The ERK1/2 pathway regulates testosterone synthesis by coordinately regulating the expression of steroidogenic genes in Leydig cells

Molecular and Cellular Endocrinology

Volumn 370, Issue 1-2, 2013, Pages 130-137

  Matzkin, Maria Eugenia ^a,b   Yamashita, Soichi ^a   Ascoli, Mario ^a  

^a UNIVERSITY OF IOWA   (United States)

^b INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

Author keywords

Androgens; Leydig cells; Luteinizing hormone; MAP kinase (ERK); MAPK kinase (MEK); Steroidogenesis

Indexed keywords

CHOLESTEROL; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NUCLEAR RECEPTOR DAX 1; TESTOSTERONE;

ANDROGEN METABOLISM; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CREB1 GENE; CYP11A1 GENE; CYP17A1 GENE; DHRS9 GENE; DOWN REGULATION; GENE; GENE DELETION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; HSD17B3 GENE; HSD3B6 GENE; LEYDIG CELL; MALE; MAPK KINASE 1 GENE; MAPK KINASE 2 GENE; MOUSE; NONHUMAN; NR0B1 GENE; NR5A1 GENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SRDA1 GENE; STAR GENE; TESTOSTERONE SYNTHESIS; WESTERN BLOTTING;

ANDROGENS; ANDROSTENEDIONE; ANIMALS; CELLS, CULTURED; CHOLESTEROL; DIHYDROTESTOSTERONE; GENE EXPRESSION; GENOTYPE; HYPOGONADISM; LEYDIG CELLS; MALE; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; PROGESTERONE; TESTOSTERONE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84876386472     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2013.02.017     Document Type: Article

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