Using drug-discrimination techniques to study the abuse-related effects of psychoactive drugs in rats

Nature Protocols

Volumn 1, Issue 3, 2006, Pages 1194-1206

  Solinas, Marcello ^a   Panlilio, Leigh V ^b   Justinova, Zuzana ^c   Yasar, Sevil ^d   Goldberg, Steven R ^b  

^a UNIVERSITÉ DE POITIERS   (France)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^c MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; COCAINE; PSYCHOTROPIC AGENT;

ADDICTION; ANIMAL; ARTICLE; DOSE RESPONSE; DRUG EFFECT; FEEDING BEHAVIOR; INSTRUMENTAL CONDITIONING; METABOLISM; PATHOPHYSIOLOGY; RAT; REINFORCEMENT;

ANIMALS; COCAINE; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDING BEHAVIOR; NEUROTRANSMITTER AGENTS; PSYCHOTROPIC DRUGS; RATS; REINFORCEMENT (PSYCHOLOGY); SUBSTANCE-RELATED DISORDERS;

EID: 33947433399     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2006.167     Document Type: Article

References (70)

1. Colpaert, F.C. Drug discrimination in neurobiology. Pharmacol. Biochem. Behav. 64, 337-345 (1999).
2. Balster, R.L. & Prescott, W.R. Delta 9-tetrahydrocannabinol discrimination in rats as a model for cannabis intoxication. Neurosci. Biobehav. Rev. 16, 55-62 (1992).
3. Callahan, P.M., de la Garza, R. & Cunningham, K.A. Mediation of the discriminative stimulus properties of cocaine by mesocorticolimbic dopamine systems. Pharmacol. Biochem. Behav. 57, 601-607 (1997).
4. Dykstra, L.A., Preston, K.L. & Bigelow, G.E. Discriminative stimulus and subjective effects of opioids with mu and kappa activity: Data from laboratory animals and human subjects. Psychopharmacology (Berl) 130, 14-27 (1997).
5. Herling, S. & Woods, J.H. Discriminative stimulus effects of narcotics: evidence for multiple receptor-mediated actions. Life Sci. 28 1571-1584 (1981).
6. Holtzman, S.G. Caffeine as a model drug of abuse. Trends Pharmacol. Sci. 11, 355-356 (1990).
7. Shoaib, M. Is dopamine important in nicotine dependence? J. Physiol. Paris 92, 229-233 (1998).
8. Spealman, R.D. Use of cocaine-discrimination techniques for preclinical evaluation of candidate therapeutics for cocaine dependence. NIDA Res. Monogr. 119, 175-179 (1992).
9. Stoleman, I.P., Kumar, R. & Reavill, C. Discriminative stimulus effects of cholinergic agonists and the actions of their antagonists. Psychopharmacol. Ser. 4, 32-43 (1988).
10. Wiley, J.L. Cannabis: Discrimination of "internal bliss"? Pharmacol Biochem. Behav. 64, 257-260 (1999).
11. Hill, H.E., Haertzen, C.A., Wolbach, A.B. & Miner, E.J. The addiction research center inventory: Standardization of scales which evaluate subjective effects of morphine, amphetamine, pentobarbital, alcohol, LSD-25, pyrahexyl and chlorpromazine. Psychopharmacologia 65 167-183 (1963).
12. Schuster, C.R. & Johanson, C.E. Relationship between the discriminative stimulus properties and subjective effects of drugs. Psychopharmacol. Ser. 4, 161-175 (1988).
13. Kamien, J.B., Bickel, W.K., Hughes, J.R., Higgins, S.T. & Smith, B.J. Drug discrimination by humans compared to nonhumans: Current status and future directions. Psychopharmacology (Berl.) 111, 259-270 (1993).
14. Colpaert, F.C. Drug discrimination: No evidence for tolerance to opiates. Pharmacol. Rev. 47, 605-629 (1995).
15. Stolerman, I.P. & Jarvis, M.J. The scientific case that nicotine is addictive. Psychopharmacology (Berl.) 117, 2-10-discussion 14-20 (1995).
16. Stolerman, I.P. Components of drug dependence: Reinforcement, discrimination and adaptation. Biochem. Soc. Symp. 59, 1-12 (1993).
17. Koob, G.F. & Weiss, F. Pharmacology of drug self-administration. Alcohol 7, 193-197 (1990).
18. Bardo, M.T. & Bevins, R.A. CondWtioned place preference: what does it add to our preclinical understanding of drug reward? Psychopharmacology (Berl.) 153, 31-43 (2000).
19. Colpaert, F.C., Niemegeers, C.J., Lal, H. & Janssen, P.A. Investigations on drug produced and subjectively experienced discriminative stimuli. 2. Loperamide, an antidiarrheal devoid of narcotic cue producing actions. Life Sci. 16, 717-727 (1975).
20. Gobbi, G. et al. Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proc. Natl. Acad Sci. USA 102, 18620-18625 (2005).
21. Di Chiara, G. Nucleus accumbens shell and core dopamine: Differential role in behavior and addiction. Behav. Brain Res. 137, 75-114 (2002).
