메뉴 건너뛰기




Volumn 23, Issue 4, 2013, Pages 537-551

A trans-spliced telomerase RNA dictates telomere synthesis in Trypanosoma brucei

Author keywords

noncoding RNA; telomerase; telomere; Trypanosoma brucei

Indexed keywords

PROTOZOAL PROTEIN; PROTOZOAL RNA; RNA; TELOMERASE; TELOMERASE RNA;

EID: 84876413702     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2013.35     Document Type: Article
Times cited : (32)

References (76)
  • 1
    • 0023663881 scopus 로고
    • The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity
    • Greider CW, Blackburn EH. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 1987; 51:887-898.
    • (1987) Cell , vol.51 , pp. 887-898
    • Greider, C.W.1    Blackburn, E.H.2
  • 2
    • 0032055375 scopus 로고    scopus 로고
    • Telomerase and chromosome end maintenance
    • Lingner J, Cech TR. Telomerase and chromosome end maintenance. Curr Opin Genet Dev 1998; 8:226-232.
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 226-232
    • Lingner, J.1    Cech, T.R.2
  • 3
    • 71149093724 scopus 로고    scopus 로고
    • How telomeres solve the end-protection problem
    • de Lange T. How telomeres solve the end-protection problem. Science 2009; 326:948-952.
    • (2009) Science , vol.326 , pp. 948-952
    • De Lange, T.1
  • 4
    • 0024978857 scopus 로고
    • A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
    • Greider CW, Blackburn EH. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 1989; 337:331-337.
    • (1989) Nature , vol.337 , pp. 331-337
    • Greider, C.W.1    Blackburn, E.H.2
  • 5
    • 38849191137 scopus 로고    scopus 로고
    • Physiological assembly and activity of human telomerase complexes
    • Collins K. Physiological assembly and activity of human telomerase complexes. Mech Ageing Dev 2008; 129:91-98.
    • (2008) Mech Ageing Dev , vol.129 , pp. 91-98
    • Collins, K.1
  • 6
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345:458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 7
    • 0030931491 scopus 로고    scopus 로고
    • Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
    • Blasco MA, Lee HW, Hande MP, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997; 91:25-34.
    • (1997) Cell , vol.91 , pp. 25-34
    • Blasco, M.A.1    Lee, H.W.2    Hande, M.P.3
  • 8
    • 0033593035 scopus 로고    scopus 로고
    • Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA
    • Fitzgerald MS, Riha K, Gao F, Ren S, McKnight TD, Shippen DE. Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA. Proc Natl Acad Sci USA 1999; 96:14813-14818.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14813-14818
    • Fitzgerald, M.S.1    Riha, K.2    Gao, F.3    Ren, S.4    McKnight, T.D.5    Shippen, D.E.6
  • 9
    • 33645512251 scopus 로고    scopus 로고
    • Trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase
    • Meier B, Clejan I, Liu Y, et al. trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase. PLoS Genet 2006; 2:e18.
    • (2006) PLoS Genet , vol.2
    • Meier, B.1    Clejan, I.2    Liu, Y.3
  • 10
    • 0030455861 scopus 로고    scopus 로고
    • Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
    • Lendvay TS, Morris DK, Sah J, Balasubramanian B, Lundblad V. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 1996; 144:1399-1412.
    • (1996) Genetics , vol.144 , pp. 1399-1412
    • Lendvay, T.S.1    Morris, D.K.2    Sah, J.3    Balasubramanian, B.4    Lundblad, V.5
  • 11
    • 0030819894 scopus 로고    scopus 로고
    • Telomerase catalytic subunit homologs from fission yeast and human
    • Nakamura TM, Morin GB, Chapman KB, et al. Telomerase catalytic subunit homologs from fission yeast and human. Science 1997; 277:955-959.
    • (1997) Science , vol.277 , pp. 955-959
    • Nakamura, T.M.1    Morin, G.B.2    Chapman, K.B.3
  • 12
    • 0031932446 scopus 로고    scopus 로고
    • Plasmodium falciparum telomerase: de novo telomere addition to telomeric and nontelomeric sequences and role in chromosome healing
    • Bottius E, Bakhsis N, Scherf A. Plasmodium falciparum telomerase: de novo telomere addition to telomeric and nontelomeric sequences and role in chromosome healing. Mol Cell Biol 1998; 18:919-925.
