Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement

Neuropharmacology

Volumn 62, Issue 7, 2012, Pages 2288-2298

  Fletcher, Paul J ^a,b   Rizos, Zouml ^a   Noble, Kevin ^a   Soko, Ashlie D ^a   Silenieks, Leo B ^c   Lê, Anh Dzung ^a,b   Higgins, Guy A ^b,c  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c InterVivo Solutions Inc   (Canada)

Author keywords

5 HT2C; Nicotine; Reinstatement; Self administration; Serotonin

Indexed keywords

2 (6 CHLORO 5 FLUORO 1 INDOLYL) 1 METHYLETHYLAMINE; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; NICOTINE; VOLINANSERIN;

ADULT ANIMAL; ANIMAL EXPERIMENT; ARTICLE; ASSOCIATION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESPONSE; MALE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; REINFORCEMENT; TOBACCO DEPENDENCE;

EID: 84859103717     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.01.023     Document Type: Article

References (84)

1. K.D. Alex, and E.A. Pehek Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission Pharmacol. Ther. 113 2007 296 320 (Pubitemid 46149046)
2. A. Auclair, G. Blanc, J. Glowinski, and J.P. Tassin Role of serotonin 2A receptors in the D-amphetamine-induced release of dopamine: comparison with previous data on alpha1b-adrenergic receptors J. Neurochem. 91 2004 318 326 (Pubitemid 39363431)
3. A.Y. Bespalov, O.A. Dravolina, I. Sukhanov, E. Zakharova, E. Blokhina, E. Zvartau, W. Danysz, G. van Heeke, and A. Markou Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats Neuropharmacology 49 Suppl. 1 2005 167 178 (Pubitemid 41115903)
4. B. Borrelli, and R. Mermelstein The role of weight concern and self-efficacy in smoking cessation and weight gain among smokers in a clinic-based cessation program Addict. Behav. 23 1998 609 622 (Pubitemid 28410842)
5. 2C receptors as potential targets for modulation of psychostimulant use and dependence Curr. Top. Med. Chem. 6 2006 1971 1985 (Pubitemid 44524471)
6. M.J. Bubar, and K.A. Cunningham Prospects for serotonin 5-HT2R pharmacotherapy in psychostimulant abuse Prog. Brain. Res. 172 2008 319 346
7. 2C receptors influences cocaine-seeking behavior in response to drug-associated stimuli in rats Psychopharmacology (Berl) 196 2008 15 27
8. J.J. Burmeister, E.M. Lungren, K.F. Kirschner, and J.L. Neisewander Differential roles of 5-HT receptor subtypes in cue and cocaine reinstatement of cocaine-seeking behavior in rats Neuropsychopharmacology 29 2004 660 668 (Pubitemid 38402473)
9. 2A receptors in the medial prefrontal cortex to different aspects of executive control such as impulsivity and compulsive perseveration in rats Neuropsychopharmacology 31 2006 757 767
10. I. Ceglia, M. Carli, M. Baviera, G. Renoldi, E. Calcagno, and R.W. Invernizzi The 5-HT receptor antagonist M100,907 prevents extracellular glutamate rising in response to NMDA receptor blockade in the mPFC J. Neurochem. 91 2004 189 199 (Pubitemid 39314949)
11. P.B. Clarke, D.S. Fu, A. Jakubovic, and H.C. Fibiger Evidence that mesolimbic dopaminergic activation underlies the locomotor stimulant action of nicotine in rats J. Pharmacol. Exp. Ther. 246 1988 701 708
12. W.A. Corrigall, K.B. Franklin, K.M. Coen, and P.B. Clarke The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine Psychopharmacology (Berl) 107 1992 285 289
13. W.A. Corrigall, K.M. Coen, and K.L. Adamson Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area Brain. Res. 653 1994 278 284 (Pubitemid 24252850)
14. 2B/2C receptor subtypes in the control of accumbal and striatal dopamine release elicited in vivo by dorsal raphe nucleus electrical stimulation J. Neurochem. 73 1999 1033 1042 (Pubitemid 29395459)
