Telomere structure and shortening in telomerase-deficient Trypanosoma brucei

Nucleic Acids Research

Volumn 33, Issue 14, 2005, Pages 4536-4543

  Dreesen, Oliver ^a   Li, Bibo ^a   Cross, George A M ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTOZOAL DNA; RNA DIRECTED DNA POLYMERASE; TELOMERASE; VARIANT SURFACE GLYCOPROTEIN; DNA BINDING PROTEIN; GUANINE;

AGING; ARTICLE; CARCINOGENESIS; CELL STRUCTURE; CONTROLLED STUDY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HYBRIDIZATION; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SEQUENCE ALIGNMENT; TELOMERE; TRYPANOSOMA BRUCEI; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; ENZYMOLOGY; GENE DELETION; GENE SILENCING; GENETICS; MOLECULAR GENETICS; NUCLEIC ACID HYBRIDIZATION;

KINETOPLASTIDA; PROTOZOA; TRYPANOSOMA BRUCEI;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; DNA, PROTOZOAN; DNA-BINDING PROTEINS; GENE DELETION; GENE SILENCING; GUANINE; MOLECULAR SEQUENCE DATA; NUCLEIC ACID HYBRIDIZATION; SEQUENCE ALIGNMENT; TELOMERASE; TELOMERE; TRYPANOSOMA BRUCEI BRUCEI;

EID: 23344454718     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gki769     Document Type: Article

References (50)