22. Koob, G.F. Neurobiology of addiction. Toward the development of new therapies. Ann. NY Acad. Sci. 909, 170-185 (2000).
23. Wise, R.A. Drug-activation of brain reward pathways. Drug Alcohol Depend. 51, 13-22 (1998).
24. Barrett, R.L. & Appel, J.B. Effects of stimulation and blockade of dopamine receptor subtypes on the discriminative stimulus properties of cocaine. Psychopharmacology (Berl.) 99, 13-16 (1989).
25. Munzar, P. & Goldberg, S.R. Dopaminergic involvement in the discriminative-stimulus effects of methamphetamine in rats. Psychopharmacology (Berl.) 148, 209-216 (2000).
26. Munzar, P., Tanda, G., Justinova, Z. & Goldberg, S.R. Histamine h3 receptor antagonists potentiate methamphetamine self-administration and methamphetamine-induced accumbal dopamine release. Neuropsychopharmarcology 29, 705-717 (2004).
27. Justinova, Z. et al. Involvement of adenosine A1 and A2A receptors in the adenosinergic modulation of the discriminative-stimulus effects of cocaine and methamphetamine in rats. J. Pharmacol. Exp. Ther. 307, 977-986 (2003).
28. Solinas, M., Zangen, A., Thiriet, N. & Goldberg, S.R. Beta-endorphin elevations in the ventral tegmental area regulate the discriminative effects of delta-g-tetrahydrocannabinol. Eur J. Neurosci. 19 3183-3192 (2004).
29. Solinas, M. & Goldberg, S.R. Involvement of mu-, delta- and kappa-opioid receptor subtypes in the discriminative-stimulus effects of delta-9-tetrahydrocannabinol (THC) in rats. Psychopharmacology (Berl.) 179, 804-812 (2005).
30. Solinas, M., Pantilio, L.V., Antoniou, K., Pappas, L.A. & Goldberg, S.R. The cannabinoid CB1 antagonist N-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl) -4-methylpyrazole-3-carboxamide (SR-141716A) differentially alters the reinforcing effects of heroin under continuous reinforcement, fixed ratio, and progressive ratio schedules of drug self-administration in rats. J. Pharmacol Exp. Ther. 306, 93-102 (2003).
31. Corwin, R.L., Woolverton, W.L. & Schuster, C.R. Effects of cholecystokinin, d-amphetamine and fenfluramine in rats trained to discriminate 3 from 22 hr of food deprivation. J. Pharmacol. Exp. Ther. 253, 720-728 (1990).
32. Benoit, S.C. & Davidson, T.L. Interoceptive sensory signals produced by 24-hr food deprivation, pharmacological glucoprivation, and lipoprivation. Behav. Neurosci. 110, 168-180 (1996).
33. Weissman, A. The discriminability of apsirin in arthritic and nonarthritic rats. Pharmacol. Biochem. Behav. 5, 583-586 (1976).
34. Colpaert, F.C., Niemegeers, C.J. & Janssen, P.A. Fentanyl and apomorphine: Asymmetrical generalization of discriminative stimulus properties. Neuropharmacology 15, 541-545 (1976).
35. Colpaert, F.C. Intrinsic activity and discriminative effects of drugs. Psychopharmacol. Ser. 4, 154-160 (1988).
36. Colpaert, F.C. Discovering risperidone: The LSD model of psychopathology. Nat Rev. Drug Discov. 2, 315-320 (2003).
37. Yokel, R.A. & Pickens, R. Self-administration of optical isomers of amphetamine and methylamphetamine by rats. J. Pharmacol. Exp. Ther. 187, 27-33 (1973).
38. Wise, R.A. et al. Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats. Psychopharmacology (Berl.) 120, 10-20 (1995).
39. Wise, R.A., Leone, P., Rivest R. & Leeb, K. Elevations of nucleus accumbens dopamine and DOPAC levels during intravenous heroin self-administration. Synapse 21, 140-148 (1995).
40. Gerber, G.J. & Wise, R.A. Pharmacological regulation of intravenous cocaine and heroin self-administration in rats: A variable dose paradigm. Pharmacol. Biochem. Behav. 32, 527-531 (1989).
41. Colpaert, F.C. Increased naloxone reversibility in fentanyl dose-dose discrimination. Eur J. Pharmacol. 84 229-231 (1982).
42. Colpaert, F.C. & Janssen, P.A. OR discrimination: A new drug discrimination method. Eur. J. Pharmacol. 78, 141-144 (1982).
43. Stolerman, I.P., Mariathasan, E.A., White, J.A. & Olufsen, K.S. Drug mixtures and ethanol as compound internal stimuli. Pharmacol. Biochem. Behav. 64, 221-228 (1999).
44. Ahmed, S.H. & Koob, G.F. Transition from moderate to excessive drug intake: Change in hedonic set point. Science 282, 298-300 (1998).
45. Deroche-Gamonet, V., Belin, D. & Piazza, P.V. Evidence for addiction-like behavior in the rat. Science 305, 1014-1017 (2004).