15. G. Di Chiara Role of dopamine in the behavioural actions of nicotine related to addiction Eur. J. Pharmacol. 393 2000 295 314 (Pubitemid 30193428)
16. 2C/2B receptor agonists: a combined in vivo electrophysiological and microdialysis study Synapse 35 2000 53 61
17. 2C/2B receptors enhances dopamine release in the rat nucleus accumbens Neuropharmacology 37 1998 265 272 (Pubitemid 28293766)
18. 2C receptor antagonist, increases dopaminergic transmission in the mesolimbic system Neuropharmacology 38 1999 1195 1205 (Pubitemid 29292408)
19. 2C receptors Brain. Res. 865 2000 85 90 (Pubitemid 30256209)
20. 2C receptors blocks the enhancement of striatal and accumbal dopamine release induced by nicotine administration J. Neurochem. 89 2004 418 429 (Pubitemid 38495990)
21. V. Di Matteo, M. Pierucci, G. Di Giovanni, A. Benigno, and E. Esposito The neurobiological bases for the pharmacotherapy of nicotine addiction Curr. Pharm. Des. 13 2007 1269 1284 (Pubitemid 46739334)
22. V. Di Matteo, G. Di Giovanni, M. Pierucci, and E. Esposito Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies Prog. Brain. Res. 172 2008 7 44
23. O.A. Dravolina, E.S. Zakharova, E.V. Shekunova, E.E. Zvartau, W. Danysz, and A.Y. Bespalov mGlu1 receptor blockade attenuates cue- and nicotine-induced reinstatement of extinguished nicotine self-administration behavior in rats Neuropharmacology 52 2007 263 269 (Pubitemid 46123346)
24. 2C) receptors in rat prefrontal cortex J. Pharmacol. Exp. Ther. 306 2003 734 743 (Pubitemid 36886175)
25. M. Filip, M.J. Bubar, and K.A. Cunningham Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses J. Pharmacol. Exp. Ther. 310 2004 1246 1254 (Pubitemid 39108947)
26. 2C receptor antagonist SB242084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding Neuropsychopharmacology 27 2002 576 586
27. 2C receptor agonist Ro60-0175 into the ventral tegmental area reduces cocaine-induced locomotor activity and cocaine self-administration Neuropsychopharmacology 29 2004 308 318 (Pubitemid 38175149)
28. 2C receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test Psychopharmacology (Berl) 195 2007 223 234 (Pubitemid 350045843)
29. P.J. Fletcher, A.D. Le, and G.A. Higgins Serotonin receptors as potential targets for modulation of nicotine use and dependence Prog. Brain. Res. 172 2008 361 383
30. 2C receptors on cocaine- and food-maintained behavior J. Pharmacol. Exp. Ther. 295 2000 1183 1191
31. 2C receptors reduces the locomotor and rewarding effects of nicotine Psychopharmacology (Berl) 157 2001 292 298 (Pubitemid 32905571)
32. 2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats Behav. Brain. Res. 197 2009 323 330
33. 2C receptors Eur. J. Pharmacol. 480 2003 151 162 (Pubitemid 37410367)
34. 2 agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine Br. J. Pharmacol. 133 2001 459 466 (Pubitemid 32591911)
35. 2A receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism Psychopharmacology (Berl) 170 2003 309 319 (Pubitemid 37491611)
36. 2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to feeding behavior and impulse control. Neuropsychopharmacology.
37. K.M. Hurren, and H.D. Berlie Lorcaserin: an investigational serotonin 2C agonist for weight loss Am. J. Health. Syst. Pharm. 68 2011 2029 2037
38. 2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat striatum Brain. Res. 698 1995 204 208
39. 2A/2C receptor agonist, attenuates clozapine-induced cortical dopamine release Brain. Res. 907 2001 151 155 (Pubitemid 32595524)
40. J.D. Jentsch, and J.R. Taylor Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli Psychopharmacology (Berl) 146 1999 373 390 (Pubitemid 29513278)