1. van Steensel, B., Smogorzewska, A. and de Lange, T. (1998) TRF2 protects human telomeres from end-to-end fusions. Cell, 92, 401-413.
2. de Lange, T. (2002) Protection of mammalian telomeres. Oncogene, 21, 532-540.
3. de Lange, T. (2004) T-loops and the origin of telomeres. Nature Rev. Mol. Cell Biol., 5, 323-329.
4. Nakamura, T.M., Morin, G.B., Chapman, K.B., Weinrich, S.L., Andrews, W.H., Lingner, J., Harley, C.B. and Cech, T.R. (1997) Telomerase catalytic subunit homologs from fission yeast and human. Science, 277, 955-959.
5. Meyerson, M., Counter, C.M., Eaton, E.N., Ellisen, L.W., Steiner, P., Caddle, S.D., Ziaugra, L., Beijersbergen, R.L., Davidoff, M.J., Liu, Q. et al. (1997) hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell, 90, 785-795.
6. Lingner, J., Hughes, T.R., Shevchenko, A., Mann, M., Lundblad, V. and Cech, T.R. (1997) Reverse transcriptase motifs in the catalytic subunit of telomerase. Science, 276, 561-567.
7. Greider, C.W. and Blackburn, E.H. (1987) The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell, 51, 887-898.
8. Collins, K. and Gandhi, L. (1998) The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex. Proc. Natl Acad. Sci. USA, 95, 8485-8490.
9. Fitzgerald, M.S., Riha, K., Gao, F., Ren, S., McKnight, T.D. and Shippen, D.E. (1999) Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA. Proc. Natl Acad. Sci. USA, 96, 14813-14818.
10. Oguchi, K., Liu, H., Tamura, K. and Takahashi, H. (1999) Molecular cloning and characterization of AtTERT, a telomerase reverse transcriptase homolog in Arabidopsis thaliana. FEBS Lett., 457 465-469.
11. Smogorzewska, A. and de Lange, T. (2004) Regulation of telomerase by telomeric proteins. Annu. Rev. Biochem., 73, 177-208.
12. Watson, J.D. (1972) Origin of concatemeric T7 DNA. Nature New Biol. 239, 197-201.
13. Harley, C.B., Futcher, A.B. and Greider, C.W. (1990) Telomeres shorten during ageing of human fibroblasts. Nature, 345, 458-460.
14. Makarov, V.L., Hirose, Y. and Langmore, J.P. (1997) Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell, 88, 657-666.
15. Huffman, K.E., Levene, S.D., Tesmer, V.M., Shay, J.W. and Wright, W.E. (2000) Telomere shortening is proportional to the size of the G-rich telomeric 3′-overhang. J. Biol. Chem., 275, 19719-19722.
16. Karlseder, J., Smogorzewska, A. and de Lange, T. (2002) Senescence induced by altered telomere state, not telomere loss. Science, 295, 2446-2449.
17. Wong, K.K., Maser, R.S., Bachoo, R.M., Menon, J., Carrasco, D.R., Gu, Y., Alt, F.W. and DePinho, R.A. (2003) Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature, 421, 643-648.
18. de Lange, T. (1994) Activation of telomerase in a human tumor. Proc. Natl Acad. Sci. USA, 91, 2882-2885.
19. Counter, C.M., Hirte, H.W., Bacchetti, S. and Harley, C.B. (1994) Telomerase activity in human ovarian carcinoma. Proc. Natl Acad. Sci. USA, 91, 2900-2904.
20. Kim, N.W., Piatyszek, M.A., Prowse, K.R., Harley, C.B., West, M.D., Ho, P.L., Coviello, G.M., Wright, W.E., Weinrich, S.L. and Shay, J.W. (1994) Specific association of human telomerase activity with immortal cells and cancer. Science, 266, 2011-2015.
21. Sharpless, N.E. and DePinho, R.A. (2004) Telomeres, stem cells, senescence, and cancer. J. Clin. Invest., 113, 160-168.
22. Hide, G. (1999) History of sleeping sickness in East Africa. Clin. Microbiol. Rev., 12, 112-125.
23. De Lange, T. and Borst, P. (1982) Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosome. Nature, 299, 451-453.
24. Bernards, A., Van der Ploeg, L.H., Frasch, A.C., Borst, P., Boothroyd, J.C., Coleman, S. and Cross, G.A.M. (1981) Activation of trypanosome surface glycoprotein genes involves a duplication-transposition leading to an altered 3′ end. Cell, 27, 497-505.
25. Navarro, M. and Cross, G.A. (1996) DNA rearrangements associated with multiple consecutive directed antigenic switches in Trypanosoma brucei. Mol. Cell. Biol., 16, 3615-3625.
26. Doyle, J.J., Hirumi, H., Hirumi, K., Lupton, E.N. and Cross, G.A.M. (1980) Antigenic variation in clones of animal-infective Trypanosoma brucei derived and maintained in vitro. Parasitology, 80, 359-369.
27. Hirumi, H. and Hirumi, K. (1989) Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers. J. Parasitol., 75, 985-989.
28. Wirtz, E., Leal, S., Ochatt, C. and Cross, G.A.M. (1999) A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei. Mol. Biochem. Parasitol., 99, 89-101.
29. Munoz-Jordan, J.L., Cross, G.A., de Lange, T. and Griffith, J.D. (2001) t-loops at trypanosome telomeres. EMBO J., 20, 579-588.
30. Horn, D. and Cross, G.A. (1997) Position-dependent and promoter-specific regulation of gene expression in Trypanosoma brucei. EMBO J., 16, 7422-7431.
31. Wellinger, R.J., Wolf, A.J. and Zakian, V.A. (1993) Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase. Cell, 72, 51-60.
32. Cimino-Reale, G., Pascale, E., Alvino, E., Starace, G. and D'Ambrosio, E. (2003) Long telomeric C-rich 5′-tails in human replicating cells. J. Biol. Chem., 278, 2136-2140.
33. Griffith, J.D., Comeau, L., Rosenfield, S., Stansel, R.M., Bianchi, A., Moss, H. and de Lange, T. (1999) Mammalian telomeres end in a large duplex loop. Cell, 97, 503-514.
34. Stevens, J.R. and Gibson, W. (1999) The molecular evolution of trypanosomes. Parasitol. Today, 15, 432-437.
35. Bernards, A., Michels, P.A., Lincke, C.R. and Borst, P. (1983) Growth of chromosome ends in multiplying trypanosomes. Nature, 303, 592-597.
36. Pays, E., Laurent, M., Delinte, K., Van Meirvenne, N. and Steinert, M. (1983) Differential size variations between transcriptionally active and inactive telomeres of Trypanosoma brucei. Nucleic Acids Res., 11, 8137-8147.
37. Van der Ploeg, L.H., Liu, A.Y. and Borst, P. (1984) Structure of the growing telomeres of Trypanosomes. Cell, 36, 459-468.
38. Horn, D., Spence, C. and Ingram, A.K. (2000) Telomere maintenance and length regulation in Trypanosoma brucei. EMBO J., 19, 2332-2339.
39. Lundblad, V. and Szostak, J.W. (1989) A mutant with a defect in telomere elongation leads to senescence in yeast. Cell, 57, 633-643.
40. Singer, M.S. and Gottschling, D.E. (1994) TLC1: Template RNA component of Saccharomyces cerevisiae telomerase. Science, 266, 404-409.
41. Larrivee, M., LeBel, C. and Wellinger, R.J. (2004) The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex. Genes Dev., 18, 1391-1396.
42. Horn, D. and Cross, G.A.M. (1997) Analysis of Trypanosoma brucei vsg expression site switching in vitro. Mol. Biochem. Parasitol., 84, 189-201.
43. Li, B. and Lustig, A.J. (1996) A novel mechanism for telomere size control in Saccharomyces cerevisiae. Genes Dev., 10, 1310-1326.
44. Li, B. and de Lange, T. (2003) Rap1 affects the length and heterogeneity of human telomeres. Mol. Biol. Cell, 14, 5060-5068.
45. Riha, K., McKnight, T.D., Fajkus, J., Vyskot, B. and Shippen, D.E. (2000) Analysis of the G-overhang structures on plant telomeres: evidence for two distinct telomere architectures. Plant J., 23 633-641.
46. Cesare, A.J., Quinney, N., Willcox, S., Subramanian, D. and Griffith, J.D. (2003) Telomere looping in P. sativum (common garden pea). Plant J., 36, 271-279.
47. Murti, K.G. and Prescott, D.M. (1999) Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops. Proc. Natl Acad. Sci. USA, 96, 14436-14439.
48. Stansel, R.M., de Lange, T. and Griffith, J.D. (2001) T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang. EMBO J., 20, 5532-5540.
49. Vanhamme, L., Poelvoorde, P., Pays, A., Tebabi, P., Van Xong, H. and Pays, E. (2000) Differential RNA elongation controls the variant surface glycoprotein gene expression sites of Trypanosoma brucei. Mol. Microbiol., 36, 328-340.
50. McEachern, M.J. and Iyer, S. (2001) Short telomeres in yeast are highly recombinogenic. Mol. Cell, 7, 695-704.