    • (1998) Mol Cell Biol , vol.18 , pp. 919-925
    • Bottius, E.1    Bakhsis, N.2    Scherf, A.3
  • 13
    • 23344454718 scopus 로고    scopus 로고
    • Telomere structure and shortening in telomerase-deficient Trypanosoma brucei
    • Dreesen O, Li B, Cross GAM. Telomere structure and shortening in telomerase-deficient Trypanosoma brucei. Nuc Acids Res 2005; 33:4536-4543.
    • (2005) Nuc Acids Res , vol.33 , pp. 4536-4543
    • Dreesen, O.1    Li, B.2    Cross, G.A.M.3
  • 14
    • 0842346436 scopus 로고    scopus 로고
    • Beginning to understand the end of the chromosome
    • Cech TR. Beginning to understand the end of the chromosome. Cell 2004; 116:273-279.
    • (2004) Cell , vol.116 , pp. 273-279
    • Cech, T.R.1
  • 15
    • 84855493135 scopus 로고    scopus 로고
    • It all comes together at the ends: Telomerase structure, function, and biogenesis
    • Podlevsky JD, Chen JJ. It all comes together at the ends: telomerase structure, function, and biogenesis. Mutat Res 2012; 730:3-11.
    • (2012) Mutat Res , vol.730 , pp. 3-11
    • Podlevsky, J.D.1    Chen, J.J.2
  • 16
    • 82955237444 scopus 로고    scopus 로고
    • The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis
    • Berman AJ, Akiyama BM, Stone MD, Cech TR. The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis. Nat Struct Mol Biol 2011; 18:1371-1375.
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 1371-1375
    • Berman, A.J.1    Akiyama, B.M.2    Stone, M.D.3    Cech, T.R.4
  • 17
    • 84855359738 scopus 로고    scopus 로고
    • RNA/DNA hybrid binding affinity determines telomerase template-translocation efficiency
    • Qi X, Xie M, Brown AF, Bley CJ, Podlevsky JD, Chen JJ. RNA/DNA hybrid binding affinity determines telomerase template-translocation efficiency. EMBO J 2012; 31:150-161.
    • (2012) EMBO J , vol.31 , pp. 150-161
    • Qi, X.1    Xie, M.2    Brown, A.F.3    Bley, C.J.4    Podlevsky, J.D.5    Chen, J.J.6
  • 18
    • 0029096515 scopus 로고
    • The RNA component of human telomerase
    • Feng JL, Funk WD, Wang SS, et al. The RNA component of human telomerase. Science 1995; 269:1236-1241.
    • (1995) Science , vol.269 , pp. 1236-1241
    • Feng, J.L.1    Funk, W.D.2    Wang, S.S.3
  • 19
    • 0034598919 scopus 로고    scopus 로고
    • Secondary structure of vertebrate telomerase RNA
    • Chen JL, Blasco MA, Greider CW. Secondary structure of vertebrate telomerase RNA. Cell 2000; 100:503-514.
    • (2000) Cell , vol.100 , pp. 503-514
    • Chen, J.L.1    Blasco, M.A.2    Greider, C.W.3
  • 20
    • 0027944347 scopus 로고
    • TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
    • Singer MS, Gottschling DE. TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science 1994; 266:404-409.
    • (1994) Science , vol.266 , pp. 404-409
    • Singer, M.S.1    Gottschling, D.E.2
  • 22
    • 35548994539 scopus 로고    scopus 로고
    • Structural RNAs of known and unknown function identified in malaria parasites by comparative genomics and RNA analysis
    • Chakrabarti K, Pearson M, Grate L, et al. Structural RNAs of known and unknown function identified in malaria parasites by comparative genomics and RNA analysis. RNA 2007; 13:1923-1939.
    • (2007) RNA , vol.13 , pp. 1923-1939
    • Chakrabarti, K.1    Pearson, M.2    Grate, L.3
  • 23
    • 33744799697 scopus 로고    scopus 로고
    • Structure and function of telomerase RNA
    • Theimer CA, Feigon J. Structure and function of telomerase RNA. Curr Opin Struct Biol 2006; 16:307-318.
    • (2006) Curr Opin Struct Biol , vol.16 , pp. 307-318
    • Theimer, C.A.1    Feigon, J.2
  • 24
    • 0029144984 scopus 로고
    • Altering specific telomerase RNA template residues affects active site function
    • Gilley D, Lee MS, Blackburn EH. Altering specific telomerase RNA template residues affects active site function. Genes Dev 1995; 9:2214-2226.