41. 2C receptors suppresses behavioral responses induced by drugs of abuse Nat. Med. 12 2006 324 329 (Pubitemid 43355081)
42. 2A antagonist with a favorable CNS safety profile J. Pharmacol. Exp. Ther. 277 1996 968 981
43. 2A receptor antagonist MDL 100,907 on MDMA-induced locomotor stimulation in rats Neuropsychopharmacology 15 1996 116 124 (Pubitemid 26255158)
44. P.J. Kenny, and A. Markou Neurobiology of the nicotine withdrawal syndrome Pharmacol. Biochem. Behav. 70 2001 531 549 (Pubitemid 34131647)
45. 2A receptor occupancy Eur. J. Pharmacol. 591 2008 136 141
46. R.T. LaLumiere, and P.W. Kalivas Glutamate release in the nucleus accumbens core is necessary for heroin seeking J. Neurosci. 28 2008 3170 3177 (Pubitemid 351442289)
47. E.D. Levin, S. Slade, M. Johnson, A. Petro, K. Horton, P. Williams, A.H. Rezvani, and J.E. Rose Ketanserin, a 5-HT2 receptor antagonist, decreases nicotine self-administration in rats Eur. J. Pharmacol. 600 2008 93 97
48. M.E. Liechti, and A. Markou Role of the glutamatergic system in nicotine dependence: implications for the discovery and development of new pharmacological smoking cessation therapies CNS. Drugs. 22 2008 705 724
49. X. Liu, C. Jernigen, M. Gharib, S. Booth, A.R. Caggiula, and A.F. Sved Effects of dopamine antagonists on drug cue-induced reinstatement of nicotine-seeking behavior in rats Behav. Pharmacol. 21 2010 153 160
50. A. Markou Review. Neurobiology of nicotine dependence Philos. Trans. R Soc. Lond. B Biol. Sci. 363 2008 3159 3168
51. 2C receptor agonists: pharmacological characteristics and therapeutic potential J. Pharmacol. Exp. Ther. 286 1998 913 924 (Pubitemid 29003485)
52. J.F. Marwood Influence of alpha 1-adrenoceptor antagonism of ketanserin on the nature of its 5-HT2 receptor antagonism Clin. Exp. Pharmacol. Physiol. 21 1994 955 961
53. 2C/2B antagonist SB 206553 on hyperactivity induced by cocaine Neuropsychopharmacology 20 1999 556 564 (Pubitemid 29189260)
54. K. McFarland, C.C. Lapish, and P.W. Kalivas Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior J. Neurosci. 23 2003 3531 3537 (Pubitemid 36531996)
55. L.R. McMahon, and K.A. Cunningham Antagonism of 5-hydroxytryptamine2A receptors attenuates the behavioral effects of cocaine in rats J. Pharmacol. Exp. Ther. 297 2001 357 363 (Pubitemid 32242596)
56. 2C receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine Neuropsychopharmacology 33 2008 237 246 (Pubitemid 350243355)
57. 2C receptors attenuates cue and cocaine-primed reinstatement of cocaine-seeking behavior in rats Behav. Pharmacol. 18 2007 791 800 (Pubitemid 350076436)
58. 2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model Behav. Neurosci. 123 2009 382 396
59. M.F. O'Neill, C.L. Heron-Maxwell, and G. Shaw 5-HT2 receptor antagonism reduces hyperactivity induced by amphetamine, cocaine, and MK-801 but not D1 agonist C-APB Pharmacol. Biochem. Behav. 63 1999 237 243 (Pubitemid 29234102)
60. 2A antagonist MDL 100,907 on disruption of sound and light prepulse inhibition produced by 5-HT agonists in Wistar rats Psychopharmacology (Berl) 124 1996 107 116
61. A.C. Parsons, M. Shraim, J. Inglis, P. Aveyard, and P. Hajek Interventions for preventing weight gain after smoking cessation Cochrane. Database. Syst. Rev. 2009 CD006219
62. E.A. Pehek, H.G. McFarlane, K. Maguschak, B. Price, and C.P. Pluto M100,907, a selective 5-HT(2A) antagonist, attenuates dopamine release in the rat medial prefrontal cortex Brain. Res. 888 2001 51 59 (Pubitemid 32056261)
63. 2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex Neuropsychopharmacology 31 2006 265 277 (Pubitemid 43113392)