46. Vanderschuren, L.J. & Everitt B.J. Drug seeking becomes compulsive after prolonged cocaine self-administration. Science 305, 1017-1019 (2004).
47. Holtzman, S.G. Discriminative stimulus effects of morphine withdrawal in the dependent rat: Suppression by opiate and nonopiate drugs. J. Pharmacol. Exp. Ther. 233, 80-86 (1985).
48. Holtzman, S.G. Discrimination of a single dose of morphine followed by naltrexone: Substitution of other agonists for morphine and other antagonists for naltrexone in a rat model of acute dependence. J. Pharmacol. Exp. Ther. 304, 1033-1041 (2003).
49. Yasar, S., Schindler, C.W., Thorndike, E.B. & Goldberg, S.R. Evaluation of deprenyl for cocaine-like discriminative stimulus effects in rats. Eur J. Pharmacol. 259, 243-250 (1994).
50. Mastropaolo, J.P., Moskowitz, K.H., Dacanay, R.J. & Riley, A.L. Conditioned taste aversions as a behavioral baseline for drug discrimination learning: An assessment with phencyclidine. Pharmacol. Biochem. Behav. 32, 1-8 (1989).
51. White, J.M. & Holtzman, S.G. Three-choice drug discrimination: phencyclidine-like stimulus effects of opioids. Psychopharmacology (Berl.) 80, 1-9 (1983).
52. Swedberg, M.D. & Jarbe, T.U. Drug discrimination procedures: differential characteristics of the drug A vs drug B and the drug A vs drug B vs no drug cases. Psychopharmocology (Berl.) 90, 341-346 (1986).
53. Overton, D.A. A historical perspective on drug discrimination. NIDA Res. Monogr. 5-24 (1991).
54. Colpaert, F.C. The discriminative response: An elementary particle of behavior Commentary on Stolerman "Measures of stimulus generalization in drug discrimination experiments". Behav. Pharmacol. 2, 283-286 (1991).
55. Stolerman, I. Measures of stimulus generalization in drug discrimination experiments. Behav. Pharmacol. 2, 265-282 (1991).
56. Stolerman, I.P. & Mariathasan, E.A. Nicotine brace discrimination in rats with midazolam as a mediating stimulus. Behav. Pharmacol. 14, 55-66 (2003).
57. Stolerman, I.P., Childs, E., Hahn, B. & Morley, A. Drug trace discrimination with nicotine and morphine in rats. Behav. Pharmacol. 13, 49-58 (2002).
58. Colpaert, F.C., Niemegeers, C.J. & Janssen, P.A. Differential haloperidol effect on two indices of fentanyl-saline discrimination. Psychopharmacology (Berl.) 53, 169-173 (1977).
59. Yasar, S. & Bergman, J. Amphetamine-like effect of l-deprenyl (selegiline) in drug discrimination studies. Clin. Pharmacol. Ther. 56, 768-773 (1994).
60. Mattson, M.P., Duan, W. & Guo, Z. Meal size and frequency affect neuronal. plasticity and vulnerability to disease: Cellular and molecular mechanisms. J. Neurochem. 84, 417-431 (2003).
61. Ghozland, S. et al. Motivational effects of cannabinoids am mediated by mu-opioid and kappa-opioid receptors. J. Neurosci. 22, 1146-1154 (2002).
62. Jarbe, T.U., Lamb, R.J., Makriyannis, A., Lin, S. & Goutopoulos, A. Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats. Psychopharmacology (Berl.) 140, 519-522 (1998).
63. Jarbe, T.U., Lamb, R.J., Lin, S. & Makriyannis, A. Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats: A systematic replication. Behav. Pharmacol. 11, 81-86 (2000).
64. Colombo, G. et al. T-maze and food reinforcement: An inexpensive drug discrimination procedure. J. Neurosci. Methods 67, 83-87 (1996).
65. Extance, K. & Goudie, A.J. Inter-animal olfactory cues in operant drug discrimination procedures in rats. Psychopharmacology (Berl.) 73, 363-371 (1981).
66. Powell, K.R., Koppelman, L.F. & Holtzman, S.G. Differential involvement of dopamine in mediating the discriminative stimulus effects of low and high doses of caffeine in rats. Behav. Pharmacol. 10, 707-716 (1999).
67. Solinas, M. et al. Involvement of adenosine A1 receptors in the discriminative-stimulus effects of caffeine in rats. Psychopharmacology (Berl.) 179, 576-586 (2005).
68. Mumford, G.K. & Holtzman, S.G. Qualitative differences in the discriminative stimulus effects of low and high doses of caffeine in the rat. J. Pharmacol. Exp. Ther. 258, 857-865 (1991).
69. Holtzman, S.G. Discriminative stimulus properties of caffeine in the rat: Noradrenergic mediation. J. Pharmacol. Exp. Ther. 239, 706-714 (1986).
70. Munzar, P., Justinova, Z., Kutkat, S.W., Ferre, S. & Goldberg, S.R. Adenosinergic modulation of the discriminative-stimulus effects of methamphetamine in rats. Psychopharmacology (Berl.) 161, 348-355 (2002).