    • (1995) Genes Dev , vol.9 , pp. 2214-2226
    • Gilley, D.1    Lee, M.S.2    Blackburn, E.H.3
  • 25
    • 0035222844 scopus 로고    scopus 로고
    • Antigenic variation in trypanosomes: Enhanced phenotypic variation in a eukaryotic parasite
    • Barry JD, McCulloch R. Antigenic variation in trypanosomes: enhanced phenotypic variation in a eukaryotic parasite. Adv Parasitol 2001; 49:1-70.
    • (2001) Adv Parasitol , vol.49 , pp. 1-70
    • Barry, J.D.1    McCulloch, R.2
  • 26
    • 22244441812 scopus 로고    scopus 로고
    • The genome of the African trypanosome Trypanosoma brucei
    • Berriman M, Ghedin E, Hertz-Fowler C, et al. The genome of the African trypanosome Trypanosoma brucei. Science 2005; 309:416-422.
    • (2005) Science , vol.309 , pp. 416-422
    • Berriman, M.1    Ghedin, E.2    Hertz-Fowler, C.3
  • 27
    • 0016809286 scopus 로고
    • Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei
    • Cross GAM. Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei. Parasitology 1975; 71:393-417.
    • (1975) Parasitology , vol.71 , pp. 393-417
    • Cross, G.A.M.1
  • 29
    • 0020583113 scopus 로고
    • Growth of chromosome ends in multiplying trypanosomes
    • Bernards A, Michels PAM, Lincke CR, Borst P. Growth of chromosome ends in multiplying trypanosomes. Nature 1983; 303:592-597.
    • (1983) Nature , vol.303 , pp. 592-597
    • Bernards, A.1    Michels, P.A.M.2    Lincke, C.R.3    Borst, P.4
  • 31
    • 63049115947 scopus 로고    scopus 로고
    • RAP1 is essential for silencing telomeric variant surface glycoprotein genes in Trypanosoma brucei
    • Yang X, Figueiredo LM, Espinal A, Okubo E, Li B. RAP1 is essential for silencing telomeric variant surface glycoprotein genes in Trypanosoma brucei. Cell 2009; 137:99-109.
    • (2009) Cell , vol.137 , pp. 99-109
    • Yang, X.1    Figueiredo, L.M.2    Espinal, A.3    Okubo, E.4    Li, B.5
  • 32
    • 0033525524 scopus 로고    scopus 로고
    • A tightly regulated inducible expression system for dominant negative approaches in Trypanosoma brucei
    • Wirtz E, Leal S, Ochatt C, Cross GAM. A tightly regulated inducible expression system for dominant negative approaches in Trypanosoma brucei. Mol Biochem Parasitol 1999; 99:89-101.
    • (1999) Mol Biochem Parasitol , vol.99 , pp. 89-101
    • Wirtz, E.1    Leal, S.2    Ochatt, C.3    Cross, G.A.M.4
  • 33
    • 80052344748 scopus 로고    scopus 로고
    • RNA interference in protozoan parasites: Achievements and challenges
    • Kolev NG, Tschudi C, Ullu E. RNA interference in protozoan parasites: achievements and challenges. Eukaryot Cell 2011; 10:1156-1163.
    • (2011) Eukaryot Cell , vol.10 , pp. 1156-1163
    • Kolev, N.G.1    Tschudi, C.2    Ullu, E.3
  • 34
    • 0021256990 scopus 로고
    • Identification of a telomeric DNA sequence in Trypanosoma brucei
    • Blackburn EH, Challoner PB. Identification of a telomeric DNA sequence in Trypanosoma brucei. Cell 1984; 36:447-457.
    • (1984) Cell , vol.36 , pp. 447-457
    • Blackburn, E.H.1    Challoner, P.B.2
  • 36
    • 1842683257 scopus 로고    scopus 로고
    • T-loops and the origin of telomeres
    • de Lange T. T-loops and the origin of telomeres. Nat Rev Mol Cell Biol 2004; 5:323-329.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 323-329
    • De Lange, T.1
  • 37
    • 20344388067 scopus 로고    scopus 로고
    • Trypanosome telomeres are protected by a homologue of mammalian TRF2
    • Li B, Espinal A, Cross GAM. Trypanosome telomeres are protected by a homologue of mammalian TRF2. Mol Cell Biol 2005; 25:5011-5021.