64. 2C) receptors attenuates cocaine-seeking behavior Neuropsychopharmacology 35 2011 2037 2048
65. J.L. Perry, and M.E. Carroll The role of impulsive behavior in drug abuse Psychopharmacology (Berl) 200 2008 1 26
66. 2C receptors blocks the hyperactivation of midbrain dopamine neurons induced by nicotine administration J. Pharmacol. Exp. Ther. 309 2004 109 118 (Pubitemid 38393121)
67. 2A receptors in the medial prefrontal cortex attenuates reinstatement of cue-elicited cocaine-seeking behavior in rats Psychopharmacology (Berl) 213 2011 307 320
68. 2C/2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum Neuropsychopharmacology 26 2002 311 324 (Pubitemid 34159209)
69. 2C receptors in CHO-K1 cells Br. J. Pharmacol. 128 1999 13 20 (Pubitemid 29425262)
70. 2C) receptors in the ventrotegmental area inhibits stress-induced but not basal dopamine release in the rat prefrontal cortex J. Neurochem. 82 2002 93 100 (Pubitemid 34755253)
71. L. Pozzi, B. Greco, G. Sacchetti, G. Leoni, R.W. Invernizzi, and M. Carli Blockade of serotonin 2A receptors prevents PCP-induced attentional performance deficit and CREB phosphorylation in the dorsal striatum of DBA/2 mice Psychopharmacology (Berl) 208 2011 387 399
72. D. Quarta, C.G. Naylor, and I.P. Stolerman The serotonin 2C receptor agonist Ro-60-0175 attenuates effects of nicotine in the five-choice serial reaction time task and in drug discrimination Psychopharmacology (Berl) 193 2007 391 402 (Pubitemid 47063518)
73. N.R. Richardson, and D.C. Roberts Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy J. Neurosci. Methods. 66 1996 1 11 (Pubitemid 26180064)
74. S. Semenova, and A. Markou The alpha2 adrenergic receptor antagonist idazoxan, but not the serotonin-2A receptor antagonist M100907, partially attenuated reward deficits associated with nicotine, but not amphetamine, withdrawal in rats Eur. Neuropsychopharmacol. 20 2010 731 746
75. M.J. Shram, D. Funk, Z. Li, and A.D. Le Nicotine self-administration, extinction responding and reinstatement in adolescent and adult male rats: evidence against a biological vulnerability to nicotine addiction during adolescence Neuropsychopharmacology 33 2008 739 748 (Pubitemid 351252689)
76. 2C agonist, reduces body weight in obese men and women Obes. (Silver Spring) 17 2009 494 503
77. E. Steed, C.A. Jones, and A.C. McCreary Serotonergic involvement in methamphetamine-induced locomotor activity: a detailed pharmacological study Behav. Brain. Res. 2011
78. 2C receptor agonists Pharmacol. Biochem. Behav. 69 2001 643 652 (Pubitemid 32758752)
79. T. Wurch, F.C. Colpaert, and P.J. Pauwels Chimeric receptor analysis of the ketanserin binding site in the human 5-Hydroxytryptamine1D receptor: importance of the second extracellular loop and fifth transmembrane domain in antagonist binding Mol. Pharmacol. 54 1998 1088 1096 (Pubitemid 29002053)
80. Q. Yan, M.E. Reith, and S. Yan Enhanced accumbal dopamine release following 5-HT(2A) receptor stimulation in rats pretreated with intermittent cocaine Brain. Res. 863 2000 254 258 (Pubitemid 30201606)
81. 2C receptor ligands on the discriminative stimulus effects of nicotine in rats Eur. J. Pharmacol. 571 2007 156 165 (Pubitemid 47385898)
82. M. Zaniewska, A.C. McCreary, and M. Filip Interactions of serotonin 5-HT2 receptor-targeting ligands and nicotine: locomotor activity studies in rats Synapse 63 2009 653 661
83. 2 receptor ligands on depression-like behavior during nicotine withdrawal Neuropharmacology 58 2010 1140 1146
84. 2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in rats Psychopharmacology (Berl) 213 2011 321 335