1997) Central 5-HT depletion enhances impulsive responding without affecting the accuracy of attentional performance: interactions with dopaminergic mechanisms. Psychopharmacology (Berl) 133:329-342
25. 2A receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism. Psychopharmacology (Berl) 170:309-319
26. Koelega HS (1993) Stimulant drugs and vigilance performance: a review. Psychopharmacology (Berl) 111:1-16
27. Lemmonds CA, Wenger GR (2003) Effects of drugs of abuse and signal predictability in two models of sustained attention in pigeons. Behav Pharmacol 14:279-294
28. Levin ED, Simon BB (1998) Nicotinic acetylcholine involvement in cognitive function in animals. Psychopharmacology (Berl) 138:217-230
29. Louis M, Clarke PBS (1998) Effects of ventral tegmental 6-hydroxydopamine lesions on the locomotor stimulant action of nicotine in rats. Neuropharmacology 37:1503-1518
30. Mansbach RS, Rovetti CC, Freedland CS (1998) The role of monoamine neurotransmitter systems in the nicotine discriminative stimulus. Drug Alcohol Depend 52:125-134
31. Mansvelder HD, van Aerde KI, Couey JJ, Brussaard AB (2006) Nicotinic modulation of neuronal networks: from receptors to cognition. Psychopharmacology (Berl) 184:292-305
32. 2C receptor antagonist SB 206,553. Neuropharmacology 36:743-745
33. Mirza NR, Stolerman IP (1998) Nicotine enhances sustained attention in the rat under specific task conditions. Psychopharmacology (Berl) 138:266-274
34. Miyata H, Ando K, Yanagita T (2002) Brain regions mediating the discriminative stimulus effects of nicotine in rats. Ann N Y Acad Sci 965:354-363
35. 2C receptor antagonist but not agonist modulates cocaine-induced dopamine outflow in the rat nucleus accumbens and striatum. Neuropsychopharmacology 29:319-326
36. Picciotto MR, Corrigall WA (2002) Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics. J Neurosci 22:3338-3341
37. Pidoplichko VI, DeBiasi M, Williams JT, Dani JA (1997) Nicotine activates and desensitizes midbrain dopamine neurons. Nature 390:401-404
38. Pierucci M, Di Matteo V, Esposito E (2004) Stimulation of serotonin2C receptors blocks the hyperactivation of midbrain dopamine neurons induced by nicotine administration. J Pharmacol Exp Ther 309:109-118
39. 2C receptors. Brain Res Mol Brain Res 23:163-178
40. 2C receptors in CHO-K1 cells. Br J Pharmacol 128:13-20
41. Pratt JA, Stolerman IP, Garcha HS, Giardini V, Feyerabend C (1983) Discriminative stimulus properties of nicotine: further evidence for mediation at a cholinergic receptor. Psychopharmacology (Berl) 81:54-60
42. Puttfarcken PS, Jacobs I, Faltynek CR (2000) Characterization of nicotinic acetylcholine receptor-mediated [(3)H]-dopamine release from rat cortex and striatum. Neuropharmacology 39:2673-2680
43. Quarta D, Ciruela F, Patkar K, Borycz J, Solinas M, Lluis C, Franco R, Wise RA, Goldberg SR, Hope BT, Woods AS, Ferre S (2007) Heteromeric nicotinic acetylcholine-dopamine autoreceptor complexes modulate striatal dopamine release. Neuropsychopharmacology 32:35-42
44. Rezvani AH, Caldwell DP, Levin ED (2005) Nicotinic-serotonergic drug interactions and attentional performance in rats. Psychopharmacology (Berl) 179:521-528
45. Ribeiro EB, Bettiker RL, Bogdanov M, Wurtman RJ (1993). Effects of systemic nicotine on serotonin release in rat brain. Brain Res 621:311-318
46. Robbins TW (1999) Arousal and attention: psychopharmacological and neuropsychological studies in experimental animals. In: Parasuraman R (ed) The attentive brain. MIT Press, Cambridge, MA, pp. 189-220
47. Robbins TW (2002) The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology (Berl) 163:362-380
48. Rodriguez R (1992) Effect of various psychotropic drugs on the performance of avoidance and escape behaviors in rats. Pharmacol Biochem Behav 43:1155-1159
49. Role LW, Berg DK (1996) Nicotinic receptors in the development and modulation of CNS synapses. Neuron 16:1077-1085
50. Schechter MD, Meehan SM (1992) Further evidence for the mechanisms that may mediate nicotine discrimination. Pharmacol Biochem Behav 41:807-812
51. Schechter MD, Rosecrans JA (1972) Nicotine as a discriminative cue in rats depleted of norepinephrine or 5-hydroxytryptamine. Psychopharmacologia 24:417-429
52. Schwartz RD, Lehmann J, Kellar KJ (1984) Presynaptic nicotinic cholinergic receptors labeled by [3H]acetylcholine on catecholamine and serotonin axons in brain. J Neurochem 42:1495-1498
53. Shannon HE, Love PL (2005) Effects of antiepileptic drugs on attention as assessed by a five-choice serial reaction time task in rats. Epilepsy Behav 7:620-628
54. Shearman E, Rossi S, Sershen H, Hashim A, Lajtha A (2005) Locally administered low nicotine-induced neurotransmitter changes in areas of cognitive function. Neurochem Res 30:1055-1066
55. Stolerman I (1992) Drugs of abuse: behavioural principles, methods and terms. Trends Pharmacol Sci 13:170-176
56. 3 antagonists and other drugs to block the nicotine discriminative stimulus. In: Harris LS (ed) Problems of drug dependence 1993. NIDA Research Monograph 141. U.S. Department of Health and Human Services, Rockville, MD, USA, p. 67
57. Stolerman IP, Mirza NR, Shoaib M (1995) Nicotine psychopharmacology: addiction, cognition and neuroadaptation. Med Res Rev 15:47-72
58. Stolerman IP, Pratt JA, Garcha HS, Giardini V, Kumar R (1983) Nicotine cue in rats analyzed with drugs acting on cholinergic and 5-hydroxytryptamine mechanisms. Neuropharmacology 22:1029-1037
59. Summers KL, Giacobini E (1995) Effects of local and repeated systemic administration of (-)nicotine on extracellular levels of acetylcholine, norepinephrine, dopamine, and serotonin in rat cortex. Neurochem Res 20:753-759
60. van Gaalen MM, Brueggeman RJ, Bronius PF, Schoffelmeer AN, Vanderschuren LJ (2006) Behavioral disinhibition requires dopamine receptor activation. Psychopharmacology (Berl) 187:73-85
61. Vizi ES, Lendvai B (1999) Modulatory role of presynaptic nicotinic receptors in synaptic and non-synaptic chemical communication in the central nervous system. Brain Res Brain Res Rev 30:219-235
62. Wenger GR, Wright DW (1990) Disruption of performance under a titrating matching-to-sample schedule of reinforcement by drugs of abuse. J Pharmacol Exp Ther 254:258-269
63. 2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion. Psychopharmacology (Berl) 176:376-385
64. Wonnacott S, Irons J, Rapier C, Thorne B, Lunt GG (1989) Presynaptic modulation of transmitter release by nicotinic receptors. Prog Brain Res 79:157-163
65. Zoli M, Moretti M, Zanardi A, McIntosh JM, Clementi F, Gotti C (2002) Identification of the nicotinic receptor subtypes expressed on dopaminergic terminals in the rat striatum. J Neurosci 22:8785-8789