    • (2005) Mol Cell Biol , vol.25 , pp. 5011-5021
    • Li, B.1    Espinal, A.2    Cross, G.A.M.3
  • 38
    • 4944229060 scopus 로고    scopus 로고
    • Biochemical properties of Trypanosoma cruzi telomerase
    • Munoz DP, Collins K. Biochemical properties of Trypanosoma cruzi telomerase. Nucleic Acids Res 2004; 32:5214-5222.
    • (2004) Nucleic Acids Res , vol.32 , pp. 5214-5222
    • Munoz, D.P.1    Collins, K.2
  • 39
    • 0029053720 scopus 로고
    • Revolutions in rapid amplification of cDNA ends: New strategies for polymerase chain reaction cloning of full-length cDNA ends
    • Schaefer BC. Revolutions in rapid amplification of cDNA ends: new strategies for polymerase chain reaction cloning of full-length cDNA ends. Anal Biochem 1995; 227:255-273.
    • (1995) Anal Biochem , vol.227 , pp. 255-273
    • Schaefer, B.C.1
  • 40
    • 0021269995 scopus 로고
    • Structure of the growing telomeres of trypanosomes
    • van der Ploeg LHT, Liu AYC, Borst P. Structure of the growing telomeres of trypanosomes. Cell 1984; 36:459-468.
    • (1984) Cell , vol.36 , pp. 459-468
    • Van Der Ploeg, L.H.T.1    Liu, A.Y.C.2    Borst, P.3
  • 41
    • 33745447782 scopus 로고    scopus 로고
    • Telomerase-independent stabilization of short telomeres in Trypanosoma brucei
    • Dreesen O, Cross GAM. Telomerase-independent stabilization of short telomeres in Trypanosoma brucei. Mol Cell Biol 2006; 26:4911-4919.
    • (2006) Mol Cell Biol , vol.26 , pp. 4911-4919
    • Dreesen, O.1    Cross, G.A.M.2
  • 42
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266:2011-2015.
    • (1994) Science , vol.266 , pp. 2011-2015
    • Kim, N.W.1    Piatyszek, M.A.2    Prowse, K.R.3
  • 43
    • 0021100418 scopus 로고
    • Differential size variations between transcriptionally active and inactive telomeres of Trypanosoma brucei
    • Pays E, Laurent M, Delinte K, Van Meirvenne N, Steinert M. Differential size variations between transcriptionally active and inactive telomeres of Trypanosoma brucei. Nucleic Acids Res 1983; 11:8137-8147.
    • (1983) Nucleic Acids Res , vol.11 , pp. 8137-8147
    • Pays, E.1    Laurent, M.2    Delinte, K.3    Van Meirvenne, N.4    Steinert, M.5
  • 44
    • 80355132914 scopus 로고    scopus 로고
    • Examination of the telomere G-overhang structure in Trypanosoma brucei
    • Sandhu R, Li B. Examination of the telomere G-overhang structure in Trypanosoma brucei. Journal of Visualized Experiments 2011; 47:1959.
    • (2011) Journal of Visualized Experiments , vol.47 , pp. 1959
    • Sandhu, R.1    Li, B.2
  • 45
    • 0021722311 scopus 로고
    • Trypanosome mRNAs share a common 5′ spliced leader sequence
    • Parsons M, Nelson RG, Watkins KP, Agabian N. Trypanosome mRNAs share a common 5′ spliced leader sequence. Cell 1984; 38:309-316.
    • (1984) Cell , vol.38 , pp. 309-316
    • Parsons, M.1    Nelson, R.G.2    Watkins, K.P.3    Agabian, N.4
  • 46
    • 0026661825 scopus 로고
    • Trypanosoma brucei splicedleader RNA methylations are required for trans splicing in vivo
    • Perry-McNally K, Agabian N. Trypanosoma brucei splicedleader RNA methylations are required for trans splicing in vivo. Mol Cell Biol 1992; 12:4844-4851.
    • (1992) Mol Cell Biol , vol.12 , pp. 4844-4851
    • Perry-Mcnally, K.1    Agabian, N.2
  • 47
    • 0036178152 scopus 로고    scopus 로고
    • Unconventional rules of small nuclear RNA transcription and cap modification in trypanosomatids
    • Tschudi C, Ullu E. Unconventional rules of small nuclear RNA transcription and cap modification in trypanosomatids. Gene expression 2002; 10:3-16.
    • (2002) Gene Expression , vol.10 , pp. 3-16
    • Tschudi, C.1    Ullu, E.2
  • 48
    • 0026730321 scopus 로고
    • Mass spectrometry of mRNA cap 4 from trypanosomatids reveals two novel nucleosides
    • Bangs JD, Crain PF, Hashizume T, McCloskey JA, Boothroyd JC. Mass spectrometry of mRNA cap 4 from trypanosomatids reveals two novel nucleosides. J Biol Chem 1992; 267:9805-9815.
    • (1992) J Biol Chem , vol.267 , pp. 9805-9815
    • Bangs, J.D.1    Crain, P.F.2    Hashizume, T.3    McCloskey, J.A.4    Boothroyd, J.C.5
  • 49
    • 0021827982 scopus 로고
    • The spliced leader sequence of Trypanosoma brucei has a potential role as a cap donor structure
    • Lenardo MJ, Dorfman DM, Donelson JE. The spliced leader sequence of Trypanosoma brucei has a potential role as a cap donor structure. Molecular and Cellular Biology 1985; 9:2487-2490.
    • (1985) Molecular and Cellular Biology , vol.9 , pp. 2487-2490
    • Lenardo, M.J.1    Dorfman, D.M.2    Donelson, J.E.3
  • 50
    • 0023811730 scopus 로고
    • Discontinuously synthesized mRNA from Trypanosoma brucei contains the highly methylated 5′ cap structure, m7GpppA*A*C(2'-O) mU*A
    • Freistadt MS, Cross GAM, Robertson HD. Discontinuously synthesized mRNA from Trypanosoma brucei contains the highly methylated 5′ cap structure, m7GpppA*A*C(2'-O) mU*A. J Biol Chem 1988; 263:15071-15075.
    • (1988) J Biol Chem , vol.263 , pp. 15071-15075
    • Freistadt, M.S.1    Cross, G.A.M.2    Robertson, H.D.3
  • 51
    • 0028329601 scopus 로고
    • RNA polymerase III-mediated transcription of the trypanosome U2 small nuclear RNA gene is controlled by both intragenic and extragenic regulatory elements
    • Fantoni A, Dare AO, Tschudi C. RNA polymerase III-mediated transcription of the trypanosome U2 small nuclear RNA gene is controlled by both intragenic and extragenic regulatory elements. Mol Cell Biol 1994; 14:2021-2028.
    • (1994) Mol Cell Biol , vol.14 , pp. 2021-2028
    • Fantoni, A.1    Dare, A.O.2    Tschudi, C.3
  • 52
    • 79954576993 scopus 로고    scopus 로고
    • TurboFold: Iterative probabilistic estimation of secondary structures for multiple RNA sequences
    • Harmanci AO, Sharma G, Mathews DH. TurboFold: iterative probabilistic estimation of secondary structures for multiple RNA sequences. BMC Bioinformatics 2011; 12:108.
    • (2011) BMC Bioinformatics , vol.12 , pp. 108
    • Harmanci, A.O.1    Sharma, G.2    Mathews, D.H.3
  • 54
    • 0033524952 scopus 로고    scopus 로고
    • A dynamic programming algorithm for RNA structure prediction including pseudoknots
    • Rivas E, Eddy SR. A dynamic programming algorithm for RNA structure prediction including pseudoknots. J Mol Biol 1999; 285:2053-2068.
    • (1999) J Mol Biol , vol.285 , pp. 2053-2068
    • Rivas, E.1    Eddy, S.R.2
  • 55
    • 77957314359 scopus 로고    scopus 로고
    • Chemical probing of RNA and RNA/protein complexes
    • Xu Z, Culver GM. Chemical probing of RNA and RNA/protein complexes. Methods Enzymol 2009; 468:147-165.
    • (2009) Methods Enzymol , vol.468 , pp. 147-165
    • Xu, Z.1    Culver, G.M.2
  • 56
    • 0141525391 scopus 로고    scopus 로고
    • Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends
    • Stellwagen AE, Haimberger ZW, Veatch JR, Gottschling DE. Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes Dev 2003; 17:2384-2395.
    • (2003) Genes Dev , vol.17 , pp. 2384-2395
    • Stellwagen, A.E.1    Haimberger, Z.W.2    Veatch, J.R.3    Gottschling, D.E.4
  • 57
    • 0025280085 scopus 로고
    • Destruction of U2, U4, or U6 small nuclear RNA blocks trans splicing in trypanosome cells
    • Tschudi C, Ullu E. Destruction of U2, U4, or U6 small nuclear RNA blocks trans splicing in trypanosome cells. Cell 1990; 61:459-466.
    • (1990) Cell , vol.61 , pp. 459-466
    • Tschudi, C.1    Ullu, E.2
  • 58
    • 0026048779 scopus 로고
    • Affinity purification of Trypanosoma brucei small nuclear ribonucleoproteins reveals common and specific protein components
    • Palfi Z, Gunzl A, Cross M, Bindereif A. Affinity purification of Trypanosoma brucei small nuclear ribonucleoproteins reveals common and specific protein components. Proc Natl Acad Sci USA 1991; 88:9097-9101.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 9097-9101
    • Palfi, Z.1    Gunzl, A.2    Cross, M.3    Bindereif, A.4
  • 59
    • 0347695987 scopus 로고    scopus 로고
    • Silencing of Sm proteins in Trypanosoma brucei by RNA interference captured a novel cytoplasmic intermediate in spliced leader RNA biogenesis
    • Mandelboim M, Barth S, Biton M, Liang XH, Michaeli S. Silencing of Sm proteins in Trypanosoma brucei by RNA interference captured a novel cytoplasmic intermediate in spliced leader RNA biogenesis. J Biol Chem 2003; 278:51469-51478.
    • (2003) J Biol Chem , vol.278 , pp. 51469-51478
    • Mandelboim, M.1    Barth, S.2    Biton, M.3    Liang, X.H.4    Michaeli, S.5
  • 60
    • 57749186870 scopus 로고    scopus 로고
    • Spliceosomal cleavage generates the 3′ end of telomerase RNA
    • Box JA, Bunch JT, Tang W, Baumann P. Spliceosomal cleavage generates the 3′ end of telomerase RNA. Nature 2008; 456:910-914.
    • (2008) Nature , vol.456 , pp. 910-914
    • Box, J.A.1    Bunch, J.T.2    Tang, W.3    Baumann, P.4
  • 61
    • 84859580726 scopus 로고    scopus 로고
    • Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes
    • Tang W, Kannan R, Blanchette M, Baumann P. Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes. Nature 2012; 484:260-264.
    • (2012) Nature , vol.484 , pp. 260-264
    • Tang, W.1    Kannan, R.2    Blanchette, M.3    Baumann, P.4
  • 62
    • 0030721677 scopus 로고    scopus 로고
    • Polyadenylation of telomerase RNA in budding yeast
    • Chapon C, Cech TR, Zaug AJ. Polyadenylation of telomerase RNA in budding yeast. RNA 1997; 3:1337-1351.
    • (1997) RNA , vol.3 , pp. 1337-1351
    • Chapon, C.1    Cech, T.R.2    Zaug, A.J.3
  • 63
    • 0034933876 scopus 로고    scopus 로고
    • A low threshold level of expression of mutanttemplate telomerase RNA inhibits human tumor cell proliferation
    • Kim MM, Rivera MA, Botchkina IL, Shalaby R, Thor AD, Blackburn EH. A low threshold level of expression of mutanttemplate telomerase RNA inhibits human tumor cell proliferation. Proc Natl Acad Sci USA 2001; 98:7982-7987.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7982-7987
    • Kim, M.M.1    Rivera, M.A.2    Botchkina, I.L.3    Shalaby, R.4    Thor, A.D.5    Blackburn, E.H.6
  • 64
    • 33748183271 scopus 로고    scopus 로고
    • Low abundance of telomerase in yeast: Implications for telomerase haploinsufficiency
    • Mozdy AD, Cech TR. Low abundance of telomerase in yeast: implications for telomerase haploinsufficiency. RNA 2006; 12:1721-1737.
    • (2006) RNA , vol.12 , pp. 1721-1737
    • Mozdy, A.D.1    Cech, T.R.2
  • 65
    • 0025840610 scopus 로고
    • Trans splicing in trypanosomes requires methylation of the 5′ end of the spliced leader RNA
    • Ullu E, Tschudi C. Trans splicing in trypanosomes requires methylation of the 5′ end of the spliced leader RNA. Proc Natl Acad Sci USA 1991; 88:10074-10078.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10074-10078
    • Ullu, E.1    Tschudi, C.2
  • 66
    • 0030739492 scopus 로고    scopus 로고
    • The U5 RNA of trypanosomes deviates from the canonical U5 RNA: The Leptomonas collosoma U5 RNA and its coding gene
    • Xu YX, Benshlomo H, Michaeli S. The U5 RNA of trypanosomes deviates from the canonical U5 RNA: the Leptomonas collosoma U5 RNA and its coding gene. Proc Natl Acad Sci USA 1997; 94:8473-8478.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8473-8478
    • Xu, Y.X.1    Benshlomo, H.2    Michaeli, S.3
  • 67
    • 0025237190 scopus 로고
    • Trans-spliced Caenorhabditis elegans mRNAs retain trimethylguanosine caps
    • Liou RF, Blumenthal T. trans-spliced Caenorhabditis elegans mRNAs retain trimethylguanosine caps. Mol Cell Biol 1990; 10:1764-1768.
    • (1990) Mol Cell Biol , vol.10 , pp. 1764-1768
    • Liou, R.F.1    Blumenthal, T.2
  • 68
    • 0037439107 scopus 로고    scopus 로고
    • Determinants in mammalian telomerase RNA that mediate enzyme processivity and crossspecies incompatibility
    • Chen JL, Greider CW. Determinants in mammalian telomerase RNA that mediate enzyme processivity and crossspecies incompatibility. EMBO J 2003; 22:304-314.
    • (2003) EMBO J , vol.22 , pp. 304-314
    • Chen, J.L.1    Greider, C.W.2
  • 69
    • 32544443342 scopus 로고    scopus 로고
    • Telomere length homeostasis requires that telomerase levels are limiting
    • Cristofari G, Lingner J. Telomere length homeostasis requires that telomerase levels are limiting. EMBO J 2006; 25:565-574.
    • (2006) EMBO J , vol.25 , pp. 565-574
    • Cristofari, G.1    Lingner, J.2
  • 70
    • 14644435818 scopus 로고    scopus 로고
    • Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for function
    • Theimer CA, Blois CA, Feigon J. Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for function. Mol Cell 2005; 17:671-682.
    • (2005) Mol Cell , vol.17 , pp. 671-682
    • Theimer, C.A.1    Blois, C.A.2    Feigon, J.3
  • 71
    • 33947277419 scopus 로고    scopus 로고
    • A triple helix within a pseudoknot is a conserved and essential element of telomerase RNA
    • Shefer K, Brown Y, Gorkovoy V, Nussbaum T, Ulyanov NB, Tzfati Y. A triple helix within a pseudoknot is a conserved and essential element of telomerase RNA. Mol Cell Biol 2007; 27:2130-2143.
    • (2007) Mol Cell Biol , vol.27 , pp. 2130-2143
    • Shefer, K.1    Brown, Y.2    Gorkovoy, V.3    Nussbaum, T.4    Ulyanov, N.B.5    Tzfati, Y.6
  • 72
    • 0033636897 scopus 로고    scopus 로고
    • Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase
    • Mitchell JR, Collins K. Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase. Mol Cell 2000; 6:361-371.
    • (2000) Mol Cell , vol.6 , pp. 361-371
    • Mitchell, J.R.1    Collins, K.2
  • 73
    • 33845631261 scopus 로고    scopus 로고
    • Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei
    • Dreesen O, Cross GAM. Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei. Eukaryot Cell 2006; 5:2114-2119.
    • (2006) Eukaryot Cell , vol.5 , pp. 2114-2119
    • Dreesen, O.1    Cross, G.A.M.2
  • 75
    • 47949123390 scopus 로고    scopus 로고
    • Spliceosomal snRNAs in the unicellular eukaryote Trichomonas vaginalis are structurally conserved but lack a 5′-cap structure
    • Simoes-Barbosa A, Meloni D, Wohlschlegel JA, Konarska MM, Johnson PJ. Spliceosomal snRNAs in the unicellular eukaryote Trichomonas vaginalis are structurally conserved but lack a 5′-cap structure. RNA 2008; 14:1617-1631.
    • (2008) RNA , vol.14 , pp. 1617-1631
    • Simoes-Barbosa, A.1    Meloni, D.2    Wohlschlegel, J.A.3    Konarska, M.M.4    Johnson, P.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.